Person: YURTSEVER, İSMAİL
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Publication Open Access Diffusion Tensor Imaging Can Discriminate the Primary Cell Type of Intracranial Metastases for Patients with Lung Cancer.(2021-03-04T00:00:00Z) Bilgin, Sabriye Sennur; Gultekin, Mehmet Ali; Yurtsever, Ismail; Yilmaz, Temel Fatih; Cesme, Dilek Hacer; Bilgin, Melike; Topcu, Atakan; Besiroglu, Mehmet; Turk, Haci Mehmet; Alkan, ALPAY; Bilgin, Mehmet; GÜLTEKİN, MEHMET ALİ; YURTSEVER, İSMAİL; YILMAZ, TEMEL FATİH; ÇEŞME, DİLEK HACER; TÜRK, HACI MEHMET; ALKAN, ALPAY; BİLGİN, MEHMETPurpose: Histopathological differentiation of primary lung cancer is clinically important. We aimed to investigate whether diffusion tensor imaging (DTI) parameters of metastatic brain lesions could predict the histopathological types of the primary lung cancer. Methods: In total, 53 patients with 98 solid metastatic brain lesions of lung cancer were included. Lung tumors were subgrouped as non-small cell carcinoma (NSCLC) (n = 34) and small cell carcinoma (SCLC) (n = 19). Apparent diffusion coefficient (ADC) and Fractional anisotropy (FA) values were calculated from solid enhanced part of the brain metastases. The association between FA and ADC values and histopathological subtype of the primary tumor was investigated. Results: The mean ADC and FA values obtained from the solid part of the brain metastases of SCLC were significantly lower than the NSCLC metastases (P < 0.001 and P = 0.003, respectively). ROC curve analysis showed diagnostic performance for mean ADC values (AUC=0.889, P = < 0.001) and FA values (AUC = 0.677, P = 0.002). Cut-off value of > 0.909 × 10-3 mm2/s for mean ADC (Sensitivity = 80.3, Specificity = 83.8, PPV = 89.1, NPV = 72.1) and > 0.139 for FA values (Sensitivity = 80.3, Specificity = 54.1, PPV = 74.2, NPV= 62.5) revealed in differentiating NSCLC from NSCLC. Conclusion: DTI parameters of brain metastasis can discriminate SCLC and NSCLC. ADC and FA values of metastatic brain lesions due to the lung cancer may be an important tool to differentiate histopathological subgroups. DTI may guide clinicians for the management of intracranial metastatic lesions of lung cancer.Publication Open Access Relationship of white matter hyperintensities with clinical features of seizures in patients with epilepsy(2021-11-19T00:00:00Z) Uslu, Ferda Ilgen; Çetintaş, Elif; Alkan, ALPAY; Kolukisa, Mehmet; USLU, FERDA; YURTSEVER, İSMAİL; ALKAN, ALPAYBackground: Although epilepsy is primarily known as a cortical disorder, there is growing body of research demonstrating white matter alterations in patients with epilepsy. Objective: To investigate the prevalence of white matter hyperintensities (WMH) and its association with seizure characteristics in patients with epilepsy. Methods: The prevalence of WMH in 94 patients with epilepsy and 41 healthy controls were compared. Within the patient sample, the relationship between the presence of WMH and type of epilepsy, frequency of seizures, duration of disease and the number of antiepileptic medications were investigated. Results: The mean age and sex were not different between patients and healthy controls (p>0.2). WMH was present in 27.7% of patients and in 14.6% of healthy controls. Diagnosis of epilepsy was independently associated with the presence of WMH (ß=3.09, 95%CI 1.06-9.0, p=0.039). Patients with focal epilepsy had higher prevalence of WMH (35.5%) than patients with generalized epilepsy (14.7%). The presence of WMH was associated with older age but not with seizure characteristics. Conclusions: WMH is more common in patients with focal epilepsy than healthy controls. The presence of WMH is associated with older age, but not with seizure characteristics.Publication Metadata only The Utility and Efficiency of Diffusion Tensor Imaging Values to Determine Epidermal Growth Factor Receptor Gene Mutation Status in Brain Metastasis from Lung Adenocarcinoma; A Preliminary Study(2021-02-01T00:00:00Z) Gültekin, Mehmet Ali; Alkan, Alpay; Yılmaz, Temel Fatih; Yurtsever, İsmail; Atasoy, Bahar; Aliyev, Altay; GÜLTEKİN, MEHMET ALİ; TÜRK, HACI MEHMET; YURTSEVER, İSMAİL; YILMAZ, TEMEL FATİH; ALKAN, ALPAYPublication Metadata only Relationship with programmed cell death ligand 1 (PD-L1) and DTI features in brain metastases of non-small cell lung cancer; Preliminary study.(2021-02-17T00:00:00Z) Yurtsever, İsmail; Yilmaz, Temel Fatih; Turk, Hacı Mehmet; Gultekin, Mehmet Ali; Besiroglu, Mehmet; Cesme, DİLEK HACER; Shbair, Abdallah T M; Alkan, ALPAY; YILMAZ, TEMEL FATİH; YURTSEVER, İSMAİL; TÜRK, HACI MEHMET; GÜLTEKİN, MEHMET ALİ; ÇEŞME, DİLEK HACER; ALKAN, ALPAYPublication Metadata only The Effectiveness of Diffusion Tensor Imaging in Determining Radiological Response after Radiosurgery in Patients with Vestibular Schwannoma.(2021-01-27T00:00:00Z) Cesme, DİLEK HACER; Alkan, Alpay; Sari, Lutfullah; Kaya, Ahmet; Yurtsever, Ismail; Alkan, Gokberk; Seyithanoglu, Mehmet Hakan; ÇEŞME, DİLEK HACER; ALKAN, ALPAY; YURTSEVER, İSMAİL; SEYİTHANOĞLU, MEHMET HAKAN; HATİBOĞLU, MUSTAFA AZİZPublication Metadata only Brain Diffusion Tensor Imaging Findings in Hashimoto-s Thyroiditis.(2020-11-06T00:00:00Z) Gultekin, MA; Yurtsever, I; Cesme, DİLEK HACER; Karaman, O; Yilmaz, TF; Alkan, ALPAY; GÜLTEKİN, MEHMET ALİ; ÇEŞME, DİLEK HACER; KARAMAN, ÖZCAN; YURTSEVER, İSMAİL; YILMAZ, TEMEL FATİH; ALKAN, ALPAYPublication Metadata only Diffusion Tensor Imaging of Brain Metastases in Patients with Breast Cancer According to Molecular Subtypes.(2020-06-21T00:00:00Z) Turk, HM; Sari, L; Yurtsever, I; Yabaci, A; Peker, AA; Alkan, ALPAY; YURTSEVER, İSMAİL; GÜLTEKİN, MEHMET ALİ; TOPRAK, HÜSEYİN; TÜRK, HACI MEHMET; YABACI TAK, AYŞEGÜL; ALKAN, ALPAYPublication Metadata only Apparent Diffusion Coefficient Values for Neuroendocrine Liver Metastases.(2020-11-07T00:00:00Z) Gultekin, MA; Cesme, DH; Yurtsever, I; Turk, HM; Seker, M; Besiroglu, M; Alkan, ALPAY; GÜLTEKİN, MEHMET ALİ; TÜRK, HACI MEHMET; YURTSEVER, İSMAİL; ÇEŞME, DİLEK HACER; ALKAN, ALPAY