Goal: 03 - Sağlık ve Kaliteli Yaşam
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AMAÇ 3: SAĞLIKLI BİREYLER
Çocuk ölüm oranlarının azaltılması, anne sağlığının iyileştirilmesi, HIV/AIDS, sıtma ve diğer hastalıklar ile mücadelede büyük aşama kaydetmiş durumdayız. 1990 yılından bu yana, önlenebilir çocuk ölümlerinde dünya genelinde %50’yi aşan azalma olmuştur. Anne ölümleri de dünya genelinde %45 azalmıştır. 2000 ile 2013 arasında HIV/AIDS bulaşma oranı %30 azalmış, 6,2 milyonu aşkın insan sıtmadan kurtarılmıştır.
Bu ölümler; önleme ve tedavi, eğitim, aşı kampanyaları, cinsel ve üreme sağlığı hizmetleri vasıtasıyla önlenebilir. Sürdürülebilir Kalkınma Amaçları; AIDS, verem, sıtma ve diğer bulaşıcı hastalık salgınlarını 2030 yılına kadar ortadan kaldırmaya yönelik cesur bir taahhüttür. Amaç, herkesin genel sağlık hizmeti, güvenli ve erişilebilir ilaç ve aşıya kavuşmasını sağlamaktır. Aşı araştırma ve geliştirmelerinin desteklenmesi, bu sürecin vazgeçilmez bir parçasıdır.
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Publication Open Access A novel indicator predicts 2019 novel coronavirus infection in subjects with diabetes(2020-08-01T00:00:00Z) ÖZDER, ACLAN; ÖZDER, ACLANAims: Diabetes mellitus (DM) is associated with significant morbidity and mortality. The disease severity in 2019 novel coronavirus (Covid 19) infection has varied from mild self-limiting flu-like illness to fulminant pneumonia, respiratory failure and death. Since DM and Covid 19 infection are closely associated with inflammatory status, mean platelet volume (MPV) was suggested to be useful in predicting Covid infection onset. This study aimed to evaluate the diagnostic role of MPV in Covid patients with diabetes. Methods: A total of 640 subjects (160 Covid patients with type 2 diabetes, 160 healthy controls, 160 patients with non-spesific infections and 160 Covid patients without type 2 diabetes) enrolled in the study. Results: MPV was significantly higher (11.21 ± 0.61 fL) as compared to the results from the last routine visits of the the same individuals with diabetes (10.59 ± 0.96 fL) (p = 0.000). Conclusions: MPV could be used as a simple and cost-effective tool to predict the Covid infection in subjects with diabetes in primary care.Publication Open Access Associations between recently diagnosed conditions and hospitalization due to COVID-19 in patients aged 50 years and older- A SHARE-based analysis.(2021-07-12T00:00:00Z) López-Bueno, Rubén; Torres-Castro, Rodrigo; Koyanagi, Ai; Smith, Lee; Soysal, PINAR; Calatayud, Joaquín; SOYSAL, PINARBackground: Only a few studies have been carried out with a large sample size on the relationship between chronic conditions and hospitalization for coronavirus disease 2019 (COVID-19), and there is no research examining recently diagnosed conditions. Our purpose was to evaluate this association in a large sample including the older population from Europe and Israel. Method: Data from the Survey of Health, Ageing and Retirement in Europe COVID-19 Survey, a representative survey of individuals aged 50 or older residing in 27 European countries and Israel, were retrieved. Associations between recently diagnosed chronic conditions (ie, conditions detected over the last 3 years) (exposure) and hospitalization due to COVID-19 (outcome) were assessed using multivariable logistic regression. Results: A total of 51 514 participants on average 71.0 (SD = 9.2) years old were included. Participants with multimorbidity (ie, 2 or more recently diagnosed conditions) had significantly higher odds for COVID-19 hospitalization (adjusted odds ratio [AOR] = 3.91 [95% CI = 2.14-7.12]). Independent conditions such as lung disease (AOR = 16.94 [95% CI = 9.27-30.95]), heart disease (AOR = 3.29 [95% CI = 1.50-7.21]), or cancer (AOR = 3.45 [95% CI = 1.26-9.48]) showed particularly high odds for hospitalization due to COVID-19. Conclusions: People with recently diagnosed diseases, and in particular those having lung disease, heart disease, or cancer, were significantly more likely to be hospitalized for COVID-19.Publication Open Access Association between sarcopenia and diabetes: a systematic review and meta-analysis of observational studies(2019-10-01) Veronese, Nicola; Pizzol, Damiano; Demurtas, Jacopo; Smith, Lee; Sieber, Cornel; Strandberg, Timo; Bourdel-Marchasson, Isabelle; Sinclair, Alan; Petrovic, Mirko; Maggi, Stefania; SOYSAL, PINARAbstract Purpose Sarcopenia and diabetes are two common conditions in older people. Some recent literature has proposed that these two conditions can be associated. However, to date, no attempt has been made to collate this literature. Therefore, we aimed to summarize the prevalence of sarcopenia in diabetes (and vice versa) and the prevalence of sarcopenia in people with diabetes complications, through a systematic review and meta-analysis. Methods Two authors searched major electronic databases from inception until March 2019 for case control/cross-sectional/longitudinal studies investigating sarcopenia and diabetes. The strength of the reciprocal associations between sarcopenia and diabetes was assessed through odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for potential confounders, where possible. Results From 953 potential eligible articles, 20 were included in the systematic review, with 17 providing data for meta-analysis. Overall, 54,676 participants were included (mean age = 65.4 years). Diabetic participants had an increased prevalence of sarcopenia compared to controls (n = 10; OR = 1.635; 95% CI 1.204-2.220; p = 0.002; I-2 = 67%), whilst, after adjusting for potential confounders, sarcopenia was