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TAŞLIDERE, ELİF

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End date: 2016 × Start date: 2012 × Has files: true ×

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    PublicationOpen Access
    Role of endothelial nitric oxide synthases system on acute appendicitis
    (2016-07-01) TASLIDERE, BAHADIR; ŞENER, Elif Funda; Taslidere, ELİF; GUNAY, Nahide Ekici; BOL, Oguzhan; BULBUL, Emre; Aktas, Ramazan Sami; GÜNAY, Nurullah; TAŞLIDERE, BAHADIR; TAŞLIDERE, ELİF
    BACKGROUND: Obstruction and inflammation of the appendix lumen is the leading physiopathological process during acute appendicitis (AA). Although the relationship between inflammation and endothelial nitric oxide synthases (eNOS) has been well described, no recent data describing the relationship between inflammation during AA and polymorphism of the eNOS gene has been reported. Given the limited data available, we believed that defining the relationship between AA and eNOS would be a beneficial contribution. METHODS: A total of 201 patients admitted to the emergency department with AA and 201 healthy volunteers selected from among the relatives of patients were included. Polymorphism of the eNOS was assessed. RESULTS: Intron 4a/4a was positive in 119 participants, genotype G894T GT was positive in 71 patients with AA, and 786-1 was positive in 71 patients with AA. These results suggest that no statistically significant correlation exists between genotypes of AA patients and control subjects regarding 4a/b, G894-GT, and 786-1 eNOS polymorphisms. CONCLUSION: Though the present results suggest that no statistically significant correlation exists between AA and eNOS gene polymorphism, to claim otherwise is also impractical. We believe that the present results will lay the groundwork for future, larger studies.
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    PublicationOpen Access
    Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats
    (2014-01-01T00:00:00Z) Esrefoglu, MUKADDES; AKINCI, Aysin; Elbe, Hulya; TAŞLIDERE, ELİF; Cetin, Asli; ATEŞ, BURHAN; EŞREFOĞLU, MUKADDES; TAŞLIDERE, ELİF
    In the present study, we tried to investigate the effects of melatonin, a novel antioxidant and a potent free radical scavenger, in stress-induced cerebral, cerebellar, cardiac, and hepatic oxidative damage using microscopic and biochemical analysis. A total of 32 male Wistar albino rats were divided into control, stress, stress + saline, and stress + melatonin groups. The rats from the stress groups were exposed to high stress conditions of starvation, immobilization, and cold exposure. The rats from the stress + melatonin group received melatonin daily at 20 mg/kg body weight intraperitoneally for 7 days. At the end of the experiment, the brain, cerebellum, heart, and liver were rapidly removed. The main histopathological damage scores (MHDSs) of the stress and stress + saline groups were higher than those of control group for all of the organs. The MHDSs of melatonin-administered group were lower than those of stress and stress + saline groups. The main tissue superoxide dismutase activities of the stress + melatonin group were even higher than those of the control group in the cerebellum and liver, and main tissue catalase activities of the stress + melatonin group were even higher than those of control group in all of the organs. As a conclusion, we found melatonin very effective in reducing stress-induced organ damage by inhibiting lipid peroxidation and supporting the cellular antioxidant defense system.