Person: ŞENOL, HALIL
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Publication Metadata only Synthesis of new hydrazide-hydrazone derivatives of salicylic acid as potential anti-inflammatory agents(2022-10-12T00:00:00Z) Şenol, Halil; ŞENOL, HALILPublication Open Access Synthesis of oleanolic acid hydrazide-hydrazone hybrid derivatives and investigation of their cytotoxic effects on A549 human lung cancer cells(2022-01-01T00:00:00Z) Şenol, Halil; Mercümek, Berre; Şahin, Rabia Büşra; Kapucu, Halil Burak; Hacıosmanoğlu, Ebru; ŞENOL, HALIL; MERCÜMEK, BERRE; HACIOSMANOĞLU, EBRUPublication Metadata only Synthesis and Structure Elucidation of Potential Bioactive Some Novel Triterpene-Triazole-Arylidenehydrazide Hybrid Compounds(2022-10-12T00:00:00Z) Şenol, Halil; ŞENOL, HALILPublication Open Access Synthesis of ursolic acid arylidene-hydrazide hybrid compounds and investigation of their cytotoxic and antimicrobial effects(2022-03-01T00:00:00Z) Şenol, Halil; Mercümek, Berre; Kapucu, Halil Burak; Hacıosmanoğlu, Ebru; Dinç, Harika Öykü; Yüksel Mayda, Pelin; ŞENOL, HALIL; MERCÜMEK, BERRE; HACIOSMANOĞLU, EBRU; DİNÇ, HARİKA ÖYKÜPublication Metadata only Synthesis of new fatty acid derivatives of oleanane and ursane triterpenoids and investigation of their in vitro cytotoxic effects on 3T3 fibroblast and PC3 prostate cancer cell lines(2020-09-01T00:00:00Z) Şenol, Halil; Çokuludağ, Kübra; Aktaş, Asude Sena; Atasoy, Sezen; Dağ, Aydan; Topçu, Gülaçtı; ŞENOL, HALIL; ATASOY, SEZEN; DAĞ, AYDAN; TOPÇU, GÜLAÇTIPublication Metadata only Grateloupia turuturu ekstrelerinin anti-bakteriyel ve anti-fungal aktivitesi(2022-06-11T00:00:00Z) Zengin, Begüm; Dinç, Harika Öykü; Şenol, Halil; ALİM TORAMAN, GÜLBAHAR ÖZGE; DİNÇ, HARİKA ÖYKÜ; ŞENOL, HALILPublication Metadata only Investigation of the potential use of Euphorbia latex as an insecticide in biological control against Dendroctonus micans(2021-06-01T00:00:00Z) Gülmez, Özlem; Albayrak İskender, Nurcan; Şenol, Halil; Algur, Ömer Faruk; ŞENOL, HALILPublication Open Access Natural Alkaloids as Potential Anti-Coronavirus Compounds(2020-12-01T00:00:00Z) Topçu, Gülaçtı; Şenol, Halil; Alim Toraman, Gülbahar Özge; Altan, Vecdi Melih; TOPÇU, GÜLAÇTI; ŞENOL, HALIL; ALİM TORAMAN, GÜLBAHAR ÖZGE; ALTAN, VECDİ MELİHCoronaviruses are causative agents of the last three epidemics/pandemic; Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) and the last one Severe Acute Respiratory Syndrome-Cov-2 (SARS-CoV-2). Although meta-analysis of treatment studies against these three coronaviruses found no clear benefit of any spesific regimen, currently, remdesivir and favipiravir are promising potential therapies for SARS-CoV-2. On the other hand, since natural products have always played a crucial role in drug discovery and development process against various diseases, many groups in the world, are now trying to find new or repurposed natural or naturally originated drugs against viruses and coronaviruses. Secondary metabolites of the plants, particularly alkaloids and terpenoids have been exhibited strong antimicrobial and anticancer activities besides synthetic drugs and other natural compounds (nucleosides and nucleotides and bacterial and fungi originated ones). The first isolated secondary metabolites have been converted into important drugs since 1800’s such as morphine, codeine, cocaine, and quinine have alkaloid skeleton as well as some of the recent anticancer drugs vinblastine, vincristine, taxol, etc. This review includes the last two decades of publications about natural alkaloids rather than their plant extracts which showed some promising results against coronaviruses. Marine organisms are also another rich source to discover new lead drugs, however they were excluded in the present review article.