Goal: 03 - Sağlık ve Kaliteli Yaşam
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AMAÇ 3: SAĞLIKLI BİREYLER
Çocuk ölüm oranlarının azaltılması, anne sağlığının iyileştirilmesi, HIV/AIDS, sıtma ve diğer hastalıklar ile mücadelede büyük aşama kaydetmiş durumdayız. 1990 yılından bu yana, önlenebilir çocuk ölümlerinde dünya genelinde %50’yi aşan azalma olmuştur. Anne ölümleri de dünya genelinde %45 azalmıştır. 2000 ile 2013 arasında HIV/AIDS bulaşma oranı %30 azalmış, 6,2 milyonu aşkın insan sıtmadan kurtarılmıştır.
Bu ölümler; önleme ve tedavi, eğitim, aşı kampanyaları, cinsel ve üreme sağlığı hizmetleri vasıtasıyla önlenebilir. Sürdürülebilir Kalkınma Amaçları; AIDS, verem, sıtma ve diğer bulaşıcı hastalık salgınlarını 2030 yılına kadar ortadan kaldırmaya yönelik cesur bir taahhüttür. Amaç, herkesin genel sağlık hizmeti, güvenli ve erişilebilir ilaç ve aşıya kavuşmasını sağlamaktır. Aşı araştırma ve geliştirmelerinin desteklenmesi, bu sürecin vazgeçilmez bir parçasıdır.
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Publication Metadata only The effect of tumor size on overall survival in patients with pT3 gastric cancer: experiences from 3 centers.(2010-01-01T00:00:00Z) BILICI, A; UYGUN, K; Seker, MESUT; USTAALIOĞLU, BB; ALIUSTAOGLU, M; TEMIZ, S; AKSU, G; GEZEN, C; YAVUZER, D; KAYA, S; SALEPCI, T; MAYADAGLI, ALPASLAN; GUMUS, M; ŞEKER, MESUT; MAYADAĞLI, ALPASLANPublication Metadata only Measurement of Strain Imaging, Troponin-I and Brain Natriuretic Peptide Levels in Radiotherapy-Induced Cardiac Injury(2016-01-01T00:00:00Z) Ekici, Kemal; Cakal, Beytullah; Baydar, Onur; MAYADAĞLI, Alpaslan; Cakal, Sinem D.; Karaca, Oguz; Omaygenc, M. Onur; MAYADAĞLI, ALPASLANRadiotherapy (RT) of the thorax can damage the pericardium, myocardium, heart valves, and coronary vessels, with the pericardium being the most frequently damaged. The objectives of this study were to evaluate RT-induced left ventricular dysfunction and myocardial injury by measuring cardiac biomarkers, troponin I (TnI) and brain natriuretic peptide (BNP), as well as determin cardiotoxicity and early signs of cardiovascular dysfunction using strain rate imaging (SRI) prior to and following RT. This study included 35 patients diagnosed with thoracic malignancy between January 2011 and October 2013. Of the 35 patients, 22 had left-sided lung cancer and 13 had left-sided breast cancer. SRI was performed and TnI and BNP levels were measured prior to and following RT. A total radiation dose of 40-60 Gy (mean, 54.9 +/- 8.9 Gy) was applied in lung cancer patients and 50-60 Gy (mean, 51.6 +/- 4.9 Gy) was applied in breast cancer patients. No significant difference was observed in TnI or BNP levels prior to and one month following RT. The left ventricular ejection fraction (LVEF) did not differ prior to or after the first month of RT. However, lower right ventricular strain (RVS) and left ventricular strain (LVS) SRI values were detected within the first month following RT. From the results of this study, we conclude that SRI is a sensitive method to detect RT-induced changes in cardiac function that are not typically detected by conventional echocardiographic methods and cardiac biomarkers.Publication Metadata only Prognostic significance of protein kinase B/Akt pathway in patients with non-small cell lung cancer(2014-01-01T00:00:00Z) Mayadagli, Alpaslan; Gul, Sule Karabulut; Bilici, Ahmet; Oruc, Ahmet Fatih; Kocak, Mihriban; Ozkan, Alper; Aksu, Atinc; Barisik, Nagehan Ozdemir; Gumus, Mahmut; MAYADAĞLI, ALPASLANPurpose: Akt, also known as protein kinase B (PKB), is an intracellular signal transduction protein activated by growth hormones. PKB/Akt is frequently activated in a variety of cancer types, but its role in the development and progression of lung cancer has not been completely elucidated yet. The aim of the present study was to determine the prognostic value of PKB/Akt in non-small cell lung cancer (NSCLC).Publication Metadata only COULD PRETREATMENT PET-CT STANDART UPTAKE VALUES HAVE A ROLE IN THE RESPONSE TO TREATMENT AND THE SURVIVAL IN PATIENTS WITH SMALL CELL LUNG CANCER?