Person: ELİBOL, BİRSEN
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Publication Metadata only Association of reelin silencing and topo isomerase IIβ expression in human SH-SY5Y neuroblastoma cell line(2019-09-07) TERZİOĞLU UŞAK, ŞULE; BEKER, MERVE; ELİBOL, BİRSEN; TERZİOĞLU, ŞULE; ELİBOL, BİRSEN; BEKER, MERVEPublication Metadata only Farklı Türde Uygulanmış Stresin Sıçanların HPA Ekseni ve Paratiroid Hormon Düzeyleri Üzerindeki Etkileri(2018-06-22) ELİBOL, BİRSEN; TERZİOĞLU, ŞULE; ELİBOL, BİRSEN; TERZİOĞLU, ŞULEPublication Metadata only Thymoquinone administration ameliorates Alzheimer-s disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta(1-42) infused rat model(2020-12-01T00:00:00Z) ELİBOL, BİRSEN; Beker, Merve; Terzioglu-Usak, Sule; Dalli, Tugce; Kilic, Ulkan; ELİBOL, BİRSEN; BEKER, MERVE; TERZİOĞLU, ŞULEBackground: Thymoquinone (TQ), a biologically active ingredient of Nigella sativa, has anti-inflammatory, antioxidative and neuroprotective properties. Therefore, it could be a good candidate in the recovery of Alzheimer-s disease (AD) pathology rather than current symptomatic reliefs.Publication Metadata only Thymoquinone activates MAPK pathway in hippocampus of streptozotocin-treated rat model(2018-03-01) Elibol, BİRSEN; Akbas, FAHRİ; dallı, Tugce; Terzioglu-Usak, ŞULE; Beker, MERVE; BEKER, MERVE; TERZİOĞLU, ŞULE; AKBAŞ, FAHRİ; ELİBOL, BİRSENStreptozotocin (STZ), a glucosamine-nitrosourea compound, produces deficiencies in learning, memory, and cognitive functions when it was administered intracerebroventricularly (i.c.v). In molecular level, increase in neuroinflammation and oxidative stress in brain, and decrease in the number of surviving neurons are the outcomes of STZ administration. Herein, we aimed to investigate the effect of thymoquinone (TQ), an anti-inflammatory, immunomodulatory and neuroprotective agent, on STZ-induced neurodegeneration in rats. For this purpose, bilateral i.c.v. injection of STZ (3 mg/kg) was given to adult female rats on days 1 and 3. TQ (20 mg/kg/day in cornoil) was administered intragastrically to rats for 15 days starting from the 15th day of STZ injection. The Morris water maze test and passive avoidance test were applied to measure the learning and memory performance of animals. Following the behavioral tests, all of the rats were sacrificed for evaluation of molecular alterations. Rats in the STZ-TQ group showed higher performance in passive avoidance test than rats in the STZ group whose memory performance declined compared to control group. The worse memory performance in STZ group was correlated with low number of surviving neurons and high number of degenerating neurons. In addition, an increase in APOE expression and a decrease in NGF expression were observed with STZ injection. Administration of TQ reversed these STZ-triggered cognitive and molecular alterations. In the present study, we observed the neuroregenerative effects of TQ by activation of JNK protein, upregulation of mir-124, and downregulation of ERK1/2 and NOS enzymes. The same ameliorative effect of TQ was also observed in the pTau protein expression. To sum up, we can say that the healing effect of TQ on STZ induced neurodegeneration opens a new door for the development of Alzheimer-s disease treatment using natural products as an adjuvant when their action mechanism was explained in detail.Publication Metadata only Timokinon Amyloid beta toksisitesini önlemek için töropatik amaçla kullanılabilir mi?