Person: YAZICI, MEBRURE
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Publication Metadata only Early infant feeding practice and childhood obesity: the relation of breast-feeding and timing of solid food introduction with childhood obesity(2014-11-01) Vehapoglu, AYSEL; Yazici, MEBRURE; DEMIR, Aysegul Dogan; NURSOY, Mustafa; TURKMEN, Serdar; Ozkaya, EMİN; VEHAPOĞLU TÜRKMEN, AYSEL; YAZICI, MEBRURE; NURSOY, MUSTAFA ATİLLA; ÖZKAYA, EMİNObjective: We assessed the association of breast-feeding and timing of solid food introduction with childhood obesity.Publication Open Access Effect of Montelukast Monotherapy on Oxidative Stress Parameters and DNA Damage in Children with Asthma(2015-01-01) DILEK, Fatih; Ozkaya, EMİN; Kocyigit, ABDÜRRAHİM; Yazici, MEBRURE; KESGIN, Siddika; GEDIK, Ahmet Hakan; Cakir, ERKAN; ÖZKAYA, EMİN; KOÇYİĞİT, ABDÜRRAHİM; YAZICI, MEBRURE; ÇAKIR, ERKANBackground: There is ample knowledge reported in the literature about the role of oxidative stress in asthma pathogenesis. It is also known that the interaction of reactive oxygen species with DNA may result in DNA strand breaks. The aim of this study was to investigate if montelukast monotherapy affects oxidative stress and DNA damage parameters in a population of pediatric asthma patients. Methods: Group I consisted of 31 newly diagnosed asthmatic patients not taking any medication, and group II consisted of 32 patients who had been treated with montelukast for at least 6 months. Forty healthy control subjects were also enrolled in the study. Plasma total oxidant status (TOS) and total antioxidant status (TAS) were measured to assess oxidative stress. DNA damage was assessed by means of alkaline comet assay. Results: The patients in both group I and group II had statistically significant higher plasma TOS (13.1 ± 4 and 11.1 ± 4.1 μmol H2O2 equivalent/liter, respectively) and low TAS levels (1.4 ± 0.5 and 1.5 ± 0.5 mmol Trolox equivalent/liter, respectively) compared with the control group (TOS: 6.3 ± 3.5 μmol H2O2 equivalent/liter and TAS: 2.7 ± 0.6 mmol Trolox equivalent/liter; p < 0.05). DNA damage was 18.2 ± 1.0 arbitrary units (a.u.) in group I, 16.7 ± 8.2 a.u. in group II and 13.7 ± 3.4 a.u. in the control group. There were statistically significant differences only between group I and the control group (p < 0.05). Conclusions: According to the findings, montelukast therapy makes only minimal but not statistically significant improvement in all TOS, TAS and DNA damage parameters.Publication Open Access Renal tubular function and urinary N-acetyl-beta-d-glucosaminidase and kidney injury molecule-1 levels in asthmatic children(2016-12-01) DEMIR, Aysegul Dogan; GOKNAR, Nilufer; OKTEM, Faruk; Ozkaya, EMİN; Yazici, MEBRURE; Torun, EMEL; Vehapoglu, Aysel; KUCUKKOC, Mehmet; ÖZKAYA, EMİN; YAZICI, MEBRURE; TORUN, EMEL; VEHAPOĞLU TÜRKMEN, AYSELBackground: Asthma is a chronic inflammatory disorder of the airways which results in chronic hypoxia. Chronic hypoxia and inflammation can affect renal tubular function. Objectives: The aim of this study was to investigate renal tubular function and early kidney injury molecules such as urinary N-acetyl-betaglucosaminidase (NAG) and kidney injury molecule-1 (KIM-1) excretion in children with asthma. Methods: Enrolled in the study were 73 children diagnosed with asthma and 65 healthy age- and gender-matched control subjects. Urine pH, sodium, phosphorus, potassium, microalbumin, creatinine, NAG, KIM-1, and serum creatinine, sodium, phosphorus were evaluated. The diagnosis of asthma and classification of mild or moderate were done according to the Global Initiative for Asthma guidelines. Results: Serum sodium, phosphorus, creatinine, and urinary microalbumin were within normal levels in the both groups. Urinary pH, sodium, potassium, phosphorus, microalbumin, and KIM-1 excretions were similar between the control and study groups. Tubular phosphorus reabsorption was within normal limits in two groups. Urine NAG was elevated in the study group (P = 0.001). Urinary KIM-1 and NAG levels were positively correlated (r = 0.837; P = 0.001). When children with mild and moderate asthma were compared, all of the parameters were similar (P >0.05). Conclusions: This study showed that chronic asthma can lead to subtle renal impacts. We suggest that in children with asthma, urinary NAG level is a more valuable parameter to show degree of renal tubular injury than markers such as microalbumin and KIM-1. Chronic hypoxy and inflammation probably contributes to these subclinical renal effects.Publication Open Access Oxidative Stress in Children with Chronic Spontaneous Urticaria(2016-01-01) DILEK, Fatih; Ozceker, Deniz; Ozkaya, EMİN; Guler, Nermin; Tamay, Zeynep; KESGIN, Siddika; Yazici, MEBRURE; Kocyigit, ABDÜRRAHİM; ÖZKAYA, EMİN; YAZICI, MEBRURE; KOÇYİĞİT, ABDÜRRAHİMThe pathogenesis of chronic spontaneous urticaria (CSU) has not been fully understood; nevertheless, significant