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BÜYÜKPINARBAŞILI, NUR

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PublicationOpen Access

Parathyroid allotransplantation in rabbits without cultivation.

2014-01-15, CAN, I, YUCESAN, E, Aysan, E, SAYITOGLU, M, OZBEK, U, ERCIVAN, M, ATASOY, H, BUYUKPINARBASILI, NUR, MUSLUMANOGLU, M, AYŞAN, MUSTAFA ERHAN, YÜCESAN, EMRAH, BÜYÜKPINARBAŞILI, NUR

Permanent hypoparathyroidism is a serious clinical situation. Allotransplantation of the parathyroid cells is relatively new approach to treatment. Non-cultivated allotransplantation in rabbits is not tried before. In this research parathyroidectomy was performed in six female New Zealand white rabbits. After division of surgically removed tissues into two, cryopreservation after cell isolation was done. Non-cultivated cross allotransplantation was performed under immunosuppression. Serum calcium and phosphorus levels were observed 15 days and histopathological analyses of the transplanted parathyroid tissues were studied. Significant changes in serum calcium and phosphorus levels during the experiment were observed (p=0.001 for both). Calcium levels which were significantly dropped to 6.66±0.7 mg/dL after parathyroidectomy and progressively increased up to 15.98±1.25 mg/dL at the end of the experiment (p=0.004). Phosphorus levels which were increased to 9.38±0.63 mg/dL after parathyroidectomy and stabilized to 4.46±1.06 mg/dL at the end of the experiment (p=0.007). All allotransplanted parathyroid tissues showed normal tissue architecture without evidence of cellular rejection. In conclusion allotransplantation of the parathyroid tissues without cultivation may be considered as an alternative and safe approach for the treatment of permanent hypoparathyroidism.

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Incidental detection of prostate-specific antigen-negative metastatic prostate cancer initially presented with solitary pulmonary nodule on fluorodeoxyglucose positron emission tomography/computed tomography

2015-01-01, ERDOĞAN, EZGİ BAŞAK, Buyukpinarbasili, NUR, ZİYADE, SEDAT, AKMAN, Tolga, TÜRK, HACI MEHMET, AYDIN, MEHMET, ERDOĞAN, EZGİ BAŞAK, BÜYÜKPINARBAŞILI, NUR, ZİYADE, SEDAT, TÜRK, HACI MEHMET, AYDIN, MEHMET

A 71-year-old male patient with solitary pulmonary nodule underwent fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) showing slightly increased FDG uptake in this nodule. In addition, PET/CT detected hypermetabolic sclerotic bone lesions in the right second rib and 7(th) thoracic vertebrae, which were interpreted as possible metastases, and mildly increased FDG uptake in the prostate gland highly suspicious of malignancy. The patient's prostate-specific antigen (PSA) level was within normal range (3.8 ng/dL). The histopathological examination of the lung nodule and right second rib lesion proved metastases from prostate cancer, then the prostate biopsy-confirmed prostate adenocarcinoma. The unique feature of this case is to emphasize the importance of performing PET/CT for solitary pulmonary nodule in detecting PSA-negative metastatic prostate cancer. This case indicated that it should be kept in mind that, even if the PSA is negative, a lung metastasis of prostate cancer may be an underlying cause in patients evaluated for solitary pulmonary nodule by FDG PET/CT.

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Sternal metastasis from uterine leiomyosarcoma treated by near-total sternectomy and reconstruction with titanium sternal stabilization and fixation system

2015-01-01, Soysal, Omer, ERGUN, Selma Sonmez, Ziyade, SEDAT, Buyukpinarbasili, NUR, Akdemir, OSMAN CEMİL, SOYSAL, ÖMER, ZİYADE, SEDAT, ERGÜN, SELMA, BÜYÜKPINARBAŞILI, NUR, AKDEMİR, OSMAN CEMİL

Uterine leiomyosarcomas are rare soft tissue neoplasms. Although they have a tendency to metastasize to distant organs, most commonly to the lung, liver and brain, rarely, sternal metastasis from a uterine leiomyosarcoma can occur. In this article, we report a 50-year-old female patient whose uterine leiomyosarcoma was treated with total abdominal hysterectomy and bilateral salphingo-oopherectomy, and who developed sternal metastasis five years later, which was completely resected and successfully repaired during the same session.

