Person: SOYSAL, PINAR
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Publication Metadata only Body mass index categories and anxiety symptoms among adults aged ≥ 50 years from low and middle income countries.(2021-10-18T00:00:00Z) Smith, Lee; Pizzol, Damiano; López-Sánchez, Guillermo F; Oh, Hans; Jacob, Louis; Yang, Lin; Veronese, Nicola; Soysal, PINAR; McDermott, Daragh; Barnett, Yvonne; Butler, Laurie; Koyanagi, Ai; SOYSAL, PINARPublication Metadata only Excessive daytime sleepiness is associated with an increased frequency of falls and sarcopenia.(2021-04-20T00:00:00Z) Soysal, PINAR; Smith, Lee; Tan, Semen Gokce; Capar, Emre; Veronese, Nicola; Yang, Lin; SOYSAL, PINARPublication Metadata only Anxiety symptoms among informal caregivers in 47 low- and middle-income countries: a cross-sectional analysis of community-based surveys.(2021-11-14T00:00:00Z) Smith, Lee; Shin, Jae Il; Oh, Hans; López Sánchez, Guillermo F; Underwood, Benjamin; Jacob, Louis; Veronese, Nicola; Soysal, PINAR; Butler, Laurie; Barnett, Yvonne; Tully, Mark A; Koyanagi, Ai; SOYSAL, PINARPublication Metadata only Body Mass Index and Mild Cognitive Impairment Among Middle-Aged and Older Adults from Low- and Middle-Income Countries.(2021-12-10T00:00:00Z) Smith, Lee; Shin, Jae Il; Oh, Hans; Carmichael, Christina; Jacob, Louis; Stefanac, Sinisa; Lindsay, Rosie K; Soysal, PINAR; Veronese, Nicola; Tully, Mark A; Butler, Laurie; Barnett, Yvonne; Koyanagi, Ai; SOYSAL, PINARBackground: The effect of weight modification on future dementia risk is currently a subject of debate and may be modified by age. Objective: The aim of the present study was to investigate the association between body mass index (BMI) status with mild cognitive impairment (MCI) (a preclinical stage of dementia) in middle-aged and older adults residing in six low- and middle-income countries using nationally representative data. Methods: Cross-sectional data from the Study on Global Ageing and Adult Health (SAGE) were analyzed. MCI was defined using the National Institute on Aging-Alzheimer's Association criteria. BMI (kg/m2) was based on measured weight and height and categorized as: underweight (<18.5), normal (18.5-24.9), overweight (25.0-29.9), and obese (≥30.0). Multivariable logistic regression analysis and meta-analysis were conducted to assess associations. Results: Data on 32,715 individuals aged ≥50 years with preservation in functional abilities were analyzed [mean (SD) age 62.1 (15.6) years; 51.7% females]. Among those aged 50-64 years, compared to normal weight, underweight (OR = 1.44; 95% CI = 1.14-1.81), overweight (OR = 1.17; 95% CI = 1.002-1.37), and obesity (OR = 1.46; 95% CI = 1.09-1.94) were all significantly associated with higher odds for MCI. In those aged ≥65 years, underweight (OR = 0.71; 95% CI = 0.54-0.95) and overweight (OR = 0.72; 95% CI = 0.55-0.94) were associated with significantly lower odds for MCI, while obesity was not significantly associated with MCI. Conclusion: The results of the study suggest that the association between BMI and MCI is likely moderated by age. Future longitudinal studies are required to confirm or refute the present findings before recommendations for policy and practice can be made.Publication Metadata only Urinary incontinence and quality of life: A longitudinal analysis from the English Longitudinal Study of Ageing(2022-06-01T00:00:00Z) Veronese, Nicola; Smith, Lee; Pizzol, Damiano; SOYSAL, PINAR; Maggi, Stefania; Ilie, Petre-Cristian; Dominguez, Ligia J.; Barbagallo, Mario; SOYSAL, PINARObjectives: To explore the longitudinal association between urinary incontinence (UI) and quality of life (QoL) in the English Longitudinal Study on Ageing, a large study of older UK adults with ten years of follow-up. Study design: Cohort study.Main outcomes interest: To determine the presence of UI, participants reported whether they had lost urine beyond their control in the last 12 months. Participants also reported whether UI lasted more than one month, indicating a more chronic problem. QoL was measured using the CASP (control, autonomy, self-realisation and pleasure)-19, with higher values indicating a higher QoL. Results: Of the 8028 participants (mean age: 65.2 years; 56.7% females) included, 1172 reported UI at baseline. No significant differences in CASP-19 score were found at baseline (p = 0.24). In people with UI, a significant decline in CASP-19 score (from 34.3 +/- 14.0 at baseline to 30.9 +/- 16.1 in wave 7) (p = 0.016) was observed. The results were stronger in men than in women and with a longer duration of UI. Conclusion: UI was associated with poor QoL over ten years of follow-up in a large cohort of UK participants. Our findings further suggest the importance of UI as a potential risk factor for poor QoL.Publication Metadata only Physical multimorbidity predicts the onset and persistence of anxiety: A prospective analysis of the Irish Longitudinal Study on Ageing.