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03 - Sağlık ve Kaliteli Yaşam

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AMAÇ 3: SAĞLIKLI BİREYLER Çocuk ölüm oranlarının azaltılması, anne sağlığının iyileştirilmesi, HIV/AIDS, sıtma ve diğer hastalıklar ile mücadelede büyük aşama kaydetmiş durumdayız. 1990 yılından bu yana, önlenebilir çocuk ölümlerinde dünya genelinde %50’yi aşan azalma olmuştur. Anne ölümleri de dünya genelinde %45 azalmıştır. 2000 ile 2013 arasında HIV/AIDS bulaşma oranı %30 azalmış, 6,2 milyonu aşkın insan sıtmadan kurtarılmıştır. Bu ölümler; önleme ve tedavi, eğitim, aşı kampanyaları, cinsel ve üreme sağlığı hizmetleri vasıtasıyla önlenebilir. Sürdürülebilir Kalkınma Amaçları; AIDS, verem, sıtma ve diğer bulaşıcı hastalık salgınlarını 2030 yılına kadar ortadan kaldırmaya yönelik cesur bir taahhüttür. Amaç, herkesin genel sağlık hizmeti, güvenli ve erişilebilir ilaç ve aşıya kavuşmasını sağlamaktır. Aşı araştırma ve geliştirmelerinin desteklenmesi, bu sürecin vazgeçilmez bir parçasıdır.

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End date: 2024 × Start date: 2020 × Has files: false × Rights: info:eu-repo/semantics/openAccess ×

