Person: TORUN, EMEL
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Publication Metadata only Carotid intima-media thickness and flow-mediated dilation in obese children with non-alcoholic fatty liver disease.(2014-12-01T00:00:00Z) Torun, EMEL; Aydin, Sinem; Gokce, Selim; Ozgen, Ilker Tolga; Donmez, Tugrul; Cesur, Yasar; TORUN, EMEL; AYDIN, SİNEM; ÖZGEN, İLKER TOLGA; CESUR, YAŞARBackground/Aims: This study aimed to understand the role of non-alcoholic fatty liver disease (NAFLD) in increasing the risk of atherosclerosis in obese pediatric patients.Publication Open Access Thyroid Hormone Levels in Obese Children and Adolescents with Non-Alcoholic Fatty Liver Disease(2014-01-01) Torun, EMEL; Ozgen, Ilker Tolga; Gokce, Selim; Aydin, SİNEM; Cesur, YAŞAR; TORUN, EMEL; ÖZGEN, İLKER TOLGA; VEHAPOĞLU TÜRKMEN, AYSEL; AYDIN, SİNEM; CESUR, YAŞARObjective: We aimed to determine the association of thyroid functions with the components of metabolic syndrome (MS) and non-alcoholic fatty liver disease (NAFLD) in pediatric obese patients. Methods: The study included 109 obese children (aged 9-15 years) and a control group of 44 healthy age and gender-matched children of normal weight. NAFLD was diagnosed by conventional ultrasound examination. We assessed the anthropometric data and serum biochemical parameters including lipid profile, alanine aminotransferase (ALT), fasting glucose and insulin levels and thyroid stimulating hormone (TSH), free thyroxine (fT4) and free triiodothyronine (fT3) levels. The homeostasis model assessment of insulin resistance (HOMA-IR) was calculated as a measure of IR. Results: The mean age and gender distributions in the groups were similar (p=0.23). The mean body mass index (BMI) z-scores of obese children with grade 2-3 NAFLD were significantly higher than those of the obese children without hepatic steatosis (p<0.001). Mean ALT, triglyceride (TG) and LDL cholesterol increased and HDL-cholesterol significantly decreased as the hepatic steatosis increased (p<0.05). HOMA-IR levels in obese subjects with grade 2-3 NAFLD were significantly higher than those in both obese children without NAFLD and grade 1 NADFL (p=0.05 and 0.001, respectively). In the obese subjects, TSH levels were increased significantly as the degree of steatosis increased (p=0.04) but fT3 and fT4 levels were not different. In correlation analysis, TSH was significantly correlated with ALT, BMI SDS and the degree of steatosis. Conclusions: Obese children demonstrate an increase in TSH levels as the degree of steatosis increased.Publication Open Access Vitamin D Deficiency and Insufficiency in Obese Children and Adolescents and Its Relationship with Insulin Resistance(2013-01-01) Torun, EMEL; GONULLU, Erdem; Ozgen, Ilker Tolga; CINDEMIR, Ergul; OKTEM, Faruk; TORUN, EMEL; ÖZGEN, İLKER TOLGAObjectives. We aimed to determine the relationship between insulin resistance and serum 25-hydroxyvitamin D (25-OHD) levels in obese children and their nonobese peers. Materials and Methods. Included in the study group were 188 obese children (aged 9-15 years), and 68 age- and gender-matched healthy children of normal weight as control group. Anthropomorphic data were collected on patients and fasting serum glucose, insulin, serum lipids, alanine aminotransaminase (ALT) and 25-OHD were measured. The homeostatic model assessment of insulin resistance (HOMA-IR) was calculated in both groups. Results. The levels of 25-OHD in the obese group were significantly lower than those of the nonobese (P = 0.002). HOMA-IR, triglycerides, low-density lipoprotein, and ALT levels in the obese group were significantly higher than values of control group (P < 0.001 and P = 0.002, resp.). In the obese group, vitamin D deficiency, insufficiency, and sufficiency (25-OHD < 10 ng/dl, < 20, >10 ng/dl; > 20 ng/dl, resp.) were not correlated with HOMA-IR (r : -0.008, P = 0.935). HOMA-IR was negatively correlated with BMI, BMI SDS, and BMI%, and triglycerides, low-density lipoprotein, and ALT levels (P < 0.001). Conclusion. The insulin resistance of the obese subjects who were vitamin D deficient and insufficient did not