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BOLUKÇU, SİBEL

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SİBEL
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BOLUKÇU
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Now showing 1 - 10 of 25
  • PublicationOpen Access
    Presence of Status Epilepticus with Ebstein Barr Virus Encephalitis
    (2018-04-01T00:00:00Z) DENİZ, ÇİĞDEM; ASİL, Talip; BOLUKÇU, SİBEL; Zengin, S. Ulgen; DENİZ, ÇİĞDEM; ASİL, TALIP; BOLUKÇU, SİBEL
    Neurological involvement, mostly in the form of meningoencephalitis or encephalitis, represents the leading cause of death in patients with infectious mononucleosis (EF). Central nervous system involvement usually occurs after the first 1 to 3 weeks of disease, although patients presenting with neurological signs and symptoms have been rarely reported. In this case presentation, our aim was to examine the association between acute Ebstein barr virus (EBV) infection and refractory myoclonic convulsions in a patient presenting with myodonic status.
  • PublicationOpen Access
    Analysis of infectious spondylodiscitis: 7-years data
    (2018-11-01) Koc, Meliha Meric; Okay, GÜLAY; Akkoyunlu, YASEMİN; Bolukcu, SİBEL; Durdu, BÜLENT; Hakyemez, Ismail Necati; OKAY, GÜLAY; AKKOYUNLU, YASEMİN; BOLUKÇU, SİBEL; DURDU, BÜLENT; HAKYEMEZ, İSMAİL NECATİ; MERİÇ KOÇ, MELİHA
    Objective: Infectious spondylodiscitis (SD) is an infectious disease that is rare and difficult to diagnose due to its non-specific clinical features. In this study, we aimed to describe the clinical and diagnostic features of infectious spondylodiscitis. Methods: All patients who were diagnosed with SD at our hospital during a 7-year period from January 1, 2011 through December 31, 2017 were included in the study. Spondylodiscitis is divided into the following three types: pyogenic, tuberculous, and brucellar. Clinical and laboratory data were collected retrospectively from the medical records of the patients. Results: Of the 118 patients, 66 (55.9%) were female, 81 (68.6%) had pyogenic SD (PSD), 21 (17.8%) had tuberculous SD (TSD), and 16 (13.6%) had brucellar SD (BSD). The mean age was 59.3 ± 14.6 years. Leucocytosis was significantly higher in patients with PSD (p=0.01) than in patients with other types of SD. Thoracic involvement (47.6%) was significantly higher in patients with TSD (p=0.005) than in other patients. Sacral involvement (12.5%) was significantly higher in patients with BSD (p=0.01) than in other patients. Paravertebral abscess formation (42.8%) occurred most frequently in patients with TSD. Microbiologic agents were defined in 50% (18/36) of the surgical specimens and in 12.5% of the fine needle aspiration biopsy (FNAB) specimens. Staphylococcus aureus was the most common microbiological agent in patients with PSD. Spinal surgery was defined as a risk factor for PSD (p = 0.0001). Binary logistic regression analysis revealed that female gender, thoracic involvement and night sweats were the predictive markers for TSD (OR 4.5 [95% CI 1.3-15.3] and OR 5 [95% CI 1.7-14.6]). Conclusion: PSD is the most frequent form of SD. Leucocytosis is most common in patients with PSD. Thoracic involvement and paraspinal abscess were prominent in patients with TSD. Sacral involvement was most common in patients with BSD. Thoracic involvement, female gender and night sweats were the predictive markers for TSD. The microbiological culture positivity rate was higher in surgical specimens compared to FNAB specimens. The need for surgical treatment was most common in patients with TSD.
  • PublicationMetadata only
    Red Cell Volume Distribution Width to Platelet Ratio is an Important Predictor of Liver Fibrosis and Cirrhosis in Chronic Hepatitis B
    (2016-08-01) Hakyemez, Ismail Necati; BOLUKÇU, SİBEL; Durdu, BÜLENT; ASLAN, Turan; HAKYEMEZ, İSMAİL NECATİ; BOLUKÇU, SİBEL; DURDU, BÜLENT
    Objective: In recent years, a lot of non-invasive tests have been examined for estimating the severity of liver fibrosis in patients with chronic hepatitis B (CHB). We aimed to evaluate the role of simple and valuable platelet-derived indices in estimating the stage of fibrosis and cirrhosis in patients with CHB.
