Goal: 03 - Sağlık ve Kaliteli Yaşam
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AMAÇ 3: SAĞLIKLI BİREYLER
Çocuk ölüm oranlarının azaltılması, anne sağlığının iyileştirilmesi, HIV/AIDS, sıtma ve diğer hastalıklar ile mücadelede büyük aşama kaydetmiş durumdayız. 1990 yılından bu yana, önlenebilir çocuk ölümlerinde dünya genelinde %50’yi aşan azalma olmuştur. Anne ölümleri de dünya genelinde %45 azalmıştır. 2000 ile 2013 arasında HIV/AIDS bulaşma oranı %30 azalmış, 6,2 milyonu aşkın insan sıtmadan kurtarılmıştır.
Bu ölümler; önleme ve tedavi, eğitim, aşı kampanyaları, cinsel ve üreme sağlığı hizmetleri vasıtasıyla önlenebilir. Sürdürülebilir Kalkınma Amaçları; AIDS, verem, sıtma ve diğer bulaşıcı hastalık salgınlarını 2030 yılına kadar ortadan kaldırmaya yönelik cesur bir taahhüttür. Amaç, herkesin genel sağlık hizmeti, güvenli ve erişilebilir ilaç ve aşıya kavuşmasını sağlamaktır. Aşı araştırma ve geliştirmelerinin desteklenmesi, bu sürecin vazgeçilmez bir parçasıdır.
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Publication Metadata only Kanser ve D vitamini ilişkisi/ The relationship between cancer and vitamin D(2021-08-01T00:00:00Z) Usul, Melisa; GÜNEŞ BAYIR, AYŞE; GÜNEŞ BAYIR, AYŞEPublication Metadata only Measles Seroprevalence among Health Care Workersin a Tertiary Hospital, Istanbul Turkey(2018-04-01) DURDU, BÜLENT; DURDU, YASEMİN; Güleç, Nuray; ASLAN, TURAN; DURDU, BÜLENTPublication Metadata only Intracellular cytokine and cathelicidin secretion from monocytes and neutrophils in childhood lung tuberculosis and its relationship with vitamin D levels(2013-09-07T00:00:00Z) Çakır, Erkan; Torun, Emel; Aktaş, Esin; Deniz, Gülnur; ÇAKIR, ERKAN; TORUN, EMELPublication Metadata only huriye şenay kiziltan jst.go.jp alanından [PDF] Bone mineral density evaluation of patients with type 2 diabetes mellitus(2015-12-01) CAMLI, A; AYDIN, TEOMAN; TAŞPINAR, ÖZGÜR; KIZILTAN, HURİYE ŞENAY; ERIS, ALİ HİKMET; KESKİN, YAŞAR; HOCAOĞLU, İLKNUR TÜRK; POSUL, SEVDE; KEPEKÇİ, MÜGE; DENİZLİ, EBRU; GÜLER, MUSTAFA; AYDIN, TEOMAN; KIZILTAN, HURİYE ŞENAY; ERİŞ, ALİ HİKMETPublication Open Access Synthetic DNA Vaccines Adjuvanted with pIL-33 Drive Liver-Localized T Cells and Provide Protection from <i>Plasmodium</i> Challenge in a Mouse Model.(2020-01-10T00:00:00Z) Reeder, SM; Reuschel, EL; Bah, MA; Yun, K; Tursi, NJ; Kim, KY; Chu, J; Zaidi, FI; Yilmaz, I; Hart, RJ; Perrin, B; Xu, Z; Humeau, L; Weiner, DB; Aly, Ahmed Sayed Ibrahım; ALY, AHMED SAYED IBRAHıMThe need for a malaria vaccine is indisputable. A single vaccine for Plasmodium pre-erythrocytic stages targeting the major sporozoite antigen circumsporozoite protein (CSP) has had partial success. Additionally, CD8+ T cells targeting liver-stage (LS) antigens induced by live attenuated sporozoite vaccines were associated with protection in human challenge experiments. To further evaluate protection mediated by LS antigens, we focused on exported pre-erythrocytic proteins (exported protein 1 (EXP1), profilin (PFN), exported protein 2 (EXP2), inhibitor of cysteine proteases (ICP), transmembrane protein 21 (TMP21), and upregulated in infective sporozoites-3 (UIS3)) expressed in all Plasmodium species and designed optimized, synthetic DNA (synDNA) immunogens. SynDNA antigen cocktails were tested with and without the molecular adjuvant plasmid IL-33. Immunized animals developed robust T cell responses including induction of antigen-specific liver-localized CD8+ T cells, which were enhanced by the co-delivery of plasmid IL-33. In total, 100% of mice in adjuvanted groups and 71%–88% in non-adjuvanted groups were protected from