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Now showing 1 - 5 of 5
  • Publication
    Metadata only
    Neurocognitive functioning in a group of offspring genetically at high-risk for schizophrenia in Eastern Turkey
    (2010-05-31T00:00:00Z) Ozan, Erol; Deveci, ERDEM; ORAL, Meltem; Karahan, Utku; Oral, Elif; Aydin, Nazan; Kirpinar, Ismet; DEVECİ, ERDEM; KIRPINAR, İSMET
    We assessed major cognitive domains in symptom-free children of patients with schizophrenia compared to the healthy children of parents with no psychopathology using neurocognitive tests. We hypothesized that, offspring at high-risk for schizophrenia would have significant impairment in major domains: attention, memory, verbal-linguistic ability and executive functions. Thirty symptom-free children (17-males, 13-females: intelligence quotient = 99.6 +/- 13.6: age = 12.69 +/- 2.32 and education = 5.8 +/- 2.3 years) having a parent diagnosed with schizophrenia and 37 healthy children matched for gender (19-males, 18-females), IQ (106.05 +/- 14.70), age (12.48 +/- 2.58) and years of education (6.0 +/- 2.5) were evaluated. The study group showed significant poor performance in cognitive domains, such as working memory (assessed with Auditory consonant trigram test), focused attention (Stroop test), attention speed (Trail making test), divided attention (Auditory consonant trigram test), executive functions (Wisconsin card sorting test), verbal fluency (Controlled word association test) and declarative memory (Rey verbal learning and Short-term memory test). However, no group differences were detected either on verbal attention (Digit span forward test) or sustained attention (TOVA, a continuous performance task): the latter as consistently reported to be a predictor of schizophrenia. In order to determine the cognitive endophenotype of schizophrenia, it seems more rational to conduct comprehensive evaluation of neurocognitive domains in well-matched groups via using sufficiently challenging tests to detect slight deficits. In addition, longitudinal studies with a larger sample size evaluating neurocognitive functions combined with genetic analysis may provide clues about explaining the genetic background of the disorder within the endophenocognitype concept and serve as new targets for early interventions. (C) 2010 Elsevier Inc. All rights reserved.
  • Publication
    Metadata only
    Neuro cognitive functioning in young high-risk offspring having a parent with bipolar I disorder
    (2013-01-01) Deveci, ERDEM; Ozan, Erol; Kirpinar, Ismet; ORAL, Meltem; DALOGLU, Ali Gokhan; Aydin, Nazan; Ozturk, AHMET; DEVECİ, ERDEM; KIRPINAR, İSMET; ÖZTÜRK, AHMET
    Aim: To investigate attention, memory, verbal-linguistic ability, and executive functions in symptom-free young offspring having a parent with bipolar I disorder (BD1O) in comparison with healthy controls (CO).
  • Publication
    Metadata only
    Global assessment of functioning and associated factors in psychiatric inpatients: a retrospective study
    (2012-09-01) Kirpinar, Ismet; ORAL, Meltem; KIRPINAR, İSMET
    Objective: Axis V in the DSM classification system uses The Global Assessment of Functioning Scale (GAF) to assess the levels of functional impairment due to by Axis I and Axis II disorders. However, GAF considers social, occupational and psychological functioning as a whole and therefore leading to a rapid decrease in functioning scores as far as the high psychopathology levels are concerned. In this study, we tested our hypothesis that the GAF scores mainly reflect the type and severity of psychopathology. Methods: The hospital records of 100 psychiatric inpatients were examined retrospectively. All the patients have been administered by GAF and some other scales at the time of admission and discharge. A statistical analysis was performed to evaluate the relationships between GAF scores and demographic and clinical variables. Results: A negative correlation was found between GAF scores and the scores of Brief Psychiatric Rating Scale and Clinical Global Impression at the time of admission. The GAF scores of patients with psychotic disorders were much lower when compared to patients with other diagnosis. Furthermore, it was found that being male, low educated, unemployed and having had long length of stays and numerous hospitalizations were associated with lower functioning levels. The GAF scores obtained at the time of discharge were significantly higher than the scores obtained at the time of admission. Discussion: Our findings are consistent with other studies indicating that GAF scores are associated with the type and severity of symptoms rather than social and occupational functioning. GAF is a useful tool in measuring treatment effects and monitoring progress. However, it has some limitations as far as measuring longer term functioning. (Anatolian Journal of Psychiatry 2012; 13:198-204)
  • Publication
    Metadata only
    Is there a relationship between attention deficit/hyperactivity disorder and manic symptoms among children with mental retardation of unknown etiology?
    (2011-11-01T00:00:00Z) Fidan, Tulin; Kirpinar, Ismet; ORAL, Meltem; Kocak, Kubra; KIRPINAR, İSMET
    Mental retardation (MR) is common and lifelong. In children and adolescents with MR, the rate of attention deficit/hyperactivity disorder (ADHD) and bipolar disorder is higher than that in the general population. However, there are no previous sufficient data that exist in establishing a relationship between ADHD and manic symptoms. The aim of the present study was to examine the relationship between manic symptoms and ADHD as well as oppositional-defiant disorder (ODD) and conduct disorder (CD) in children with MR of unknown etiology (MR-UE).
  • Publication
    Metadata only
    Male Genital Self-mutilation as a Psychotic Solution
    Ozan, Erol; Deveci, Erdem; ORAL, Meltem; Yazici, Esra; Kirpinar, Ismet; DEVECİ, ERDEM; KIRPINAR, İSMET
    Background: Male genital self-mutilation (GSM) is a rare, but serious phenomenon. Some of the risk factors for this act are: presence of religious delusions, command hallucinations, low self-esteem and feelings of guilt associated with sexual offences. Other risk factors include failures in the male role, problems in the early developmental period, such as experiencing difficulties in male identification and persistence of incestuous desires; depression and having a history of GSM. The eponym Klingsor Syndrome, which involves the presence of religious delusions, is proposed for GSM.