Person: COŞKUN, HALIL
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Publication Metadata only The effects of different mechanisms on the development of post-ERCP pancreatitis in an ERCP model in rats(2013-12-01T00:00:00Z) Bozkurt, SÜLEYMAN; GUNER, Ali; Kadioglu, HÜSEYİN; KECE, Can; REIS, Erhan; COSKUN, HALİL; BOZKURT, SÜLEYMAN; KADIOĞLU, HÜSEYİN; COŞKUN, HALILBackground/aims: To investigate the effects of different mechanisms on the development of pancreatitis after endoscopic retrograde cholangiopancreatography. Material and Methods: 40 male rats were randomly divided into four groups. After laparotomy, in Group 1, only duodenum was reached by a 24G cannula without performing any other procedure. In Groups 2, 3, and 4, biliopancreatic duct was cannulated transduodenally. Group 2 received no additional intervention after the cannulation. Group 3 received saline, whereas Group 4 received contrast agent into the duct. After a period of 24 hours, all rats were sacrificed. Laboratory tests for blood samples were performed and pancreatic tissue was also evaluated histopathologically. Results: Leukocyte, blood sugar, serum glutamic oxaloacetic transaminase, lactate dehydrogenase, amylase, C-reactive protein, and base excess parameters were evaluated. The values in Groups 2, 3, and 4 were found to be significantly higher than those in the control group, except for leukocyte count and base excess (p=0.551, p=0.031, p=0.0001, p=0.0001, p=0.0001, p=0.0001, p=0.683, respectively). Histopathological results demonstrated significant differences between the groups. Highest pathological damage scores were observed in Groups 3 and 4. Conclusion: Among different theories for the pathogenesis of post-endoscopic retrograde cholangiopancreatography pancreatitis, elevated intraductal hydrostatic pressure was observed to be the main underlying cause.Publication Open Access Remission of ulcerated necrobiosis lipoidica diabeticorum after bariatric surgery.(2013-01-01) BOZKURT, SÜLEYMAN; COSKUN, HALİL; Kadioglu, HÜSEYİN; MEMMI, NAİM; CIPE, G; ERSOY, YELİZ EMİNE; LEBE, B; MUSLUMANOGLU, M; BOZKURT, SÜLEYMAN; COŞKUN, HALIL; KADIOĞLU, HÜSEYİN; MEMMİ, NAİM; ERSOY, YELIZ EMINEA 32-year-old woman with type 2 diabetes mellitus suffering from morbid obesity with BMI 45,14 kg/m2 was operated on. Not only the type 2DM but also one of its complication known as necrobiosis lipoidica diabeticorum remitted postoperatively. Obesity should no longer be regarded simply as a cosmetic problem affecting certain individuals but an epidemic that threatens global well-being. It causes or exacerbates many health problems, and in particular, it is associated with the type 2 diabetes. Necrobiosis lipoidica is a granulomatous skin disease of unknown etiology, associated mainly with diabetes mellitus. We presented in this paper a morbid obese case of necrobiosis lipoidica diabeticorum with dramatic good response to bariatric surgery.Publication Metadata only Effect of probiotic supplementation after laparoscopic sleeve gastrectomy on constipation and gastrointestinal quality of life(2021-12-01T00:00:00Z) Yıldız, Nida; Baş, Murat; Coşkun, Halil; Batar, Nazlı; Yardımcı, Erkan; COŞKUN, HALIL; YARDIMCI, ERKANAim: In this study, we aimed to investigate the early effect of probiotic supplementation after Laparoscopic Sleeve Gastrectomy (LSG) on constipation and gastrointestinal quality of life compared to control group. Methods: This study was a prospective, randomized clinical trial. Participants were recruited to Bariatriklab Obesity and Metabolic Surgery Center for LSG. All patients were divided into 2 groups as probiotic and control by using simple randomization. The probiotic group consumed Bifidobacterium animalis lactis BB-12 strain as a probiotic supplement during 6 weeks after LSG. Gastrointestinal Symptom Rating Scale (GSRS), Constipation Severity Instrument (CSI), Patient Assessment of Constipation Quality of Life Scale (PAC-QOL), Bristol Stool Form Scale (BSFS), Gastrointestinal Quality of Life Index (GIQLI) of the patients were recorded before LSG and at the 2nd, 4th, 6th weeks after LSG. Results: The probiotic group had an average age of 37.00±8.92 years (18 female, 12 male), the control group had an average age of 41.03±11.29 years (23 female, 7 male). CSI (16.50 ± 14.76 vs. 31.37 ± 15.34), PAC-QOL (58.53 ± 12.59 vs 72.30 ± 19.70), GSRS (26.83 ± 9.14 vs. 37.93 ± 16.59) and total score mean were lower compared to the control group, GIQLI total score average (147.50 ± 11.79 vs 136.87 ± 18.98) was found higher (p <0.05) in probiotic group. Conclusions: Probiotic supplementationimproved the constipation and gastrointestinal quality of life in the early post LSG-period in the brobiotic group compared to the control group.Publication Open Access Single Incision Laparoscopic Cholecystectomy in situs Inversus Totalis.(2012-07-01T00:00:00Z) BOZKURT, SÜLEYMAN; COSKUN, HALİL; ATAK, T; Kadioglu, HÜSEYİN; BOZKURT, SÜLEYMAN; COŞKUN, HALIL; KADIOĞLU, HÜSEYİNPublication Open Access Effect of the -Recruitment- Maneuver on Respiratory Mechanics in Laparoscopic Sleeve Gastrectomy Surgery(2020-03-23T04:00:00Z) SÜMER, İSMAİL; Topuz, Ufuk; Alver, Selcuk; Umutoglu, Tarik; Bakan, Mefkur; ZENGİN, SENİYYE ÜLGEN; COŞKUN, Halil; SALİHOĞLU, Ziya; SÜMER, İSMAİL; COŞKUN, HALILPurpose LSG surgery is used for surgical treatment of morbid obesity. Obesity, anesthesia, and pneumoperitoneum cause reduced pulmoner functions and a tendency for atelectasis. The alveolar -recruitment- maneuver (RM) keeps airway pressure high, opening alveoli, and increasing arterial oxygenation. The aim of our study is to research the effect on respiratory mechanics and arterial blood gases of performing the RM in LSG surgery. Materials and Methods Sixty patients undergoing LSG surgery were divided into two groups (n = 30) Patients in group R had the RM performed 5 min after desufflation with 100% oxygen, 40 cmH(2)O pressure for 40 s. Group C had standard mechanical ventilation. Assessments of respiratory mechanics and arterial blood gases were made in the 10th min after induction (T1), 10th min after insufflation (T2), 5th min after desufflation (T3), and 15th min after desufflation (T4). Arterial blood gases were assessed in the 30th min (T5) in the postoperative recovery unit. Results In group R, values at T5, PaO2 were significantly high, while PaCO2 were significantly low compared with group C. Compliance in both groups reduced with pneumoperitoneum. At T4, the compliance in the recruitment group was higher. In both groups, there was an increase in PIP with pneumoperitoneum and after desufflation this was identified to reduce to levels before pneumoperitoneum. Conclusion Adding the RM to PEEP administration for morbidly obese patients undergoing LSG surgery is considered to be effective in improving respiratory mechanics and arterial blood gas values and can be used safely.