(2022-04-19T00:00:00Z) Smith, Lee; Shin, Jae Il; Jacob, Louis; Schuch, Felipe; Pizzol, Damiano; López Sánchez, Guillermo F; Soysal, PINAR; Tully, Mark A; Butler, Laurie T; Barnett, Yvonne; Veronese, Nicola; Park, Seoyeon; Koyanagi, Ai; SOYSAL, PINARPublication Metadata only Physical multimorbidity and depression: A mediation analysis of influential factors among 34,129 adults aged ≥50 years from low- and middle-income countries.(2022-03-21T00:00:00Z) Smith, Lee; Shin, Jae Il; Butler, Laurie; Barnett, Yvonne; Oh, Hans; Jacob, Louis; Kostev, Karel; Veronese, Nicola; Soysal, PINAR; Tully, Mark; López Sánchez, Guillermo F; Koyanagi, Ai; SOYSAL, PINARPublication Metadata only Physical Activity and Exercise in Mild Cognitive Impairment and Dementia: An Umbrella Review of Intervention and Observational Studies(2020-10-01T00:00:00Z) Demurtas, Jacopo; Schoene, Daniel; Torbahn, Gabriel; Marengoni, Alessandra; Grande, Giulia; Zou, Liye; Petrovic, Mirko; Maggi, Stefania; Cesari, Matteo; Lamb, Sarah; Soysal, Pınar; Kemmler, Wolfgang; Sieber, Cornel; Mueller, Christoph; Shenkin, Susan D.; Schwingshackl, Lukas; Smith, Lee; Veronese, Nicola; SOYSAL, PINARObjectives: The aim of this umbrella review was to determine the effect of physical activity/exercise on improving cognitive and noncognitive outcomes in people with MCI (mild cognitive impairment) and dementia.Publication Metadata only Role of physical activity in ameliorating neuropsychiatric symptoms in Alzheimer disease: A narrative review(2019-09-01T00:00:00Z) Veronese, Nicola; Solmi, Marco; Basso, Cristina; Smith, Lee; SOYSAL, PINAR; SOYSAL, PINARObjective Neuropsychiatric symptoms (NPs) affect almost all patients with Alzheimer disease (AD). Because of the complications associated with the pharmacological treatment, nonpharmacological treatment (such as physical activity) can be considered as an additional complementary treatment option for NPs. The aim of this review is to evaluate the impact of physical activity on NPs in patients with AD. Methods We searched Pubmed and Google Scholar for potential eligible articles until March 1, 2018. Results Although there are contradictory results showing the impact of physical exercise on NPs, most of them reported that it had a significant effect on depression and sleep disturbances in patients with AD. The beneficial effects could be explained through several mechanisms, including modulated production of neurotransmitters; increasing neurotrophins, such as brain-derived neurotrophic factor; reduction of oxidative stress and inflammation; elevation of cerebral blood flow; hypothalamic pituitary adrenal axis regulation; and support of neurogenesis and synaptogenesis. Physical activity can also improve cardiovascular risk factors, which may exaggerate NPs. There is limited evidence for other NPs such as agitation, disinhibition, apathy, hallucinations, and anxiety. Conclusion Physical activity may ameliorate depression and sleep disturbances in patients with AD. Therefore, physical activity can be a -potential- add-on treatment to drugs to reduce or prevent these symptoms onset and recurrence in patients with AD. However, further studies are needed to focus on relationship between physical activity and other NPs.Publication Metadata only Sleep problems and subjective cognitive complaints among middle-aged and older adults in 45 low- and middle-income countries.(2022-01-05T00:00:00Z) Smith, Lee; Oh, Hans; Jacob, Louis; López-Sánchez, Guillermo F; Veronese, Nicola; Soysal, PINAR; Shin, Jae Il; Schuch, Felipe; Tully, Mark A; Butler, Laurie; Barnett, Yvonne; Koyanagi, Ai; SOYSAL, PINAR
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