Person: MİRİOĞLU, ŞAFAK
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Publication Metadata only Oxidative stress and macrophage infiltration in IgA nephropathy.(2021-11-16T00:00:00Z) Çalışkan, Yaşar; Demir, Erol; Karatay, Ecem; Özlük, Mesude Yasemin; Mirioğlu, Şafak; Dirim, Ahmet Burak; Artan, Ayşe Serra; Usta Akgül, Sebahat; Oto, Özgür Akın; Savran Oğuz, Fatma; Türkmen, Aydın; Lentıne, Krista L.; Yazıcı, Halil; MİRİOĞLU, ŞAFAKPublication Metadata only Co-Deposition of IgM and C3 May Indicate Unfavorable Renal Outcomes in Adult Patients with Primary Focal Segmental Glomerulosclerosis(2019-10-01T00:00:00Z) Mirioglu, ŞAFAK; Caliskan, Yasar; Ozluk, Yasemin; DİRİM, Ahmet Burak; Istemihan, Zulal; Akyildiz, Arif; YAZICI, Halil; TÜRKMEN, Aydın; KILIÇASLAN, Işın; SEVER, Mehmet Şükrü; MİRİOĞLU, ŞAFAKBackground/Aims: We aimed to investigate the effects of glomerular IgM and C3 deposition on outcomes of adult patients with primary focal segmental glomerulosclerosis (FSGS). Methods: In this retrospective analysis, 86 consecutive adult patients with biopsy-proven primary FSGS were stratified into 3 groups according to their histopathological features: IgM- C3-, IgM+ C3-, and IgM+ C3+. Primary outcome was defined as at least a 50% reduction in baseline estimated glomerular filtration rate (eGFR) or development of kidney failure, while complete or partial remission rates were secondary outcomes. Results: Glomerular IgM deposits were found in 44 (51.1%) patients, 22 (25.5%) of which presented with accompanying C3 deposition. Patients in IgM+ C3+ group had higher level of proteinuria (5.6 g/24 h [3.77-8.5], p = 0.073), higher percentage of segmental glomerulosclerosis (20% [12.3-27.2], p = 0.001), and lower levels of eGFR (69 +/- 37.2 mL/min/1.73 m(2), p = 0.029) and serum albumin (2.71 +/- 0.85 g/dL, p = 0.045) at the time of diagnosis. Despite 86.3% of patients in IgM+ C3+ group (19/22) received immunosuppressive treatment, the primary outcome was more common in patients in the IgM+ C3+ group compared with patients in IgM+ C3- and IgM- C3- groups (11 [50%] vs. 2 [9%] and 11 [26.1%] respectively [p = 0.010]). Complete or partial remission rates were lower in patients in the IgM+ C3+ group (5/22, 22.7%), as well (p = 0.043). Multivariate Cox regression analysis revealed that IgM and C3 co-deposition was an independent risk factor associated with primary outcome (hazard ratio 3.355, 95% CI 1.349-8.344, p = 0.009). Conclusions: Glomerular IgM and C3 co-deposition is a predictor of unfavorable renal outcomes in adult patients with primary FSGS.Publication Metadata only Lower baseline eGFR levels and IgA nephropathy prediction tool.(2021-08-01T00:00:00Z) Artan, Ayşe Serra; Mirioğlu, Şafak; Demir, Erol; Dirim, Ahmet Burak; Şafak, Seda; Garayeva, Nurana; Özlük, Mesude Yasemin; Oto, Özgür Akın; Yazıcı, Halil; Çalışkan, Yaşar; MİRİOĞLU, ŞAFAKPublication Metadata only Diffuse Cavernous Hemangioma of the Colon(2016-07-01T00:00:00Z) Mirioglu, ŞAFAK; ÇAVUŞ, Bilger; Iliaz, Raim; Besisik, Fatih; MİRİOĞLU, ŞAFAKA 70-year-old man was admitted to our clinic with a history of rectal bleeding and constipation, his colonoscopy revealed varicosities and bluish nodular lesions of the rectum (Figure 1). Abdominal CT showed multiple nodular lesions beginning from the distal descending colon and extending to the rectum, calcifications suggesting phleboliths were also seen in these lesions. A contrast