statistically differ from those with vitamin D sufficiency. Low 25-hydroxyvitamin D levels were not related with higher insulin resistance in obese children and adolescents. In obese subjects, insulin resistance was affected more from BMI, BMI SDS, and BMI% than from 25-hydroxyvitamin D levels.Publication Metadata only The clinical and biochemical presentation of vitamin D deficiency and insufficiency in children and adolescents(2013-05-01) Torun, EMEL; GENC, Habibe; GONULLU, Erdem; AKOVALI, Burak; Ozgen, Ilker Tolga; TORUN, EMEL; ÖZGEN, İLKER TOLGAAim: To evaluate the clinical and biochemical findings of the children and adolescents with vitamin D deficiency and insufficiency in order to determine the clinical and biochemical presentation differences between age groups.Publication Metadata only Relationship Between Functional Exercise Capacity and Lung Functions in Obese Chidren.(2015-09-01T00:00:00Z) Ozgen, Ilker Tolga; Cakir, Erkan; Torun, EMEL; Gules, Alper; Hepokur, Merve Nur; Cesur, Yasar; ÖZGEN, İLKER TOLGA; ÇAKIR, ERKAN; TORUN, EMEL; CESUR, YAŞARObjective: Cardiovascular, respiratory and musculoskeletal system disorders which may affect the functional exercise capacity are common in obese patients. We aimed to investigate the functional exercise capacity and its relationship with functional pulmonary capacity in obese children.Publication Metadata only Determination of early urinary renal injury markers in obese children.(2015-01-01T00:00:00Z) Goknar, Nilufer; Oktem, Faruk; Ozgen, Ilker Tolga; Torun, EMEL; Kucukkoc, Mehmet; Demir, Aysegul Dogan; Cesur, Yasar; ÖZGEN, İLKER TOLGA; TORUN, EMEL; CESUR, YAŞARObesity is an important health issue, the prevalence of which is increasing in childhood. The aim of this study was to examine urinary renal injury markers in order to determine the renal effect of obesity and its comorbidities in a pediatric population.Publication Open Access The Effect of Obesity Degree on Childhood Pulmonary Function Tests(2014-09-01) Torun, EMEL; Cakir, ERKAN; OZGUC, Fatma; Ozgen, Ilker Tolga; TORUN, EMEL; ÇAKIR, ERKAN; ÖZGEN, İLKER TOLGABackground: Childhood obesity has become a global epidemic. It is related to several chronic diseases such as essential hypertension, type 2 diabetes mellitus, and renal disease. The relationship between the degree of obesity and lung functions is well defined in adults, but limited information is available about the childhood period. Aims: This study aims to determine the impact of the degree of obesity on the pulmonary functions of school children and adolescents. Study Design: Cross sectional study. Methods: Included in the study were a total of 170 school children and adolescents (9-17 years old) referred to our paediatric outpatient clinic. Of these subjects, 42 were lean and non-obese (BMI % <85), 30 subjects were overweight (BMI % ˃85, <95), 34 subjects were obese (BMI % ˃95, <97), and 64 subjects were morbidly obese (BMI % ˃97). Anthropometric measurements were taken and spirometry was performed on all subjects. Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1 ), forced vital capacity 25-75 (FEV25-75) and peak expiratory flow (PEF) were used to measure the ventilatory functions for all the subjects. Results: The groups showed no significant differences in age or gender. Despite no statistically significant differences in FEV1 , FVC, or FEV1 /FVC, there were significant reductions in PEF (p<0.001) and FEV25-75 (p<0.001) in the overweight, obese and morbidly obese subjects, when compared with those who were non-obese. Conclusion: Overweight, obese and morbidly obese children have no obstructive abnormalities compared with healthy lean subjects.Publication Metadata only Myeloperoxidase 463 G > A and superoxide dismutase Ala16Val gene polymorphisms in obese children(2014-09-01) Ozgen, Ilker Tolga; Torun, EMEL; Ergen, Arzu; Cesur, YAŞAR; Karagedik, Hande; Zeybek, Umit; AKSU, Mehmet Sirin; OKTEM, Faruk; ÖZGEN, İLKER TOLGA; TORUN, EMEL; CESUR, YAŞARThe aim of the study was to determine the role of MnSOD Ala16Val and MPO G-463A gene polymorphisms in the pathogenesis of metabolic syndrome in obese children.