2017-10-17, KÖK, ABDÜLAZİZ, AKDEMİR, OSMAN CEMİL, ZİYADE, SEDAT, SOYSAL, ÖMER, BÜYÜKPINARBAŞILI, NUR, KÖK, ABDÜLAZİZ, AKDEMİR, OSMAN CEMİL, ZİYADE, SEDAT, SOYSAL, ÖMER, BÜYÜKPINARBAŞILI, NUR

2013-04-07, KUTBAY ÖZÇELİK, HATİCE, BAYRAM, MEHMET, BÜYÜKPINARBAŞILI, NUR, KANSU, ABDULLAH, AKKOYUNLU, MUHAMMED EMİN, SEZER, MURAT, KARAKÖSE, FATMANUR, YAKAR, FATİH, KART, LEVENT, BAYRAM, MEHMET, BÜYÜKPINARBAŞILI, NUR, KANSU, ABDULLAH, AKKOYUNLU, MUHAMMED EMİN, OKYALTIRIK, FATMANUR

2016-09-01, TURNA, Seval, Tosuner, ZEYNEP, Gucin, ZÜHAL, Kiran, TUĞÇE, Buyukpinarbasili, NUR, TASKIRAN, Olcay, Arici, DİLEK SEMA, TOSUNER, ZEYNEP, GÜCİN, ZÜHAL, KIRAN, TUĞÇE, BÜYÜKPINARBAŞILI, NUR, TURNA, SEVAL, ARICI, DILEK SEMA

Objective: The aim of this study is to determine differences of levels of empathy among undergraduates in each year of their four-year programs of physiotherapy. Methods: During the 2014-2015 academic school year, 381 physiotherapy students were enlisted from two universities in Istanbul, one a foundation and the other a government university. The Turkish version of the Jefferson Scale of Physician Empathy was administered. Students were asked to indicate interest in particular physiotherapy specialties as well as their region of origin in Turkey. The Kruskal-Wallis analysis was used to determine differences among the four study years, and also to measure relationships between specialty interest, home-region, and empathy scores of the students. Empathy scores were also compared according to gender. Results: The difference of empathy scores between the students of the two universities was borderline significant (p=0.057). Empathy scores in both universities increased to a significant degree after school entrance and decreased in the final year. Levels of empathy did not change according to gender, specialty interest, or home-region (p=0.722, 0.524, and 0.309, respectively). Conclusions: This study points to the need for physiotherapy curricula that would enhance empathy and give students practice in exhibiting this valuable attribute. Additional studies are needed that would include larger study populations and track the same students year by year as to how and why their empathy levels change during their training.

2015-01-01, ERDOĞAN, EZGİ BAŞAK, Buyukpinarbasili, NUR, ZİYADE, SEDAT, AKMAN, Tolga, TÜRK, HACI MEHMET, AYDIN, MEHMET, ERDOĞAN, EZGİ BAŞAK, BÜYÜKPINARBAŞILI, NUR, ZİYADE, SEDAT, TÜRK, HACI MEHMET, AYDIN, MEHMET

A 71-year-old male patient with solitary pulmonary nodule underwent fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) showing slightly increased FDG uptake in this nodule. In addition, PET/CT detected hypermetabolic sclerotic bone lesions in the right second rib and 7(th) thoracic vertebrae, which were interpreted as possible metastases, and mildly increased FDG uptake in the prostate gland highly suspicious of malignancy. The patient's prostate-specific antigen (PSA) level was within normal range (3.8 ng/dL). The histopathological examination of the lung nodule and right second rib lesion proved metastases from prostate cancer, then the prostate biopsy-confirmed prostate adenocarcinoma. The unique feature of this case is to emphasize the importance of performing PET/CT for solitary pulmonary nodule in detecting PSA-negative metastatic prostate cancer. This case indicated that it should be kept in mind that, even if the PSA is negative, a lung metastasis of prostate cancer may be an underlying cause in patients evaluated for solitary pulmonary nodule by FDG PET/CT.

2019-04-01, UNVER, NURCAN, COBAN, GANİME, ARıCı, DİLEK SEMA, BUYUKPıNARBASıLı, NUR, Gucin, ZÜHAL, MALYA, FATMA ÜMİT, ONARAN, OI, TOPALAN, K, ÜNVER, NURCAN, ÇOBAN, GANİME, ARICI, DILEK SEMA, BÜYÜKPINARBAŞILI, NUR, GÜCİN, ZÜHAL, MALYA, FATMA ÜMİT

2016-04-01, Buyukpinarbasili, NUR, Gucin, ZÜHAL, Ersoy, YELİZ EMİNE, ILBAK, Ayca, Kadioglu, HÜSEYİN, Muslumanoglu, Mahmut, BÜYÜKPINARBAŞILI, NUR, GÜCİN, ZÜHAL, ERSOY, YELIZ EMINE, KADIOĞLU, HÜSEYİN

