Person: TOK, OLGU ENİS
Search Results
The Effect of Apelin on Podocytes in Doxorubicin Induced Nephrotic Syndrome.
2017-05-21, Özkan, Naziye, SEHIRLI, AHMET OZER, Yüksel, Meral, Çilingir, Özlem Tuğçe, TOK, OLGU ENİS, Aydemir, Sezgin, Koç, Mehmet, CETINEL, SULE, TOK, OLGU ENİS
Melatonin protects against ischemic heart failure in rats
2013-09-01T00:00:00Z, Sehirli, Ahmet Ozer, Koyun, Derya, TETİK, ŞERMİN, ÖZSAVCI, DERYA, YIGINER, Omer, ÇETİNEL, ŞULE, Tok, Olgu Enis, Kaya, Zehra, AKKİPRİK, MUSTAFA, Kilic, Ertugrul, Sener, Goksel, TOK, OLGU ENİS
Ischemic injury, which occurs as a result of sympathetic hyperactivity, plays an important role in heart failure. Melatonin is thought to have antiatherogenic, antioxidant, and vasodilatory effects. In this study, we investigated whether melatonin protects against ischemic heart failure (HF). In Wistar albino rats, HF was induced by left anterior descending (LAD) coronary artery ligation and rats were treated with either vehicle or melatonin (10 mg/kg) for 4 weeks. At the end of this period, echocardiographic measurements were recorded and the rats were decapitated to obtain plasma and cardiac tissue samples. Lactate dehydrogenase, creatine kinase, aspartate aminotransferase, alanine aminotransferase, and lysosomal enzymes (beta-D-glucuronidase, beta-galactosidase, beta-D-N-acetyl-glucosaminidase, acid phosphatase, and cathepsin-D) were studied in plasma samples, while malondialdehyde and glutathione levels and Na+, K+-ATPase, caspase-3 and myeloperoxidase activities were determined in the cardiac samples. Sarco/endoplasmic reticulum calcium ATPase (SERCA) and caveolin-3 levels in cardiac tissues were evaluated using Western blot analyses. Furthermore, caveolin-3 levels were also determined by histological analyses. In the vehicle-treated HF group, cardiotoxicity resulted in decreased cardiac Na+, K+-ATPase and SERCA activities, GSH contents and caveolin-3 levels, while plasma LDH, CK, and lysosomal enzyme activities and cardiac MDA and Myeloperoxidase (MPO) activities were found to be increased. On the other hand, melatonin treatment reversed all the functional and biochemical changes. The present results demonstrate that Mel ameliorates ischemic heart failure in rats. These observations highlight that melatonin is a promising supplement for improving defense mechanisms in the heart against oxidative stress caused by heart failure.
Success rate of different surgical methods for sperm retrieval: a study of 211 azoospermic Turkish patients with normal karyotype
2012-01-01T00:00:00Z, OZDEMIR, A. A., Aktas, R. G., TOK, OLGU ENİS, TOK, OLGU ENİS
Expression patterns of F-Actin and Nanog, an embryonic stem cell marker, in monolayer and spheroid culture of human liver carcinoma cell line.
2014-12-01, Aktas, R. G., Tok, OLGU ENİS, TOK, OLGU ENİS
Shea Yağının Yara İyileşmesi Üzerine Etkisi.
2016-05-03, BAYINDIR, NİHAN, TOK, OLGU ENİS, EŞREFOĞLU, MUKADDES, Kılıç, Elif, BULUT, HURİ, BAYINDIR, NİHAN, TOK, OLGU ENİS, EŞREFOĞLU, MUKADDES, BULUT, HURI
Antioxidant and anti-inflammatory effects of curcumin against hepatorenal oxidative injury in an experimental sepsis model in rats
2013-11-01T00:00:00Z, SAVCUN, Gulay Yilmaz, OZKAN, Erkan, DULUNDU, ENDER, TOPALOGLU, Umit, Sehirli, Ahmet Ozer, Tok, Olgu Enis, ERCAN, FERİHA, ŞENER, GÖKSEL, TOK, OLGU ENİS
BACKGROUND: To investigate the effects of curcumin, an antioxidant and anti-inflammatory agent, on free oxygen radicals and lipid peroxidation in an experimental sepsis model, as well as to determine the role of curcumin in preventing hepatorenal tissue damage caused by sepsis.
Cep Telefonları Kaynaklı Elektromanyetik Dalgaların Sıçan Trigeminal Siniri Üzerine Etkileri
2016-05-03, Akakın, Dilek, TOK, OLGU ENİS, Dağbaşı, Nükhet, Anıl, Damla, Akakın, Akın, Şirvancı, Serap, ERCAN, FERIHA, TOK, OLGU ENİS
Mito Tracker labeling in HepG2 Cell Cultures: Influence of different staining techniques on the morphology of mitochondria.
2012-01-01T00:00:00Z, Aktasl, R. G., KARAHUSEYINOGLU, S., Karabork, M., TOK, OLGU ENİS, Yucel, D., TOK, OLGU ENİS
Electromagnetic Waves Emitted By Mobile Phones Effect On The Testis Morphology Of Rat, Cell Death and Blood-Testis Barrier: Evaluation for Infertility.
2014-09-12, TOK, OLGU ENİS, SEHIRLI, AHMET OZER, ERCAN, FERIHA, TOK, OLGU ENİS
Genç Ve Yaşlı Sprague-Dawley Sıçanlarda Parsiyel Hepatektomi Sonrası Melatoninin Karaciğer Rejenerasyonuna Etkisi.
2016-05-03, TOK, OLGU ENİS, AYDIN, M. S., ESREFOGLU, MUKADDES, IRAZ, M., KESKİN, Sıdıka, KOÇYİĞİT, ABDÜRRAHİM, TOK, OLGU ENİS, EŞREFOĞLU, MUKADDES, KOÇYİĞİT, ABDÜRRAHİM