Person: ELİBOL, BİRSEN
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Publication Metadata only Effects of fetal alcohol and maternal intubation stress on the expression of proteins controlling postnatal development of male rat hippocampus(2020-09-01T00:00:00Z) ELİBOL, BİRSEN; BEKER, MERVE; KILIÇ, ÜLKAN; Jakubowska-Dogru, Ewa; ELİBOL, BİRSEN; BEKER, MERVEBackground Developing brains can partially get over prenatal alcohol exposure-related detrimental conditions by activating some mechanisms involved in survival. Objectives This study aimed to shed light on the molecular correlates of compensatory mechanisms by examining temporal profiles in the expression of proteins controlling postnatal development in the rat hippocampus prenatally exposed to intubation stress/ethanol. Methods Male pups were randomly assigned to age subgroups (n = 21/age) which were sacrificed on postnatal day (PD)1, PD10, PD30, and PD60. Ethanol (6 g/kg/day) were intragastrically intubated to the dams throughout 7-21 gestation days. The expression of neurogenesis and angiogenesis markers, extracellular matrix proteins, and growth-promoting ligands were examined by western blot. Results The most rapid increase in the index of neuronal maturation was noted between PD10-PD30 (p< .05). Prenatal stress caused a decrease of neurogenesis markers at birth and an increase of their expressions at PD10 and PD30 to reach control levels (p< .001). The impact of fetal-alcohol was observed as a decrease in the expression of synaptic plasticity protein versican at birth (p< .001), an increase in the synaptic repulsion protein ephrin-B2 at PD10 (p< .001), and a decrease in the maturation of BDNF at PD30 (p< .001) with a decrease in the mature neuron markers at PD30 (p< .001) and PD60 (p= .005) which were compensated with upregulation of angiogenesis and increasing brevican expression, a neuronal maturation protein (p< .001). Conclusion These data providein vivoevidence for the potential therapeutic factors related to neurogenesis, angiogenesis, and neurite remodeling which may tolerate the alcohol/stress dependent teratogenicity in the developing hippocampus.Publication Metadata only Thymoquinone administration ameliorates Alzheimer-s disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta(1-42) infused rat model(2020-12-01T00:00:00Z) ELİBOL, BİRSEN; Beker, Merve; Terzioglu-Usak, Sule; Dalli, Tugce; Kilic, Ulkan; ELİBOL, BİRSEN; BEKER, MERVE; TERZİOĞLU, ŞULEBackground: Thymoquinone (TQ), a biologically active ingredient of Nigella sativa, has anti-inflammatory, antioxidative and neuroprotective properties. Therefore, it could be a good candidate in the recovery of Alzheimer-s disease (AD) pathology rather than current symptomatic reliefs.Publication Metadata only Perinatal dönemde farklı müzik türlerine maruz kalmanın genç yaştaki sıçanların motor aktiviteleri üzerine etkileri(2020-08-01T00:00:00Z) Elibol, Birsen; Beker, Merve; Kırpınar, İsmet; ELİBOL, BİRSEN; BEKER, MERVE; KIRPINAR, İSMETPublication Metadata only Wistar sıçanlarda nörogenezden sorumlu dentate girus bölgesindeki granül hücrelerinin yaşa bağlı morfolojik ve fizyolojik değişimleri(2020-11-09T00:00:00Z) Dursun, İlknur; Elibol, Birsen; ELİBOL, BİRSENPublication Open Access Chemopreventive efficacy of stampidine in a murine breast cancer model(2020-02-07T00:00:00Z) Sahin, Kazim; Orhan, Cemal; Ozercan, Ibrahim Hanifi; Tuzcu, Mehmet; ELİBOL, BİRSEN; ŞAHİN, TAHA KORAY; Kilic, Ulkan; Qazi, Sanjive; Uckun, Fatih Mehmet; ELİBOL, BİRSENBackground: The purpose of the present study was to examine the chemopreventive effect of stampidine, an aryl phosphate derivative of stavudine, in side by side comparison with the standard anti-breast cancer drug paclitaxel in the well-established 7,12-dimethylbenz(a)anthracene (DMBA)-induced murine breast cancer model. Methods: Groups of 20 female mice were challenged with the DMBA. DMBA-challenged mice were assigned to various chemoprevention treatments, including stampidine, paclitaxel, and stampidine plus paclitaxel according to the same treatment schedules for 25 weeks. Results: Stampidine resulted in substantially reduced numbers of tumors, tumor weight as well as tumor size in DMBA-treated mice. Stampidine was as effective as paclitaxel in the model and their combination exhibited greater chemopreventive activity, as measured by reduced tumor incidence and improved tumor-free survival as well as overall survival of DMBA-treated mice. The length of time for the initial tumor to appear in DMBA-challenged mice treated with stampidine was longer than that of mice treated DMBA-challenged control mice. Tumors from mice treated with stampidine or stampidine plus paclitaxel displayed unique changes of a signature protein cassette comprised BRCA1, p21, Bax, and Bcl-2. Conclusion: Stampidine has potent chemopreventive activity and is as effective as the standard chemotherapy drug paclitaxel in the chemical carcinogenesis.Publication Metadata only Investigation of Inflammatory Cytokines and Response to Treatment in Patients With Obsessive- Compulsive Disorder(2020-05-01T00:00:00Z) Şahbaz, Çiğdem Dilek; Terzioglu Usak, Sule; Döner, Çağıl; Elibol, Birsen; TERZİOĞLU, ŞULE; ELİBOL, BİRSENPublication Metadata only Effects of music on stress-induced hormones and oxidative stress levels(2020-09-01T00:00:00Z) Elibol, Birsen; ELİBOL, BİRSENPublication Open Access Unraveling the Role of Inwardly Rectifying Potassium Channels in the Hippocampus of an Aβ<sub>(1-42)</sub>-Infused Rat Model of Alzheimer-s Disease.(2020-03-13T00:00:00Z) Akyuz, E; Villa, C; Beker, M; Elibol, BİRSEN; ELİBOL, BİRSENPublication Metadata only Anvirzel<sup>TM</sup>regulates cell death through inhibiting GSK-3 activity in human U87 glioma cells.(2020-01-01T00:00:00Z) Ozek, E; Terzioglu-Usak, Şule; Nalli, A; Elibol, Birsen; Hatiboglu, MUSTAFA AZİZ; TERZİOĞLU, ŞULE; ELİBOL, BİRSEN; ÖZEK, ERDİNÇ; HATİBOĞLU, MUSTAFA AZİZ