2018-01-01, Dundar, TOLGA TURAN, Kits, Serkan, Ozdemir, HÜSEYİN, Seyithanoglu, MEHMET HAKAN, Uysal, Omer, Toprak, HÜSEYİN, Ozek, ERDİNÇ, Alkan, ALPAY, DÜNDAR, TOLGA TURAN, ARALAŞMAK, AYŞE, ÖZDEMİR, HÜSEYIN, SEYİTHANOĞLU, MEHMET HAKAN, UYSAL, ÖMER, TOPRAK, HÜSEYİN, KİTİŞ, SERKAN, ÖZEK, ERDİNÇ, ALKAN, ALPAY

AIM: To compare effectiveness of contrast-enhanced magnetic resonance angiography (CE-MRA), 3D-Time-of-flight magnetic resonance angiography (3D-TOF-MRA) and subtracted computed tomography angiography from computed tomography perfusion (sub-CTA) in residue evaluation of intracranial aneurysms treated either with coiling or clipping.

2016-12-11, CIKRIKCIOGLU, Mehmet Ali, Ozcan, Muhammed Emin, HALAC, Gulistan, GULTEPE, Ilhami, CELIK, Kenan, SEKIN, Yahya, ESER, Elif Ece, Burhan, Sebnem, ÇETİN, GÜVEN, UYSAL, ÖMER, BURHAN, ŞEBNEM, ÇETİN, GÜVEN, UYSAL, ÖMER

2021-10-01T00:00:00Z, Gareayaghi, Nesrin, Akkus, Seher, Saribas, Suat, Demiryas, Suleyman, Ozbey, Dogukan, Kepil, Nuray, Demirci, Mehmet, DİNÇ, HARİKA ÖYKÜ, Akcin, Ruveyda, Uysal, Omer, Tokman, Hrisi Bahar, Kocazeybek, Bekir, DİNÇ, HARİKA ÖYKÜ, UYSAL, ÖMER

We aimed to detect EBV/Hp (Epstein-Barr Virus/Helicobacter pylori) co-infection by determining the number of copies of EBV/EBER-1 in the gastric biopsy samples of the Hp (+) GC, peptic ulcer (PU), and non-ulcer dyspepsia (NUD) cases.

2017-01-01, Habip, Z., Sohrabi, P., Saribas, S., Caliskan, R., Demirci, M., Karakullukcu, A., Atalik, K., Yuksel, P., Uysal, ÖMER, Kosan, E., Tokman, H. Bahar, Kocazeybek, B., YÜKSEL MAYDA, PELİN, UYSAL, ÖMER

Neopterin and soluble CD14 (sCD14) are detected at high levels in hepatitis C virus (HCV) infections. We aimed to evaluate the role of these plasma immune activation biomarkers, for the indirect assessment of immune activation status of patients with low anti-HCV reactivity and a HCV infection. Low anti-HCV reactivity group (LRG, n: 70), true positive HCV infection group (THG, 30) and healthy control group (HCG, 30) were analyzed in this study. We have used ELISA, HCV RIBA/LIA and HCV-RNA methods. Mean neopterin levels were significantly lower in LRG than THG (p 0.05). Mean sCD14 were significantly higher in LRG than THG and HCG (p <0.05, p <0.001). Values of 3.95 mu g/ml and 5.36 nmol/l for sCD14 and neopterin resulted in the maximum area under the receiver operating characteristic curves (ROC), which were 0.859 (95% CI, 0.745 to 0.935; <0.0001) and 0.788 (95% CI, 0.663 to 0.883; <0.0001), respectively. These cut-offs corresponded to a sensitivity of 73.3% and a specificity of 73.3% for neopterin and of 100% and 76.7% for sCD14. Our results suggest that a specific immunoactivation might be caused by true positive HCV infection. Due to the significant results sCD14 in LRG might be non-specifically affected by some underlying atypical immunohematological pathologies. Only neopterin might be used to exclude low anti-HCV reactivity from a true HCV infection. The use of neopterin but not sCD14 in combination with fourth-generation EIA/CMIA combo tests will be useful when nucleic acid tests are not available for screening blood donors at blood banks.

2014-09-01, Aydin, TEOMAN, TASPINAR, Ozgur, Akbal, YILDIZ, PERU, Celaleddin, GULER, Mustafa, Uysal, Omer, Yakicier, M. Cengiz, AYDIN, TEOMAN, AKBAL, YILDIZ, UYSAL, ÖMER

[Purpose] The aim of this study was to measure bone mineral density, serum and urinary bone turnover parameters, and to evaluate the influence of demographic and genetic factors on these parameters in FMF patients. [Subjects and Methods] Twenty-seven attack-free patients who were diagnosed with FMF (in accordance with Tel Hashomer criteria) were recruited at outpatient rheumatology clinics. We investigated whether there were any differences between the FMF patients and a control group in terms of lumbar and femur bone mineral density (BMD), standard deviation scores (Z scores and T scores) and bone markers. [Results] In terms of the median values of lumbar BMD (p = 0.21), lumbar T (p = 0.098) and Z (p = 0.109) scores, femoral neck BMD, femoral T and Z scores and total femur BMD, T (p = 0.788) and Z scores, there were no significant differences. [Conclusion] In our study, no statistically significant differences were found between FMF patients and a control group in terms of osteoporosis. The 25-OH vitamin D was found to be significantly lower in FMF patients than in the control group.

