Person: ELİBOL, BİRSEN
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ELİBOL
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BİRSEN
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- PublicationMetadata onlyTimokinon Amiloid Beta Toksisitesini Engellemek için Terapötik Amaçla Kullanılabilir mi?(2017-05-08) Dallı T.; BEKER M.; TERZİOĞLU UŞAK Ş.; AKBAŞ F.; KILIÇ Ü.; ELİBOL B.; AKBAŞ, FAHRİ; ELİBOL, BİRSEN
- PublicationMetadata onlyInflammatory Cytokines are in Action: Brain Plasticity and Recovery after Brain Ischemia Due to Delayed Melatonin Administration.(2021-09-18T00:00:00Z) Kilic, Ulkan; Elibol, BİRSEN; Beker, Merve; Altug-Tasa, Burcugul; Caglayan, Ahmet Burak; Beker, Mustafa Caglar; Yilmaz, Bayram; Kilic, Ertugrul; ELİBOL, BİRSEN
- PublicationMetadata onlyEffects of early postnatal alcohol exposure on the developing retinogeniculate projections in C57BL/6 mice(2013-05-01T00:00:00Z) Dursun, Ilknur; Jakubowska-Dogru, Ewa; Elibol-Can, BİRSEN; VAN DER LIST, Deborah; CHAPMAN, Barbara; QI, Lihong; BERMAN, Robert F.; ELİBOL, BİRSENPrevious studies on the adverse effects of perinatal exposure to ethanol (EtOH) on the developing visual system mainly focused on retinal and optic nerve morphology. The aim of the present study was to investigate whether earlier reported retinal and optic nerve changes are accompanied by anomalies in eye-specific fiber segregation in the dorsal lateral geniculate nucleus (dLGN). C57BL/6 mice pups were exposed to ethanol by intragastric intubation at either 3 or 4 g/kg from postnatal days (PD) 3-10, the third trimester equivalent to human gestation. Control (C) and intubation control (IC) groups not exposed to ethanol were included. On PD9, retinogeniculate projections were labeled by intraocular microinjections of cholera toxin-beta (CTB) either conjugated to Alexa 488 (green) or 594 (red) administrated to the left and right eye, respectively. Pups were sacrificed 24 h after the last CTB injection. The results showed that ethanol exposure decreased the total number of dLGN neurons and significantly reduced the total dLGN projection as well as the contralateral and ipsilateral projection areas. (c) 2013 Elsevier Inc. All rights reserved.
- PublicationMetadata onlyThe Interaction of SIRT1, TLR4 and IL7 in Human Dementia(2018-07-01) Kılıç, Ülkan; Sayın Şakul, Arzu; ELİBOL, BİRSEN; ELİBOL, BİRSEN
- PublicationMetadata onlyAnvirzel<sup>TM</sup>regulates cell death through inhibiting GSK-3 activity in human U87 glioma cells.(2020-01-01T00:00:00Z) Ozek, E; Terzioglu-Usak, Şule; Nalli, A; Elibol, Birsen; Hatiboglu, MUSTAFA AZİZ; TERZİOĞLU, ŞULE; ELİBOL, BİRSEN; ÖZEK, ERDİNÇ; HATİBOĞLU, MUSTAFA AZİZ
- PublicationOpen AccessSIRT1 Gene Polymorphisms Affect the Protein Expression in Cardiovascular Diseases(2014-02-28) KILIC, Ulkan; GOK, Ozlem; Bacaksiz, AHMET; IZMIRLI, Muzeyyen; Elibol-Can, BİRSEN; Uysal, Omer; BACAKSIZ, AHMET; ELİBOL, BİRSEN; UYSAL, ÖMERCardiovascular disease (CVD), the leading cause of death worldwide, is related to gene-environment interactions due to epigenetic factors. SIRT1 protein and its downstream pathways are critical for both normal homeostasis and protection from CVD-induced defects. The aim of this study was to investigate the association between SIRT1 single nucleotide polymorphisms (SNPs) (rs7895833 A.G in the promoter region, rs7069102 C.G in intron 4 and rs2273773 C.T in exon 5 silent mutation) and SIRT1 and eNOS (endothelial nitric oxide synthase) protein expression as well as total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) in CVD patients as compared to controls. The frequencies of mutant genotypes and alleles for rs7069102 and rs2273773 were significantly higher in patients with CVD compared to control group. The risk for CVD was increased by 2.4 times for rs7069102 and 1.9 times for rs2273773 in carriers of mutant allele compared with carriers of wild-type allele pointing the protective role of C allele for both SNPs against CVD. For rs7895833, there was no significant difference in genotype and allele distributions between groups. SIRT1 protein, TAS, TOS and OSI levels significantly increased in patients as compared to control group. In contrast, level of eNOS protein was considerably low in the CVD patients. An increase in the SIRT1 expression in the CVD patients carrying mutant genotype for rs7069102 and heterozygote genotype for all three SNPs was observed. This is the first study reporting an association between SIRT1 gene polymorphisms and the levels of SIRT1 and eNOS expressions as well as TAS, TOS and OSI
- PublicationMetadata onlyTimokinon-un yaşa bağlı olarak öğrenme-bellek mekanizması ve hipkampal nörogenez üzerindeki etkisi(2018-05-13) ELİBOL, BİRSEN; ELİBOL, BİRSEN
- PublicationMetadata onlyMoleküler Biyoloji Güncel Araştırma Teknikleri(2022-04-01T00:00:00Z) Korkmaz, Nur Damla; Elibol, Birsen; KORKMAZ, NUR DAMLA; ELİBOL, BİRSEN
- PublicationMetadata onlyVitamin A deficiency affects the hippocampal molecular composition of the rats exposed to chronic ethanol intoxication and ethanol withdrawal: an FT-IR study(2016-11-16) Dursun, İlknur; Severcan, Feride; Jakubowska-Doğru, Ewa; ELİBOL, BİRSEN
- PublicationMetadata onlyMide kanserli hastalarda PTCH1 genindeki epigenetik değişimlerin araştırılması ve bu değişimlerin gen ve protein miktarları üzerindeki etkisi(2022-07-05T00:00:00Z) Matpan, Erce; Toruntay, Ceyhun; Fırtına, Sinem; Akçakaya, Adem; Elibol, Birsen; TORUNTAY, CEYHUN; AKÇAKAYA, ADEM; ELİBOL, BİRSEN