blood-stage disease following Plasmodium yoelii sporozoite challenge. This study supports the potential of synDNA LS antigens as vaccine components for malaria parasite infection.Publication Metadata only The effect of dapagliflozin treatment on cardiac parameters in high fat fed and low dose STZ induced diabetic rat(2019-08-01T00:00:00Z) Karaomerlioglu, I.; Erdogan, B. R.; Mutlu, G. Kayki; Yesilyurt, Z. E.; Muderrisoglu, E.; Ozturk, N.; ALTAN, VECDİ MELİH; Inan, E. Arioglu; ALTAN, VECDİ MELİHPublication Open Access COVİD-19 PANDEMİSİNDE Hastalık/Hastane Yönetimi-COVID-19 VE SOLUNUM REHABİLİTASYONU(2021-09-01T00:00:00Z) Aydın, Teoman; AYDIN, TEOMANPublication Metadata only Türk Toraks Derneği 14. Yıllık Kongresi- bildiri kitapçığındaki -Perikardiyal efüzyon: küçük hücreli dışı akciğer kanserinde ilk bulgu-(2011-04-17) ZİYADE, SEDAT; ZİYADE, SEDATPublication Metadata only The Effects of Complex Decongestive Therapy on the Functional Capacity in Elderly Patient with Breast Cancer-Related Lymphedema: A Case Report(2018-12-22T00:00:00Z) ACAR, TEVFİK; BAŞBUĞ, GÖZDE; KOSTANOĞLU, ALİS; BAŞBUĞ, GÖZDE; KOSTANOĞLU, ALİSPublication Open Access Comparative Evaluation of Orthostatic Hypotension in Patients with Diabetic Nephropathy.(2021-07-20T00:00:00Z) Aytaş, Gamze; Elçioğlu, Ömer C; Kazancıoğlu, Rümeyza; Gürsu, Meltem; Artan, A Serra; Yabacı, Ayşegül; Soysal, PINAR; Bilgi, Kadir; Özçelik, Semra; KAZANCIOĞLU, RÜMEYZA; ELÇİOĞLU, ÖMER CELAL; GÜRSU, MELTEM; YABACI TAK, AYŞEGÜL; SOYSAL, PINAR; ÖZÇELİK, SEMRAIntroduction: Orthostatic hypotension (OH) affects 5-20% of the population. Our study investigates the presence of OH in diabetic nephropathy (DNP) patients and the factors affecting OH in comparison with nondiabetic chronic kidney disease (NDCKD) patients. Method: Patients presented to the nephrology clinic, and those who consented were included in the study. DNP was defined by kidney biopsy and/or clinical criteria. NDCKD patients of the same sex, age, and eGFR were matched to DNP patients. Demographic parameters and medications were obtained from the records. OH was determined by Mayo clinic criteria. The same researcher used an electronic device to measure blood pressure (BP). All samples were taken and analyzed the same day for biochemical and hematologic parameters and albuminuria. Results: 112 (51 F, 61 M, mean age: 62.56 ± 9.35 years) DNP and 94 (40 F, 54 M, mean age: 62.23 ± 10.08 years) NDCKD patients were included. There was no significant difference between DNP and NDCKD groups in terms of OH prevalence (70.5 vs. 61.7%, p = 0.181). Male patients had significantly higher OH prevalence than female patients (74.7 vs. 60.0%, p = 0.026). There was no significant difference in change in systolic BP between the groups (24.00 [10.00-32.00] mm Hg vs. 24.00 [13.75-30.25] mm Hg, p = 0.797), but the change in diastolic BP was significantly higher in the DNP group (8.00 [2.00-13.00] mm Hg vs. 6.00 [2.00-9.00] mm Hg, p = 0.025). In the DNP group, patients with OH had significantly higher uric acid levels than those without OH (7.18 ± 1.55 vs. 6.36 ± 1.65 mg/dL, p = 0.017). And, 73.7% of patients on calcium channel blockers developed OH (p = 0.015), and OH developed in 80.6% of 36 patients on alpha-blockers (p = 0.049). Conclusion: OH prevalence is very high in CKD, and etiology of CKD does not have a statistically significant effect on the frequency of OH, despite a difference that could be meaningful clinically. Therefore, patients with CKD are checked for OH, with or without concurrent diabetes mellitus. Evaluation of postural BP changes should be a part of nephrology practice.