Person: TUĞCU, BETÜL
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Publication Metadata only Sensoryal şaşılıkta botulinum toksin ile kombine edilen horizontal kas cerrrahisinin sonuçları.(2015-11-05T00:00:00Z) Tuğcu, Betül; Öner, E; Özdemir, Mehmet Hakan; TUĞCU, BETÜL; ÖZDEMİR, MEHMET HAKANPublication Metadata only Evaluation of retinal alterations in Parkinson disease and tremor diseases.(2019-11-02T00:00:00Z) TUĞCU, BETÜL; Arif, Melikov; Babacan, Yildiz Gulsen; Gokcal, Elif; Ercan, Rukiye; UYSAL, ÖMER; Ozdemir, Hakan; TUĞCU, BETÜL; BABACAN YILDIZ, GÜLSEN; GÖKÇAL, ELİF; ERCAN, RUKIYE; UYSAL, ÖMER; ÖZDEMİR, MEHMET HAKANOptical coherence tomography (OCT) has been suggested as a method for detection of retinal alterations in neurodegenerative diseases. The usefulness of OCT as a diagnostic tool to differentiate Parkinson-s disease (PD) from other tremor diseases, remains unknown. We aimed to evaluate morphological changes of the retina in patients with PD, essential tremor (ET), essential tremor-Parkinson-s disease (ET-PD) using OCT. Forty-two eyes of 21 patients with PD, 24 eyes of 12 patients with ET, 24 eyes of 12 patients with ET-PD and 44 eyes of 22 age-matched healthy controls were included in the study. All participants underwent detailed neurological and ophthalmological examination. Measurements in all quadrants of macula and retinal nerve fiber layer (RNFL) thickness using OCT were recorded. There was no significant difference among the groups regarding age, sex. The average RNFL thickness was thinner in PD patients than that of ET (p = 0.032). The RNFL thickness in superior quadrant was lower in PD group compared with the ET and control group (p = 0.001, p = 0.016). Significant differences were observed in most of the macular thickness parameters excluding foveolar and foveal thickness (p = 0.865, 0.394). Correlations were found among several OCT parameters and disease duration or severity in all patient groups (p > 0.05). Retinal alterations were found in PD patients compared to ET. However, no significant retinal changes were detected by OCT in patients with ET and ET-PD compared to controls. According to our data, retinal assessments by OCT do not seem to be satisfactory for differentiation of these disorders.Publication Metadata only Anjioid çatlaklı bir Çocukta Bilateral Optik Disk Druseni ve Travmatik Koroid Rüptürü.(2016-03-01T00:00:00Z) Toklu, Enes; Özdemir, Mehmet Hakan; Tuğcu, Betül; Sezer, Taha; ÖZDEMİR, MEHMET HAKAN; TUĞCU, BETÜLPublication Metadata only Eğik optik disk.(2016-11-01T00:00:00Z) Tuğcu, Betül; Nuhoğlu, Fadime; Melikov, Arif; Özdemir, Mehmet Hakan; TUĞCU, BETÜL; NUHOĞLU, FADİME; ÖZDEMİR, MEHMET HAKANPublication Open Access Protective effect of pomegranate juice on retinal oxidative stress in streptozotocin-induced diabetic rats.(2017-11-18) Tugcu, BETÜL; NACAROGLU, SA; GEDIKBASI, A; UHRI, M; ACAR, N; ÖZDEMIR, HÜSEYİN; TUĞCU, BETÜL; ÖZDEMİR, MEHMET HAKANAim: To investigate the effect of pomegranate juice (PJ) intake on overall oxidation status in retinas of diabetic rats. Methods: Twenty-seven rats were divided into four groups as control (CO), diabetic (DM), control treated with PJ (CO-PJ), and diabetic treated with PJ (DM-PJ).The retina tissues were used to determine 8-hydroxy-2'-deoxyguanosine (8OHdG), malondialdehyde (MDA), reduced glutathione (GSH) levels, and the enzyme activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). Results: The levels of 8OHdG and MDA were significantly increased in the retina of DM group compared to CO group (P=0.001, P<0.001 respectively). Both 8OHdG and MDA levels were decreased in PJ-DM group compared to DM group (P=0.004, P<0.001 respectively). The activities of antioxidant enzymes GSH, SOD, and GDH-Px were significantly decreased in the retina of DM group compared to CO group (P≤0.01). GSH and GSH-Px activities were higher in PJ-DM group compared with DM group (P=0.010, P=0.042, respectively) but SOD activity was not statistically different (P=0.938). Conclusion: PJ intake is found to be effective in decreasing oxidative end products, and in increasing the activities of antioxidant enzymes in diabetic retinas of rats, which suggests it may be effective against oxidative stress in diabetic retinas.Publication Open Access Imaging Methods in the Diagnosis of Optic Disc Drusen.(2016-10-01) Tuğcu, BETÜL; Özdemir, HÜSEYİN; TUĞCU, BETÜL; ÖZDEMİR, MEHMET HAKANOptic disc drusen (ODD) are benign congenital anomalies of the optic nerve characterized by calcified hyaline bodies. While superficial drusen can be diagnosed easily during fundus examination, detecting buried drusen requires the use of additional imaging methods such as B-scan ultrasonography (USG), fundus fluorescein angiography (FFA), computed tomography (CT) and fundus autofluorescence (FAF). ODD can be detected by USG with the presentation of highly reflective round structures. ODD appear as hyperautofluorescent areas on FAF and bright spots on CT scans. FFA can be helpful in differentiating ODD from true optic disc edema. Optic disc edema shows early hyperfluorescence due to diffuse leakage whereas ODD presents as well-defined hyperfluorescence in the late phase. In recent years, it has been reported that optical coherence tomography (OCT) examination has allowed more detailed evaluation of ODD and yielded useful findings for the differentiation of optic disc edema from ODD. In this review, the role of OCT in the diagnosis of ODD is discussed.Publication Metadata only Botulinum toxin as an adjunct to monocular recession-resection surgery for large-angle sensory strabismus.(2017-04-01) Tuğcu, BETÜL; SÖNMEZAY, E; Nuhoğlu, FADİME; ÖZDEMIR, HÜSEYİN; ÖZKAN, SB; TUĞCU, BETÜL; NUHOĞLU, FADİME; ÖZDEMİR, MEHMET HAKANPublication Open Access Angioid streaks in a case of Camurati-Engelmann disease.(2017-07-01) ÖZDEMIR, HÜSEYİN; Tugcu, BETÜL; SEZER, TAHA; ELBAY, AHMET; TUĞCU, BETÜL; SEZER, TAHA; ELBAY, AHMET; ÖZDEMİR, MEHMET HAKAN