Person: YABACI TAK, AYŞEGÜL
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Publication The Influence of Gender and Age on Laparoscopic Sleeve Gastrectomy Short-Term Outcomes in Type-2 Diabetic Obese Patients(2021-06-01T00:00:00Z) Elbasan, Onur; Şişman, Pınar; Peynirci, Hande; Yabacı, Ayşegül; Ersoy, Canan; YABACI TAK, AYŞEGÜLBackground Bariatric surgery has come out as an effective treatment for morbid obesity due to its effects as stabilized weight loss and remission of obesity related comorbidities like type 2 diabetes. Postoperative weight loss is affected by many factors and predictors of weight loss after bariatric surgery are controversial.This study has been performed to evaluate the impact of gender and age on the shortterm outcomes of laparoscopic sleeve gastrectomy (LSG) in type 2 diabetic(T2D) obese patients. Material and Methods In this retrospective study,the records of morbidly obese patients with a body mass index(BMI)≥40 kg/m2,aged between 18-65 years old who underwent LSG and were followed-up for at least 6 months postoperatively were reviewed.Patients were subdivided into two groups according to age(≥50 y,<50 y),gender(female, male) and compared. Results The study included 25 patients, 17(68%) female and 8(32%) male, 14(56%) were in <50 years old group and 11(44%) were in ≥50 years old group.At the postoperative 6th month,there was a significant decrease in weight,BMI,diastolic blood pressure,fasting blood glucose,postprandial glucose and HbA1c in both gender and age groups (p<0.05).A significant decrease was observed in Triglyceride(TG) at 6th month in both gender.While a significant increase in High-density Lipoprotein (HDL) was observed in patients aged ≥50 (p=0.028),no significant change was observed in the younger group.There was a positive correlation between change in Total Cholesterol(TCh),TG and age (respectively;r=0.436,p=0.030, r=0.528,p=0.007). Conclusions LSG is an effective treatment method for morbid obesity for younger(<50 y) and advanced aged(≥50 y) T2D patients in both genders. The percentage changes in the decreament of TG in male gender and TCh in younger age were more prominent in short-term follow-upPublication SHORT TERM EFFECT OF LAPAROSCOPIC SLEEVE GASTRECTOMY ON CLINICAL, RENAL PARAMETERS AND URINARY NGAL LEVELS IN DIABETIC AND NON DIABETIC OBESITY(2019-09-01T00:00:00Z) Elbasan, Onur; Şişman, Pınar; Peynirci, Hande; Yabacı, Ayşegül; Dirican, Melehat; Öz Gül, Özen; Cander, Soner; Ersoy, Canan; YABACI TAK, AYŞEGÜLBackground. Although diseases such as diabetes, hypertension, obstructive sleep apnea and hyperlipidemia are clearly documented as obesity associated diseases, it is not wellknown whether obesity causes renal pathologies. The aim of the present study was to evaluate the effect of weight loss following laparoscopic sleeve gastrectomy on clinical, renal parameters and urinary Neutrophil gelatinase-associated lipocalin (NGAL) levels in diabetic and non-diabetic obese patients. Methods. Nineteen morbidly obese patients (10 diabetic and 9 non diabetic) who underwent laparoscopic sleeve gastrectomy were evaluated clinically (anthropometric measurements) and biochemically before surgery and at 6 months from surgery. Results. Significant decreases in weight, BMI, FPG, PPG and HbA1c levels were observed in the diabetic group when the baseline and 6th month parameters of the patients were compared. There was also a significant decrease in SBP and DBP. At 6th month following laparoscopic sleeve gastrectomy, renal parameters such as creatinine, mAlb/creatinine, NGAL/ creatinine did not differ in the diabetic group. In the nondiabetic group, serum creatinine levels were significantly decreased, but other renal parameters such as mAlb/creatinine and NGAL/ creatinine were not significantly different. Conclusions. Our findings revealed significant decreases in weight, body mass index and glycemic parameters after sleeve gastrectomy in diabetic and non-diabetic patients, while no significant alteration was noted in renal functions, urinary NGAL and microalbumin levels. Key words: sleeve gastrectomy, obesity, urinary NGAL, kidney, weight loss, T2DM.Publication Retention and survival rate of etanercept in psoriasis over 15 years and patient outcomes during the COVID-19 pandemic: The real-world experience of a single center(2020-12-01T00:00:00Z) GÜNEŞ, BEGÜM; ONSUN, Nahide; YABACI, AYŞEGÜL; ONSUN, NAHIDE; GÜNEŞ, BEGÜM; YABACI TAK, AYŞEGÜLThere have been a number of investigations of the efficacy and safety of etanercept. This study was performed to obtain long-term drug survival data (ie, time to drug discontinuation) for etanercept, and the reasons for its discontinuation. The study population consisted of patients with psoriatic arthritis and psoriasis followed up by our clinic, registered in the Turkish Psoriasis Registry (PSR-TR) and treated with etanercept for at least 4 weeks between January 1, 2005, and January 31, 2020. The efficacy of etanercept was evaluated in terms of the Psoriasis