Person: SOYSAL, PINAR
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Publication Metadata only Inflammation, Frailty and Cardiovascular Disease(2020-01-01T00:00:00Z) SOYSAL, PINAR; Arik, Ferhat; Smith, Lee; Jackson, Sarah E.; IŞIK, AHMET TURAN; SOYSAL, PINARChronic inflammation, which is called -inflamm-aging-, is characterized by an increased level of inflammatory cytokines in response to physiological and environmental stressors, and causes the immune system to function consistently at a low level, even though it is not effective. Possible causes of inflammaging include genetic susceptibility, visceral obesity, changes in gut microbiota and permeability, chronic infections and cellular senescence. Inflammation has a role in the development of many age-related diseases, such as frailty. Low grade chronic inflammation can also increase the risk of atherosclerosis and insulin resistance which are the leading mechanisms in the development of cardiovascular diseases (CVD). As it is well known that the risk of CVD is higher in older people with frailty and the risk of frailty is higher in patients with CVD, there may be relationship between inflammation and the development of CVD and frailty. Therefore, this important issue will be discussed in this chapter.Publication Metadata only Physical multimorbidity and incident urinary incontinence among community-dwelling adults aged ≥50 years: findings from a prospective analysis of the Irish Longitudinal Study on Ageing.(2021-07-17T00:00:00Z) Smith, Lee; Shin, Jae Il; Ghayda, Ramy Abou; Hijaz, Adonis; Sheyn, David; Pope, Rachel; Hong, Sun Hwi; Kim, Sung Eun; Ilie, Petre Cristian; Carrie, Anne Marie; Ippoliti, Simona; Soysal, PINAR; Barnett, Yvonne; Pizzol, Damiano; Koyanagi, Ai; SOYSAL, PINARPublication Metadata only Body mass index categories and anxiety symptoms among adults aged ≥ 50 years from low and middle income countries.(2021-10-18T00:00:00Z) Smith, Lee; Pizzol, Damiano; López-Sánchez, Guillermo F; Oh, Hans; Jacob, Louis; Yang, Lin; Veronese, Nicola; Soysal, PINAR; McDermott, Daragh; Barnett, Yvonne; Butler, Laurie; Koyanagi, Ai; SOYSAL, PINARPublication Metadata only Excessive daytime sleepiness is associated with an increased frequency of falls and sarcopenia.(2021-04-20T00:00:00Z) Soysal, PINAR; Smith, Lee; Tan, Semen Gokce; Capar, Emre; Veronese, Nicola; Yang, Lin; SOYSAL, PINARPublication Metadata only Anxiety symptoms among informal caregivers in 47 low- and middle-income countries: a cross-sectional analysis of community-based surveys.(2021-11-14T00:00:00Z) Smith, Lee; Shin, Jae Il; Oh, Hans; López Sánchez, Guillermo F; Underwood, Benjamin; Jacob, Louis; Veronese, Nicola; Soysal, PINAR; Butler, Laurie; Barnett, Yvonne; Tully, Mark A; Koyanagi, Ai; SOYSAL, PINARPublication Metadata only The development of a short depression screening tool in older adults.(2022-05-07T00:00:00Z) Soysal, PINAR; Smith, Lee; SOYSAL, PINARPublication Metadata only Body Mass Index and Mild Cognitive Impairment Among Middle-Aged and Older Adults from Low- and Middle-Income Countries.(2021-12-10T00:00:00Z) Smith, Lee; Shin, Jae Il; Oh, Hans; Carmichael, Christina; Jacob, Louis; Stefanac, Sinisa; Lindsay, Rosie K; Soysal, PINAR; Veronese, Nicola; Tully, Mark A; Butler, Laurie; Barnett, Yvonne; Koyanagi, Ai; SOYSAL, PINARBackground: The effect of weight modification on future dementia risk is currently a subject of debate and may be modified by age. Objective: The aim of the present study was to investigate the association between body mass index (BMI) status with mild cognitive impairment (MCI) (a preclinical stage of dementia) in middle-aged and older adults residing in six low- and middle-income countries using nationally representative data. Methods: Cross-sectional data from the Study on Global Ageing and Adult Health (SAGE) were analyzed. MCI was defined