Person: ELİBOL, BİRSEN
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Publication Metadata only Effects of fetal alcohol and maternal intubation stress on the expression of proteins controlling postnatal development of male rat hippocampus(2020-09-01T00:00:00Z) ELİBOL, BİRSEN; BEKER, MERVE; KILIÇ, ÜLKAN; Jakubowska-Dogru, Ewa; ELİBOL, BİRSEN; BEKER, MERVEBackground Developing brains can partially get over prenatal alcohol exposure-related detrimental conditions by activating some mechanisms involved in survival. Objectives This study aimed to shed light on the molecular correlates of compensatory mechanisms by examining temporal profiles in the expression of proteins controlling postnatal development in the rat hippocampus prenatally exposed to intubation stress/ethanol. Methods Male pups were randomly assigned to age subgroups (n = 21/age) which were sacrificed on postnatal day (PD)1, PD10, PD30, and PD60. Ethanol (6 g/kg/day) were intragastrically intubated to the dams throughout 7-21 gestation days. The expression of neurogenesis and angiogenesis markers, extracellular matrix proteins, and growth-promoting ligands were examined by western blot. Results The most rapid increase in the index of neuronal maturation was noted between PD10-PD30 (p< .05). Prenatal stress caused a decrease of neurogenesis markers at birth and an increase of their expressions at PD10 and PD30 to reach control levels (p< .001). The impact of fetal-alcohol was observed as a decrease in the expression of synaptic plasticity protein versican at birth (p< .001), an increase in the synaptic repulsion protein ephrin-B2 at PD10 (p< .001), and a decrease in the maturation of BDNF at PD30 (p< .001) with a decrease in the mature neuron markers at PD30 (p< .001) and PD60 (p= .005) which were compensated with upregulation of angiogenesis and increasing brevican expression, a neuronal maturation protein (p< .001). Conclusion These data providein vivoevidence for the potential therapeutic factors related to neurogenesis, angiogenesis, and neurite remodeling which may tolerate the alcohol/stress dependent teratogenicity in the developing hippocampus.Publication Metadata only Thymoquinone administration ameliorates Alzheimer-s disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta(1-42) infused rat model(2020-12-01T00:00:00Z) ELİBOL, BİRSEN; Beker, Merve; Terzioglu-Usak, Sule; Dalli, Tugce; Kilic, Ulkan; ELİBOL, BİRSEN; BEKER, MERVE; TERZİOĞLU, ŞULEBackground: Thymoquinone (TQ), a biologically active ingredient of Nigella sativa, has anti-inflammatory, antioxidative and neuroprotective properties. Therefore, it could be a good candidate in the recovery of Alzheimer-s disease (AD) pathology rather than current symptomatic reliefs.Publication Metadata only Perinatal dönemde farklı müzik türlerine maruz kalmanın genç yaştaki sıçanların motor aktiviteleri üzerine etkileri(2020-08-01T00:00:00Z) Elibol, Birsen; Beker, Merve; Kırpınar, İsmet; ELİBOL, BİRSEN; BEKER, MERVE; KIRPINAR, İSMETPublication Metadata only Wistar sıçanlarda nörogenezden sorumlu dentate girus bölgesindeki granül hücrelerinin yaşa bağlı morfolojik ve fizyolojik değişimleri(2020-11-09T00:00:00Z) Dursun, İlknur; Elibol, Birsen; ELİBOL, BİRSENPublication Metadata only Investigation of Inflammatory Cytokines and Response to Treatment in Patients With Obsessive- Compulsive Disorder(2020-05-01T00:00:00Z) Şahbaz, Çiğdem Dilek; Terzioglu Usak, Sule; Döner, Çağıl; Elibol, Birsen; TERZİOĞLU, ŞULE; ELİBOL, BİRSENPublication Metadata only Effects of music on stress-induced hormones and oxidative stress levels(2020-09-01T00:00:00Z) Elibol, Birsen; ELİBOL, BİRSENPublication Metadata only Anvirzel<sup>TM</sup>regulates cell death through inhibiting GSK-3 activity in human U87 glioma cells.(2020-01-01T00:00:00Z) Ozek, E; Terzioglu-Usak, Şule; Nalli, A; Elibol, Birsen; Hatiboglu, MUSTAFA AZİZ; TERZİOĞLU, ŞULE; ELİBOL, BİRSEN; ÖZEK, ERDİNÇ; HATİBOĞLU, MUSTAFA AZİZ