Person: UMURHAN AKKAN, JÜLİDE CANAN
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Publication Open Access Effect of a single intravitreal bevacizumab injection on different optical coherence tomographic patterns of diabetic macular oedema(2013-06-01) KOYTAK, A.; ALTINISIK, M.; Sari, E. Sogutlu; ARTUNAY, O.; Akkan, JÜLİDE CANAN; TUNCER, K.; KOYTAK, İBRAHİM ARİF; UMURHAN AKKAN, JÜLİDE CANANPurpose: The aim of this study is to compare the therapeutic effect of a single intravitreal bevacizumab (IVB) injection in eyes with diabetic macular oedema (DMO) of different patterns determined by optical coherence tomography (OCT). Methods: Medical records of patients who had a single IVB injection for DMO were analysed retrospectively. Eyes with a clinically significant DMO and a central foveal thickness (CFT) of 250 μm or more determined by OCT were included in the analysis. Best-corrected visual acuity (BCVA), CFT and total macular volume values before and after the injection were recorded. Eyes were divided into sponge-like diffuse retinal thickening (DRT), cystoid macular oedema (CMO) and serous retinal detachment (SRD) groups according to the morphology on OCT. Results: A total of 92 eyes (42 with DRT, 31 with CMO and 19 with SRD) were included in the study. There was no statistically significant variation between three groups regarding the change in BCVA (P=0.695). CMO and SRD groups had greater reductions in their mean CFT, and the amount of reduction showed statistically significant variation between three groups (P=0.048). However, no statistically significant difference was found between groups in terms of percentage of change in CFT (P=0.278). Conclusion: CMO and SRD subtypes are associated with a greater reduction in the CFT than the DRT subtype. Although the change in BCVA was not significantly different between groups, the DRT group showed markedly better visual improvement in proportion to the decrease in CFT.Publication Metadata only Repeated bevacizumab injections versus mitomycin C in rotational conjunctival flap for prevention of pterygium recurrence(2014-04-01) ÖZSÜTÇÜ, Mustafa; AYINTAP, Emre; Akkan, JÜLİDE CANAN; KOYTAK, Arif; ARAS, Cengiz; UMURHAN AKKAN, JÜLİDE CANAN; KOYTAK, İBRAHİM ARİFAims: To evaluate the efficacy of repeated bevacizumab injection in rotational conjunctival flap surgery versus rotational conjunctival flap with adjunctive mitomycin C (MMC) or rotational conjunctival flap alone. Materials and methods: Ninety eyes of 90 patients who underwent primary pterygium surgery with rotational flap were evaluated. Patients were randomly assigned to undergo conjunctival rotational flap alone (Group A) or conjunctival rotational flap with either 0.02% MMC application (Group B) or adjunctive subconjunctival 2.5 mg/0.1 ml bevacizumab injection (Group C). Each group consisted of 30 eyes. Recurrence rates at 9 months were evaluated. Results: There were no statistically significant differences in mean size of the pterygium across the limbus in terms of length (P > 0.5). The recurrence rates at 9 months were 26.6% (n = 8) in Group A, 13.3% (n = 4) in Group B, and 10% (n = 3) in Group C. The recurrence rates in Group B and C were significantly lower than in Group A (P = 0.1806). The recurrence rates were similar in Group B and C (P > 0.05). Conclusions: Subconjunctival bevacizumab injection may decrease the recurrence rate of primary pterygium surgery with rotational conjunctival flap. Further studies with a larger population and longer follow-up period are needed to supplement this study.Publication Metadata only Peripapillary retinal nerve fiber layer changes in asymptomatic essential thrombocythemia patients(2014-01-01) AYINTAP, Emre; ÇETİN, GÜVEN; SADIGOV, Fariz; ARTUNAY, Ozgur; Akkan, Julide C. U.; KOYTAK, İBRAHİM ARİF; TUNCER, Kemal; ÇETİN, GÜVEN; UMURHAN AKKAN, JÜLİDE CANAN; KOYTAK, İBRAHİM ARİF