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ELİBOL, BİRSEN

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BİRSEN
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ELİBOL
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Item Type: Publication × Start date: 2020 × End date: 2022 ×

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Now showing 1 - 10 of 25
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    What Inflammasomes Tell Us About Multiple Sclerosis
    (2021-06-04T00:00:00Z) Hocaoğlu, Nisa; Gürsoy, Azize Esra; Elibol, Birsen; Korkmaz, Nur Damla; Karakayali, Zehra Cemre; GÜRSOY, AZIZE ESRA; ELİBOL, BİRSEN; KORKMAZ, NUR DAMLA
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    Atak ve iyileşmelerle giden multiple skleroz hastalığında inflamazomların değerlendirilmesi
    (2021-10-29T00:00:00Z) Korkmaz, Nur Damla; Elibol, Birsen; Gürsoy, Azize Esra; KORKMAZ, NUR DAMLA; ELİBOL, BİRSEN; GÜRSOY, AZIZE ESRA
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    Delayed Therapeutic Administration of Melatonin Enhances Neuronal Survival Through AKT and MAPK Signaling Pathways Following Focal Brain Ischemia in Mice
    (2022-03-01T00:00:00Z) Kilic, Ulkan; ELİBOL, BİRSEN; ÇAĞLAYAN, AHMET BURAK; Beker, Mustafa Caglar; Beker, Merve; Altug-Tasa, Burcugul; UYSAL, ÖMER; YILMAZ, BAYRAM; KILIÇ, ERTUĞRUL; ELİBOL, BİRSEN
    Melatonin has a role in the cell survival signaling pathways as a candidate for secondary stroke prevention. Therefore, in the present study, the coordination of ipsilateral and contralateral hemispheres to evaluate delayed post-acute effect of melatonin was examined on recovery of the cell survival and apoptosis after stroke. Melatonin was administered (4 mg/kg/day) intraperitoneally for 45 days, starting 3 days after 30 min of middle cerebral artery occlusion. The genes and proteins related to the cell survival and apoptosis were investigated by immunofluorescence, western blotting, and RT-PCR techniques after behavioral experiments. Melatonin produced delayed neurological recovery by improving motor coordination on grip strength and rotarod tests. This neurological recovery was also reflected by high level of NeuN positive cells and low level of TUNEL-positive cells suggesting enhanced neuronal survival and reduced apoptosis at the fifty-fifth day of stroke. The increase of NGF, Nrp1, c-jun; activation of AKT; and dephosphorylation of ERK and INK at the fifty-fifth day showed that cell survival and apoptosis signaling molecules compete to contribute to the remodeling of brain. Furthermore, an increase in the CREB and Atf-1 expressions suggested the melatonin-s strong reformative effect on neuronal regeneration. The contralateral hemisphere was more active at the latter stages of the molecular and functional regeneration which provides a further proof of principle about melatonin-s action on the promotion of brain plasticity and recovery after stroke.
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    Inflammatory Cytokines are in Action: Brain Plasticity and Recovery after Brain Ischemia Due to Delayed Melatonin Administration.