using the National Institute on Aging-Alzheimer's Association criteria. BMI (kg/m2) was based on measured weight and height and categorized as: underweight (<18.5), normal (18.5-24.9), overweight (25.0-29.9), and obese (≥30.0). Multivariable logistic regression analysis and meta-analysis were conducted to assess associations. Results: Data on 32,715 individuals aged ≥50 years with preservation in functional abilities were analyzed [mean (SD) age 62.1 (15.6) years; 51.7% females]. Among those aged 50-64 years, compared to normal weight, underweight (OR = 1.44; 95% CI = 1.14-1.81), overweight (OR = 1.17; 95% CI = 1.002-1.37), and obesity (OR = 1.46; 95% CI = 1.09-1.94) were all significantly associated with higher odds for MCI. In those aged ≥65 years, underweight (OR = 0.71; 95% CI = 0.54-0.95) and overweight (OR = 0.72; 95% CI = 0.55-0.94) were associated with significantly lower odds for MCI, while obesity was not significantly associated with MCI. Conclusion: The results of the study suggest that the association between BMI and MCI is likely moderated by age. Future longitudinal studies are required to confirm or refute the present findings before recommendations for policy and practice can be made.Publication Metadata only Effects of a Change in the Definition of Chronic Kidney Disease on Geriatric Assessment Parameters(2022-07-01T00:00:00Z) Heybeli, Cihan; SOYSAL, PINAR; Smith, Lee; Keskin, Elmas Biberci; KAZANCIOĞLU, Rümeyza; SOYSAL, PINAR; KAZANCIOĞLU, RÜMEYZAObjectives: Geriatric syndromes are common in elderly subjects with chronic kidney disease. An age-adapted definition of chronic kidney disease has recently been proposed. This study aimed to investigate the effects of this change in the definition of chronic kidney disease (from an estimated glomerular filtration rate of <60 to <45 mL/min/1.73 m(2)) on geriatric assessments. Methods: Records of an elderly outpatient population were retrospectively reviewed. Subjects underwent comprehensive geriatric assessment including the Basic and Instrumental Activities of Daily Living, Mini-Mental State Examination, Geriatric Depression Score, Tinetti Mobility test, the Timed Up and Go test, the Mini Nutritional Assessment, the handgrip test, and the Insomnia Severity Index. Logistic regression analysis was performed in order to determine the odds ratio of each chronic kidney disease definition on geriatric syndromes. Results: Of the 1222 patients, 832 (68.1%) were women and the median age was 73 (interquartile range, 67-80) years. Patients with an estimated glomerular filtration rate of <45 and <60 mL/min/1.73 m(2) comprised 8.3% (n = 101) and 21.6% (n = 264) of the cohort, respectively. Both estimated glomerular filtration rates of <45 and <60 mL/min/1.73 m(2) were significantly associated with more unfavorable geriatric assessment scores in univariate analysis. After adjustments, associations of an estimated glomerular filtration rate <60 mL/min/1.73 m(2) with the Timed Up and Go test and polypharmacy remained significant; however, none of the geriatric assessment measures remained significantly associated with an estimated glomerular filtration rate of <45 mL/min/1.73 m(2). Conclusion: Chronic kidney disease was more significantly associated with impairments in geriatric assessment parameters when the cut-off of estimated glomerular filtration rate for the definition of chronic kidney disease was kept as <60 mL/min/1.73 m(2) in comparison to modification of <45 mL/min/1.73 m(2).Publication Metadata only The clinical implications and importance of anemia in older women.(2021-04-07T00:00:00Z) Kara, Osman; Smith, Lee; Tan, Semen Gokce; Soysal, PINAR; SOYSAL, PINARPublication Metadata only What are optimum target levels of hemoglobin in older adults?(2021-04-28T00:00:00Z) Kara, Osman; Soysal, PINAR; Smith, Lee; Kiskac, Muharrem; SOYSAL, PINAR