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PublicationOpen Access

General Overview of Renal Cell Carcinoma with the Evaluation of our cases

2015-12-01, Yildiz, PELİN, Sonmez, FATMA CAVİDE, Buyukpinarbasili, NUR, Gucin, ZÜHAL, Arici, DİLEK SEMA, KOCAKOC, Ercan, Akcay, MUZAFFER, YILDIZ, PELİN, SÖNMEZ, FATMA CAVİDE, BÜYÜKPINARBAŞILI, NUR, GÜCİN, ZÜHAL, ARICI, DILEK SEMA, AKÇAY, MUZAFFER

Objective: Renal cell carcinoma (RCC) is the 14th most common tumor in the world. In 2010, the protocol for the examination of kidney specimens with invasive carcinoma of renal tubular origin was updated. The aim of our study was to review 1-year RCC patients of our hospital according to the new protocol, classification, and staging systems with respect to their morphological and immunohistochemical features.. Methods: The medical records of 54 RCC patients between July 2012 and July 2013 were retrospectively reviewed. They were classified according to the WHO 2004 classification system and newly defined subtypes. The following variables were determined in each case: age, sex, histological subtype, stage, and Fuhrman nuclear grade. Results: In our study, 30 (55.6%) men and 24 (44.4%) women were diagnosed with RCC out of 54 patients. The median age was 56 years. In total, 21 patients had (55.2%) right-and 17 had (44.74%) left-sided tumors. Thirty-eight (70.3%) clear cell, 6 (11.1%) papillary, 7 (12.96%) chromophobe, 1 (1.85%) multilocular, 1 (1.85%) unclassified, and 1 (1.85%) tubulocystic RCC were seen. According to primary tumor, 33 (61.1%) pT1, 10 (18.51%) pT2, 9 (16.66%) pT3, and 2 (3.70%) pT4 patients were reported. Chromophobe RCCs were excluded from the Fuhrman grading (G) system; of the remaining 2 (4.17%) were G1, 30 (62.5%) were G2, 13 (27.08%) were G3, and 3 (6.25%) were G4 tumors. Conclusion: Although RCC constitutes the majority of renal tumors, different subtypes are also encountered. In our study, clear cell RCCs were the most common type of tumors consistent with the literature. The remarkable point was that chromophobe RCCs were more frequent in our study. Because of infrequency, more examples are required to distinguish newly defined subtypes.

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Does Every Necrotizing Granulomatous Inflammation Identified by NSCLC Resection Material Require Treatment?

2016-04-01T00:00:00Z, Yakar, Fatih, Yakar, Aysun, BÜYÜKPINARBAŞILI, NUR, Erelel, Mustafa, BÜYÜKPINARBAŞILI, NUR

Background: Lung cancer and tuberculosis (TB) are two major public health problems. They can coexist or appear sequentially. In patients with TB, lung cancer risk is increased. However, vice versa is not crystal clear. In this study, we aimed to determine the development of TB in patients with resectabled non-small cell lung cancer (NSCLC) in a 2-year postoperative follow-up period.

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PublicationOpen Access

A novel sutureless colonic anastomosis with self-gripping mesh: an experimental model.

2014-05-15, CIPE, G, Malya, FATMA ÜMİT, HASBAHCECI, M, ATUKEREN, P, BUYUKPINARBASILI, NUR, KARATEPE, O, MUSLUMANOGLU, M, MALYA, FATMA ÜMİT, BÜYÜKPINARBAŞILI, NUR

Introduction: Anastomotic leakage is one of the most feared complications of colorectal surgery. High morbidity and mortality rates are related to this complication and several studies had been performed to test new techniques which are suggested to reduce leakage rates. The aim of our study was to evaluate the safety and effectiveness of a novel technique sutureless anastomosis with self-gripping mesh in an animal model by examining wound healing process in anastomosis. Methods: In this study sixteen Norwegian Wistar Albino female rats were used. The rats' weights ranged from 250 to 300 g. The rats were divided into control and study groups. The control group underwent a colocolic anastomosis using the conventional method of hand-sewing with single-layer interrupted nonabsorbable sutures. The study group underwent a colocolic anastomosis using self-gripping mesh without sutures. These rats were sacrificed on the 10th postoperative day. The sample pieces obtained from the groups were subjected to anastomotic bursting pressure tests, to a test for hydroxyproline levels in the tissue and to histopathological examinations. The tissue was evaluated in terms of quantity of inflammatory cells, fibroblasts, neovascularization level and collagen content and classified according to the Ehrlich-Hunt model. Statistical analysis was done by using Mann-Whitney U test. Results: The burst pressure mean ± range of control and study groups were 162 ± 78 and 123 ± 35, respectively (P = 0.049). The mean peritoneal adhesion grades were 3.2 ± 0.7 in the study group and 2.3 ± 0.7 in the control group (P = 0.036). The operative time was significantly shorter in the study group. The difference between the groups by mean of hydroxyproline levels was found to be significant (P = 0.001). According to histopathological examinations by means of the Ehrlich-Hunt model, the fibroblast activation and collagen fiber ratio were higher in the study group and the difference between these measurements was statistically significant (P = 0.006; P = 0.028). Conclusion: This study showed that use of self-gripping meshes for colocolic anastomosis in rats is a safe and feasible method. It is suggested that the most important advantage of this technique is the shorter operative time.

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PublicationOpen Access

Disseminated scar sarcoidosis may predict pulmonary involvement in sarcoidosis.

