Person: UYSAL, ÖMER
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Publication Open Access Ambulatory Blood Pressure Monitoring Could Unmask Hypertension in Patients with Psoriasis Vulgaris(2013-10-29) BACAKSIZ, AHMET; Erdogan, Ercan; Sonmez, Osman; Sevgili, Emrah; Tasal, Abdurrahman; ONSUN, NAHİDE; Topukcu, Bugce; Kulac, Beytullah; UYSAL, ÖMER; Goktekin, Omer; BACAKSIZ, AHMET; ONSUN, NAHIDE; UYSAL, ÖMERBackground: Psoriasis vulgaris is one of the most prevalent chronic, inflammatory skin disorders. Patients with psoriasis have excess risk of essential hypertension. Masked hypertension (MH), defined as normal office blood pressure (BP) with elevated ambulatory BP (ABPM), has been drawing attention recently due to its association with increased risk of developing sustained hypertension, cardiovascular morbidity, and mortality. The aim of this study was to investigate the prevalence of MH in psoriatic patients. Material and Methods: On hundred and ten middle-aged, normotensive, non-obese patients with psoriasis vulgaris and 110 age- and sex-matched normotensive controls were included in the study. ABPM was performed in all participants over a 24-h period. The clinical severity of the disease was determined according to current indexes. Results: The prevalence of MH among subjects with psoriasis vulgaris was 31.8% and increased compared to control subjects (p<0.01). Predictors of MH in patients with psoriasis vulgaris were detected as male sex, smoking, obesity-related anthropometric measures, and disease activity. Male sex, waist circumference, and diffuse psoriatic involvement were detected as independent predictors of MH. Conclusions: MH is prevalent in patients with psoriasis vulgaris. Assessment with ABPM and close follow-up for development of hypertension is reasonable.Publication Open Access The relationship between pruritus and clinical variables in patients with psoriasis(2017-07-01) Su, Ozlem; Bahali, ANIL GÜLSEL; Onsun, NAHİDE; OZKAYA, Dilek Biyik; Dizman, DİDEM; TOPUKCU, Bugce; Uysal, Omer; BAHALI, ANIL GÜLSEL; ONSUN, NAHIDE; SU KÜÇÜK, ÖZLEM; DİZMAN, DİDEM; UYSAL, ÖMERPruritus is the most commonly occurring subjective symptom of dermatological disease. Published data on both prevalence and intensity of pruritus in psoriasis is limited. Objective: In this study we aimed to investigate the prevalence of pruritus and its relation with psoriasis area severity index, body mass index and presence of systemic disease in patients with psoriasis. Methods: We analyzed data of psoriatic patients diagnosed in our psoriasis outpatient clinic between March 2013 and June 2014 collected retrospectively from PSR-TR registration system. Results: In total, 880 patients were analyzed. Pruritus was more prominent in female patients. This difference was statistically significant. No significant associations were found between age of patients, clinical type of disease and pruritus. The itching was more common in patients with higher body mass index. Presence of pruritus was correlated significantly with severity of psoriasis. Five hundred and sixty of 880 patients had no systemic disease. The presence of pruritus was not related with presence of systemic disease. Existence of systemic disease with psoriasis has minimal effect on pruritus. Study Limitations: We did not evaluate intensity of pruritus. Conclusions: Pruritus is not mentioned within the classical symptoms of psoriasis. Pruritus in psoriasis is a very unpleasant symptom with great potential to impair patient’s quality of life and may exacerbate psoriasis as a Koebner phenomenon. Keywords: Patients; Psoriasis; PruritusPublication Open Access The relationship between body mass index, waist circumference and psoriatic arthritis in the Turkish population(2016-01-01) OZKAYA, Dilek Biyik; Onsun, NAHİDE; Su, Ozlem; Bahali, ANIL GÜLSEL; Dizman, DİDEM; Rezvani, AYLİN; Uysal, Omer; ONSUN, NAHIDE; SU KÜÇÜK, ÖZLEM; BAHALI, ANIL GÜLSEL; DİZMAN, DİDEM; REZVANİ, AYLİN; UYSAL, ÖMERIntroduction: Psoriasis is a chronic, immune-mediated inflammatory disease predominantly affecting the skin, with a complex aetiology. Recently it has been suggested that the chronic inflammation of psoriasis may cause metabolic and vascular disorders. The relationship between obesity and psoriatic arthritis (PsA) is not clear, and there are insufficient prospective studies addressing this subject. Aim: To investigate the relationship between psoriatic arthritis, severity of psoriasis and obesity in the Turkish population. Material and methods: Patient data from psoriasis outpatient clinics from February 2007 to July 2013 were reviewed retrospectively using the Psoriasis-Turkey (PSR-TR) registration system. Patients' age, onset age, body mass index (BMI), waist circumference, psoriasis area and severity index (PASI), and arthritis information were reviewed. In the outpatient clinics, patients who had joint pain consulted rheumatology clinics. The CASPAR criteria were used for the diagnosis of arthritis. Results: A total of 443 males and 495 females enrolled in this study. The mean age of females was 43.9 years (18-93 years) and the mean age of males was 44.6 years (18-89 years). A total of 231 (25%) patients had psoriatic arthritis. Investigation of the relationship between PASI, BMI, waist circumference (WC) and arthritis revealed a statistically significant relationship between each variable. Conclusions: In this study we observed a relationship between PsA and high BMI, high WC and high PASI. Psoriatic arthritis is a chronic inflammatory disorder and a chronic inflammatory state induced by adiposity may lead to PsA.Publication Open Access Body mass index and psoriasis area and severity index relation in Turkish psoriasis population(2014-09-01) OZKAYA, Dilek Biyik; Onsun, NAHİDE; TOPUKCU, Bugce; Su, Ozlem; Dizman, DİDEM; Uysal, Omer; ONSUN, NAHIDE; SU KÜÇÜK, ÖZLEM; DİZMAN, DİDEM; UYSAL, ÖMERBackground and Design: Psoriasis is a chronic immune-mediated inflammatory disease affecting 1-3% of the general population. Recently, it has been suggested that chronic inflammation in psoriasis may cause metabolic and vascular disorders. Most of recent studies focused on the comorbidities and the mechanisms of comorbidities associated with psoriasis. Obesity may lead to cardiovascular disorders, diyabetes mellitus, hypertension, malignancies, musculoskeleteal system diseases, impaired quality of life, and death. In this study, we aimed to investigate the prevalence of obesity in patients with psoriasis and the relationship between the disease severity and body mass index (BMI) in Turkish psoriasis population.