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15 - Karasal Yaşam

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Karasal Yaşam Karasal ekosistemleri korumak, iyileştirmek ve sürdürülebilir kullanımını desteklemek; sürdürülebilir orman yönetimini sağlamak; çölleşme ile mücadele etmek; arazi bozunumunu durdurmak ve tersine çevirmek; biyolojik çeşitlilik kaybını engellemek. İnsan yaşamı gıda ve geçim kaynakları bakımından okyanuslara olduğu kadar karaya da bağımlıdır. Bitkiler, insanların besin kaynaklarının %80’ini sağlar, önemli bir ekonomik kaynak ve kalkınma vasıtası olarak tarıma dayanırız. Ormanlar, Yerküre’nin yüzeyinin %30’nu kaplıyor; milyonlarca tür için hayati önem taşıyan yaşam alanları ve önemli temiz hava ve su kaynakları sağlıyor; ve aynı zamanda iklim değişikliği ile mücadele açısından kritik önem taşıyor.

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    PublicationOpen Access
    Factors Influencing Epiphytic Lichen Species Distribution in a Managed Mediterranean Pinus nigra Arnold Forest
    (2019-04-01) SEVGİ, ECE; YILMAZ, OSMAN YALÇIN; ÇOBANOĞLU, GÜLŞAH; TECİMEN, HÜSEYİN BARIŞ; SEVGİ, ORHAN; SEVGİ, ECE
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    PublicationOpen Access
    Synthesis of oleanolic acid hydrazide-hydrazone hybrid derivatives and investigation of their cytotoxic effects on A549 human lung cancer cells
    (2022-01-01T00:00:00Z) Şenol, Halil; Mercümek, Berre; Şahin, Rabia Büşra; Kapucu, Halil Burak; Hacıosmanoğlu, Ebru; ŞENOL, HALIL; MERCÜMEK, BERRE; HACIOSMANOĞLU, EBRU
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    PublicationOpen Access
    Anticholinesterase furocoumarins from Heracleum platytaenium, a species endemic species to Ida Mountains
    (2013-01-01) Dincel, DEMET; Hatipoglu, Seda Damla; GOREN, AHMET CEYHAN; Topcu, Gulacti; DİNCEL, DEMET; GÖREN, AHMET CEYHAN; TOPÇU, GÜLAÇTI
    The petroleum ether extract of Heracleum platytaenium afforded 8 furocoumarins (psoralen, bergapten, xanthotoxin, pimpinellin, isopimpinellin, sphondin, byakangelicin, and heraclenol) and the methanol extract of H. platytaenium gave only 1 glycosylated dihydrofurocoumarin, apterin. In addition, stigmasterol was also obtained from petroleum ether extract. Structure identification of the isolated compounds has been achieved by using spectroscopic methods, namely 1D and 2D NMR experiments and mass spectral analyses. The antioxidant activity of the extracts and pure compounds was investigated by 2 methods, including DPPH free radical scavenging activity and lipid peroxidation inhibitory activity by beta-carotene-linoleic acid assays. The anticholinesterase activity of petroleum ether and methanol extracts of the plant and the isolated furocoumarins was investigated against acetylcholinesterase and butyrylcholinesterase enzymes by the Ellman method in vitro.
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    PublicationOpen Access
    Quercus pyrenaica Honeydew Honey With High Phenolic Contents Cause DNA Damage, Apoptosis, and Cell Death Through Generation of Reactive Oxygen Species in Gastric Adenocarcinoma Cells
    (2019-09-01) KOÇYİĞİT, ABDÜRRAHİM; Aydogdu, Gokhan; BALKAN, EZGİ; GÜLER, Eray Metin; BULUT, HURİ; KÖKTAŞOĞLU, FATMANUR; Goeren, AHMET CEYHAN; Atayoglu, Ali Timucin; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; YENİGÜN, VILDAN BETÜL; GÜLER, ERAY METİN; BULUT, HURI; KÖKTAŞOĞLU, FATMANUR; GÖREN, AHMET CEYHAN
    Many studies have shown that honey with high phenolic contents prevents cancer formation. Furthermore, recent studies have demonstrated that honey can be used for the treatment of cancer as well as cancer prevention. Antineoplastic effects of honey are often associated with their antioxidant phenolic contents. However, very few studies have dealt with the association of phenolic contents of honeys in terms of antiproliferative effects. The aim of this study was, therefore, to elucidate the cytotoxic, genotoxic, apoptotic, and reactive oxygen species (ROS) generating effects of honey samples on the basis of their phenolic and flavonoid contents. Fourteen different honey varieties were collected from various parts of Turkey, and their characteristics regarding total phenols, flavonoids, and antioxidant contents were determined to test their effects on gastric cancer cells (AGS). For convenience, 2 honey varieties were selected, namely, Ida Mountains Quercus pyrenaica honeydew honey (QPHH-IM) having the highest phenolic and antioxidant content and Canakkale multifloral honey (MFH-C) with the lowest phenolic and antioxidant content. Levels of 11 different phenolic compounds in QPHH-IM and MFH-C samples were determined by LC-MS/MS. AGS cells were incubated with different concentrations of QPHH-IM and MFH-C for 24 hours, then the cell viability, DNA damage, apoptosis, and generation of ROS were determined. We found that QPHH-IM had more cytotoxic, genotoxic, and apoptotic effects than that of MFH-C. We think that these effects are probably related to pro-oxidant activities due to the high phenolic contents present. Therefore, further research on high-phenolic honey may contribute to the future development of cancer therapeutics.