2013-09-01, Su, O, ONSUN, NAHİDE, TOPUKÇU, B, OZÇELIK, HK, CAKıTER, AU, BÜYÜKPıNARBAŞıLı, NUR, SU KÜÇÜK, ÖZLEM, ONSUN, NAHIDE, BÜYÜKPINARBAŞILI, NUR

Sarcoidosis is a chronic, inflammatory, multi-organ disease of unknown origin that is characterized by non-caseating granuloma formation in affected organs. Cutaneous involvement is reported in 25% of patients with sarcoidosis. Scar sarcoidosis is rare but is clinically specific for skin sarcoidosis. Systemic involvement is seen in most patients with scar sarcoidosis. We present a case of scar sarcoidosis in a 30-year-old male that developed infiltrated nodules on old scars, including on his penile shaft, which is rare, and that also had pulmonary involvement. Scar sarcoidosis should be considered in the differential diagnosis of changes in all scar areas and should be investigated for systemic involvement.

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PublicationOpen Access

A Six Sigma Trial For Reduction of Error Rates in Pathology Laboratory

2016-09-01, TURNA, Seval, Tosuner, ZEYNEP, Gucin, ZÜHAL, Kiran, TUĞÇE, Buyukpinarbasili, NUR, TASKIRAN, Olcay, Arici, DİLEK SEMA, TOSUNER, ZEYNEP, GÜCİN, ZÜHAL, KIRAN, TUĞÇE, BÜYÜKPINARBAŞILI, NUR, TURNA, SEVAL, ARICI, DILEK SEMA

Objective: The aim of this study is to determine differences of levels of empathy among undergraduates in each year of their four-year programs of physiotherapy. Methods: During the 2014-2015 academic school year, 381 physiotherapy students were enlisted from two universities in Istanbul, one a foundation and the other a government university. The Turkish version of the Jefferson Scale of Physician Empathy was administered. Students were asked to indicate interest in particular physiotherapy specialties as well as their region of origin in Turkey. The Kruskal-Wallis analysis was used to determine differences among the four study years, and also to measure relationships between specialty interest, home-region, and empathy scores of the students. Empathy scores were also compared according to gender. Results: The difference of empathy scores between the students of the two universities was borderline significant (p=0.057). Empathy scores in both universities increased to a significant degree after school entrance and decreased in the final year. Levels of empathy did not change according to gender, specialty interest, or home-region (p=0.722, 0.524, and 0.309, respectively). Conclusions: This study points to the need for physiotherapy curricula that would enhance empathy and give students practice in exhibiting this valuable attribute. Additional studies are needed that would include larger study populations and track the same students year by year as to how and why their empathy levels change during their training.

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PublicationOpen Access

Xenotransplantation of human cryopreserved parathyroid tissue isolated from parathyroid adenomas to normocalcemic rabbits

2017-06-01, Aysan, Erhan, DUZKOYLU, Yigit, Can, Ismail, Buyukpinarbasili, NUR, AYŞAN, MUSTAFA ERHAN, BÜYÜKPINARBAŞILI, NUR

Objective: Parathyroid allotransplantation is a new method for the treatment of permanent hypoparathyrodism. Adenoma cells are not used for transplantation because of the potential for functional or histopathologic transformation. In this study, we transplanted human adenomatous parathyroid cells to rabbits. Material and Methods: Parathyroid adenoma tissue taken from a male patient was cryopreserved and transplanted into seven New Zealand white rabbits (mean weight, 3700±220 g; mean age, 4.5 months) under immunosuppression. The levels of parathormone, calcium and phosphorus were measured before and after transplantation, and the parathyroid cells were observed histopathologically. Results: Mean parathyroid hormone level was 0.5 pg/dL before transplantation and 6.6 pg/dL after transplantation (p<0.05). Preoperative mean calciumlevel was 14.1 mg/dL, and mean phosporus level was 3.5 mg/dL before transplantation while these values were 14.4 mg/dL and 3.3mg/dL, respectively, after transplantation (p>0.05). Morphologic transformation was not observed in parathyroid cells after transplantation. Conclusion: In short-term observation, adenomatous parathyroid cells can function without malignant transformation. In the future, the preliminary methodology in this study may serve as a safe alternative for allotransplantation into patients with permanent hypoparathyroidism. Keywords: Hypoparathyroidism, xenotransplantation, parathyroid adenoma

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PublicationOpen Access

Leiomyoma of the esophagus: open versus thoracoscopic enucleation

2014-01-01, Ziyade, SEDAT, Buyukpinarbasili, NUR, YEDIYILDIZ, Senel, Kadioglu, HÜSEYİN, Soysal, Omer, ZİYADE, SEDAT, KADIOĞLU, HÜSEYİN, BÜYÜKPINARBAŞILI, NUR, SOYSAL, ÖMER

Background/aim: To describe a novel, easy, and secure thoracoscopic surgical approach for esophageal leiomyomas.