associated with an increased odds of having diabetes (OR = 2.067; 95% CI 1.396-3.624; p < 0.0001; I-2 = 0%). In 1868 diabetic participants with a complication, there was an increased prevalence of sarcopenia (OR = 2.446; 95% CI 1.839-3.254; p < 0.0001; I-2 = 0%), as compared with those with no complication. Very limited data existed regarding studies with a longitudinal design. Conclusions Our study suggests a bidirectional association between diabetes and sarcopenia, particularly when diabetic complications are present.Publication Open Access The Effect of Type 2 Diabetes Mellitus on the Development of Alzheimer's Disease and Its Molecular Mechanism(2022-01-01T00:00:00Z) DURAN, RABİA; Pancur, Sumeyra; BAHADORİ, FATEMEH; DURAN, RABİA; BAHADORİ, FATEMEHFollowing increased epidemiological studies indicating the relationship between diabetes and Alzheimer-s disease (AD), Type 2 diabetes has been reported to be a risk factor for the progress of AD pathology. Insulin resistance that develops in the brain, impairment in the insulin signal delivery system and glucose metabolism have been shown among the most likely pathophysiological causes of AD. It has been reported that the increase in AD markers such as phospho tau and A beta in the type 2 diabetes model of rats is associated with the decrease in the insulin receptor (IR) signaling and insulin-like growth factor-1 receptors (IGF-1R) ratio. Furthermore, intracellular components such as phospho-AKT (protein kinase B) and phospho-glycogen synthase kinase-3 beta (GSK3 beta), which are members of IR pathway, have been proved to be reduced in AD. Due to the common molecular mechanisms underlying the pathological development of Type 2 Diabetes and AD, treatment protocols indicated in diabetes have been used in the treatment of AD.Publication Open Access Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Plants(2017-04-01T00:00:00Z) Daskaya-Dikmen, Ceren; Yucetepe, Aysun; Karbancioglu-Guler, Funda; Daşkaya, Hayrettin; Özçelik, Beraat; DAŞKAYA, HAYRETTİNHypertension is an important factor in cardiovascular diseases. Angiotensin-I-converting enzyme (ACE) inhibitors like synthetic drugs are widely used to control hypertension. ACE-inhibitory peptides from food origins could be a good alternative to synthetic drugs. A number of plant-based peptides have been investigated for their potential ACE inhibitor activities by using in vitro and in vivo assays. These plant-based peptides can be obtained by solvent extraction, enzymatic hydrolysis with or without novel food processing methods, and fermentation. ACE-inhibitory activities of peptides can be affected by their structural characteristics such as chain length, composition and sequence. ACE-inhibitory peptides should have gastrointestinal stability and reach the cardiovascular system to show their bioactivity. This paper reviews the current literature on plant-derived ACE-inhibitory peptides including their sources, production and structure, as well as their activity by in vitro and in vivo studies and their bioavailability.Publication Open Access Determine the relationship between perceived social support and depression level of patients with diabetic foot(2015-07-16T00:00:00Z) YILDIZ, Ebru; Aşti, Türkinaz; AŞTI, TÜRKINAZBackground: As a lifelong disease, diabetes impairs the quality of life by limiting the eating and drinking habits and by bringing out the risk of kidney, eye, cardiovascular and diabetic neurological diseases in the long run. Loss of health might result in mourning, grief, rebellion, denial, anxiety, rage and sometimes these feelings might overcome the patient's coping skills leading to depression [Clinical Psychiatry 11 (Suppl 3) 3-18, 2008]. How individuals suffering from depression perceive and interpret the incidents around them is also important [Rel. Scie. Acad. J. III, 2: 129-152, 2003]. Accordingly, the determination of the correlation of the depression with the perceived social support level by the patients with diabetic foot was programmed and performed in order to take essential precautions, to generate proper solutions and treatment process and to make supportive plans for patients with developing diabetic foot and depression. Methods: The data was obtained from 128 patients who applied to hospital within the scope of research between July 1st 2011 and January 31st 2012 that were diagnosed with diabetes and had diabetic foot. Pearson chi-square, Fisher Exact and Likelihood ratio, chi-square, Student t test and one way analysis of variance, Levene' s test, One way ANOVA, Welch and Games Howell tests were used in the analysis and evaluation. The data was collected by meeting face to face the individuals and by making use of the patient files and using the "Personal Information Form" which includes introductory information about individuals with diabetic foot, "Beck Depression Scale" which is applied to determine emotion status of individuals and "Multidimensional Scale of Perceived Social Support" which is applied to determine the level of social support individuals perceive. Results: In the performed statistical evaluation, mean scores of Beck Depression scale and MSPSS family support, friend support, special person support sub-dimension and scale total scores were found to be in negative statistical correlation (p < 0.01). Conclusions: In the treatment and care of the patients with diabetic foot; anxiety and depression status of the patients, as well as physical status, should also be evaluated routinely. The individuals provided to take professional care. Keywords Author Keywords:Diabetes; Diabetic foot; Depression; Social support