enhanced pelvic MRI demonstrated multiple tubular lesions showing hyperintensity on T2-weighted images and hypointensity on T1-weighted images, consistent with the affected areas on the CT scan (Figure 2). It was a diffuse cavernous hemangioma, which mostly affects the rectosigmoid colon in the gastrointestinal tract, and can clinically mimic internal hemorrhoids, ulcerative colitis or cancer (1). Gastrointestinal hemangioma is a rare benign vascular neoplasm, and might be associated with a congenital disorder like Osler-Weber-Rendu disease, Maffucci-s syndrome, Klippel-Trenaunay syndrome, or the congenital blue rubber bleb nevus syndrome (2). Even though there are different medical treatment options targeting VEGF and FGF-mediated pathways such as bevacizumab and thalidomide, and endoscopic approaches like sclerotherapy and electrocautery; complete resection of the hemangioma is the only curative treatment method (1, 3). Therefore, the patient was referred to department of surgery for a definitive treatment, and lost to follow-up.Publication Metadata only The importance of glomerular C3 accumulation in elderly patients with primary membranous nephropathy(2022-05-01T00:00:00Z) Oto, Özgür Akın; Mirioğlu, Şafak; Dirim, Ahmet Burak; Şafak, Seda; Güller, Nurana; Demir, Erol; Artan, Ayşe Serra; Özlük, Mesude Yasemin; Uçar, Ali Rıza; Soltanova, Lala; Nuriyev, Kanan; Yazıcı, Halil; Çalışkan, Yaşar Kerem; MİRİOĞLU, ŞAFAKPublication Metadata only LIMS1 Risk Genotype and T-Cell Mediated Rejection in Kidney Transplant Recipients.(2021-04-28T00:00:00Z) Çalışkan, Yaşar; Karahan, Gonca; Usta Akgül, Sebahat; Mirioğlu, Şafak; Özlük, Mesude Yasemin; Yazıcı, Halil; Demir, Erol; Dirim, Ahmet Burak; Türkmen, Aydın; Edwards, John; Oğuz Savran, Fatma; Sever, Mehmet Şükrü; Kiryluk, Krzysztof; Gharavi, Ali; Lentine, Krista L; MİRİOĞLU, ŞAFAKBackground:This study aims to examine the association of LIM Zinc Finger Domain Containing 1 (LIMS1) genotype with allograft rejection in an independent kidney transplant cohort.Methods:We genotyped 841 kidney transplant recipients for LIMS1 rs893403 variant by Sanger sequencing followed by PCR confirmation of the deletion. Recipients who were homozygous for LIMS1 rs893403 genotype GG were compared to AA/AG genotypes. The primary outcome was T-cell mediated (TCMR) or antibody mediated rejection (ABMR) and secondary outcome was allograft loss.Results:After a median follow-up of 11.4 years, the rate of TCMR was higher in recipients with the GG (n = 200) compared to AA/AG (n = 641) genotypes [25 (12.5%) vs 35 (5.5%); p = 0.001] while ABMR did not differ by genotype [18 (9.0%) vs 62 (9.7%)]. Recipients with GG genotype had 2.4-times higher risk of TCMR than those who did not have this genotype (adjusted hazard ratio (aHR), 1.442.434.12, p = 0.001). A total of 189 (22.5%) recipients lost their allografts during follow up. Kaplan-Meier estimates of 5-year (94.3% vs. 94.4%, p = 0.99) and 10-year graft survival rates (86.9% vs. 83.4%, p = 0.31) did not differ significantly in those with GG compared to AA/AG groups.Conclusions:Our study demonstrates that recipient LIMS1 risk genotype is associated with increased risk of TCMR after kidney transplantation, confirming the role of LIMS1 locus in allograft rejection. These findings may have clinical implications for the prediction and clinical management of kidney transplant rejection by pretransplant genetic testing