Person: BOLUKÇU, SİBEL
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Publication Metadata only Red Cell Volume Distribution Width to Platelet Ratio is an Important Predictor of Liver Fibrosis and Cirrhosis in Chronic Hepatitis B(2016-08-01) Hakyemez, Ismail Necati; BOLUKÇU, SİBEL; Durdu, BÜLENT; ASLAN, Turan; HAKYEMEZ, İSMAİL NECATİ; BOLUKÇU, SİBEL; DURDU, BÜLENTObjective: In recent years, a lot of non-invasive tests have been examined for estimating the severity of liver fibrosis in patients with chronic hepatitis B (CHB). We aimed to evaluate the role of simple and valuable platelet-derived indices in estimating the stage of fibrosis and cirrhosis in patients with CHB.Publication Metadata only Infective endocarditis case due to streptococcus parasanguinis presented with spondylodiscitis(2016-01-01) Hakyemez, Ismail Necati; Durdu, BÜLENT; Okay, GÜLAY; GULTEPE, Bilge; Bolukcu, SİBEL; ASLAN, Turan; HAKYEMEZ, İSMAİL NECATİ; DURDU, BÜLENT; OKAY, GÜLAY; BOLUKÇU, SİBEL; SÜMBÜL, BİLGEStreptococcus parasanguinis is a natural member of oral flora. It is an opportunistic pathogen, and rarely cause systemic infections due to it-s low virulence. Subacute infective endocarditis may present with various clinical manifestations (eg., spondylodiscitis). A sixty-five years old male patient from Northern Iraq has referred to our emergency service with high fever, weight loss, back pain and inability to walk. The patient was a veterinarian. He was operated three years ago for colonic carcinoma and irradiated. In magnetic resonance imaging, spondylodiscitis was detected localized in lumbar 1-2 region. Transthorasic echocardiography demonstrated aortic valve vegetation. S. parasanguinis was identified in the blood cultures. In conclusion; all in all, it-s remarkable to isolate S. parasanguinis as a causal agent of infective endocarditis in a patient who is a veterinarian with history of colonic carcinoma presented with clinical manifestation of spondylodiscitis.Publication Metadata only Impact of switching to E/C/F/TAF on lipid profile and renal function in HIV-infected patients(2019-11-01T00:00:00Z) Mete, B.; Gunduz, A.; Zerdali, E.; Senoglu, S.; BOLUKÇU, SİBEL; Nakir, I. Yilmaz; Karaosmanoglu, H. Kumbasar; Koc, MELİHA; Bilge, B.; Dokmetas, I.; Tabak, F.; BOLUKÇU, SİBEL; MERİÇ KOÇ, MELİHAPublication Metadata only Evaluation of the Relationship Between ABO/Rh Blood Groups and Severity of Liver Fibrosis in Patients with Chronic Hepatitis B(2016-04-01) Hakyemez, Ismail Necati; Durdu, BÜLENT; BOLUKÇU, SİBEL; ASLAN, Turan; HAKYEMEZ, İSMAİL NECATİ; DURDU, BÜLENT; BOLUKÇU, SİBELObjective: Studies on the severity of fibrosis in chronic viral hepatitis are scarce and limited with only hepatitis C infection. The aim of this study was to determine the role of ABO-Rh blood groups in the severity of fibrosis and progression to cirrhosis in patients with chronic hepatitis B (CHB).Publication Metadata only A novel id-iri score: development and internal validation of the multivariable community acquired sepsis clinical risk prediction model(2020-04-01T00:00:00Z) Diktas, Husrev; Uysal, Serhat; Erdem, Hakan; Cag, Yasemin; Miftode, Egidia; Durmus, Gul; ULU KILIÇ, AYŞEGÜL; Alabay, Selma; Szabo, Balint Gergely; Lakatos, Botond; Fernandez, Ricardo; Korkmaz, Pinar; Caliz, Michael Cruz; Argemi, Xavier; Kulzhanova, Sholpan; Kormaz, Fatime; Yilmaz-Karadag, Fatma; Ergen, Pinar; Atilla, Aynur; Puca, Edmond; Dogan, Mustafa; Mangani, Francesca; Sahin, Suzan; Grgic, Svjetlana; Grozdanovski, Krsto; Yilmaz, Gul Ruhsar; Del-Vecchio, Rosa Fontana; Demirel, Aslihan; SIRMATEL, FATMA; ŞENER, ALPER; Sacar, Suzan; Aydin, Emsal; Batirel, Ayse; Dragovac, Gorana; El-Sokkary, Rehab; Alexandru, Crisan; Arslan-Ozel, Selcan; BOLUKÇU, SİBEL; Ozkaya, H. Deniz; Nayman-Alpat, Saygin; Inan, Asuman; Al-majid, Fahad; Kaya-Ugur, Berna; Rello, Jordi; BOLUKÇU, SİBELWe aimed to develop a scoring system for predicting in-hospital mortality of community-acquired (CA) sepsis patients. This was a prospective, observational multicenter study performed to analyze CA sepsis among adult patients through ID-IRI (Infectious Diseases International Research Initiative) at 32 centers in 10 countries between December 1, 2015, and May 15, 2016. After baseline evaluation, we used univariate analysis at the second and logistic regression analysis at the third phase. In this prospective observational study, data of 373 cases with CA sepsis or septic shock were submitted from 32 referral centers in 10 countries. The median age was 68 (51-77) years, and 174 (46,6%) of the patients were females. The median hospitalization time of the patients was 15 (10-21) days. Overall mortality rate due to CA sepsis was 17.7% (n = 66). The possible predictors which have strong correlation and the variables that cause collinearity are acute oliguria, altered consciousness, persistent