2020-06-01T00:00:00Z, Sahbaz, Cigdem, Zibandey, Noushin, KURTULMUŞ, AYŞE, Duran, Yazgul, Gokalp, Muazzez, KIRPINAR, İSMET, ŞAHİN, FİKRETTİN, Guloksuz, Sinan, AKKOÇ, TUNÇ, ŞAHBAZ, ÇIĞDEM DILEK, KURTULMUŞ, AYŞE, KIRPINAR, İSMET

Aim To investigate whether circulating T cells including regulatory T cells (Treg) and derived cytokines contribute to the immune imbalance observed in schizophrenia. Methods Forty patients with schizophrenia and 40 age, sex, body mass index, education, and smoking status-matched healthy controls (HC) are included in the study. We stained cells with anti-CD14, anti-CD3, anti-CD4, anti-CD8, anti-CD19, anti-CD20, and anti-CD16/56. Peripheral blood mononuclear cells (PBMCs) were isolated and stained with the human FoxP3 kit containing anti-CD4/anti-CD25 and intracellular anti-Foxp3. PBMCs were cultured for 72 h and stimulated with anti-CD3/anti-CD28. Cytokines (IL-2, IL-4, IL-6, IL-10, IFN-gamma, TNF-alpha, and IL-17A) were measured from the culture supernatant and plasma using the Th1/Th2/Th17 cytokine bead array kit. Results In comparison with HC, Treg percentages in schizophrenia were higher (1.17 +/- 0.63 vs 0.81 +/- 0.53, P = 0.005) in unstimulated but lower in the stimulated condition (0.73 +/- 0.69 vs 0.97 +/- 0.55, P = 0.011). Activated T cell percentages were higher in schizophrenia than HC in unstimulated (2.22 +/- 0.78 vs 1.64 +/- 0.89, P = 0.001) and stimulated (2.25 +/- 1.01 vs 1.72 +/- 1.00, P = 0.010) conditions. The culture supernatant levels of IL-6 (7505.17 +/- 5170.07 vs 1787.81 +/- 1363.32, P < 0.001), IL-17A (191.73 +/- 212.49 vs 46.43 +/- 23.99, P < 0.001), TNF-alpha (1557 +/- 1059.69 vs 426.57 +/- 174.62, P = 0.023), and IFN-gamma (3204.13 +/- 1397.06 vs 447.79 +/- 270.13, P < 0.001); and plasma levels of IL-6 (3.83 +/- 3.41vs 1.89 +/- 1.14, P = 0.003) and IL-17A (1.20 +/- 0.84 vs 0.83 +/- 0.53, P = 0.033) were higher in patients with schizophrenia than HC. Conclusion Our explorative study shows reduced level of Foxp3 expressing Treg in a stimulated condition with induced levels of proinflammatory cytokines in patients with schizophrenia.

2016-09-20, KIRPINAR, İSMET, Görmez, Aynur, Kurtulmuş, AYŞE, KIRPINAR, İSMET, KURTULMUŞ, AYŞE

2014-11-16, KURTULMUŞ, AYŞE, KIRPINAR, İSMET, DEVECİ, ERDEM, KURTULMUŞ, AYŞE, KIRPINAR, İSMET, DEVECİ, ERDEM

2018-06-01, GÖRMEZ, AYNUR, Kurtulmus, AYŞE, Kirpinar, Ismet, KURTULMUŞ, AYŞE, KIRPINAR, İSMET

2020-12-01T00:00:00Z, Kayar, Yusuf, Agin, Mehmet, Dertli, Ramazan, Kurtulmus, Ayse, Boyraz, Rabia Keyser, Onur, Nafiye Selcan, KIRPINAR, İSMET, KURTULMUŞ, AYŞE, ÖNÜR, NAFIYE SELCAN, KIRPINAR, İSMET

Introduction: Eating disorders (ED) constitute an important group of conditions that commonly occur in adolescents. Gastrointestinal complaints are frequently reported in ED patients. Few studies assessed the association of irritable bowel syndrome (IBS) with ED. The aim of the current study is to determine the prevalence of ED in a group of IBS patients and compare it with a healthy control group and assess the relationship of IBS sub-types, it-s duration and severity with ED.

2015-04-19, KURTULMUŞ, AYŞE, KIRPINAR, İSMET, DEVECİ, ERDEM, KOÇER, EMEL, GÖRMEZ, AYNUR, KURTULMUŞ, AYŞE, KIRPINAR, İSMET, DEVECİ, ERDEM

2016-10-01, Kirpinar, I., GORMEZ, A., KURTULMUS, AYŞE, KIRPINAR, İSMET, KURTULMUŞ, AYŞE

2018-05-01, SAHBAZ, Cigdem, Zibandeyeh, Noushin, Kurtulmus, AYŞE, AVAROGLU, Gamze, Kirpinar, Ismet, Sahin, Fikrettin, AKKOÇ, TUNÇ, ŞAHBAZ, ÇIĞDEM DILEK, KURTULMUŞ, AYŞE, KIRPINAR, İSMET

2019-06-01, SAHBAZ, C, Özer, OF, KURTULMUS, AYŞE, KıRPıNAR, I, SAHIN, F, GULOKSUZ, S, ŞAHBAZ, ÇIĞDEM DILEK, ÖZER, ÖMER FARUK, KURTULMUŞ, AYŞE, KIRPINAR, İSMET

2017-04-01, GÖRMEZ, AYNUR, KOCER, E., KURTULMUS, AYŞE, Kirpinar, I., KURTULMUŞ, AYŞE, KIRPINAR, İSMET