progress has been achieved in recent years. The aim of this study was to investigate the possible role of reactive oxygen species (ROS) in the pathogenesis of CSU. Sixty-two children with CSU and 41 healthy control subjects were enrolled in the study. An extensive evaluation of demographic and clinical features was done, and serum oxidative stress was evaluated by plasma total oxidant status (TOS) and total antioxidant status (TAS) measurements.The median value of plasma TOS was found to be 10.49 𝜇mol H2O2 equiv./L (interquartile range, 7.29–17.65) in CSU patients and 7.68 𝜇mol H2O2 equiv./L (5.95–10.39) in the control group. The difference between the groups was statistically significant (𝑝 = 0.003). Likewise, the median plasma TAS level in the CSU group was decreased significantly compared to that of the control group (2.64 [2.30–2.74] versus 2.76 [2.65–2.86] mmol Trolox equiv./L, resp., 𝑝 = 0,001). Our results indicated that plasma oxidative stress is increased in children with CSU when compared to healthy subjects, and plasma oxidative stress markers are positively correlated with disease activityPublication Open Access Plasma total thiol pool in children with asthma: Modulation during montelukast monotherapy(2016-03-01) DILEK, Fatih; Ozkaya, EMİN; Kocyigit, ABDÜRRAHİM; Yazici, MEBRURE; Guler, ERAY METİN; DUNDAROZ, Mehmet Rusen; ÖZKAYA, EMİN; KOÇYİĞİT, ABDÜRRAHİM; YAZICI, MEBRURE; GÜLER, ERAY METİNBackground: Inflammation, which is a hallmark of asthma, is one of the main sources of oxidative stress in the human body. Thiols are powerful antioxidants that protect cells against the consequences of oxidative stress. We aimed to investigate whether asthma and montelukast monotherapy affect the total plasma thiol pool in children. Methods: A total of 60 children with asthma and 35 healthy controls participated in the study. Group I consisted of newly diagnosed asthmatics who did not have regular anti-asthmatic therapy previously. Group II consisted of patients who had been undertaking montelukast monotherapy regularly for at least 4 months. Plasma total antioxidant status (TAS) and plasma total thiol (PTT) were measured using spectrophotometric methods. Results: Bronchial asthma patients in both groups I and II had decreased median TAS levels compared with the control group (1.59 [interquartile range, 1.04–1.70] and 1.67 [1.50–1.75] vs. 2.98 [2.76–3.16] Trolox equiv./L, respectively; P <0.001). Group I had decreased PTT concentrations compared with the control group (0.18 [0.16–0.20] vs. 0.21 [0.19–0.22] mmol/L; P <0.001), and group II had similar PTT levels to the control group (0.20 [0.17–0.22] mmol/L; P >0.05). In addition, the median TAS and PTT levels for groups I and II were not statistically different (P >0.05). There was a positive correlation between TAS and PTT levels (rho = 0.38, P <0.05) in group I. Conclusion: In order to balance the oxidative stress, both TAS and PTT which are markers of the antioxidant system are reduced in children with asthma. Montelukast monotherapy can limit oxidative stress and thus restore PTT levels but not TAS levels in asthmatic children.Publication Metadata only Elevated Nitrosative Stress in Children with Chronic Spontaneous Urticaria(2017-01-01) DILEK, Fatih; Ozceker, Deniz; Ozkaya, EMİN; Guler, ERAY METİN; Yazici, MEBRURE; Tamay, Zeynep; Kocyigit, ABDÜRRAHİM; Guler, Nermin; ÖZKAYA, EMİN; GÜLER, ERAY METİN; YAZICI, MEBRURE; KOÇYİĞİT, ABDÜRRAHİMBackground: Chronic spontaneous urticaria (CSU) is an idiopathic condition that seriously affects quality of life. It is well known that oxidative stress and nitrosative stress (NS) are generally involved in many chronic inflammatory diseases. This study aimed to evaluate the possible role of NS in the pathogenesis of CSU. Methods: Thirty-two children with CSU and 22 healthy control subjects were enrolled in the study. Demographic and clinical features were defined, and disease activity was quantified using the urticaria activity score (UAS). Serum NS was assessed by the plasma levels of total nitric oxide (NOx) metabolites and nitrite and nitrate measurements using a Griess method -based commercial kit. Results: Plasma NOx levels were 82.5 11.3 mol/L in the CSU group and 50.9 9.4 mol/L in the control group. The difference was statistically significant (p < 0.001). CSU patients also had higher plasma nitrite levels than controls (53.3 13.8 vs. 30.2 10.1 mol/L, respectively, p < 0.001). The median values of plasma nitrate were 27.5 mon (IQR 19.1-35.5) in CSU patients and 20.9 rnol/L (IQR 17.9-23.2) in the control group, and the difference was statistically significant (p = 0.009). In addition, plasma NOx and nitrite levels were positively correlated with the UAS (rho = 0.512, p = 0.03 and rho = 0.452, p = 0.011, respectively). Conclusion: Plasma NS is elevated and positively correlated with disease activity in children with CSU. (C) 2017 S. Ka rger AG, Basel