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BÜYÜKPINARBAŞILI, NUR

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BÜYÜKPINARBAŞILI

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Now showing 1 - 3 of 3
  • Publication
    A Rare Case: Mucous Membrane Plasmacytosis in the Larynx
    (2014-07-01) BÜYÜKPINARBAŞILI, NUR; ÇOBAN, GANİME; GÜCİN, ZÜHAL; Meriç, Ayşenur; BÜYÜKPINARBAŞILI, NUR; ÇOBAN, GANİME; GÜCİN, ZÜHAL
    Mucous membrane plasmacytosis is a rare reactive process characterized by plasma cell infiltration of mucous membranes for unknown reasons. It may be confused with malignancy because of its exophytic structure and pavement appereances. A laryngeal polypoid lesion was sent to the pathology department, clinically called fibroma, and presented to emphasize the diagnostic and differential diagnostic criteria.
  • Publication
    Immunoexpression of TTF-1 in Non-Lung Tumors
    (2014-12-01T00:00:00Z) TOSUNER, ZEYNEP; ARICI, Dilek Sema; GÜCİN, ZÜHAL; BÜYÜKPINARBAŞILI, NUR; SÖNMEZ, FATMA CAVİDE; YILDIZ, PELİN; TOSUNER, ZEYNEP; ARICI, DILEK SEMA; GÜCİN, ZÜHAL; BÜYÜKPINARBAŞILI, NUR; SÖNMEZ, FATMA CAVİDE; YILDIZ, PELİN
    Objective: Thyroid transcription factor-1 (TTF-1) immunoexpression is frequently determined in small-cell lung carcinomas, as well as primary lung adenocarcinomas. While dealing with metastatic carcinomas, TTF-1 immunoexpression is a significant indicator of primary lung carcinomas. Recent studies have revealed that TTF-1 immunoexpression is also defined in non-lung cancers, such as squamous cell carcinomas of different sites and certain neuroendocrine tumors. The verified data obtained from these studies indicate that a straightforward diagnosis of primary lung carcinoma in cases with positive TTF-1 immunoexpression can cause diagnostic contradictions. The aim of our study is to investigate the immunoexpression status of TTF-1 in common non-lung tumors. Methods: A total of 85 cases that were diagnosed in our institute between the years 2011-2012 were included in our study. After a review of the pathological slides prepared from these tumors [colon adenocarcinoma (n: 15), renal cell carcinoma (n: 15), prostate adenocarcinoma (n: 15), invasive papillary urothelial carcinoma (n: 15), invasive ductal carcinoma of breast (n: 15), and neuroendocrine tumors (n: 10)] TTF-1 immunohistochemistry was applied. Semiquantative evaluation based on the distribution and intensity of the staining was performed by two pathologists, respectively. Results: Positive immunostaining was evident in only 1 case of colon adenocarcinoma out of 85 cases. Conclusion: Our study demonstrated that TTF-1 immunoexpression is a very rare finding (1%) in non-lung tumors. This result provides that anti-TTF-1 is a reliable antibody in the interpretation of primary lung carcinomas. In fact, further studies with a large number of cases are needed to confirm the sensitivity and specificity of TTF-1.
  • Publication
    Helicobacter pylori as an Etiologic Factor in Primary Lung Carcinoma
    (2018-04-01T00:00:00Z) BÜYÜKPINARBAŞILI, NUR; BÜYÜKPINARBAŞILI, NUR
    Objective: Although the importance of environmental and occupational exposure to carcinogenic agents in pulmonary carcinoma is well known, some other factors, such as familial predisposition, genetic abnormalities, and recently, the presence of Helicobacter pylori infection, are being disputed. This study focused on the relationship between pulmonary carcinoma and H. pylori infection. Methods: In total, 48 histologically verified and operated patients with pulmonary carcinoma, including 38 males and 10 females, were included; 22 of the cases were of squamous cell carcinomas and 26 were adenocarcinomas. The control group composed of 20 patients who underwent pulmonary operation for causes other than lung cancer. Adjacent non-neoplastic parenchymal and bronchial tissue examples were stained using the Giemsa stain in carcinoma cases. The pulmonary tissue-contained bronchial sections were stained in control cases. The bronchial epithelia and lumina in the Giemsa stained slides were examined for H. pylori bacilli. Results: H. pylori was found in 2 of 48 carcinoma cases. The histopathological diagnosis of these 2 cases was squamous cell carcinoma. But there wasn't any case stained for H.pylori in the control group. Conclusion: The relationship between pulmonary carcinoma and H. pylori infection had been researched through serological studies; however, conflicting evidences have been obtained. The bacterium is transmitted to the lungs via seeding and inhalation was reported to be effective directly. Chronic H. pylori infection leads to bronchial epithelial proliferation via increased gastrin level and cyclooxygenase-2. Moreover, it contributes to pulmonary carcinogenesis. In conclusion, an association between H. pylori infection and pulmonary carcinoma may be revealed by variable studies, and the underlying mechanisms can be understood.