Person: ELİBOL, BİRSEN
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BİRSEN
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ELİBOL
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Publication Metadata only Mesenchymal stem cell therapy for the streptozotocin-induced neurodegeneration in rats(2016-01-01) Isik, Ahmet Turan; Celik, Turgay; URAL, Ali Ugur; Tosun, Murat; ULUSOY, Gokhan; Elibol, BİRSEN; ELİBOL, BİRSENBackground and Aim: Bone marrow-derived mesenchymal stem cells (BM-MSCs) are one of the sources of adult stem cells being explored for potential use in repairing neurodegenerative disorders. In this study, it was aimed to investigate the useful effects of BM-MSCs therapy on the streptozotocin-induced neurodegeneration in rats.Publication Metadata only Thymoquinone Can Improve Neuronal Survival and Promote Neurogenesis in Rat Hippocampal Neurons.(2018-03-01) Beker, M; Dallı, T; ELİBOL, BİRSENPublication Metadata only Behavioral and molecular effects of perinatal music on rat pups(2016-11-16) Yanık, Hilal; CAN, BİRSEN; KIRPINAR, İSMET; BEKER, MERVE; ELİBOL, BİRSEN; KIRPINAR, İSMET; BEKER, MERVEPublication Metadata only Melatonin promotes neurological recovery, peri-lesional tissue remodeling, and contralesional pyramidal tract plasticity after focal cerebral ischemia(2015-10-21) kılıç, ülkan; Beker, mustafa çağlar; çağlayan, ahmet burak; ELİBOL, BİRSEN; BEKER, MERVE; altuğ, burcugül; gök, özlem; keleştemur, taha; kılıç, ertuğrul; ELİBOL, BİRSEN; BEKER, MERVEPublication Metadata only Examination of Age-dependent effects of fetal ethanol exposure on behavior, hippocampal cell counts, and doublecortin immunoreactivity in rats(2014-05-01T00:00:00Z) Elibol-Can, BİRSEN; Dursun, Ilknur; Telkes, Ilknur; Kilic, Ertugrul; Canan, Sinan; Jakubowska-Dogru, Ewa; ELİBOL, BİRSENEthanol is known as a potent teratogen having adverse effects on brain and behavior. However, some of the behavioral deficits caused by fetal alcohol exposure and well expressed in juveniles ameliorate with maturation may suggest some kind of functional recovery occurring during postnatal development. The aim of this study was to reexamine age-dependent behavioral impairments in fetal-alcohol rats and to investigate the changes in neurogenesis and gross morphology of the hippocampus during a protracted postnatal period searching for developmental deficits and/or delays that would correlate with behavioral impairments in juveniles and for potential compensatory processes responsible for their amelioration in adults. Ethanol was delivered to the pregnant dams by intragastric intubation throughout 7-21 gestation days at daily dose of 6 g/kg. Isocaloric intubation and intact control groups were included. Locomotor activity, anxiety, and spatial learning tasks were applied to juvenile and young-adult rats from all groups. Unbiased stereological estimates of hippocampal volumes, the total number of pyramidal and granular cells, and double cortin expressing neurons were carried out for postnatal days (PDs) PD1, PD10, PD30, and PD60. Alcohol insult during second trimester equivalent caused significant deficits in the spatial learning in juvenile rats; however, its effect on hippocampal morphology was limited to a marginally lower number of granular cells in dentate gyrus (DG) on PD30. Thus, initial behavioral deficits and the following functional recovery in fetal-alcohol subjects may be due to more subtle plastic changes within the hippocampal formation but also in other structures of the extended hippocampal circuit. Further investigation is required. (c) 2013 Wiley Periodicals, Inc. Develop Neurobiol 74: 498-513, 2014Publication Metadata only Farklı Türde Uygulanmış Stresin Sıçanların HPA Ekseni ve Paratiroid Hormon Düzeyleri Üzerindeki Etkileri(2018-06-22) ELİBOL, BİRSEN; TERZİOĞLU, ŞULE; ELİBOL, BİRSEN; TERZİOĞLU, ŞULEPublication Metadata only Atak ve iyileşmelerle giden multiple skleroz hastalığında inflamazomların değerlendirilmesi(2021-10-29T00:00:00Z) Korkmaz, Nur Damla; Elibol, Birsen; Gürsoy, Azize Esra; KORKMAZ, NUR DAMLA; ELİBOL, BİRSEN; GÜRSOY, AZIZE ESRAPublication Metadata only Delayed Therapeutic Administration of Melatonin Enhances Neuronal Survival Through AKT and MAPK Signaling Pathways Following Focal Brain Ischemia in Mice(2022-03-01T00:00:00Z) Kilic, Ulkan; ELİBOL, BİRSEN; ÇAĞLAYAN, AHMET BURAK; Beker, Mustafa Caglar; Beker, Merve; Altug-Tasa, Burcugul; UYSAL, ÖMER; YILMAZ, BAYRAM; KILIÇ, ERTUĞRUL; ELİBOL, BİRSENMelatonin has a role in the cell survival signaling pathways as a candidate for secondary stroke prevention. Therefore, in the present study, the coordination of ipsilateral and contralateral hemispheres to evaluate delayed post-acute effect of melatonin was examined on recovery of the cell survival and apoptosis after stroke. Melatonin was administered (4 mg/kg/day) intraperitoneally for 45 days, starting 3 days after 30 min of middle cerebral artery occlusion. The genes and proteins related to the cell survival and apoptosis were investigated by immunofluorescence, western blotting, and RT-PCR techniques after behavioral experiments. Melatonin produced delayed neurological recovery by improving motor coordination on grip strength and rotarod tests. This neurological recovery was also reflected by high level of NeuN positive cells and low level of TUNEL-positive cells suggesting enhanced neuronal survival and reduced apoptosis at the fifty-fifth day of stroke. The increase of NGF, Nrp1, c-jun; activation of AKT; and dephosphorylation of ERK and INK at the fifty-fifth day showed that cell survival and apoptosis signaling molecules compete to contribute to the remodeling of brain. Furthermore, an increase in the CREB and Atf-1 expressions suggested the melatonin-s strong reformative effect on neuronal regeneration. The contralateral hemisphere was more active at the latter stages of the molecular and functional regeneration which provides a further proof of principle about melatonin-s action on the promotion of brain plasticity and recovery after stroke.Publication Metadata only Timokinon Amiloid Beta Toksisitesini Engellemek için Terapötik Amaçla Kullanılabilir mi?(2017-05-08) Dallı T.; BEKER M.; TERZİOĞLU UŞAK Ş.; AKBAŞ F.; KILIÇ Ü.; ELİBOL B.; AKBAŞ, FAHRİ; ELİBOL, BİRSENPublication Metadata only Inflammatory Cytokines are in Action: Brain Plasticity and Recovery after Brain Ischemia Due to Delayed Melatonin Administration.(2021-09-18T00:00:00Z) Kilic, Ulkan; Elibol, BİRSEN; Beker, Merve; Altug-Tasa, Burcugul; Caglayan, Ahmet Burak; Beker, Mustafa Caglar; Yilmaz, Bayram; Kilic, Ertugrul; ELİBOL, BİRSEN