Person: BOLUKÇU, SİBEL
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BOLUKÇU
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SİBEL
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- PublicationMetadata onlyHIV care in Istanbul, Turkey: How far is it from the UNAIDS 90-90-90 targets?(2019-11-15T00:00:00Z) Mete, Bilgul; Gunduz, Alper; BOLUKÇU, SİBEL; Karaosmanoglu, Hayat K.; Yildiz, Dilek; Koc, MELİHA; Aydin, Ozlem A.; Dokmetas, Ilyas; Tabak, Fehmi; BOLUKÇU, SİBEL; MERİÇ KOÇ, MELİHAThe prevalence of human immunodeficiency virus (HIV) infection is low but it is steadily increasing in Turkey. In the current study, we aimed to assess the status of HIV infection management with the proposed 90-90-90 targets in a large HIV cohort in Istanbul, Turkey. The cohort included 2382 patients (2082 male, 300 female, mean age was 36.3 +/- 11.3 years). Mean CD4 cell count was 399 cells/mm(3) and HIV-RNA level was 576,235 copies/ml. According to the modeling by the Modeling tool of European Center for Diseases Control Software, 72 and 74% of all HIV patients had been diagnosed in 2016 and 2017, respectively (the first target). Among 2382 patients, 2191 (92%) were on antiretroviral therapy (the second target). The third target of virally suppressing those on treatment was achieved among 70.2% of the patients. The current study suggests that both the fraction of those living with undiagnosed HIV and the proportion of those on treatment who are virally suppressed should be targeted to sustain optimal HIV care. Efforts should continue to surpass the targets of 90-90-90.
- PublicationMetadata onlyImpact of switching to E/C/F/TAF on lipid profile and renal function in HIV-infected patients(2019-11-01T00:00:00Z) Mete, B.; Gunduz, A.; Zerdali, E.; Senoglu, S.; BOLUKÇU, SİBEL; Nakir, I. Yilmaz; Karaosmanoglu, H. Kumbasar; Koc, MELİHA; Bilge, B.; Dokmetas, I.; Tabak, F.; BOLUKÇU, SİBEL; MERİÇ KOÇ, MELİHA
- PublicationMetadata onlyEvaluation of the Relationship Between ABO/Rh Blood Groups and Severity of Liver Fibrosis in Patients with Chronic Hepatitis B(2016-04-01) Hakyemez, Ismail Necati; Durdu, BÜLENT; BOLUKÇU, SİBEL; ASLAN, Turan; HAKYEMEZ, İSMAİL NECATİ; DURDU, BÜLENT; BOLUKÇU, SİBELObjective: Studies on the severity of fibrosis in chronic viral hepatitis are scarce and limited with only hepatitis C infection. The aim of this study was to determine the role of ABO-Rh blood groups in the severity of fibrosis and progression to cirrhosis in patients with chronic hepatitis B (CHB).
- PublicationMetadata onlySolunum Yolu Enfeksiyonu Etkeni Olarak İzole Edilen Haemophilus influenzae ve Moraxella catarrhalis-in Mevsimlere Göre Dağılımı(2017-03-19) GÜLTEPE, BİLGE; DURDU, BÜLENT; CEYLAN, AYŞE NUR; BOLUKÇU, SİBEL; OKAY, GÜLAY; AKKOYUNLU, MUHAMMED EMİN; DOYMAZ, MEHMET ZİYA; SÜMBÜL, BİLGE; DURDU, BÜLENT; CEYLAN, AYŞE NUR; BOLUKÇU, SİBEL; AKKOYUNLU, MUHAMMED EMİN; DOYMAZ, MEHMET ZIYA
- PublicationOpen AccessInvestigation the Relationship Between Body Mass Index and Mortality in COVID-19 Patients(2021-02-01T00:00:00Z) BOLUKÇU, SİBEL; ÖZMEN, MEHMET EMİN; EKŞİ, ÇAĞLA; OKAY, GÜLAY; SÜMBÜL, BİLGE; KAÇMAZ, ASİYE BAHAR; DURDU, BÜLENT; AKKOYUNLU, YASEMİN; MERİÇ KOÇ, MELİHA; BOLUKÇU, SİBEL; ÖZMEN, MEHMET EMİN; EKŞİ, ÇAĞLA; OKAY, GÜLAY; SÜMBÜL, BİLGE; KAÇMAZ, ASİYE BAHAR; DURDU, BÜLENT; AKKOYUNLU, YASEMİN; MERİÇ KOÇ, MELİHAObjective: Obesity might be a risk factor for patients with Coronavirus disease-19 (COVID-19). We aimed to investigate the association of the obesity with intensive care need and mortality caused by severe acute respiratory syndrome-CoV-2 (SARS-CoV-2) infection in this retrospective cohort.
