Person: ELİBOL, BİRSEN
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Publication The combination of A. membranaceus with calorie restriction increases neurogenesis on hippocampus(2018-05-27) Setel, Deniz Dilan; ELİBOL, BİRSEN; ELİBOL, BİRSENPublication Association of reelin silencing and topo isomerase IIβ expression in human SH-SY5Y neuroblastoma cell line(2019-09-07) TERZİOĞLU UŞAK, ŞULE; BEKER, MERVE; ELİBOL, BİRSEN; TERZİOĞLU, ŞULE; ELİBOL, BİRSEN; BEKER, MERVEPublication Insight into hippocampus development during the first two postnatal months in control and fetal alcohol rats(2015-07-11) Jakubowska-Doğru , ewa; ELİBOL-CAN, BİRSEN; Dursun, İlknur; canan, sinan; yürüker, sinan; kılıç, ertuğrul; ELİBOL, BİRSENPublication SIRT1 gene variants are related to risk of childhood obesity(2015-04-01) Kilic, Ulkan; GOK, Ozlem; ELIBOL-CAN, BİRSEN; Ozgen, Ilker Tolga; Erenberk, UFUK; Uysal, Omer; DUNDAROZ, Mehmet Rusen; ELİBOL, BİRSEN; ÖZGEN, İLKER TOLGA; ERENBERK, UFUK; UYSAL, ÖMERObesity is a multifactorial disorder resulting from the interaction between genetic, psychological, physical, environmental, and socioeconomic factors. SIRT1 gene has important effects on the regulation of adiponectin, caloric restriction, insulin sensitivity, coronary atherosclerosis, and cardiovascular diseases. The aim of this study was to investigate the association between childhood obesity and SIRT1 gene polymorphisms regarding rs7895833 A > G in the promoter region, rs7069102 C > G in intron 4, and rs2273773 C > T in exon 5 using PCR-CTPP method in 120 obese and 120 normal weight children. In this study, BMI, systolic and diastolic blood pressure, LDL cholesterol, triglyceride, and insulin levels were significantly higher and HDL-cholesterol levels were significantly lower in obese children compared to normal weight children. For rs7895833 A > G, the rate of having AG genotype and G allele was significantly higher in obese children compared to non-obese group (p T. There was no significant difference for rs7069102 C > G gene polymorphism between groups.Publication What Inflammasomes Tell Us About Multiple Sclerosis(2021-06-04T00:00:00Z) Hocaoğlu, Nisa; Gürsoy, Azize Esra; Elibol, Birsen; Korkmaz, Nur Damla; Karakayali, Zehra Cemre; GÜRSOY, AZIZE ESRA; ELİBOL, BİRSEN; KORKMAZ, NUR DAMLAPublication Effects of Angiotensin IV on Learning-Memory and Hippocampal Oxidative Stress in Diabetic Rats(2019-12-01T00:00:00Z) KILIÇ, Aysu; ÜSTÜNOVA, SAVAŞ; ELİBOL, BİRSEN; Bulut, Huri; MERAL, İSMAİL; Sahin, Emine Gulderen; KILIÇ, AYSU; ÜSTÜNOVA, SAVAŞ; ELİBOL, BİRSEN; BULUT, HURI; MERAL, İSMAİLPublication Both activation and inhibition of SIRT1 may act via exosomal GSK3α/β in the in vitro amyloid beta toxicity model(2019-12-01) Elibol, Birsen; ELİBOL, BİRSENPublication SIRT1 Gene Polymorphisms Affect the Protein Expression in Cardiovascular Diseases(2014-02-28) KILIC, Ulkan; GOK, Ozlem; Bacaksiz, AHMET; IZMIRLI, Muzeyyen; Elibol-Can, BİRSEN; Uysal, Omer; BACAKSIZ, AHMET; ELİBOL, BİRSEN; UYSAL, ÖMERCardiovascular disease (CVD), the leading cause of death worldwide, is related to gene-environment interactions due to epigenetic factors. SIRT1 protein and its downstream pathways are critical for both normal homeostasis and protection from CVD-induced defects. The aim of this study was to investigate the association between SIRT1 single nucleotide polymorphisms (SNPs) (rs7895833 A.G in the promoter region, rs7069102 C.G in intron 4 and rs2273773 C.T in exon 5 silent mutation) and SIRT1 and eNOS (endothelial nitric oxide synthase) protein expression as well as total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) in CVD patients as compared to controls. The frequencies of mutant genotypes and alleles for rs7069102 and rs2273773 were significantly higher in patients with CVD compared to control group. The risk for CVD was increased by 2.4 times for rs7069102 and 1.9 times for rs2273773 in carriers of mutant allele compared with carriers of wild-type allele pointing the protective role of C allele for both SNPs against CVD. For rs7895833, there was no significant difference in genotype and allele distributions between groups. SIRT1 protein, TAS, TOS and OSI levels significantly increased in patients as compared to control group. In contrast, level of eNOS protein was considerably low in the CVD patients. An increase in the SIRT1 expression in the CVD patients carrying mutant genotype for rs7069102 and heterozygote genotype for all three SNPs was observed. This is the first study reporting an association between SIRT1 gene polymorphisms and the levels of SIRT1 and eNOS expressions as well as TAS, TOS and OSIPublication Mesenchymal stem cell therapy for the streptozotocin-induced neurodegeneration in rats(2016-01-01) Isik, Ahmet Turan; Celik, Turgay; URAL, Ali Ugur; Tosun, Murat; ULUSOY, Gokhan; Elibol, BİRSEN; ELİBOL, BİRSENBackground and Aim: Bone marrow-derived mesenchymal stem cells (BM-MSCs) are one of the sources of adult stem cells being explored for potential use in repairing neurodegenerative disorders. In this study, it was aimed to investigate the useful effects of BM-MSCs therapy on the streptozotocin-induced neurodegeneration in rats.Publication Statin Kullanımının Koroner Ateroskleroz Hastalarında SIRT1 ve eNOS Ekspresyonları Üzerindeki Etkisi(2014-09-06) kılıç, ülkan; gök, özlem; ELİBOL, BİRSEN; ERCAN, ÇİLEM; UYSAL, ÖMER; BACAKSIZ, AHMET; ELİBOL, BİRSEN; ERCAN, ÇİLEM; UYSAL, ÖMER; BACAKSIZ, AHMET