Area and Severity Index (PASI) 75, PASI 90 and PASI 100 response rates at 12, 24, 36, and 48 weeks, and annually thereafter. The behaviors of the patients with respect to the use of etanercept, and the outcomes of those who continued to use it during the COVID-19 pandemic, were also investigated.Publication Comparison of tree-based methods used in survival data(2022-03-01T00:00:00Z) Yabacı Tak, Ayşegül; Sığırlı, Deniz; YABACI TAK, AYŞEGÜLSurvival trees and forests are popular non-parametric alternatives to parametric and semiparametric survival models. Conditional inference trees (Ctree) form a non-parametric class of regression trees embedding tree-structured regression models into a well-defined theory of conditional inference procedures. The Ctree is applicable in a varietyof regression-related issues, involving nominal, ordinal, numeric, censored, as well as multivariate response variables and arbitrary measurement scales of covariates. Conditional inference forests (Cforest) consitute a survival forest method which combines a large number of Ctrees. The Cforest provides a unified and flexible framework for ensemble learning in the presence of censoring. The random survival forests (RSF) methodology extends the random forests method enabling the approximation of rich classes of functions while maintaining generalisation errors low. In the present study, the Ctree, Cforest and RSF methods are discussed in detail and the performances of the survival forest methods, namely the Cforest and RSF have been compared with a simulation study. The results of the simulation demonstrate that the RSF method with a log-rank score distinction criteria outperforms the Cforest and the RSF with log-rank distinction criteria. Key words: tree-based methods, conditional inference trees, conditional inference forests, random survival forests.Publication Effects of TNF inhibitors and an IL12/23 inhibitor on changes in body weight and adipokine levels in psoriasis patients: A 48-week comparative study.(2021-03-11T00:00:00Z) Onsun, Nahide; Akaslan, Tahsin Çağdaş; Sallahoglu, Kadriye; Gülcan, Aliye Sevdem; Bulut, Huri; Yabacı, AYŞEGÜL; ONSUN, NAHIDE; YABACI TAK, AYŞEGÜLPublication Ensemble of Effect Size Methods Based on Meta Fuzzy Functions(2023-03-01) Yabacı Tak A.; Ercan İ.; YABACI TAK, AYŞEGÜLPublication Blefarospazm Olgularinda miRNA Alt Tipleri Ekspresyon Düzeylerinin İncelenmesi ve Aday Biyobelirteç Tayini(2024-01-01) Yaman Kula A.; Korkmaz N. D.; Düzenli Ö. F.; Yozlu M.; Kaya Güleç Z. E.; Yabacı Tak A.; Toruntay C.; Süsgün S.; Genç G.; Savrun F.; et al.; YAMAN KULA, ASLI; KORKMAZ, NUR DAMLA; YABACI TAK, AYŞEGÜL; SÜSGÜN, SEDA; MATUR, ZELİHAss1Publication İzole servikal distonilerde THAP1, GNAL, KMT2B ve ANO3 genlerine etkiyen miRNA’ların anlatımlarının incelenmesi ve aday biyobelirteç belirlenmesi(2021-12-01T00:00:00Z) Gelişin, Özlem; Süsgün, Seda; Toruntay, Ceyhun; Yabacı Tak, Ayşegül; Baran, Gözde; Gürsoy, Azize Esra; Babacan Yıldız, Gülsen; Yücesan, Emrah; GELİŞİN, ÖZLEM; SÜSGÜN, SEDA; TORUNTAY, CEYHUN; YABACI TAK, AYŞEGÜL; GÜRSOY, AZIZE ESRA; YÜCESAN, EMRAHPublication Comparison Between Sleeve Gastrectomy and Exenatide on Type 2 Diabetic Patients(2020-02-01T00:00:00Z) Elbasan, Onur; Şişman, Pınar; Peynirci, Hande; Yabacı, Ayşegül; Ersoy, Canan; YABACI TAK, AYŞEGÜLBackground: Diabetes and obesity are major causes of mortality and morbidity that are increasing all over the world. As obesity is a major risk factor for type 2 diabetic patients, weight loss is important in the treatment of type 2 diabetic patients. In our study, our aim was to evaluate the effects of exenatide and laparoscopic sleeve gastrectomy (LSG) in obese type 2 diabetic patients on the clinical and laboratory parameters. Methods: Twenty-five LSG and 25 exenatide patients followed up in our outpatient clinic were involved in the study. Results: At the end of the 6-month follow-up, weight loss was ∼35.4 kg in the surgery group and 11.5 kg in the exenatide group. Although postprandial glucose and hemoglobin A1c were significantly decreased in both groups, the decrease was significantly higher in LSG group compared to the exenatide group. Although there was no significant change in fasting blood glucose (FBG) in the exenatide group, there was a significant decrease in FBG in LSG group. Conclusion: LSG is a method that should be performed up on indication and much more radical compared to exenatide administration, but appears to be a more efficient application that corrects diabetes- and obesity-related metabolic parameters compared to exenatide therapy in type 2 diabetic obese patients. © Copyright 2020, Mary Ann Liebert, Inc., publishers 2020.Publication Evaluation of miR-145 and miR-146a as potential biomarkers for diagnosis of Myelodysplastic Syndrome(2022-06-01T00:00:00Z) Süsgün, Seda; Baykara, Onur; Yücesan, Emrah; Kuru, Rahiye Dilhan; Aslaneli Çakmak, Başak; Yabacı Tak, Ayşegül; Öngören, Şeniz; Deviren, Ayhan; Argüden, Yelda; SÜSGÜN, SEDA; YÜCESAN, EMRAH; YABACI TAK, AYŞEGÜL