hypotension, fever, serum creatinine, age, and serum total protein. CAS (%) is a new scoring system and works in accordance with the parameters in third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). The system has yielded successful results in terms of predicting mortality in CA sepsis patients.Publication Metadata only Changes in HIV demographic patterns in a low prevalence population: no evidence of a shift towards men who have sex with men(2016-07-01) SARGIN, Fatma; YILDIZ, Dilek; AYDIN, Ozlem Altuntas; Mete, Bilgul; GUNDUZ, Alper; KARAOSMANOGLU, Hayat Kumbasar; Yemisen, Mucahit; YAZICI, Saadet; BOLUKÇU, SİBEL; Durdu, BÜLENT; SENATES, Ebubekir; Ozaras, Resat; DOKMETAS, Ilyas; Tabak, Fehmi; BOLUKÇU, SİBEL; DURDU, BÜLENTObjectives: This study aimed to examine the changes in HIV demographics over time in an exceptionally low prevalence population, with particular emphasis on men who have sex with men (MSM).Publication Metadata only A rare cause of liver abscess secondary to hydatid cyst: pseudomonas stutzeri(2016-01-01) Durdu, BÜLENT; Hakyemez, Ismail Necati; Bolukcu, SİBEL; Okay, GÜLAY; ASLAN, Turan; DURDU, BÜLENT; HAKYEMEZ, İSMAİL NECATİ; BOLUKÇU, SİBEL; OKAY, GÜLAYPseudomonas stutzeri is non-fermentative gram negative bacteria which rarely leads to infections. In this report, we presented for the first time a liver abscess which was caused by P.stutzeri.Publication Metadata only Prospective Assessment of Blood Cultures Which Were Sent to the Clinical Microbiology Laboratory(2018-08-01T00:00:00Z) BOLUKÇU, SİBEL; Basran, Seniha; Cagatay, Atahan; Ozsut, Halit; Eraksoy, Haluk; BOLUKÇU, SİBELObjective: We aimed to evaluate the patient factors which increase the probability of achieving a positive blood culture, distribution of microorganisms grown, and to reveal the impact of various factors during collection of blood on blood culture positivity.Publication Metadata only HIV care in Istanbul, Turkey: How far is it from the UNAIDS 90-90-90 targets?(2019-11-15T00:00:00Z) Mete, Bilgul; Gunduz, Alper; BOLUKÇU, SİBEL; Karaosmanoglu, Hayat K.; Yildiz, Dilek; Koc, MELİHA; Aydin, Ozlem A.; Dokmetas, Ilyas; Tabak, Fehmi; BOLUKÇU, SİBEL; MERİÇ KOÇ, MELİHAThe prevalence of human immunodeficiency virus (HIV) infection is low but it is steadily increasing in Turkey. In the current study, we aimed to assess the status of HIV infection management with the proposed 90-90-90 targets in a large HIV cohort in Istanbul, Turkey. The cohort included 2382 patients (2082 male, 300 female, mean age was 36.3 +/- 11.3 years). Mean CD4 cell count was 399 cells/mm(3) and HIV-RNA level was 576,235 copies/ml. According to the modeling by the Modeling tool of European Center for Diseases Control Software, 72 and 74% of all HIV patients had been diagnosed in 2016 and 2017, respectively (the first target). Among 2382 patients, 2191 (92%) were on antiretroviral therapy (the second target). The third target of virally suppressing those on treatment was achieved among 70.2% of the patients. The current study suggests that both the fraction of those living with undiagnosed HIV and the proportion of those on treatment who are virally suppressed should be targeted to sustain optimal HIV care. Efforts should continue to surpass the targets of 90-90-90.Publication Metadata only Investigation of the changing etiology and risk factors of prosthetic joint infections : a university hospital surveillance study from 2011-2017(2020-03-01T00:00:00Z) Gultepe, Bilge Sumbul; OKAY, GÜLAY; Bolukcu, Sibel; DURDU, BÜLENT; Koc, Meliha Meric; TUNCAY, İBRAHİM; BOLUKÇU, SİBEL; DURDU, BÜLENT; SÜMBÜL, BİLGE; TUNCAY, İBRAHİM; MERİÇ KOÇ, MELİHAWe sought to characterize the causative pathogens of prosthetic joint infections (PJIs), evaluate the trends in microbial etiologies, and identify potential risk factors for PJI. This was a retrospective study analyzing 70 patients with PJI following 3,253 total joint arthroplasties between 2011 and 2017. Staphylococci were the most common cause of infection (52.9%). There was a significant trend in the percentage of carbapenem-resistant gram-negative bacilli (GNB) (increased to 66.7% in 2016 from 0.0% in 2011) (p=0.021). GNB and polymicrobial etiology were found at significantly high levels in cases involving early PJIs (p=0.005 and p=0.048, respectively). While staphylococci were significantly higher in PJIs after total knee arthroplasty (75%), GNB were significantly higher in PJIs after total hip arthroplasty (49.1%) (p<0.001 and p=0.001, respectively). Binary logistic regression analysis showed that the risk of PJI was significantly higher in cases with fracture and diabetes mellitus (odds ratio [OR], 4.3, 95% confidence interval [CI], 1.78-10.5; OR, 4.1, 95% CI, 1.66-10.5, respectively). These results suggest that the empirical and targeted antimicrobial treatment of PJIs may become more difficult in the future.