(2017-05-10) dallı, Tuğçe; beker, merve; TERZİOĞLU UŞAK, ŞULE; AKBAŞ, FAHRİ; KILIÇ, ÜLKAN; ELİBOL, BİRSEN; BEKER, MERVE; TERZİOĞLU, ŞULE; AKBAŞ, FAHRİ; ELİBOL, BİRSENPublication Metadata only Thymoquinone (TQ) demonstrates its neuroprotective effect via an anti-inflammatory action on the Aβ(1–42)-infused rat model of Alzheimer-s disease(2019-10-01) Elibol, Birsen; Şahbaz, Çiğdem Dilek; Beker, Merve; Terzioğlu, Şule; ELİBOL, BİRSEN; TERZİOĞLU, ŞULE; BEKER, MERVE; ŞAHBAZ, ÇIĞDEM DILEKOBJECTIVES: Alzheimer-s disease (AD) is a severe neurodegenerative disease with presentation of the neuronal death, memory loss and cognitive decline. The relationship between neuroinflammation and AD has been well documented. However, the options of anti-inflammatory treatment are very limited in patients with AD. Previous studies showed that flavonoids might be an effective treatment and thymoquinone (TQ), an aromatic hydrocarbon found in Nigella sativa suggested as a candidate molecule due to having strong anti-inflammatory effects. Our study aimed to investigate the effects of TQ on neuroinflammation and neuroprotection in A beta((1-42)) infused rat model of AD.Publication Metadata only Functional and Molecular Effects of Astragalus membranaceus Treatment Combined with Calorie Restriction on Rat Hippocampus(2018-07-11) ELİBOL, BİRSEN; Dursun, İlknur; Setel, Deniz Dilan; TERZİOĞLU, ŞULE; BEKER, MERVE; Dallı, Tuğçe; ELİBOL, BİRSEN; TERZİOĞLU, ŞULE; BEKER, MERVEPublication Metadata only Therapeutic effect of thymoquinon on amyloid beta-induced neurotoxicity in rats(2017-09-29) ELİBOL, BİRSEN; AYDOGAN, TUĞÇE; BEKER, MERVE; TERZİOĞLU UŞAK, ŞULE; KILIÇ, ÜLKAN; ELİBOL, BİRSEN; TERZİOĞLU, ŞULEPublication Metadata only Neuroprotective effects of thymoquinone on the learning and memory mechanisms and hippocampal neurogenesis in aged rats(2019-10-22) Elibol, Birsen; Terzioğlu, Şule; Beker, Merve; ELİBOL, BİRSEN; TERZİOĞLU, ŞULE; BEKER, MERVEPublication Open Access Effect of Restraint Stress on Plasma PTH Concentration and Its Molecular Targets Expressions in Wistar Rats(2018-10-01) ELİBOL, BİRSEN; Terzioglu-Usak, Sule; Güler, Cansu; Dalli, Tugce; Aysan, Erhan; TERZİOĞLU, ŞULE; ELİBOL, BİRSENBackground: There are limited numbers of experimental studies related to the potential role of parathormone/parathyroid hormone (PTH) in response to psychological stress. In the current study, we aimed to cross-examine, for the first time, changes in PTH plasma concentration and the expression of its molecular targets mediated by restraint stress in rats. Methods: Male Wistar rats (n = 42) were separated into control and stressed groups. They were further divided into two groups that received chronic restraint stress (CRS) for 7 and 28 consecutive days (n = 7 for each group). Elevated plus maze and tail suspension test were used to determine the anxiety- and depressive-like behaviors of a different set of rats including stress and control groups (n = 7 for each group). The plasma levels of adrenocorticotropic hormone (ACTH), corticosterone, and intact parathormone (iPTH) were measured by enzyme-linked immunosorbent assay (ELISA). In addition, alterations in the expressions of glucocorticoid receptor (GR), calcium sensing receptor (CaSR), and parathormone receptor (PTHR1) of kidney and total thyroid gland tissues were estimated by Western Blotting. Results: There was no significant difference in the plasma level of iPTH while significant increases in the levels of ACTH and corticosterone were noted in the stressed-animals at day 7 and 21 (P = 0.010 and P = 0.016, respectively) of restraint stress. However, we found a negative correlation between iPTH and corticosterone levels in acute restraint stress (r = 0.771, P = 0.002). In addition, the expression of PTHR1 significantly decreased in the kidney at day 7 (P = 0.001) and in the thyroid gland at day 28 (P = 0.05) in response to CRS. Conclusions: To sum up, CRS has a significant effect on the expression of parathormone receptor rather than the iPTH concentration. The present results add a new dimension to stress research through the negative effect of chronic stress on the PTH signaling pathway.