Person: YABACI TAK, AYŞEGÜL
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Publication Metadata only Prevalence and intensity of Allocreadium isoporum (Digenea: Allocreadiidae) in three endemic species of cyprinids (Capoeta spp.) in Turkey, in relation to season, host size and sex(2018-02-01T00:00:00Z) Aydogdu, Ali; PEREZ-PONCE DE LEON, Gerardo; EMRE, YILMAZ; EMRE, NESRİN; Yabaci, AYŞEGÜL; YABACI TAK, AYŞEGÜLThree species of cyprinids, i.e., Capoeta antalyensis (n=112), C. caelestis (n=99) and C. angorae (n=178) were collected from the Anatolian Region of Turkey to carry out this investigation. A total of 389 specimens of Capoeta were examined for Allocreadium isoporum infections throughout the four different seasons of 2012. The prevalence and mean intensity of infection of A. isoporum was investigated in relation to the host species, the seasons across the year, host size, and sex. Two-hundred and twenty-two specimens of a trematode identified as A. isoporum were found in these fishes. One-hundred seventy-eight C. angorae were caught, and 70 A. isoporum were recorded in 8 of 178 fish examined, with prevalence and mean intensity of infection of 4.49% and 8.7% parasites per infected fish, respectively. In the 112 specimens of C. antalyensis, 73 individuals of A. isoporum were found, with a prevalence of 19.6% and a mean intensity of 3.3. As for the infection in C. caelestis, a total of 79 specimens of A. isoporum were found in 17 of the 99 fish examined, with prevalence and mean intensity of infection of 17.1% and 4.6%, respectively. Prevalence and mean intensity values in relation to host size and sex, as well as the seasonality of infections was analyzed and the results were compared with other studies. The trematode A. isoporum is reported for the first time parasitising three endemic species of Capoeta spp. in Turkey, adding to the knowledge of geographical distribution and host range of this trematode species.Publication Open Access Comparative Evaluation of Orthostatic Hypotension in Patients with Diabetic Nephropathy.(2021-07-20T00:00:00Z) Aytaş, Gamze; Elçioğlu, Ömer C; Kazancıoğlu, Rümeyza; Gürsu, Meltem; Artan, A Serra; Yabacı, Ayşegül; Soysal, PINAR; Bilgi, Kadir; Özçelik, Semra; KAZANCIOĞLU, RÜMEYZA; ELÇİOĞLU, ÖMER CELAL; GÜRSU, MELTEM; YABACI TAK, AYŞEGÜL; SOYSAL, PINAR; ÖZÇELİK, SEMRAIntroduction: Orthostatic hypotension (OH) affects 5-20% of the population. Our study investigates the presence of OH in diabetic nephropathy (DNP) patients and the factors affecting OH in comparison with nondiabetic chronic kidney disease (NDCKD) patients. Method: Patients presented to the nephrology clinic, and those who consented were included in the study. DNP was defined by kidney biopsy and/or clinical criteria. NDCKD patients of the same sex, age, and eGFR were matched to DNP patients. Demographic parameters and medications were obtained from the records. OH was determined by Mayo clinic criteria. The same researcher used an electronic device to measure blood pressure (BP). All samples were taken and analyzed the same day for biochemical and hematologic parameters and albuminuria. Results: 112 (51 F, 61 M, mean age: 62.56 ± 9.35 years) DNP and 94 (40 F, 54 M, mean age: 62.23 ± 10.08 years) NDCKD patients were included. There was no significant difference between DNP and NDCKD groups in terms of OH prevalence (70.5 vs. 61.7%, p = 0.181). Male patients had significantly higher OH prevalence than female patients (74.7 vs. 60.0%, p = 0.026). There was no significant difference in change in systolic BP between the groups (24.00 [10.00-32.00] mm Hg vs. 24.00 [13.75-30.25] mm Hg, p = 0.797), but the change in diastolic BP was significantly higher in the DNP group (8.00 [2.00-13.00] mm Hg vs. 6.00 [2.00-9.00] mm Hg, p = 0.025). In the DNP group, patients with OH had significantly higher uric acid levels than those without OH (7.18 ± 1.55 vs. 6.36 ± 1.65 mg/dL, p = 0.017). And, 73.7% of patients on calcium channel blockers developed OH (p = 0.015), and OH developed in 80.6% of 36 patients on alpha-blockers (p = 0.049). Conclusion: OH prevalence is very high in CKD, and etiology of CKD does not have a statistically significant effect on the frequency of OH, despite a difference that could be meaningful clinically. Therefore, patients with CKD are checked for OH, with or without concurrent diabetes mellitus. Evaluation of postural BP changes should be a part of nephrology practice.Publication Open Access Comparison Between Sleeve Gastrectomy and Exenatide on Type 2 Diabetic Patients(2020-02-01T00:00:00Z) Elbasan, Onur; Şişman, Pınar; Peynirci, Hande; Yabacı, Ayşegül; Ersoy, Canan; YABACI TAK, AYŞEGÜLBackground: Diabetes and obesity are major causes of mortality and morbidity that are increasing all over the world. As obesity is a major risk factor for type 2 diabetic