Goal: 03 - Sağlık ve Kaliteli Yaşam
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AMAÇ 3: SAĞLIKLI BİREYLER
Çocuk ölüm oranlarının azaltılması, anne sağlığının iyileştirilmesi, HIV/AIDS, sıtma ve diğer hastalıklar ile mücadelede büyük aşama kaydetmiş durumdayız. 1990 yılından bu yana, önlenebilir çocuk ölümlerinde dünya genelinde %50’yi aşan azalma olmuştur. Anne ölümleri de dünya genelinde %45 azalmıştır. 2000 ile 2013 arasında HIV/AIDS bulaşma oranı %30 azalmış, 6,2 milyonu aşkın insan sıtmadan kurtarılmıştır.
Bu ölümler; önleme ve tedavi, eğitim, aşı kampanyaları, cinsel ve üreme sağlığı hizmetleri vasıtasıyla önlenebilir. Sürdürülebilir Kalkınma Amaçları; AIDS, verem, sıtma ve diğer bulaşıcı hastalık salgınlarını 2030 yılına kadar ortadan kaldırmaya yönelik cesur bir taahhüttür. Amaç, herkesin genel sağlık hizmeti, güvenli ve erişilebilir ilaç ve aşıya kavuşmasını sağlamaktır. Aşı araştırma ve geliştirmelerinin desteklenmesi, bu sürecin vazgeçilmez bir parçasıdır.
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Publication Metadata only Measles Seroprevalence among Health Care Workersin a Tertiary Hospital, Istanbul Turkey(2018-04-01) DURDU, BÜLENT; DURDU, YASEMİN; Güleç, Nuray; ASLAN, TURAN; DURDU, BÜLENTPublication Metadata only huriye şenay kiziltan jst.go.jp alanından [PDF] Bone mineral density evaluation of patients with type 2 diabetes mellitus(2015-12-01) CAMLI, A; AYDIN, TEOMAN; TAŞPINAR, ÖZGÜR; KIZILTAN, HURİYE ŞENAY; ERIS, ALİ HİKMET; KESKİN, YAŞAR; HOCAOĞLU, İLKNUR TÜRK; POSUL, SEVDE; KEPEKÇİ, MÜGE; DENİZLİ, EBRU; GÜLER, MUSTAFA; AYDIN, TEOMAN; KIZILTAN, HURİYE ŞENAY; ERİŞ, ALİ HİKMETPublication Metadata only The use of HbA1c as an aid in the diagnosis of gestational diabetes mellitus.(2014-11-01) Sevket, OSMAN; SEVKET, A; OZEL, A; DANSUK, RAMAZAN; KELEKCI, S; ŞEVKET, OSMAN; DANSUK, RAMAZANPublication Metadata only Human In Vitro Disease Models: Dawning a New Era Away from Animal Models(2016-09-01T00:00:00Z) Senturk, HAKAN; ŞENTÜRK, HAKANPublication Metadata only The effect of tumor size on overall survival in patients with pT3 gastric cancer: experiences from 3 centers.(2010-01-01T00:00:00Z) BILICI, A; UYGUN, K; Seker, MESUT; USTAALIOĞLU, BB; ALIUSTAOGLU, M; TEMIZ, S; AKSU, G; GEZEN, C; YAVUZER, D; KAYA, S; SALEPCI, T; MAYADAGLI, ALPASLAN; GUMUS, M; ŞEKER, MESUT; MAYADAĞLI, ALPASLANPublication Metadata only Measurement of Strain Imaging, Troponin-I and Brain Natriuretic Peptide Levels in Radiotherapy-Induced Cardiac Injury(2016-01-01T00:00:00Z) Ekici, Kemal; Cakal, Beytullah; Baydar, Onur; MAYADAĞLI, Alpaslan; Cakal, Sinem D.; Karaca, Oguz; Omaygenc, M. Onur; MAYADAĞLI, ALPASLANRadiotherapy (RT) of the thorax can damage the pericardium, myocardium, heart valves, and coronary vessels, with the pericardium being the most frequently damaged. The objectives of this study were to evaluate RT-induced left ventricular dysfunction and myocardial injury by measuring cardiac biomarkers, troponin I (TnI) and brain natriuretic peptide (BNP), as well as determin cardiotoxicity and early signs of cardiovascular dysfunction using strain rate imaging (SRI) prior to and following RT. This study included 35 patients diagnosed with thoracic malignancy between January 2011 and October 2013. Of the 35 patients, 22 had left-sided lung cancer and 13 had left-sided breast cancer. SRI was performed and TnI and BNP levels were measured prior to and following RT. A total radiation dose of 40-60 Gy (mean, 54.9 +/- 8.9 Gy) was applied in lung cancer patients and 50-60 Gy (mean, 51.6 +/- 4.9 Gy) was applied in breast cancer patients. No significant difference was observed in TnI or BNP levels prior to and one month following RT. The left ventricular ejection fraction (LVEF) did not differ prior to or after the first month of RT. However, lower right ventricular strain (RVS) and left ventricular strain (LVS) SRI values were detected within the first month following RT. From the results of this study, we conclude that SRI is a sensitive method to detect RT-induced changes in cardiac function that are not typically detected by conventional echocardiographic