- PublicationOpen AccessTocilizumab treatment in severe COVID-19: a multicenter retrospective study with matched controls(2021-09-01T00:00:00Z) Mert, Ali; VAHABOĞLU, HALUK; ARSLAN, FERHAT; Batirel, Ayse; Saracoglu, Kemal Tolga; Bastug, Aliye; Cagatay, Atahan; IRMAK, İLİM; TELLİ DİZMAN, GÜLÇİN; Ertenli, Ihsan; Altunal, Lutfiye Nilsun; ERTÜRK ŞENGEL, BUKET; Bayram, Mehmet; Omma, Ahmet; Amikishiyev, Shirkhan; Aypak, Adalet; Bes, Cemal; BOLUKÇU, SİBEL; Icten, Sacit; TOPELİ İSKİT, ARZU; Bektas, Murat; Arslan, Birsen Yigit; Ozturk, Sinan; Comoglu, Senol; Aydin, Selda; Kucuksahin, Orhan; Icacan, Ozan Cemal; Ince, Burak; Aghamuradov, Sarvan; Mutlu, Melek Yalcin; Simsek, Funda; Emre, Salih; Ustun, Cemal; Ergen, Pinar; Aydin, Ozlem; MERİÇ KOÇ, MELİHA; Sevindik, Omur Gokmen; ODABAŞI, ZEKAVER; KORTEN, VOLKAN; Bodur, Hurrem; Guner, Rahmet; ÜNAL, SERHAT; Kocak, Mehmet; Gül, Ahmet; BOLUKÇU, SİBEL; MERİÇ KOÇ, MELİHACoronavirus disease-2019 (COVID-19) associated pneumonia may progress into acute respiratory distress syndrome (ARDS). Some patients develop features of macrophage activation syndrome (MAS). Elevated levels of IL-6 were reported to be associated with severe disease, and anti-IL-6R tocilizumab has been shown to be effective in some patients. This retrospective multicenter case-control study aimed to evaluate the efficacy of tocilizumab in hospitalized COVID-19 patients, who received standard of care with or without tocilizumab. Primary outcome was the progression to intubation or death. PSMATCH (SAS) procedure was used to achieve exact propensity score (PS) matching. Data from 1289 patients were collected, and study population was reduced to 1073 based on inclusion-exclusion criteria. The composite outcome was observed more frequently in tocilizumab-users, but there was a significant imbalance between arms in all critical parameters. Primary analyses were carried out in 348 patients (174 in each arm) after exact PS matching according to gender, ferritin, and procalcitonin. Logistic regression models revealed that tocilizumab significantly reduced the intubation or death (OR 0.40, p = 0.0017). When intubation is considered alone, tocilizumab-users had > 60% reduction in odds of intubation. Multiple imputation approach, which increased the size of the matched patients up to 506, provided no significant difference between arms despite a similar trend for intubation alone group. Analysis of this retrospective cohort showed more frequent intubation or death in tocilizumab-users, but PS-matched analyses revealed significant results for supporting tocilizumab use overall in a subset of patients matched according to gender, ferritin and procalcitonin levels.
- PublicationMetadata onlyA novel id-iri score: development and internal validation of the multivariable community acquired sepsis clinical risk prediction model(2020-04-01T00:00:00Z) Diktas, Husrev; Uysal, Serhat; Erdem, Hakan; Cag, Yasemin; Miftode, Egidia; Durmus, Gul; ULU KILIÇ, AYŞEGÜL; Alabay, Selma; Szabo, Balint Gergely; Lakatos, Botond; Fernandez, Ricardo; Korkmaz, Pinar; Caliz, Michael Cruz; Argemi, Xavier; Kulzhanova, Sholpan; Kormaz, Fatime; Yilmaz-Karadag, Fatma; Ergen, Pinar; Atilla, Aynur; Puca, Edmond; Dogan, Mustafa; Mangani, Francesca; Sahin, Suzan; Grgic, Svjetlana; Grozdanovski, Krsto; Yilmaz, Gul Ruhsar; Del-Vecchio, Rosa Fontana; Demirel, Aslihan; SIRMATEL, FATMA; ŞENER, ALPER; Sacar, Suzan; Aydin, Emsal; Batirel, Ayse; Dragovac, Gorana; El-Sokkary, Rehab; Alexandru, Crisan; Arslan-Ozel, Selcan; BOLUKÇU, SİBEL; Ozkaya, H. Deniz; Nayman-Alpat, Saygin; Inan, Asuman; Al-majid, Fahad; Kaya-Ugur, Berna; Rello, Jordi; BOLUKÇU, SİBELWe aimed to develop a scoring system for predicting in-hospital mortality of community-acquired (CA) sepsis patients. This was a prospective, observational multicenter study performed to analyze CA sepsis among adult patients through ID-IRI (Infectious Diseases International Research Initiative) at 32 centers in 10 countries between December 1, 2015, and May 15, 2016. After baseline evaluation, we used univariate analysis at the second and logistic regression analysis at the third phase. In this prospective observational study, data of 373 cases with CA sepsis or septic shock were submitted from 32 referral centers in 10 countries. The median age was 68 (51-77) years, and 174 (46,6%) of the patients were females. The median hospitalization time of the patients was 15 (10-21) days. Overall mortality rate due to CA sepsis was 17.7% (n = 66). The possible predictors which have strong correlation and the variables that cause collinearity are acute oliguria, altered consciousness, persistent hypotension, fever, serum creatinine, age, and serum total protein. CAS (%) is a new scoring system and works in accordance with the parameters in third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). The system has yielded successful results in terms of predicting mortality in CA sepsis patients.