    (2021-09-18T00:00:00Z) Kilic, Ulkan; Elibol, BİRSEN; Beker, Merve; Altug-Tasa, Burcugul; Caglayan, Ahmet Burak; Beker, Mustafa Caglar; Yilmaz, Bayram; Kilic, Ertugrul; ELİBOL, BİRSEN
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    Moleküler Biyoloji Güncel Araştırma Teknikleri
    (2022-04-01T00:00:00Z) Korkmaz, Nur Damla; Elibol, Birsen; KORKMAZ, NUR DAMLA; ELİBOL, BİRSEN
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    Effects of fetal alcohol and maternal intubation stress on the expression of proteins controlling postnatal development of male rat hippocampus
    (2020-09-01T00:00:00Z) ELİBOL, BİRSEN; BEKER, MERVE; KILIÇ, ÜLKAN; Jakubowska-Dogru, Ewa; ELİBOL, BİRSEN; BEKER, MERVE
    Background Developing brains can partially get over prenatal alcohol exposure-related detrimental conditions by activating some mechanisms involved in survival. Objectives This study aimed to shed light on the molecular correlates of compensatory mechanisms by examining temporal profiles in the expression of proteins controlling postnatal development in the rat hippocampus prenatally exposed to intubation stress/ethanol. Methods Male pups were randomly assigned to age subgroups (n = 21/age) which were sacrificed on postnatal day (PD)1, PD10, PD30, and PD60. Ethanol (6 g/kg/day) were intragastrically intubated to the dams throughout 7-21 gestation days. The expression of neurogenesis and angiogenesis markers, extracellular matrix proteins, and growth-promoting ligands were examined by western blot. Results The most rapid increase in the index of neuronal maturation was noted between PD10-PD30 (p< .05). Prenatal stress caused a decrease of neurogenesis markers at birth and an increase of their expressions at PD10 and PD30 to reach control levels (p< .001). The impact of fetal-alcohol was observed as a decrease in the expression of synaptic plasticity protein versican at birth (p< .001), an increase in the synaptic repulsion protein ephrin-B2 at PD10 (p< .001), and a decrease in the maturation of BDNF at PD30 (p< .001) with a decrease in the mature neuron markers at PD30 (p< .001) and PD60 (p= .005) which were compensated with upregulation of angiogenesis and increasing brevican expression, a neuronal maturation protein (p< .001). Conclusion These data providein vivoevidence for the potential therapeutic factors related to neurogenesis, angiogenesis, and neurite remodeling which may tolerate the alcohol/stress dependent teratogenicity in the developing hippocampus.
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    Aspects of Psychological Stress in Success of Parathyroid Allotransplantation
    (2022-03-01T00:00:00Z) Terzioğlu-Uşak, Şule; Elibol, Birsen; Ayşan, Erhan; ELİBOL, BİRSEN
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    Mide kanserli hastalarda PTCH1 genindeki epigenetik değişimlerin araştırılması ve bu değişimlerin gen ve protein miktarları üzerindeki etkisi
    (2022-07-05T00:00:00Z) Matpan, Erce; Toruntay, Ceyhun; Fırtına, Sinem; Akçakaya, Adem; Elibol, Birsen; TORUNTAY, CEYHUN; AKÇAKAYA, ADEM; ELİBOL, BİRSEN
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    Thymoquinone administration ameliorates Alzheimer-s disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta(1-42) infused rat model
    (2020-12-01T00:00:00Z) ELİBOL, BİRSEN; Beker, Merve; Terzioglu-Usak, Sule; Dalli, Tugce; Kilic, Ulkan; ELİBOL, BİRSEN; BEKER, MERVE; TERZİOĞLU, ŞULE
    Background: Thymoquinone (TQ), a biologically active ingredient of Nigella sativa, has anti-inflammatory, antioxidative and neuroprotective properties. Therefore, it could be a good candidate in the recovery of Alzheimer-s disease (AD) pathology rather than current symptomatic reliefs.
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    The structural effects of Vitamin A deficiency on biological macromolecules due to ethanol consumption and withdrawal: An FTIR study with chemometrics
    (2022-04-01T00:00:00Z) DURSUN, İLKNUR; Severcan, Mete; Jakubowska-Dogru, Ewa; Severcan, Feride; ELİBOL, BİRSEN
    The structural effects of vitamin A-deficiency were examined on the molecular profiles of biomolecules of male rat hippocampus during prolonged ethanol intake/withdrawal using FT-IR spectroscopy coupled with chemometrics. Liquid ethanol diet with/without vitamin A was maintained to adult rats for 3-months. The rats were decapitated at different ethanol withdrawal times and FT-IR spectra were obtained. Ethanol consumption/withdrawal produced significant changes in proteins- conformations, while having insignificant structural effects on lipids. In vitamin A deficiency, ethanol produced structural changes in lipids by lipid ordering especially in the early-ethanol withdrawal. Furthermore, an increase in lipid and protein content, saturated/unsaturated lipid ratio, a decrease in nucleic acids content and decrease in membrane fluidity were observed. These changes were less severe in the presence of Vitamin A. This study is clinically important for individuals with vitamin A deficiency because they have to be more cautious when consuming alcohol to protect themselves from cognitive dysfunctions.