Person: ÇALIM, ÖMER FARUK
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Sol orbitada ağrıya neden olan paranazal sinüs yerleşimli fibröz displazi olgusu
Effect of Submucosal Mesna Application on Mucoperichondrial Elevation in Septoplasty
Objective: It was revealed that the thiol compound named mesna chemically softens the connective tissue with submucosal injection, and facilitates the endoscopic submucosal dissection. The authors aimed to investigate the effect of mesna injection on mucoperichondrial elevation during septoplasty operation. Methods: This study was planned as a patient-control study and performed. Fifty-six patients who had septoplasty operation were divided into 2 groups that are submucosal mesna (group 1) and submucosal saline (group 2) applied ones. In both groups, the measurement was initiated by a timer during the start of septal incision and elevation processes. After bilateral subperichondrial and subperiostal elevation were finished, timer was stopped and time was recorded. After that, mucosal integrity was reviewed and mucosal damage status was recorded. The difficulty of mucoperichondrial elevation for the surgeon was recorded for each patient. Results: Twenty-five (44.7%) of the patients who participated in our study were females while 31 (55.3%) were males. The average elevation periods were 201.4 +/- 74.3 seconds in group 1 and 260.2 +/- 84.1 seconds in group 2. In mesna applied patients, elevation period was statistically and significantly shorter (P = 0.009). Impairment in mucosal integrity was observed as 33.3% in group 1 and 58.8% in group 2. In mesna applied patients, significantly less impairment in mucosal integrity was observed (P = 0.031). The average mucoperichondrial elevation difficulty for the surgeon is observed as 4.83 +/- 2.47 in group 1 and 6.5 +/- 1.9 in group 2. Mesna applied patients were defined as significantly easier patients for the surgeon (P = 0.006). Conclusion: Submucosal mesna application is an approach that provides a convenient, fast, and effective mucoperichondrial elevation in septoplasty and protects the mucosal integrity.
Serum and tonsil tissue melatonin levels o fpatients with chronic tonsillitis
Objectives: This study aims to compare the serum, tonsil surface epithelial tissue and parenchyma levels of melatonin in children who underwent tonsillectomy due to recurrent tonsillitis. Patients and Methods: The study included 33 pediatric patients (17 males, 16 females; mean age 7.3 years; range, 3 to 10 years) scheduled for tonsillectomy surgery. Five milliliter venous blood samples and 25 g of two different types of tonsil tissues, parenchyma and capsule were collected from the patients and stored. High performance liquid chromatography was used for the determination of melatonin in plasma and tissue samples. Results: The tonsil surface tissue levels of melatonin were lower than the simultaneous plasma levels of melatonin (p<0.0135). The plasma levels of melatonin were higher than the simultaneous tonsil parenchyma tissue levels of melatonin (p<0.016). The tonsil surface tissue levels of melatonin were lower than the simultaneous tonsil parenchyma tissue levels of melatonin (p<0.002). Conclusion: The plasma concentrations of melatonin and tonsil surface epithelial tissue and parenchyma concentrations of melatonin in children with chronic tonsillitis were low. According to this finding, we may recommend serum levels of melatonin to be checked in patients indicated for tonsillectomy