Person: ELİBOL, BİRSEN
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Publication Metadata only Mesenchymal stem cell therapy for the streptozotocin-induced neurodegeneration in rats(2016-01-01) Isik, Ahmet Turan; Celik, Turgay; URAL, Ali Ugur; Tosun, Murat; ULUSOY, Gokhan; Elibol, BİRSEN; ELİBOL, BİRSENBackground and Aim: Bone marrow-derived mesenchymal stem cells (BM-MSCs) are one of the sources of adult stem cells being explored for potential use in repairing neurodegenerative disorders. In this study, it was aimed to investigate the useful effects of BM-MSCs therapy on the streptozotocin-induced neurodegeneration in rats.Publication Metadata only Thymoquinone Can Improve Neuronal Survival and Promote Neurogenesis in Rat Hippocampal Neurons.(2018-03-01) Beker, M; Dallı, T; ELİBOL, BİRSENPublication Metadata only Inflammatory Cytokines are in Action: Brain Plasticity and Recovery after Brain Ischemia Due to Delayed Melatonin Administration.(2021-09-18T00:00:00Z) Kilic, Ulkan; Elibol, BİRSEN; Beker, Merve; Altug-Tasa, Burcugul; Caglayan, Ahmet Burak; Beker, Mustafa Caglar; Yilmaz, Bayram; Kilic, Ertugrul; ELİBOL, BİRSENPublication Metadata only Thymoquinone activates MAPK pathway in hippocampus of streptozotocin-treated rat model(2018-03-01) Elibol, BİRSEN; Akbas, FAHRİ; dallı, Tugce; Terzioglu-Usak, ŞULE; Beker, MERVE; BEKER, MERVE; TERZİOĞLU, ŞULE; AKBAŞ, FAHRİ; ELİBOL, BİRSENStreptozotocin (STZ), a glucosamine-nitrosourea compound, produces deficiencies in learning, memory, and cognitive functions when it was administered intracerebroventricularly (i.c.v). In molecular level, increase in neuroinflammation and oxidative stress in brain, and decrease in the number of surviving neurons are the outcomes of STZ administration. Herein, we aimed to investigate the effect of thymoquinone (TQ), an anti-inflammatory, immunomodulatory and neuroprotective agent, on STZ-induced neurodegeneration in rats. For this purpose, bilateral i.c.v. injection of STZ (3 mg/kg) was given to adult female rats on days 1 and 3. TQ (20 mg/kg/day in cornoil) was administered intragastrically to rats for 15 days starting from the 15th day of STZ injection. The Morris water maze test and passive avoidance test were applied to measure the learning and memory performance of animals. Following the behavioral tests, all of the rats were sacrificed for evaluation of molecular alterations. Rats in the STZ-TQ group showed higher performance in passive avoidance test than rats in the STZ group whose memory performance declined compared to control group. The worse memory performance in STZ group was correlated with low number of surviving neurons and high number of degenerating neurons. In addition, an increase in APOE expression and a decrease in NGF expression were observed with STZ injection. Administration of TQ reversed these STZ-triggered cognitive and molecular alterations. In the present study, we observed the neuroregenerative effects of TQ by activation of JNK protein, upregulation of mir-124, and downregulation of ERK1/2 and NOS enzymes. The same ameliorative effect of TQ was also observed in the pTau protein expression. To sum up, we can say that the healing effect of TQ on STZ induced neurodegeneration opens a new door for the development of Alzheimer-s disease treatment using natural products as an adjuvant when their action mechanism was explained in detail.Publication Metadata only Specific alterations in the circulating levels of the SIRT1, TLR4, and IL7 proteins in patients with dementia(2018-10-01) Yildiz, Gulsen Babacan; kılıç, Ulkan; Elibol, BİRSEN; Uysal, Omer; Kilic, Ertugrul; Yulug, Burak; Sakul, Arzu Sayin; ELİBOL, BİRSEN; UYSAL, ÖMER; BABACAN YILDIZ, GÜLSENSirtuins have gained considerable attention as epigenetic regulators for slowing aging and age-related disorders. The growing association between neurodegeneration and inflammation has led researchers to investigate interactions of sirtuins with inflammatory markers in neurodegenerative diseases. We analyzed SIRT1-s association with chronic inflammation in dementia as an age-related neurodegenerative condition through Toll-like receptor 4 (TLR4) and interleukin-7 (IL7) for the first time. In the present study, we observed a significant increase in the level of SIRT1 in patients with all types of dementia. Interestingly, the level of TLR4 protein was significantly lower in only the patients with Alzheimer-s disease (AD) compared to the healthy elderly subjects. There was no significant change in the level of IL7 between the diseased and healthy elderly subjects. A significant positive correlation between SIRT1 level and age in healthy elderly subjects was evident according to Pearson-s correlation test. However, this correlation was not observed in the dementia patients. Furthermore, the positive correlation between the levels of IL7 and TLR4 in the healthy elderly subjects was absent in the dementia patients. However, there was no direct association between the examined single nucleotide polymorphisms (SNPs) and dementia at the molecular level. According to logistic regression analysis, dementia risk increases 1.16 times due to an increase in the SIRT1 level and 24.23 times due to a decrease in the TLR4 level. Interestingly, a high level in the total antioxidant status (TAS) increases the risk of dementia approximately 33.32 times. Therefore, the current study, for the first time, provides a much better molecular understanding of the interaction between decreasing TLR4 levels and increasing SIRT1 levels in dementia, especially in AD. Furthermore, it highlights the importance of epigenetics in several age-related diseases and suggests that developing novel therapies to prevent or slow down the progression of dementia may support healthy aging.Publication Metadata only Astragalus membranaceus treatment combined with caloric restriction may enhance genesis factors and decrease apoptosis in the hippocampus of rats.(2021-11-20T00:00:00Z) Setel, Deniz Dilan; Beker, Merve; Terzioglu-Usak, Sule; Elibol, BİRSEN; ELİBOL, BİRSENPublication Metadata only Effects of prenatal binge-like ethanol exposure and maternal stress on postnatal morphological development of hippocampal neurons in rats.(2017-10-01) Jakubowska-Dogru, E; Elibol, BİRSEN; Dursun, I; Yürüker, S; ELİBOL, BİRSEN