Person: ELİBOL, BİRSEN
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Publication Metadata only What Inflammasomes Tell Us About Multiple Sclerosis(2021-06-04T00:00:00Z) Hocaoğlu, Nisa; Gürsoy, Azize Esra; Elibol, Birsen; Korkmaz, Nur Damla; Karakayali, Zehra Cemre; GÜRSOY, AZIZE ESRA; ELİBOL, BİRSEN; KORKMAZ, NUR DAMLAPublication Metadata only Atak ve iyileşmelerle giden multiple skleroz hastalığında inflamazomların değerlendirilmesi(2021-10-29T00:00:00Z) Korkmaz, Nur Damla; Elibol, Birsen; Gürsoy, Azize Esra; KORKMAZ, NUR DAMLA; ELİBOL, BİRSEN; GÜRSOY, AZIZE ESRAPublication Metadata only Inflammatory Cytokines are in Action: Brain Plasticity and Recovery after Brain Ischemia Due to Delayed Melatonin Administration.(2021-09-18T00:00:00Z) Kilic, Ulkan; Elibol, BİRSEN; Beker, Merve; Altug-Tasa, Burcugul; Caglayan, Ahmet Burak; Beker, Mustafa Caglar; Yilmaz, Bayram; Kilic, Ertugrul; ELİBOL, BİRSENPublication Metadata only Effects of fetal alcohol and maternal intubation stress on the expression of proteins controlling postnatal development of male rat hippocampus(2020-09-01T00:00:00Z) ELİBOL, BİRSEN; BEKER, MERVE; KILIÇ, ÜLKAN; Jakubowska-Dogru, Ewa; ELİBOL, BİRSEN; BEKER, MERVEBackground Developing brains can partially get over prenatal alcohol exposure-related detrimental conditions by activating some mechanisms involved in survival. Objectives This study aimed to shed light on the molecular correlates of compensatory mechanisms by examining temporal profiles in the expression of proteins controlling postnatal development in the rat hippocampus prenatally exposed to intubation stress/ethanol. Methods Male pups were randomly assigned to age subgroups (n = 21/age) which were sacrificed on postnatal day (PD)1, PD10, PD30, and PD60. Ethanol (6 g/kg/day) were intragastrically intubated to the dams throughout 7-21 gestation days. The expression of neurogenesis and angiogenesis markers, extracellular matrix proteins, and growth-promoting ligands were examined by western blot. Results The most rapid increase in the index of neuronal maturation was noted between PD10-PD30 (p< .05). Prenatal stress caused a decrease of neurogenesis markers at birth and an increase of their expressions at PD10 and PD30 to reach control levels (p< .001). The impact of fetal-alcohol was observed as a decrease in the expression of synaptic plasticity protein versican at birth (p< .001), an increase in the synaptic repulsion protein ephrin-B2 at PD10 (p< .001), and a decrease in the maturation of BDNF at PD30 (p< .001) with a decrease in the mature neuron markers at PD30 (p< .001) and PD60 (p= .005) which were compensated with upregulation of angiogenesis and increasing brevican expression, a neuronal maturation protein (p< .001). Conclusion These data providein vivoevidence for the potential therapeutic factors related to neurogenesis, angiogenesis, and neurite remodeling which may tolerate the alcohol/stress dependent teratogenicity in the developing hippocampus.Publication Metadata only Thymoquinone administration ameliorates Alzheimer-s disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta(1-42) infused rat model(2020-12-01T00:00:00Z) ELİBOL, BİRSEN; Beker, Merve; Terzioglu-Usak, Sule; Dalli, Tugce; Kilic, Ulkan; ELİBOL, BİRSEN; BEKER, MERVE; TERZİOĞLU, ŞULEBackground: Thymoquinone (TQ), a biologically active ingredient of Nigella sativa, has anti-inflammatory, antioxidative and neuroprotective properties. Therefore, it could be a good candidate in the recovery of Alzheimer-s disease (AD) pathology rather than current symptomatic reliefs.Publication Metadata only Perinatal dönemde farklı müzik türlerine maruz kalmanın genç yaştaki sıçanların motor aktiviteleri üzerine etkileri(2020-08-01T00:00:00Z) Elibol, Birsen; Beker, Merve; Kırpınar, İsmet; ELİBOL, BİRSEN; BEKER, MERVE; KIRPINAR, İSMETPublication Metadata only Wistar sıçanlarda nörogenezden sorumlu dentate girus bölgesindeki granül hücrelerinin yaşa bağlı morfolojik ve fizyolojik değişimleri(2020-11-09T00:00:00Z) Dursun, İlknur; Elibol, Birsen; ELİBOL, BİRSENPublication Open Access Angiotensin IV improves spatial memory in streptozotocin-induced diabetic rats by reducing oxidative stress and altering BDNF levels(2021-01-01T00:00:00Z) KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ; ELİBOL, BİRSEN; Bulut, Huri; MERAL, İSMAİL; Sahin, Gulderen; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ; ELİBOL, BİRSEN; MERAL, İSMAİLIn this study, we investigated the protective effects of angiotensin IV (Mg IV) on cognitive function in streptozotocin (STZ)-induced diabetic rats. Male Wistar albino rats, were randomly divided into four groups; control (C), diabetes (Dia, 60 mg/kg, STZ, i.p.), Mg IV (5 mu g/kg, s.c.) and Dia+Ang W. The passive avoidance and Morris water maze (MWM) tests were used to evaluate learning and memory performance. Behavioral tests were carried out between 21 and 30 days after the initial Ang IV injection. Hippocampi were dissected and retained for biochemical and Western blot analysis. The Dia group exhibited the poorest behavioral results, while the Dia+Ang W group performed highest on the MWM task. Superoxide dismutase, glutathione peroxidase, and malondialdehyde levels increased significantly in the Dia group compared to Dia+Ang IV. Brain-derived neurotrophic factor (BDNF) and N-methyl-D-aspartate levels were significantly elevated, while levels of GABA(A) significantly decreased, in the Dia+Ang IV group compared to the Dia group. These findings suggest that peripheral administration of Ang IV ameliorated spatial memory in diabetic rats by decreasing hippocampal oxidative stress and BDNF levels.Publication Metadata only The Investigation of the Effectiveness of Urtica Dioica in the Streptozotocin-Induced Neurodegeneration Model(2021-04-01T00:00:00Z) Çiftkaya, Ebru; Bahadori, Fatemeh; Terzioğlu Uşak, Şule; Elibol, Birsen; BAHADORİ, FATEMEH; ELİBOL, BİRSENPublication Metadata only Astragalus membranaceus treatment combined with caloric restriction may enhance genesis factors and decrease apoptosis in the hippocampus of rats.(2021-11-20T00:00:00Z) Setel, Deniz Dilan; Beker, Merve; Terzioglu-Usak, Sule; Elibol, BİRSEN; ELİBOL, BİRSEN