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KHAN, IMRAN

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IMRAN
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KHAN
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Type: Article × Subject: autophagy ×

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    PublicationOpen Access
    Deciphering the role of autophagy in treatment of resistance mechanisms in glioblastoma
    (2021-02-01T00:00:00Z) KHAN, IMRAN; Baig, Mohammad Hassan; Mahfooz, Sadaf; Rahim, Moniba; KARAÇAM, BÜŞRA; ELBASAN, Elif Burçe; Ulasov, Ilya; Dong, Jae-June; HATİBOĞLU, MUSTAFA AZİZ; KHAN, IMRAN; KARAÇAM, BÜŞRA; ELBASAN, ELİF BURÇE; HATİBOĞLU, MUSTAFA AZİZ
    Autophagy is a process essential for cellular energy consumption, survival, and defense mechanisms. The role of autophagy in several types of human cancers has been explicitly explained; however, the underlying molecular mechanism of autophagy in glioblastoma remains ambiguous. Autophagy is thought to be a -double-edged sword-, and its effect on tumorigenesis varies with cell type. On the other hand, autophagy may play a significant role in the resistance mechanisms against various therapies. Therefore, it is of the utmost importance to gain insight into the molecular mechanisms deriving the autophagy-mediated therapeutic resistance and designing improved treatment strategies for glioblastoma. In this review, we discuss autophagy mechanisms, specifically its pro-survival and growth-suppressing mechanisms in glioblastomas. In addition, we try to shed some light on the autophagy-mediated activation of the cellular mechanisms supporting radioresistance and chemoresistance in glioblastoma. This review also highlights autophagy’s involvement in glioma stem cell behavior, underlining its role as a potential molecular target for therapeutic interventions.