(2013-11-01T00:00:00Z) Aydin, Kubra; Odabas, Hatice; Seker, Mesut; Korkmaz, Taner; Yasar, Nurgul; Sener, Nur; Aydin, Dincer; Ercelep, Ozlem; Yuksel, Sinemis; Mert, Aslihan G.; Aliustaoglu, Mehmet; Mayadagli, Alpaslan; Dane, Faysal; Gumus, Mahmut; MAYADAĞLI, ALPASLANPublication Metadata only İnoperatif Pankreas Kanserinde Nigella Sativanın Kemoterapi ve Radyoterapinin Duyarlığını Artırıcı Etkisi(2016-03-23) KIZILTAN, HURİYE ŞENAY; TÜRKDOĞAN, KÜRŞAT; MAYADAĞLI, ALPASLAN; KIZILTAN, HURİYE ŞENAY; MAYADAĞLI, ALPASLANPublication Metadata only Radiation therapy for squamous cell cancer of the skin in a patient with xeroderma pigmentosum(2022-06-01T00:00:00Z) Altinok, Pelin; Tekçe, ERTUĞRUL; Ergün, Selmasönmez; Mayadagli, Alpaslan; TEKÇE, ERTUĞRUL; MAYADAĞLI, ALPASLANPublication Metadata only Palliative Bioresonance Therapy for metastatic cancer patients Metastatik kanser hastalarında palyatif biyorezonans tedavisi(2018-02-01) KIRSEVER, ESRA; KIZILTAN, HURİYE ŞENAY; YILMAZ, RABİYE; BAYIR, AYŞE GÜNEŞ; BAŞIBÜYÜK, MERYEM; ERİŞ, ALİ HİKMET; ÇAKIR, FATMA BETÜL; GÜL, KÜRŞAT; ŞİMŞEK, MUHARREM; KIZILTEPE, AYŞE; GÜMÜŞ, ASLI; KALAYCI, KÜBRA; AKÇAKAYA, ADEM; AYDIN, TEOMAN; AYDOĞDU, İBRAHİM; SÜT, PELİN ALTINOK; MAYADAĞLI, ALPASLAN; KIZILTAN, HURİYE ŞENAY; BAŞIBÜYÜK, MERYEM; ERİŞ, ALİ HİKMET; ÇAKIR, FATMA BETÜL; GÜL, KÜRŞAT; GÜMÜŞ, ASLI; KALAYCI, KÜBRA; AKÇAKAYA, ADEM; AYDIN, TEOMAN; AYDOĞDU, İBRAHİM; MAYADAĞLI, ALPASLANPublication Metadata only The Prognostic and Predictive Value of Expression of P-AKT in Patients with FIGO IIB Locally Advanced Cervical Cancer under Chemotherapy(2013-01-01T00:00:00Z) Kocak, Mihriban E.; Barisik, Nagehan O.; Mayadagli, Alpaslan; Gemici, Cengiz; Eren, Makbule; Naki, Murat; Ozseker, Naciye; Aksu, Atinc; MAYADAĞLI, ALPASLANTo evaluate the relation between expression of P-Akt and radiotherapy response, disease-free survival and overall survival in cervical cancer patients. A total of 50 patients with FIGO stage IIB locally advanced squamous cell cervical cancer treated primarily with chemoradiotherapy were included in the present study. All patients received external beam radiotherapy (EBRT; 46-50.4 Gy with 1.8-2 Gy of daily fraction, five times a week) followed by high-dose rate brachytherapy (HDR 26 Gy at point A, with 6.5 Gy per fraction a week for 4 weeks). Chemotherapy consisted of 40 mg/m2 cisplatin i.v. once a week for 5 weeks concomitant with external pelvic radiation. Paraffin-embedded, formalin-fixed primary tumor tissue was collected from each patient to identify P-Akt expression, retrospectively. The median follow up time for the study population was 30 (12-120) months. Expression of P-Akt was identified in 86% (43/50) of patients. Overall 3-years survival and disease free survival were 89.3% and 79%; respectively in the study population. There was no significant association between P-Akt staining and survival (89% vs 85.7%, p= 0.641) and disease-free survival (80% vs 88.2%, p= 0.498). There was no relation between expression of P-Akt and treatment response, size of the tumor, lymph node status, age, local and distant failures. Univariate analysis revealed significantly reduced overall 3-years survival and disease free survival only for patients with poor treatment response (p= 0.001). In multivariate analysis, treatment response was found to be statistically significant parameter only for DFS (p= 0.001). In conclusion, in our study, expression of P-Akt was detected in majority of cervical cancer patients. However no correlation was observed between P-Akt staining degree and treatment responsePublication Metadata only Pankreas Kanserinde Nigella Sativanın Kemoterapi ve Radyoterapinin Duyarlıgını Artırıcı Etkisi(2016-09-10) KIZILTAN, HURİYE ŞENAY; MAYADAĞLI, ALPASLAN; GÜNEŞ BAYIR, AYŞE; KÜRŞAT, TÜRKDOĞAN; KIZILTAN, HURİYE ŞENAY; MAYADAĞLI, ALPASLAN; GÜNEŞ BAYIR, AYŞEPublication Metadata only Pain management with Radiotherapy and ozone with high dose vitamin C therapy in a case of bone metastatis of breast cancer patient(2018-02-01) KIRSEVER, ESRA; KIZILTAN, HURİYE ŞENAY; YILMAZ, RABİYE; GÜNEŞ BAYIR, AYŞE; BAŞIBÜYÜK, MERYEM; ÇAKIR, FATMA BETÜL; GÜL, KÜRŞAT; ŞİMŞEK, MUHARREM; KIZILTEPE, AYŞE; GÜMÜŞ, ASLI; KALAYCI, KÜBRA; AKÇAKAYA, ADEM; MAYADAĞLI, ALPASLAN; AYDOĞDU, İBRAHİM; ALTINOK SÜT, PELİN; AYDIN, TEOMAN; KIZILTAN, HURİYE ŞENAY; ERİŞ, ALİ HİKMET; GÜNEŞ BAYIR, AYŞE; BAŞIBÜYÜK, MERYEM; ÇAKIR, FATMA BETÜL; GÜL, KÜRŞAT; GÜMÜŞ, ASLI; KALAYCI, KÜBRA; AKÇAKAYA, ADEM; MAYADAĞLI, ALPASLAN; AYDOĞDU, İBRAHİM; ALTINOK SÜT, PELİN; AYDIN, TEOMAN