  • PublicationMetadata only
    Solunum Yolu Enfeksiyonu Etkeni Olarak İzole Edilen Haemophilus influenzae ve Moraxella catarrhalis-in Mevsimlere Göre Dağılımı
    (2017-03-19) GÜLTEPE, BİLGE; DURDU, BÜLENT; CEYLAN, AYŞE NUR; BOLUKÇU, SİBEL; OKAY, GÜLAY; AKKOYUNLU, MUHAMMED EMİN; DOYMAZ, MEHMET ZİYA; SÜMBÜL, BİLGE; DURDU, BÜLENT; CEYLAN, AYŞE NUR; BOLUKÇU, SİBEL; AKKOYUNLU, MUHAMMED EMİN; DOYMAZ, MEHMET ZIYA
  • PublicationMetadata only
    Infective endocarditis case due to streptococcus parasanguinis presented with spondylodiscitis
    (2016-01-01) Hakyemez, Ismail Necati; Durdu, BÜLENT; Okay, GÜLAY; GULTEPE, Bilge; Bolukcu, SİBEL; ASLAN, Turan; HAKYEMEZ, İSMAİL NECATİ; DURDU, BÜLENT; OKAY, GÜLAY; BOLUKÇU, SİBEL; SÜMBÜL, BİLGE
    Streptococcus parasanguinis is a natural member of oral flora. It is an opportunistic pathogen, and rarely cause systemic infections due to it-s low virulence. Subacute infective endocarditis may present with various clinical manifestations (eg., spondylodiscitis). A sixty-five years old male patient from Northern Iraq has referred to our emergency service with high fever, weight loss, back pain and inability to walk. The patient was a veterinarian. He was operated three years ago for colonic carcinoma and irradiated. In magnetic resonance imaging, spondylodiscitis was detected localized in lumbar 1-2 region. Transthorasic echocardiography demonstrated aortic valve vegetation. S. parasanguinis was identified in the blood cultures. In conclusion; all in all, it-s remarkable to isolate S. parasanguinis as a causal agent of infective endocarditis in a patient who is a veterinarian with history of colonic carcinoma presented with clinical manifestation of spondylodiscitis.
  • PublicationMetadata only
    Impact of switching to E/C/F/TAF on lipid profile and renal function in HIV-infected patients
    (2019-11-01T00:00:00Z) Mete, B.; Gunduz, A.; Zerdali, E.; Senoglu, S.; BOLUKÇU, SİBEL; Nakir, I. Yilmaz; Karaosmanoglu, H. Kumbasar; Koc, MELİHA; Bilge, B.; Dokmetas, I.; Tabak, F.; BOLUKÇU, SİBEL; MERİÇ KOÇ, MELİHA
  • PublicationMetadata only
    Evaluation of the Relationship Between ABO/Rh Blood Groups and Severity of Liver Fibrosis in Patients with Chronic Hepatitis B
    (2016-04-01) Hakyemez, Ismail Necati; Durdu, BÜLENT; BOLUKÇU, SİBEL; ASLAN, Turan; HAKYEMEZ, İSMAİL NECATİ; DURDU, BÜLENT; BOLUKÇU, SİBEL
    Objective: Studies on the severity of fibrosis in chronic viral hepatitis are scarce and limited with only hepatitis C infection. The aim of this study was to determine the role of ABO-Rh blood groups in the severity of fibrosis and progression to cirrhosis in patients with chronic hepatitis B (CHB).
  • PublicationOpen Access
    Tocilizumab treatment in severe COVID-19: a multicenter retrospective study with matched controls
    (2021-09-01T00:00:00Z) Mert, Ali; VAHABOĞLU, HALUK; ARSLAN, FERHAT; Batirel, Ayse; Saracoglu, Kemal Tolga; Bastug, Aliye; Cagatay, Atahan; IRMAK, İLİM; TELLİ DİZMAN, GÜLÇİN; Ertenli, Ihsan; Altunal, Lutfiye Nilsun; ERTÜRK ŞENGEL, BUKET; Bayram, Mehmet; Omma, Ahmet; Amikishiyev, Shirkhan; Aypak, Adalet; Bes, Cemal; BOLUKÇU, SİBEL; Icten, Sacit; TOPELİ İSKİT, ARZU; Bektas, Murat; Arslan, Birsen Yigit; Ozturk, Sinan; Comoglu, Senol; Aydin, Selda; Kucuksahin, Orhan; Icacan, Ozan Cemal; Ince, Burak; Aghamuradov, Sarvan; Mutlu, Melek Yalcin; Simsek, Funda; Emre, Salih; Ustun, Cemal; Ergen, Pinar; Aydin, Ozlem; MERİÇ KOÇ, MELİHA; Sevindik, Omur Gokmen; ODABAŞI, ZEKAVER; KORTEN, VOLKAN; Bodur, Hurrem; Guner, Rahmet; ÜNAL, SERHAT; Kocak, Mehmet; Gül, Ahmet; BOLUKÇU, SİBEL; MERİÇ KOÇ, MELİHA