2013-03-01, Bacaksiz, AHMET, ERDOGAN, Ercan, TASAL, Abdurrrahman, VATANKULU, Mehmet Akif, KUL, Seref, SEVGILI, Emrah, ERTAS, Gokhan, DIZMAN, DİDEM, Onsun, NAHİDE, Uysal, Omer, BACAKSIZ, AHMET, DİZMAN, DİDEM, ONSUN, NAHIDE, UYSAL, ÖMER

Purpose. Psoriasis vulgaris is one of the most common skin disorders. Patients with psoriasis carry an excessive risk of atrial fibrillation (AF). The differences between the maximum (Pmax) and the minimum (Pmin) P-wave duration on ECG are defined as P-wave dispersion (PWD). Prolongation of PWD is an independent risk factor for the development of AF. The aim of this the study was to investigate P-wave duration and PWD in patients with psoriasis. Methods. Sixty-one adult patients with psoriasis vulgaris (group 1) and 58 age and sex-matched healthy individuals (group 2) were included in this study. ECG recordings were obtained, and the P-wave variables were calculated. Results were reported as mean ± standard deviation and percentages. Continuous variables were analysed using Student’s t test. A value of P < 0.05 was considered statistically significant. Results. Pmax and PWD were significantly higher in group 1 than in group 2 (108.8 ± 21.3 ms versus 93.3 ± 13.0 ms, P < 0.001; 67.4 ± 22.9 ms versus 45.0 ± 19.6 ms, P < 0.001, respectively). Also, Pmin was significantly lower in group 1 (41.3 ± 12.3 ms versus 48.3 ± 14.3 ms, P = 0.04). The psoriasis disease activity score and hsCRP correlated with PWD (P < 0.01). Conclusions. Atrial conduction of sinus impulses was impaired in patients with psoriasis vulgaris. It was more prominent in patients with severe disease. Physicians caring for patients with psoriasis vulgaris should screen them for AF development.

2014-04-01, Ince, ALİ TÜZÜN, YILDIZ, Kemal, BAYSAL, Birol, DANALIOGLU, Ahmet, KOCAMAN, Orhan, TOZLU, Mukaddes, GANGARAPU, Venkatanarayana, Kemik, Ahu Sarbay, Uysal, Omer, Senturk, HAKAN, İNCE, ALİ TÜZÜN, UYSAL, ÖMER, ŞENTÜRK, HAKAN

Background/Aims: Despite the presence of many diagnostic methods, the differential diagnosis between benign and malignant biliary obstructions is still not easy. We aimed to evaluate the role of serum/biliary carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA 19-9), vascular endothelial growth factor receptor-3(VEGFR-3), and total antioxidant capacity (TAC) tests in this differential diagnosis.

2021-06-01T00:00:00Z, Güler, Beril, Adilli, Adila, Uysal, Ömer, GÜLER, BERIL, ERDOĞAN, EZGİ BAŞAK, UYSAL, ÖMER

Aim: Lymphoma staging is important from the prognostic and therapeutic point of view and bone marrow biopsy performed for this purpose makes up a large part of current hematopathology practice. PET-CT is the currently preferred method to evaluate bone marrow involvement by lymphoproliferative disorders as it is non-invasive and practical. The aim of this study was to compare trephine biopsy and PET-CT results as regards determining bone marrow involvement in various lymphoma subtypes. Materials and Methods: A total number of 198 bone marrow biopsies and 185 PET-CT images of cases consisting of various lymphoma subtypes were included in the study. The results of both methods evaluated for bone marrow infiltration were grouped as positive, negative, and suspicious to compare consistency. Statistical agreement was calculated with the kappa coefficient. The sensitivity, specificity, and the positive and negative predictive values were calculated as the diagnostic test measures. Results: Twenty-six cases (15.8%) had lymphoma involvement in trephine biopsies and 36 cases (21.2%) had positive findings for lymphoma involvement of the bone marrow on PET-CT. The two methods had weak statistical agreement (κ= 0.21). Biopsy and PETCT results were similar in 132 cases (71.20%). PET-CT showed false negative results in 11 cases in which infiltration was observed with biopsy. Twenty-six cases that were negative for lymphoma involvement on biopsy were accepted as positive on PET-CT and 16 of these cases were classical Hodgkin-s lymphoma. One case with suspicious bone marrow biopsy was positive on PET-CT, while four cases with suspicious PET-CT results were positive on biopsy. Conclusion: The results showed that both of the methods have advantages and disadvantages as regards lymphoma staging. However, histopathology is globally accepted as the gold standard for a definite diagnosis. We believe that the complementary use of the two methods is more beneficial for correct guidance during clinical practice.

2015-01-01, BAYSAL, Birol, Senturk, HAKAN, MASRI, Omar, TOZLU, Mukaddes, KAYAR, Yusuf, ARABACI, ELİF, Uysal, Omer, BUGDACI, Mehmet Sait, Ince, ALİ TÜZÜN, ŞENTÜRK, HAKAN, ARABACI, ELİF, UYSAL, ÖMER, İNCE, ALİ TÜZÜN

Background/Aims: This study aimed to test the efficacy of empirical proton pump inhibitor use and Helicobacter pylori therapy for uninvestigated dyspepsia in a population with a high prevalence of H. pylori.

2010-06-01T00:00:00Z, Alikasifoglu, Muejgan, Erginoz, Ethem, Ercan, Oya, Uysal, Omer, Ekici, Bans, Ocak, Sueheyla, Oktay, Guelsah, Yucel, Ilker, Albayrak, Deniz Kaymak, UYSAL, ÖMER

Aim: The aim of the study was to determine the differences between rural and urban adolescents- health and health behaviors.