Person: TIRIS, GİZEM
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GİZEM
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TIRIS
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Publication Metadata only High performance liquid chromatographic analysis of lercanidipine in human breast milk(2019-01-01) Tekkeli, Evrim Kepekci; GAZİOĞLU, IŞIL; TIRIS, GİZEM; Onal, Cem; TEKKELİ, ŞERİFE EVRİM; GAZİOĞLU, IŞIL; TIRIS, GİZEMA simple, rapid, precise and accurate isocratic reversed phase HPLC method was developed and validated for the determination of lercanidipine hydrochloride in pharmaceutical tablets and spiked human breast milk. The chromatographic separation was achieved on C18 (250x4.6 mmx5 mu m) column using a mobile phase consisting of acetonitrile and phospate buffer (pH=4) (55:45, v/v) at a flow rate of 1.1 mL/min and UV detection at 237 nm. The linearity of the proposed method was investigated in the range of 1.0-40 mu g/mL (r(2)=0.9990). The method was validated in terms of accuracy, precision, reproducibility, specificity, robustness, and detection and quantification limits, in accordance with ICH guidelines. The proposed method is found as suitable for routine quantification of lercanidipine in human breast milk.Publication Metadata only Development and Application of Advanced Absorbance Subtraction Spectrophotometric Method for the Quantification of the Antiretroviral Compounds in Medical Dosage forms(2019-12-03T00:00:00Z) Lotfy, Hayam M; TIRIS, GİZEM; ERK, NEVİN; TIRIS, GİZEMPublication Metadata only Optimization of a new controlled release oral dexketoprofen formulation(2018-05-08) Sevim, Bilgesu Beria; Çerçi, Buse Hande; Küçük, Zeynep; BAHADORİ, FATEMEH; Kazdal, Fatma; Eskandari, Zahra; Tırıs, GİZEM; DEMIRAY, MUTLU; BAHADORİ, FATEMEH; TIRIS, GİZEMPublication Metadata only Sensitive and Rapid Determination of Protease Inhibitors in Pure Drugs and Their Mixtures using High Performance LiquidChromatography(2017-10-07T00:00:00Z) TIRIS, GİZEM; ERK, NEVİN; TIRIS, GİZEMPublication Metadata only Determination of Bisoprolol Fumarate and Hydrochlorothiazide in Combined Tablet Dosage Form By Novel Spectrophotometric Techniques(2017-09-13) ERK, Nevin; TIRIS, GİZEM; TIRIS, GİZEMPublication Metadata only High Performance Liquid Chromatographic Method For The Determination Of Amlodipine And Perindopril(2019-12-23T00:00:00Z) Lotfy, Hayam M.; Tırıs, Gizem; Erk, Nevin; TIRIS, GİZEMIn the currently work; rapid, sensitive and validated high performance liquidchromatography (HPLC) method for the simultaneous determination of Amlodipin (ADP) andPerindopril (PER) in pure forms and pharmaceutical products were presented. Amlodipine(ADP), 3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate is a vasoselective dihydropyridine calcium antagonist, hasa pharmacokinetic profile that sets it apart from other calcium antagonists (1). Perindopril(PER) (2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid is an angiotensin-converting enzyme inhibitor thatis used in the treatment of hypertension and heart failure. It is also used to reduce the risk ofcardiovascular events in patients with stable ischemic heart disease (2).Analysis was performed on the Waters Spherisorb® ODS-2 (5μm 150x4.6 mm) column.Mobile phase system has been consisted of acetonitrile : methanol : posphate buffer (65:5:30v/v/v). Specimen was enjected to column at 20 μl. Detection wavelength of 220 nm waspreferred for both compounds and flow rate was 1,5 ml/min. Analysis was completed 5minutes. Column oven temperature was adjusted 30 ºC. The retention time was observed at1.58 and 2.40 min for PER and ADP. Calibration graphs were constructed in the 10- 40μg/ml, 5-40 μg/ml concentration of per, adp respectively. The proposed method wasemployed with a high degree of precision and accuracy in the determination of all activeingredients. The method was suitable for the simultaneous determination and it can be appliedin the quality control department in industries, bio-pharmaceutics and bio-equivalence studies.Publication Metadata only RAPID DETERMINATION OF ANTIHYPERTENSIVE AGENTS USING RATIO DIFFERENCE AND RATIO DERIVATIVE SPECTROPHOTOMETRIC TECHNIQUE(2018-09-10) TIRIS, GİZEM; ERK, Nevin; TIRIS, GİZEMPublication Metadata only Quantitative Analysis Of Amlodipine And Atorvastatin By Using Constant Center Spectrophotometric Technique(2018-06-29) Lotfy, Hayam; ERK, Nevin; TIRIS, GİZEM; ŞAHİN, EGEMEN; TIRIS, GİZEMPublication Metadata only RATIO DERIVATIVE AND DIFFERENCE SPECTROPHOTOMETRIC TECHNIQUES FOR SIMULTANEOUS DETERMINATION OF CARVEDILOL AND HYDROCHLOROTHIAZIDE IN MARKETED TABLETS(2018-06-29) ERK, NEVİN; TIRIS, GİZEM; TIRIS, GİZEMPublication Metadata only Smart Spectrophotometric Determination of Tenofovir Disoproxil and Emtricitabine in Medical Dosage Formulations By Using Unified Regression Equation(2019-12-23T00:00:00Z) Lotfy, Hayam M.; Erk, Nevin; Tırıs, Gizem; TIRIS, GİZEM