methods and cardiac biomarkers.Publication Metadata only The efficacy and safety of capecitabine plus bevacizumab combination as first-line treatment in elderly metastatic colorectal cancer patients(2016-06-01T00:00:00Z) Ozcelik, M.; Odabas, H.; Ercelep, O.; Yuksel, S.; Mert, A. G.; Aydin, D.; Surmeli, H.; Isik, D.; Isik, S.; Oyman, A.; Ustaalioglu, B. B. Oven; Aliustaoglu, M.; Gumus, M.The optimal treatment in older persons with metastatic colorectal cancer (mCRC) is complicated by a lack of general agreement. The aim of this study was to evaluate the activity of bevacizumab plus capecitabine combination in elderly mCRC patients who were not suitable for chemotherapy with irinotecan and oxaliplatin-containing regimens.Publication Metadata only New approaches to in vitro diagnosis of hepatitis C infection a reason for post transfusion hepatitis: Diagnostic value of determination of hepatitis C virus core antigen.(2011-12-01T00:00:00Z) Yuksel, PELİN; CALISKAN, R; ERGIN, S; ASLAN, M; CELIK, DG; SARIBAS, S; ZIVER, T; YALCINER, A; KOCAZEYBEK, B; YÜKSEL MAYDA, PELİNPublication Metadata only Preparation and in vitro evaluation of 5-flourouracil loaded magnetite-zeolite nanocomposite (5-FU-MZNC) for cancer drug delivery applications(2016-02-01) Sagir, Tugba; Huysal, Merve; Durmus, ZEHRA; Kurt, BELMA; Senel, Mehmet; Isik, Sevim; ZENGİN KURT, BELMAIn this work, super paramagnetic magnetite nanoparticles were synthesized onto/into zeolite, then loaded with anti-cancer drug 5-fluorouracil (5-FU). The physical properties of the prepared nanocomposite and drug loaded nanocomposite were characterized using different techniques. The drug loading and releasing behavior of the magnetic nanocarrier was investigated and the drug-loaded nanoparticles exhibited a sustained release of drug without any burst release phenomenon. Furthermore, 5-FU loaded MZNC were evaluated for its biological characteristics. The functional 5-FU-MZNC has been triggered intra-cellular release of the cancer therapeutic agent 5-fluorouracil (5-FU). Cytotoxic effects of 5-FU loaded MZNC on human gastric carcinoma (AGS) cells were determined by real time cell analysis and colorimetric WST-1 cell viability assay. Apoptosis of cells was further investigated by Annexin-V staining which indicates the loss of cell membrane integrity. According to our results, 5-FU-MZNC showed a concentration-dependent cell proliferation inhibitory function against AGS cells. Morphologic and apoptotic images were consistent with the cytotoxicity results. In conclusion, 5-FU loaded MZNC efficiently inhibit the proliferation of AGS cells in vitro through apoptotic mechanisms, and may be a beneficial agent against cancer, however further animal study is still required. (C) 2015 Elsevier Masson SAS. All rights reserved.Publication Open Access Can CA-125 Predict Lymph Node Metastasis in Epithelial Ovarian Cancers in Turkish Population?(2014-01-01T00:00:00Z) Sudolmus, Sinem; Koroglu, Nadiye; Yildirim, Gokhan; Ulker, Volkan; Gulkilik, Ahmet; DANSUK, RAMAZAN; DANSUK, RAMAZANObjective. The role of single preoperative serum CA-125 levels in predicting pelvic or paraaortic lymph node metastasis in patients operated for epithelial ovarian cancer has been investigated. Methods. 176 patients diagnosed with epithelial ovarian carcinoma after staging laparotomy between January 2002 and May 2010 were evaluated retrospectively. Results. The mean, geometric mean, and median of preoperative serum CA-125 levels were 632,6, 200,29, and 191,5 U/mL, respectively. The cut-off value predicting lymph node metastases in the ROC curve was 71,92 U/mL, which is significant in logistic regression analysis (P = 0.005). The preoperative log CA-125 levels were also statistically significant in predicting lymph node metastasis in logistic regression analysis (P = 0.008). Conclusions. The tumor marker CA-125, which increases with grade independent of the effect of stage in EOC, is predictive of lymph node metastasis with a high rate of false positivity in Turkish population. The high false positive rate may obscure the predictive value of CA-125.