2021-12-10T00:00:00Z, Smith, Lee, Shin, Jae Il, Oh, Hans, Carmichael, Christina, Jacob, Louis, Stefanac, Sinisa, Lindsay, Rosie K, Soysal, PINAR, Veronese, Nicola, Tully, Mark A, Butler, Laurie, Barnett, Yvonne, Koyanagi, Ai, SOYSAL, PINAR

Background: The effect of weight modification on future dementia risk is currently a subject of debate and may be modified by age. Objective: The aim of the present study was to investigate the association between body mass index (BMI) status with mild cognitive impairment (MCI) (a preclinical stage of dementia) in middle-aged and older adults residing in six low- and middle-income countries using nationally representative data. Methods: Cross-sectional data from the Study on Global Ageing and Adult Health (SAGE) were analyzed. MCI was defined using the National Institute on Aging-Alzheimer's Association criteria. BMI (kg/m2) was based on measured weight and height and categorized as: underweight (<18.5), normal (18.5-24.9), overweight (25.0-29.9), and obese (≥30.0). Multivariable logistic regression analysis and meta-analysis were conducted to assess associations. Results: Data on 32,715 individuals aged ≥50 years with preservation in functional abilities were analyzed [mean (SD) age 62.1 (15.6) years; 51.7% females]. Among those aged 50-64 years, compared to normal weight, underweight (OR = 1.44; 95% CI = 1.14-1.81), overweight (OR = 1.17; 95% CI = 1.002-1.37), and obesity (OR = 1.46; 95% CI = 1.09-1.94) were all significantly associated with higher odds for MCI. In those aged ≥65 years, underweight (OR = 0.71; 95% CI = 0.54-0.95) and overweight (OR = 0.72; 95% CI = 0.55-0.94) were associated with significantly lower odds for MCI, while obesity was not significantly associated with MCI. Conclusion: The results of the study suggest that the association between BMI and MCI is likely moderated by age. Future longitudinal studies are required to confirm or refute the present findings before recommendations for policy and practice can be made.

2022-07-01T00:00:00Z, Heybeli, Cihan, SOYSAL, PINAR, Smith, Lee, Keskin, Elmas Biberci, KAZANCIOĞLU, Rümeyza, SOYSAL, PINAR, KAZANCIOĞLU, RÜMEYZA

Objectives: Geriatric syndromes are common in elderly subjects with chronic kidney disease. An age-adapted definition of chronic kidney disease has recently been proposed. This study aimed to investigate the effects of this change in the definition of chronic kidney disease (from an estimated glomerular filtration rate of <60 to <45 mL/min/1.73 m(2)) on geriatric assessments. Methods: Records of an elderly outpatient population were retrospectively reviewed. Subjects underwent comprehensive geriatric assessment including the Basic and Instrumental Activities of Daily Living, Mini-Mental State Examination, Geriatric Depression Score, Tinetti Mobility test, the Timed Up and Go test, the Mini Nutritional Assessment, the handgrip test, and the Insomnia Severity Index. Logistic regression analysis was performed in order to determine the odds ratio of each chronic kidney disease definition on geriatric syndromes. Results: Of the 1222 patients, 832 (68.1%) were women and the median age was 73 (interquartile range, 67-80) years. Patients with an estimated glomerular filtration rate of <45 and <60 mL/min/1.73 m(2) comprised 8.3% (n = 101) and 21.6% (n = 264) of the cohort, respectively. Both estimated glomerular filtration rates of <45 and <60 mL/min/1.73 m(2) were significantly associated with more unfavorable geriatric assessment scores in univariate analysis. After adjustments, associations of an estimated glomerular filtration rate <60 mL/min/1.73 m(2) with the Timed Up and Go test and polypharmacy remained significant; however, none of the geriatric assessment measures remained significantly associated with an estimated glomerular filtration rate of <45 mL/min/1.73 m(2). Conclusion: Chronic kidney disease was more significantly associated with impairments in geriatric assessment parameters when the cut-off of estimated glomerular filtration rate for the definition of chronic kidney disease was kept as <60 mL/min/1.73 m(2) in comparison to modification of <45 mL/min/1.73 m(2).