of recipients and donors for LIMS1 risk genotype.Publication Metadata only Clinical significance of glomerular C3 deposition in primary membranous nephropathy(2021-01-01T00:00:00Z) Oto, Özgür Akın; Demir, Erol; Mirioğlu, Şafak; Dirim, Ahmet Burak; Özlük, Mesude Yasemin; Cebeci, Egemen; Baştürk, Taner; Uçar, Ali Rıza; Soltanova, Lala; Nuriyev, Kanan; Kılıçaslan, Işın; Yazıcı, Halil; Çalışkan, Yaşar Kerem; MİRİOĞLU, ŞAFAKBackground We aimed to investigate the effects of glomerular C3 deposition on clinical, histopathological features, and outcomes of patients with primary membranous nephropathy (MN). Methods A total of 261 patients with biopsy-proven primary MN, who were on follow up for at least 6 months, were included in the study. The patients were grouped according to their C3 immunostaining in kidney biopsy samples at the time of diagnosis: Low intensity [LI; (C3 1 +)] and high intensity [HI; (C3 2 + or C3 3 +)]. The primary outcome was the development of kidney failure. Complete (CR) or partial remission (PR) was defined as secondary outcome. Results Sixteen patients reached the primary outcome after a median follow-up of 33.8 months. Patients in the high intensity group (119 cases) had lower eGFR and higher proteinuria at admission and last follow-up compared to patients in the low intensity group (142 cases). Also, more patients in the high intensity group reached the primary outcome compared to patients in the low intensity group: twelve patients (10.1%) in the high intensity group and four patients (2.8%) in the low intensity group reached the primary outcome (p = 0.015). Kaplan-Meier analysis demonstrated that patients in the high intensity group had a higher risk for kidney failure (p = 0.02). In multivariate logistic regression analysis, high intensity C3 deposition and initial estimated glomerular filtration rate (eGFR) indepenently predicted primary outcome. Conclusion Extensive glomerular C3 deposition is a predictor of kidney failure in patients with MN.Publication Metadata only Serum and urine TNF-like weak inducer of apoptosis, monocyte chemoattractant protein-1 and neutrophil gelatinase-associated lipocalin as biomarkers of disease activity in patients with systemic lupus erythematosus(2020-04-01T00:00:00Z) Mirioglu, ŞAFAK; ÇINAR, Suzan; YAZICI, Hülya; Ozluk, Y.; KILIÇASLAN, Işın; GÜL, Ahmet; Ocal, L.; İNANÇ, Murat; Artim-Esen, B.; MİRİOĞLU, ŞAFAKObjectivesPublication Metadata only A comparison of methods of plasmapheresis for the treatment of late antibody mediated rejection in kidney transplant recipients.(2022-10-06T00:00:00Z) Çalışkan, Yaşar; Mirioglu, Şafak; Dirim, Ahmet Burak; Özluk, Mesude Yasemin; Yeğit, Osman Ozan; Aksoy, Elif; Şafak, Seda; Güller, Nurana; Demir, Erol; Artan, Ayşe Serra; Oto, Özgur Akın; Beşışık, Sevgi; Yazıcı, Halil; Türkmen, Aydın; Lentine, Krista L.; MİRİOĞLU, ŞAFAKPublication Metadata only Recurrent and de novo glomerulonephritis following renal transplantation: higher rates of rejection and lower graft survival(2017-12-01T00:00:00Z) Mirioglu, ŞAFAK; Caliskan, Yasar; Goksoy, Yagmur; Gulcicek, Sibel; Ozluk, Yasemin; Sarihan, Irem; Seyahi, Nurhan; KILIÇASLAN, Işın; TÜRKMEN, Aydın; SEVER, Mehmet Şükrü; MİRİOĞLU, ŞAFAKIn this retrospective study with case-control design, we aimed to determine the clinical and pathological characteristics of post-transplant glomerulonephritis (GN), and their effects on transplant recipients.