- PublicationMetadata onlyProtez Eklem Enfeksiyonlarının Risk Faktörleri ve Etkenlerin Dağılımı Açısından İrdelenmesi: Bir Üniversite Hastanesi Verileri(2017-04-08) BOLUKÇU, SİBEL; Okay, GÜLAY; Durdu, BÜLENT; HAKYEMEZ, İSMAİL NECATİ; AKKOYUNLU, YASEMİN; ASLAN, TURAN; OKAY, GÜLAY; BOLUKÇU, SİBEL; DURDU, BÜLENT; HAKYEMEZ, İSMAİL NECATİ; AKKOYUNLU, YASEMİN
- PublicationOpen AccessEvaluation of tularaemia courses: a multicentre study from Turkey(2014-12-01T00:00:00Z) ERDEM, H.; OZTURK-ENGIN, D.; YESILYURT, M.; Karabay, O.; ELALDI, NAZİF; Celebi, G.; KORKMAZ, N.; GUVEN, T.; Sumer, S.; TULEK, N.; Ural, O.; Yilmaz, G.; ERDINC, S.; Nayman-Alpat, S.; SEHMEN, E.; Kader, C.; SARI, N.; Engin, A.; CICEK-SENTURK, G.; ERTEM-TUNCER, G.; GULEN, G.; Duygu, F.; Ogutlu, A.; Ayaslioglu, E.; Karadenizli, A.; Meric, MELİHA; ULUG, M.; ATAMAN-HATIPOGLU, C.; Sirmatel, F.; CESUR, S.; COMOGLU, S.; KADANALI, A.; KARAKAS, A.; ASAN, A.; Gonen, I.; KURTOGLU-GUL, Y.; ALTIN, N.; OZKANLI, S.; YILMAZ-KARADAG, F.; CABALAK, M.; GENCER, S.; PEKOK, A. Umut; YILDIRIM, D.; SEYMAN, D.; TEKER, B.; Yilmaz, H.; YASAR, K.; Balkan, I. Inanc; Turan, H.; Uguz, M.; KILIC, S.; Akkoyunlu, YASEMİN; Kaya, S.; ERDEM, AHMET CAN; INAN, A.; CAG, Y.; Bolukcu, SİBEL; Ulu-Kilic, A.; OZGUNES, N.; GORENEK, L.; BATIREL, A.; AGALAR, C.; MERİÇ KOÇ, MELİHA; AKKOYUNLU, YASEMİN; ERDEM, AHMET CAN; BOLUKÇU, SİBELIn this multicentre study, which is the largest case series ever reported, we aimed to describe the features of tularaemia to provide detailed information. We retrospectively included 1034 patients from 41 medical centres. Before the definite diagnosis of tularaemia, tonsillitis (n=653, 63%) and/or pharyngitis (n=146, 14%) were the most frequent preliminary diagnoses. The most frequent clinical presentations were oropharyngeal (n=832, 85.3%), glandular (n=136, 13.1%) and oculoglandular (n=105, 10.1%) forms. In 987 patients (95.5%), the lymph nodes were reported to be enlarged, most frequently at the cervical chain jugular (n=599, 58%), submandibular (n=401, 39%), and periauricular (n=55, 5%). Ultrasound imaging showed hyperechoic and hypoechoic patterns (59% and 25%, respectively). Granulomatous inflammation was the most frequent histological finding (56%). The patients were previously given antibiotics for 1176 episodes, mostly with -lactam/-lactamase inhibitors (n=793, 76%). Antituberculosis medications were provided in seven (2%) cases. The patients were given rational antibiotics for tularaemia after the start of symptoms, with a mean of 26.8 +/- 37.5days. Treatment failure was considered to have occurred in 495 patients (48%). The most frequent reasons for failure were the production of suppuration in the lymph nodes after the start of treatment (n=426, 86.1%), the formation of new lymphadenomegalies under treatment (n=146, 29.5%), and persisting complaints despite 2weeks of treatment (n=77, 15.6%). Fine-needle aspiration was performed in 521 patients (50%) as the most frequent drainage method. In conclusion, tularaemia is a long-lasting but curable disease in this part of the world. However, the treatment strategy still needs optimization.
- PublicationMetadata onlyChanges in HIV demographic patterns in a low prevalence population: no evidence of a shift towards men who have sex with men(2016-07-01) SARGIN, Fatma; YILDIZ, Dilek; AYDIN, Ozlem Altuntas; Mete, Bilgul; GUNDUZ, Alper; KARAOSMANOGLU, Hayat Kumbasar; Yemisen, Mucahit; YAZICI, Saadet; BOLUKÇU, SİBEL; Durdu, BÜLENT; SENATES, Ebubekir; Ozaras, Resat; DOKMETAS, Ilyas; Tabak, Fehmi; BOLUKÇU, SİBEL; DURDU, BÜLENTObjectives: This study aimed to examine the changes in HIV demographics over time in an exceptionally low prevalence population, with particular emphasis on men who have sex with men (MSM).
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