patients, weight loss is important in the treatment of type 2 diabetic patients. In our study, our aim was to evaluate the effects of exenatide and laparoscopic sleeve gastrectomy (LSG) in obese type 2 diabetic patients on the clinical and laboratory parameters. Methods: Twenty-five LSG and 25 exenatide patients followed up in our outpatient clinic were involved in the study. Results: At the end of the 6-month follow-up, weight loss was ∼35.4 kg in the surgery group and 11.5 kg in the exenatide group. Although postprandial glucose and hemoglobin A1c were significantly decreased in both groups, the decrease was significantly higher in LSG group compared to the exenatide group. Although there was no significant change in fasting blood glucose (FBG) in the exenatide group, there was a significant decrease in FBG in LSG group. Conclusion: LSG is a method that should be performed up on indication and much more radical compared to exenatide administration, but appears to be a more efficient application that corrects diabetes- and obesity-related metabolic parameters compared to exenatide therapy in type 2 diabetic obese patients. © Copyright 2020, Mary Ann Liebert, Inc., publishers 2020.Publication Metadata only Evaluation of miR-145 and miR-146a as potential biomarkers for diagnosis of Myelodysplastic Syndrome(2022-06-01T00:00:00Z) Süsgün, Seda; Baykara, Onur; Yücesan, Emrah; Kuru, Rahiye Dilhan; Aslaneli Çakmak, Başak; Yabacı Tak, Ayşegül; Öngören, Şeniz; Deviren, Ayhan; Argüden, Yelda; SÜSGÜN, SEDA; YÜCESAN, EMRAH; YABACI TAK, AYŞEGÜLPublication Metadata only Comparison of tree-based methods used in survival data(2022-03-01T00:00:00Z) Yabacı Tak, Ayşegül; Sığırlı, Deniz; YABACI TAK, AYŞEGÜLSurvival trees and forests are popular non-parametric alternatives to parametric and semiparametric survival models. Conditional inference trees (Ctree) form a non-parametric class of regression trees embedding tree-structured regression models into a well-defined theory of conditional inference procedures. The Ctree is applicable in a varietyof regression-related issues, involving nominal, ordinal, numeric, censored, as well as multivariate response variables and arbitrary measurement scales of covariates. Conditional inference forests (Cforest) consitute a survival forest method which combines a large number of Ctrees. The Cforest provides a unified and flexible framework for ensemble learning in the presence of censoring. The random survival forests (RSF) methodology extends the random forests method enabling the approximation of rich classes of functions while maintaining generalisation errors low. In the present study, the Ctree, Cforest and RSF methods are discussed in detail and the performances of the survival forest methods, namely the Cforest and RSF have been compared with a simulation study. The results of the simulation demonstrate that the RSF method with a log-rank score distinction criteria outperforms the Cforest and the RSF with log-rank distinction criteria. Key words: tree-based methods, conditional inference trees, conditional inference forests, random survival forests.Publication Metadata only Effects of TNF inhibitors and an IL12/23 inhibitor on changes in body weight and adipokine levels in psoriasis patients: A 48-week comparative study.(2021-03-11T00:00:00Z) Onsun, Nahide; Akaslan, Tahsin Çağdaş; Sallahoglu, Kadriye; Gülcan, Aliye Sevdem; Bulut, Huri; Yabacı, AYŞEGÜL; ONSUN, NAHIDE; YABACI TAK, AYŞEGÜLPublication Metadata only Ensemble of Effect Size Methods Based on Meta Fuzzy Functions(2023-03-01) Yabacı Tak A.; Ercan İ.; YABACI TAK, AYŞEGÜLPublication Metadata only The Influence of Gender and Age on Laparoscopic Sleeve Gastrectomy Short-Term Outcomes in Type-2 Diabetic Obese Patients(2021-06-01T00:00:00Z) Elbasan, Onur; Şişman, Pınar; Peynirci, Hande; Yabacı, Ayşegül; Ersoy, Canan; YABACI TAK, AYŞEGÜLBackground Bariatric surgery has come out as an effective treatment for morbid obesity due to its effects as stabilized weight loss and remission of obesity related comorbidities like type 2 diabetes. Postoperative weight loss is affected by many factors and predictors of weight loss after bariatric surgery are controversial.This study has been performed to evaluate the impact of gender and age on the shortterm outcomes of laparoscopic sleeve gastrectomy (LSG) in type 2 diabetic(T2D) obese patients. Material and Methods In this retrospective study,the records of morbidly obese patients with a body mass index(BMI)≥40 kg/m2,aged between 18-65 years old who underwent LSG and were followed-up for at least 6 months postoperatively were reviewed.Patients were subdivided into two groups according to age(≥50 y,<50 y),gender(female, male) and compared. Results The study included 25 patients, 17(68%) female and 8(32%) male, 14(56%) were in <50 years old group and 11(44%) were in ≥50 years old group.At the postoperative 6th month,there was a significant decrease in weight,BMI,diastolic blood pressure,fasting blood glucose,postprandial glucose and HbA1c in both gender and age groups (p<0.05).A significant decrease was observed in Triglyceride(TG) at 6th month in both gender.While a significant increase in High-density Lipoprotein (HDL) was observed in patients aged ≥50 (p=0.028),no significant change was observed in the younger group.There was a positive correlation between change in Total Cholesterol(TCh),TG and age (respectively;r=0.436,p=0.030, r=0.528,p=0.007). Conclusions LSG is an effective treatment method for morbid obesity for younger(<50 y) and advanced aged(≥50 y) T2D patients in both genders. The percentage changes in the decreament of TG in male gender and TCh in younger age were more prominent in short-term follow-upPublication Open Access SHORT TERM EFFECT OF LAPAROSCOPIC SLEEVE GASTRECTOMY ON CLINICAL, RENAL PARAMETERS AND URINARY NGAL LEVELS IN DIABETIC AND NON DIABETIC OBESITY(2019-09-01T00:00:00Z) Elbasan, Onur; Şişman, Pınar; Peynirci, Hande; Yabacı, Ayşegül; Dirican, Melehat; Öz Gül, Özen; Cander, Soner; Ersoy, Canan; YABACI TAK, AYŞEGÜLBackground. Although diseases such as diabetes, hypertension, obstructive sleep apnea and hyperlipidemia are clearly documented as obesity associated diseases, it is not wellknown whether obesity causes renal pathologies. The aim of the present study was to evaluate the effect of weight loss following laparoscopic sleeve gastrectomy on clinical, renal parameters and urinary Neutrophil gelatinase-associated lipocalin (NGAL) levels in diabetic and non-diabetic obese patients. Methods. Nineteen morbidly obese patients (10 diabetic and 9 non diabetic) who underwent laparoscopic sleeve gastrectomy were evaluated clinically (anthropometric measurements) and biochemically before surgery and at 6 months from surgery. Results. Significant decreases in weight, BMI, FPG, PPG and HbA1c levels were observed in the diabetic group when the baseline and 6th month parameters of the patients were compared. There was also a significant decrease in SBP and DBP. At 6th month following laparoscopic sleeve gastrectomy, renal parameters such as creatinine, mAlb/creatinine, NGAL/ creatinine did not differ in the diabetic group. In the nondiabetic group, serum creatinine levels were significantly decreased, but other renal parameters such as mAlb/creatinine and NGAL/ creatinine were not significantly different. Conclusions. Our findings revealed significant decreases in weight, body mass index and glycemic parameters after sleeve gastrectomy in diabetic and non-diabetic patients, while no significant alteration was noted in renal functions, urinary NGAL and microalbumin levels. Key words: sleeve gastrectomy, obesity, urinary NGAL, kidney, weight loss, T2DM.Publication Metadata only Effects of Core Stabilization Exercises on Pulmonary Function, Respiratory Muscle Strength, Peripheral Muscle Strength, Functional Capacity, and Perceived Appearance in Children With Adolescent Idiopathic Scoliosis: A Randomized Controlled Trial(2022-08-01T00:00:00Z) Yıldırım, Sefa; Özyılmaz, Semiramis; Elmadağ, Nuh Mehmet; Yabacı Tak, Ayşegül; YILDIRIM, SEFA; ÖZYILMAZ, SEMIRAMIS; ELMADAĞ, NUH MEHMET; YABACI TAK, AYŞEGÜLObjectiveThe aim of the study was to investigate the effects of core stabilization exercises on pulmonary function, respiratory muscle strength, peripheral muscle strength, walking capacity, andperceived appearancein children with adolescent idiopathic scoliosis.DesignThis is an evaluator-blinded, randomized controlled trial. A total of 30 patients were randomly allocated to either a training group (n= 15, age = 13.8 ± 2.8 yrs, Cobb angle = 19.3 ± 6 degrees, Risser sign:n(1)= 1;n(2–4)= 14) or a control group (n= 15, age = 15.8 ± 3.4 yrs, Cobb angle = 20.8 ± 7.9 degrees, Risser sign:n(1)= 1;n(2–4)= 14). The training group received core stabilization exercises in addition to the traditional scoliosis exercises for 8 wks. The control group only received the traditional scoliosis exercises for 8 wks. Spirometry, maximal inspiratory and expiratory pressures, 6-min walking test, peripheral muscle strength, and the Walter Reed Visual Assessment Scale were assessed at the beginning and end of the study.ResultsThe training group showed statistically significant improvements in maximal inspiratory pressure, maximum expiratory pressure, and Walter Reed Visual Assessment Scale score (respectively, mean changes = 17.4 ± 5.2 cmH2O; 10.6 ± 4.3 cmH2O; 2.4 ± 1.6), which were significantly larger compared with the control group (P< 0.05).ConclusionsCore stabilization exercises given in addition to the traditional scoliosis exercise can improve respiratory muscle strength andperceived appearancein patients with adolescent idiopathic scoliosis.