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SOYSAL, PINAR

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Author: Isik, Ahmet Turan × Start date: 2011 × Has files: true ×

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Now showing 1 - 4 of 4
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    PublicationOpen Access
    Orthostatic hypotension and health outcomes: an umbrella review of observational studies
    (2019-11-07) Veronese, Nicola; Smith, Lee; Torbahn, Gabriel; Jackson, Sarah E.; Yang, Lin; SOYSAL, PINAR; Rivasi, Giulia; Rafanelli, Martina; Petrovic, Mirko; Maggi, Stefania; Isik, Ahmet Turan; Demurtas, Jacopo; SOYSAL, PINAR
    Purpose Orthostatic hypotension (OH) is associated with older age and many negative clinical outcomes in geriatric practice. We aimed to capture the breadth of outcomes that have been associated with the presence of OH and systematically assess the quality, strength and credibility of these associations using an umbrella review with integrated meta-analyses. Methods We systematically searched several major databases from their commencements through to 16th May 2019 for meta-analyses of observational studies of OH and any health-related outcome. We used these metrics to categorize the strength of evidence of significant outcomes (p < 0.05) from class I (convincing) to class IV (weak), according to the pre-established criteria. Results From 975 abstracts, seven meta-analyses of 12 outcomes were included. For each outcome, the median number of studies was four, and the median number of participants was 46,493, with a median of 3630 incident cases. There was suggestive (class III) evidence that OH was associated with significantly higher risk of coronary heart disease (HR = 1.32, 95% CI 1.12-1.56), stroke (HR = 1.22, 95% CI 1.08-1.38), congestive heart failure (HR = 1.30, 95% CI 1.09-1.55), all-cause mortality (RR = 1.50, 95% CI 1.24-1.81), falls (OR = 1.84, 95% CI 1.39-2.44), and dementia (HR = 1.22, 95% CI 1.11-1.35). Conclusion The current evidence base indicates that OH is significantly associated with a range of adverse cardiovascular, cognitive, and mortality outcomes in older people, although the strength of this evidence remains only suggestive. Further research in larger samples and with lower risk of bias is required to build a fuller picture of the impact of OH on health.
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    PublicationOpen Access
    Challenges experienced by elderly people in nursing homes due to the coronavirus disease 2019 pandemic
    (2020-10-01T00:00:00Z) SOYSAL, PINAR; Aydin, Ali Ekrem; Isik, Ahmet Turan; SOYSAL, PINAR
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    PublicationOpen Access
    The evaluation of relationship between polypharmacy and anticholinergic burden scales.
    (2021-03-11T00:00:00Z) Okudur, Saadet Koc; Dokuzlar, Ozge; Aydin, Ali Ekrem; Kocyigit, Suleyman Emre; Soysal, PINAR; Isik, Ahmet Turan; SOYSAL, PINAR
    Objective: Polypharmacy and anticholinergic burden are the indicators for the evaluation of the quality of pharmacotherapy in older adults. The aim of this study was to consider which anticholinergic burden scales are more related with polypharmacy among older patients. Methods: Four hundred and twenty older adults were evaluated retrospectively in this cross-sectional study. The patient's demographic data, comorbidities, the drugs, and number of drugs were recorded. Anticholinergic burden scales were calculated by a tool named anticholinergic burden calculator. Results: The participants' mean age was 73.08±8.71. The prevalence of polypharmacy was 32.14%. The highest relationship with polypharmacy was observed for drug burden index (DBI) (odds ratio 10.87, p<0.001). Conclusion: Our study demonstrated that polypharmacy and DBI scores were more related than other anticholinergic burden scales in older adults.
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    PublicationOpen Access
    Prospective associations between alcohol use, binge drinking and sexual activity in older adults: the English Longitudinal Study Of Ageing
    (2019-11-08) Grabovac, Igor; Koyanagi, Ai; Yang, Lin; SOYSAL, PINAR; McDermott, Daragh; Isik, Ahmet Turan; Veronese, Nicola; Smith, Lee; SOYSAL, PINAR
    The present study aimed to investigate associations between alcohol consumption and sexual activity. Data were from 1,622 men and 2,195 women aged >= 50 years participating in the English Longitudinal Study of Ageing. Adjusted multivariable logistic regression was used to assess associations between baseline frequency of alcohol use in the last year or binge drinking in the last week and sexual activity at 8-year follow-up. Regular alcohol consumption in the last year at baseline was associated with 111% higher odds (95% CI 1.36-3.27) of any past-year sexual activity at follow-up in men and 76% higher odds (95% CI 1.26-2.46) in women. Frequent alcohol consumption was associated with 175% higher odds (95% CI 1.75-4.32) of sexual activity in men and 100% higher odds (95% CI 1.38-2.89) in women, relative to drinking alcohol never or rarely. Binge drinking was positively associated with sexual activity at follow-up, with odds of being sexually active at follow-up 52% higher (95% CI 1.07-2.15) among men who reported binge drinking at baseline and 57% higher (95% CI 1.11-2.23) among females. These findings do not outweigh the health risks associated with excessive alcohol consumption. Health practitioners should consider these findings when encouraging older adults to reduce their alcohol consumption.