    Coronavirus disease-2019 (COVID-19) associated pneumonia may progress into acute respiratory distress syndrome (ARDS). Some patients develop features of macrophage activation syndrome (MAS). Elevated levels of IL-6 were reported to be associated with severe disease, and anti-IL-6R tocilizumab has been shown to be effective in some patients. This retrospective multicenter case-control study aimed to evaluate the efficacy of tocilizumab in hospitalized COVID-19 patients, who received standard of care with or without tocilizumab. Primary outcome was the progression to intubation or death. PSMATCH (SAS) procedure was used to achieve exact propensity score (PS) matching. Data from 1289 patients were collected, and study population was reduced to 1073 based on inclusion-exclusion criteria. The composite outcome was observed more frequently in tocilizumab-users, but there was a significant imbalance between arms in all critical parameters. Primary analyses were carried out in 348 patients (174 in each arm) after exact PS matching according to gender, ferritin, and procalcitonin. Logistic regression models revealed that tocilizumab significantly reduced the intubation or death (OR 0.40, p = 0.0017). When intubation is considered alone, tocilizumab-users had > 60% reduction in odds of intubation. Multiple imputation approach, which increased the size of the matched patients up to 506, provided no significant difference between arms despite a similar trend for intubation alone group. Analysis of this retrospective cohort showed more frequent intubation or death in tocilizumab-users, but PS-matched analyses revealed significant results for supporting tocilizumab use overall in a subset of patients matched according to gender, ferritin and procalcitonin levels.
  • PublicationMetadata only
    A novel id-iri score: development and internal validation of the multivariable community acquired sepsis clinical risk prediction model
    (2020-04-01T00:00:00Z) Diktas, Husrev; Uysal, Serhat; Erdem, Hakan; Cag, Yasemin; Miftode, Egidia; Durmus, Gul; ULU KILIÇ, AYŞEGÜL; Alabay, Selma; Szabo, Balint Gergely; Lakatos, Botond; Fernandez, Ricardo; Korkmaz, Pinar; Caliz, Michael Cruz; Argemi, Xavier; Kulzhanova, Sholpan; Kormaz, Fatime; Yilmaz-Karadag, Fatma; Ergen, Pinar; Atilla, Aynur; Puca, Edmond; Dogan, Mustafa; Mangani, Francesca; Sahin, Suzan; Grgic, Svjetlana; Grozdanovski, Krsto; Yilmaz, Gul Ruhsar; Del-Vecchio, Rosa Fontana; Demirel, Aslihan; SIRMATEL, FATMA; ŞENER, ALPER; Sacar, Suzan; Aydin, Emsal; Batirel, Ayse; Dragovac, Gorana; El-Sokkary, Rehab; Alexandru, Crisan; Arslan-Ozel, Selcan; BOLUKÇU, SİBEL; Ozkaya, H. Deniz; Nayman-Alpat, Saygin; Inan, Asuman; Al-majid, Fahad; Kaya-Ugur, Berna; Rello, Jordi; BOLUKÇU, SİBEL
    We aimed to develop a scoring system for predicting in-hospital mortality of community-acquired (CA) sepsis patients. This was a prospective, observational multicenter study performed to analyze CA sepsis among adult patients through ID-IRI (Infectious Diseases International Research Initiative) at 32 centers in 10 countries between December 1, 2015, and May 15, 2016. After baseline evaluation, we used univariate analysis at the second and logistic regression analysis at the third phase. In this prospective observational study, data of 373 cases with CA sepsis or septic shock were submitted from 32 referral centers in 10 countries. The median age was 68 (51-77) years, and 174 (46,6%) of the patients were females. The median hospitalization time of the patients was 15 (10-21) days. Overall mortality rate due to CA sepsis was 17.7% (n = 66). The possible predictors which have strong correlation and the variables that cause collinearity are acute oliguria, altered consciousness, persistent hypotension, fever, serum creatinine, age, and serum total protein. CAS (%) is a new scoring system and works in accordance with the parameters in third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). The system has yielded successful results in terms of predicting mortality in CA sepsis patients.
  • PublicationMetadata only
    Protez Eklem Enfeksiyonlarının Risk Faktörleri ve Etkenlerin Dağılımı Açısından İrdelenmesi: Bir Üniversite Hastanesi Verileri
    (2017-04-08) BOLUKÇU, SİBEL; Okay, GÜLAY; Durdu, BÜLENT; HAKYEMEZ, İSMAİL NECATİ; AKKOYUNLU, YASEMİN; ASLAN, TURAN; OKAY, GÜLAY; BOLUKÇU, SİBEL; DURDU, BÜLENT; HAKYEMEZ, İSMAİL NECATİ; AKKOYUNLU, YASEMİN