Person: TAŞLIDERE, ELİF
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Publication Metadata only Therapeutic effects of melatonin and quercetin on carbon tetrachloride-induced cardiac damage in rats(2016-03-01) ELBE, HÜLYA; EŞREFOĞLU, MUKADDES; CETIN, A; TAŞLIDERE, ELİF; ATES, BURHAN; EŞREFOĞLU, MUKADDES; TAŞLIDERE, ELİFPublication Metadata only Ascorbic acid and beta-carotene reduce stress-induced oxidative organ damage in rats.(2016-10-01) Esrefoglu, MUKADDES; AKINCI, A; TASLIDERE, ELİF; ELBE, H; CETIN, A; ATES, B; EŞREFOĞLU, MUKADDES; TAŞLIDERE, ELİFPublication Metadata only The effects of pentoxifylline and caffeic acid phenethyl ester in the treatment of d-galactosamine-induced acute hepatitis in rats.(2016-04-01) TASLIDERE, ELİF; VARDI, N; Esrefoglu, MUKADDES; ATES, B; TASKAPAN, C; YOLOGLU, S; TAŞLIDERE, ELİF; EŞREFOĞLU, MUKADDESPublication Metadata only The protective effect of melatonin in lungs of newborn rats exposed to maternal nicotine.(2018-01-01) YILDIZ, A; VARDI, N; KARAASLAN, MG; ATES, B; TASLIDERE, ELİF; Esrefoglu, MUKADDES; TAŞLIDERE, ELİF; EŞREFOĞLU, MUKADDESPublication Open Access Development of Liver and Pancreas(2017-01-01) EŞREFOĞLU, MUKADDES; TAŞLIDERE, ELİF; CETIN, ASLI; EŞREFOĞLU, MUKADDES; TAŞLIDERE, ELİFPublication Metadata only Melatonin, quercetin and resveratrol attenuates oxidative hepatocellular injury in streptozotocin-induced diabetic rats.(2015-09-01) ELBE, H; Esrefoglu, MUKADDES; VARDI, N; TASLIDERE, ELİF; OZEROL, E; TANBEK, K; EŞREFOĞLU, MUKADDES; TAŞLIDERE, ELİFPublication Open Access Development of the Esophagus and Stomach(2017-10-01) Esrefoglu, MUKADDES; Taslidere, ELİF; Cetin, Asli; EŞREFOĞLU, MUKADDES; TAŞLIDERE, ELİFEpithelial components of the organs of the digestive system are derived from the endoderm, whereas connective tissue and muscle components are derived from the mesoderm. At the 3rd-4th week of development, as a result of cephalocaudal and lateral foldings of the embryo, a portion of the endoderm-lined yolk sac cavity is incorporated in the embryo to form the primitive gut. Primitive gut is composed of four main regions: pharyngeal gut, foregut, midgut, and hindgut. The esophagus and stomach are derived from the foregut. The development of the esophagus is characterized by lengthening, widening, thickening, and histological changes. The development of the stomach is characterized by widening, thickening, and histological changes as well as positional changes. In the present study, we tried to review the morphological and functional development of the esophagus and stomach with the aid of pictures obtained from various stages of prenatal and postnatal development of the organs of rats. Previous reviews lack information on both histological and functional development of the organs.Publication Open Access Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats(2014-01-01T00:00:00Z) Esrefoglu, MUKADDES; AKINCI, Aysin; Elbe, Hulya; TAŞLIDERE, ELİF; Cetin, Asli; ATEŞ, BURHAN; EŞREFOĞLU, MUKADDES; TAŞLIDERE, ELİFIn the present study, we tried to investigate the effects of melatonin, a novel antioxidant and a potent free radical scavenger, in stress-induced cerebral, cerebellar, cardiac, and hepatic oxidative damage using microscopic and biochemical analysis. A total of 32 male Wistar albino rats were divided into control, stress, stress + saline, and stress + melatonin groups. The rats from the stress groups were exposed to high stress conditions of starvation, immobilization, and cold exposure. The rats from the stress + melatonin group received melatonin daily at 20 mg/kg body weight intraperitoneally for 7 days. At the end of the experiment, the brain, cerebellum, heart, and liver were rapidly removed. The main histopathological damage scores (MHDSs) of the stress and stress + saline groups were higher than those of control group for all of the organs. The MHDSs of melatonin-administered group were lower than those of stress and stress + saline groups. The main tissue superoxide dismutase activities of the stress + melatonin group were even higher than those of the control group in the cerebellum and liver, and main tissue catalase activities of the stress + melatonin group were even higher than those of control group in all of the organs. As a conclusion, we found melatonin very effective in reducing stress-induced organ damage by inhibiting lipid peroxidation and supporting the cellular antioxidant defense system.Publication Metadata only Retikulum hücreleri(2012-05-01) TAŞLIDERE, ELİF; EŞREFOĞLU, MUKADDES; TAŞLIDERE, ELİF; EŞREFOĞLU, MUKADDESPublication Open Access Petroselinum Crispum is Effective in Reducing Stress-Induced Gastric Oxidative Damage.(2017-01-01) AKıNCı, Ayşin; Eşrefoğlu, MUKADDES; TASLIDERE, ELİF; ATES, B; EŞREFOĞLU, MUKADDES; TAŞLIDERE, ELİFBackground: Oxidative stress has been shown to play a principal role in the pathogenesis of stress-induced gastric injury. Parsley (Petroselinum crispum) contains many antioxidants such as flavanoids, carotenoids and ascorbic acid. Aims: In this study, the histopathological and biochemical results of nutrition with a parsley-rich diet in terms of eliminating stress-induced oxidative gastric injury were evaluated. Study design: Animal experimentation. Methods: Forty male Wistar albino rats were divided into five groups: control, stress, stress + standard diet, stress + parsley-added diet and stress + lansoprazole (LPZ) groups. Subjects were exposed to 72 hours of fasting and later immobilized and exposed to the cold at +4 degrees for 8 hours to create a severe stress condition. Samples from the animals' stomachs were arranged for microscopic and biochemical examinations. Results: Gastric mucosal injury was obvious in rats exposed to stress. The histopathologic damage score of the stress group (7.00±0.57) was higher than that of the control group (1.50±0.22) (p<0.05). Significant differences in histopathologic damage score were found between the stress and stress + parsley-added diet groups (p<0.05), the stress and stress + standard diet groups (p<0.05), and the stress and stress + LPZ groups (p<0.05). The mean tissue malondialdehyde levels of the stress + parsley-added group and the stress + LPZ group were lower than that of the stress group (p<0.05). Parsley supported the cellular antioxidant system by increasing the mean tissue glutathione level (53.31±9.50) and superoxide dismutase (15.18±1.05) and catalase (16.68±2.29) activities. Conclusion: Oral administration of parsley is effective in reducing stress-induced gastric injury by supporting the cellular antioxidant defence system.