Carcinoma of the breast, like other malignancies, is a genetic disease with multiple genetic events leading to the malignant phenotype. p53 mutations are the most common genetic events in human cancer. Inactivation of p53 can be a result of mutation in gene sequence. One of the main structures that regulate p53 stabilization is MDM2. It suppresses p53 transcriptional activation by recognizing transactivation domain of p53. The loss of MDM2 function on p53 regulation results in deprivation of p53 tumor suppressor ability. Single nucleotide polymorphisms (SNP309 T->G exchange) or MDM2 amplification has been proposed to play a role in this issue. In the present study, our aim is to analyze p53 and MDM2 status and investigate their interactions in human sporadic breast carcinoma. The study groups were separated according to their molecular classifications. In each group, histologic type of the tumor, conventional prognostic parameters, p53, and MDM2 interactions were compared statistically. Tumors are divided into 4 subtypes due to estrogen and progesterone receptor status, HER-2, and Ki-67 proliferation index results. According to this classification, 23 cases are in the luminal A, 32 cases are in the luminal B, 15 cases are in the HER-2 positive, and 22 cases are in the triple-negative group, with a total of 92 cases. p53 expression is low in luminal breast carcinomas than HER-2 and triple-negative subtypes. MDM2 amplification frequency was found to be 5.4% in total. MDM2 gene amplification does not have a significant role in breast carcinogenesis, but other possible mechanisms may play a role in its inactivation. (C) 2016 Elsevier Inc. All rights reserved.

2015-09-01, BENDER, O, BOZKURT, SÜLEYMAN, BUYUKPINARBASILI, NUR, Malya, FATMA ÜMİT, BATTAL, M, KARATEPE, O, BOZKURT, SÜLEYMAN, BÜYÜKPINARBAŞILI, NUR, MALYA, FATMA ÜMİT

2014-01-15, CAN, I, YUCESAN, E, Aysan, E, SAYITOGLU, M, OZBEK, U, ERCIVAN, M, ATASOY, H, BUYUKPINARBASILI, NUR, MUSLUMANOGLU, M, AYŞAN, MUSTAFA ERHAN, YÜCESAN, EMRAH, BÜYÜKPINARBAŞILI, NUR

Permanent hypoparathyroidism is a serious clinical situation. Allotransplantation of the parathyroid cells is relatively new approach to treatment. Non-cultivated allotransplantation in rabbits is not tried before. In this research parathyroidectomy was performed in six female New Zealand white rabbits. After division of surgically removed tissues into two, cryopreservation after cell isolation was done. Non-cultivated cross allotransplantation was performed under immunosuppression. Serum calcium and phosphorus levels were observed 15 days and histopathological analyses of the transplanted parathyroid tissues were studied. Significant changes in serum calcium and phosphorus levels during the experiment were observed (p=0.001 for both). Calcium levels which were significantly dropped to 6.66±0.7 mg/dL after parathyroidectomy and progressively increased up to 15.98±1.25 mg/dL at the end of the experiment (p=0.004). Phosphorus levels which were increased to 9.38±0.63 mg/dL after parathyroidectomy and stabilized to 4.46±1.06 mg/dL at the end of the experiment (p=0.007). All allotransplanted parathyroid tissues showed normal tissue architecture without evidence of cellular rejection. In conclusion allotransplantation of the parathyroid tissues without cultivation may be considered as an alternative and safe approach for the treatment of permanent hypoparathyroidism.

2016-04-01T00:00:00Z, Yakar, Fatih, Yakar, Aysun, BÜYÜKPINARBAŞILI, NUR, Erelel, Mustafa, BÜYÜKPINARBAŞILI, NUR

Background: Lung cancer and tuberculosis (TB) are two major public health problems. They can coexist or appear sequentially. In patients with TB, lung cancer risk is increased. However, vice versa is not crystal clear. In this study, we aimed to determine the development of TB in patients with resectabled non-small cell lung cancer (NSCLC) in a 2-year postoperative follow-up period.

2014-06-01, Yenigun, ALPER, Ozturan, ORHAN, Buyukpinarbasili, NUR, YENİGÜN, ALPER, ÖZTURAN, ORHAN, BÜYÜKPINARBAŞILI, NUR

Intumenscentia septi nasi anterior is an anatomical variation in the nasal cavity, first described by Morgagni in 1662; septal turbinate and tuberculum septi nasi anterior are among the various other names attributed to this anatomical structure. It is an expandable vascular network which develops from the septal mucosa. Computed tomography, following history-taking and physical examination, is a valuable tool in diagnosing turbinate pneumatisation. This paper reports the case of a 23-year-old female with nasal stuffiness as her primary complaint, who was found to have pneumatization of the septum mimicking the septal concha. Pneumatization of the septal turbinate may also be a cause of septal enlargement. The symptomatology, diagnosis and treatment options for cases of septal turbinate are discussed. The surgical interventions performed in the presented case are briefly described. The presented patient had a pneumatization of the septal turbinate, like those of the conchae. It is reported for the first time in medical literature, and the histological and functional similarities of the septal turbinate and of the nasal conchae are pointed out. (C) 2013 Elsevier Ireland Ltd. All rights reserved.