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    Correlation of host inflammatory cytokines and immune-related metabolites, but not viral NS1 protein, with disease severity of dengue virus infection
    (2020-08-01T00:00:00Z) Soe, Hui Jen; Manikam, Rishya; Raju, Chandramathi Samudi; Khan, MOHAMMAD ASİF; Sekaran, Shamala Devi; KHAN, MOHAMMAD ASİF
    Severe dengue can be lethal caused by manifestations such as severe bleeding, fluid accumulation and organ impairment. This study aimed to investigate the role of dengue non-structural 1 (NS1) protein and host factors contributing to severe dengue. Electrical cell-substrate impedance sensing system was used to investigate the changes in barrier function of microvascular endothelial cells treated NS1 protein and serum samples from patients with different disease severity. Cytokines and metabolites profiles were assessed using a multiplex cytokine assay and liquid chromatography mass spectrometry respectively. The findings showed that NS1 was able to induce the loss of barrier function in microvascular endothelium in a dose dependent manner, however, the level of NS1 in serum samples did not correlate with the extent of vascular leakage induced. Further assessment of host factors revealed that cytokines such as CCL2, CCL5, CCL20 and CXCL1, as well as adhesion molecule ICAM-1, that are involved in leukocytes infiltration were expressed higher in dengue patients in comparison to healthy individuals. In addition, metabolomics study revealed the presence of deregulated metabolites involved in the phospholipid metabolism pathway in patients with severe manifestations. In conclusion, disease severity in dengue virus infection did not correlate directly with NS1 level, but instead with host factors that are involved in the regulation of junctional integrity and phospholipid metabolism. However, as the studied population was relatively small in this study, these exploratory findings should be confirmed by expanding the sample size using an independent cohort to further establish the significance of this study.
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    Comparison of serratus plane block alone and in combination with pectoral type 1 block for breast cancer surgery: a randomized controlled study
    (2022-03-01T00:00:00Z) Yeşiltaş, Serdar; Türköz, Ayda; Çalım, Muhittin; Esen, Asım; Daşkaya, Hayrettin; Karaaslan, Kazım; YEŞİLTAŞ, SERDAR; TÜRKÖZ, AYDA; ÇALIM, MUHITTIN; ESEN, ASIM; DAŞKAYA, HAYRETTİN; KARAASLAN, KAZıM
    Background/Aim: Concurrent application of ultrasound-guided pectoral type 1 (PECS I) and serratus plane block (SPB) is one of the most appropriate multimodal analgesic strategies for reducing acute post-mastectomy pain. The purpose of the present study was to compare the analgesic efficacy of SPB alone, or in combination with PECS I block for postmastectomy pain following breast cancer surgery. Materials and Methods: Sixty participants undergoing breast cancer surgery were randomly assigned to two groups. After anesthesia induction, group S (n =30) received SPB alone, whereas the SPECS group (n =30) received a combination of PECS I and SPB. Pain scores at 0, 1, 2, 6, 12, 24 h postoperatively, intra-operative fentanyl consumption, postoperative time to first rescue analgesia, nausea, vomiting, patient satisfaction, and anesthesia-related complications were recorded. Results: Pain scores in the SPECS group were significantly lower than group S throughout the follow-up period (p <0.001). A significant reduction in postoperative rescue morphine consumption (p =0.01, median difference 7 mg, 95 % confidence interval: 5.1-7.9 mg) and intraoperative fentanyl consumption (p =0.01) in the SPECS group compared with group S. Moreover, postoperative nausea and vomiting were lower, and patient satisfaction was higher in the SPECS group compared with that of the group S. Conclusions: These results suggest that SPB application and PECS I provide more effective and reliable perioperative analgesia and increase patient satisfaction in breast cancer surgery
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    Tip 2 Diyabetes Mellitus hastalarında 25-(OH) D vitamini düzeyi mikroalbüminüri ve diyabetin seyri ile ilişkili midir?
    (2022-10-13) Yüksel Salduz Z. İ.; Özder A.; YÜKSEL SALDUZ, ZEYNEB İREM; ÖZDER, ACLAN
    SS-18 TIP 2 DIYABETES MELLITUS HASTALARINDA 25-(OH) D VITAMINI DÜZEYI MIKROALBÜMINÜRI VE DIYABETIN SEYRI ILE ILIŞKILI MIDIR? ZEYNEB İREM YÜKSEL SALDUZ, ACLAN ÖZDER BEZMIALEM TIP FAKÜLTESI AILE HEKIMLIĞI ANABILIM DALI Amaç: 25-(OH) D vitamini (VD) eksikliği birçok çalışmada Tip 2 Diyabetes Mellitusun (Tip 2 DM) ortaya çıkan komplikas yonları için önemli bir risk faktörü olarak tanımlanmıştır (1,2). Çalışmamızın amacı VD düzeyleri ile Tip 2 DM seyrinde ortaya çıkan albuminüri seviyesi arasındaki ilişkinin değerlendirilmesidir. Gereç-Yöntem: Çalışma kesitsel, tek merkezli, retrospektif olarak planlandı. Temmuz 2019-Aralık 2019 tarihleri arasında Bezmialem Tıp Fakültesi Hastanesi Aile Hekimliği polikliniğine ayaktan başvuran Tip 2 DM hastalarının sosyodemografik ve laboratuvar verileri elektronik hasta sisteminden tarandı. 148 hasta çalışmaya alındı. Hastalar VD düzeylerine göre ikiye ayrıldı. 25-(OH) D vitamini 20 ng/mL’ nin altında olanlar VD eksikliği olan grup; grup 1, 25-(OH) D vitamini 20 ng/mL’ nin üzerinde olanlar VD eksikliği olmayan grup; grup 2 olarak sınıflandırıldı. Hastaların Glukoz, Üre, Kreatinin, Kan üre azotu (BUN), Glomeruler filtrasyon hızı (GFR), Alanin aminotransferaz (ALT), Aspartat aminotransferaz (AST), LDL koles terol (LDL-C), HDL kolesterol (HDL-C), Trigliserid (TG), Total kolesterol, HbA1c ve hemogram parametre değerleri olarak Lökosit sayısı (WBC), Eritrosit sayısı (RBC), Trombosit sayısı (PLT), Hemoglobin (Hgb), Hematokrit (Hct), Nötrofil mutlak sayısı (Neut), Lenfosit mutlak sayısı (Lymph), Ortalama eritrosit hacmi (MCV), Ortalama trombosit hacmi (MPV), Vitamin B 12 (Vit B12), Ferritin, Tiroid stimülan hormon (TSH), 25-(OH) D vitamini, mikroalbüminüri düzeyi grup 1 ve grup 2 arasında karşılaştırıldı. Vitamin D seviyeleri ve albüminüri arasındaki ilişki incelendi. Bulgular: Çalışmaya 148 hasta dahil edildi. Hastaların yaş ortalaması 56,58±9,76 idi. 70 hasta erkek, 78 hasta kadındı. Tüm hastaların VD ortalaması 22,80±17,84 ve HbA1c ortalaması 7,56±1,65 bulundu. D vitamini 20 ng/mL’ nin altında 76, üzerinde 72 hastamız vardı. D vitamini 20 ng/mL’ nin altındaki grup 1 hastalarımızda; LDL-C, Total Kol, HbA1c, Lenfosit sayısı, mikroalbuminüri düzeyi anlamlı derecede yüksek bulundu. (p<0.05) (Tablo 1) Sonuç: Çalışmamızda D vitamini seviyesi düşük olan hastalarda mikroalbüminüri ve HbA1c düzeyi yüksek tespit edilmiş tir. Bu durum VD eksikliğinin Tip 2 DM hastalığının kontrolsüz seyrinde ve böbrek fonksiyon bozukluğunda etkili olduğunu düşündürtmektedir. Aile hekimliği kapsamında koruyucu hekimliğin önemi düşünüldüğünde VD desteği diyabetin kont rollü seyrinde ucuz ve etkili bir yöntem olarak gündemde olmalıdır. Kaynaklar 1. Kostoglou-Athanassiou, Ifigenia, et al. \"Vitamin D and glycemic control in diabetes mellitus type 2.\" Therapeutic ad vances in endocrinology and metabolism 4.4 (2013): 122-128. 2. Herrmann, Markus, et al. \"Serum 25-hydroxyvitamin D: a predictor of macrovascular and microvascular complicati ons in patients with type 2 diabetes.\" Diabetes care 38.3 (2015): 521-528. Anahtar Kelimeler:D vitamini, Mikroalbüminüri, Tip 2 diyabetes mellitus
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    Nadir Görülen Bir Kanser Türü Olarak Adrenokortikal Karsinom Olgusu
    (2020-11-01) Karadoğan M. T.; Özgen İ. T.; Çakır F. B.; Somuncu S.; Cesur Y.; ÇAKIR, FATMA BETÜL; CESUR, YAŞAR
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    Systematic versus cognitive targeted biopsy: evaluation of parameters related to clinically significant prostate cancer and comparison of detection rates
    (2022-10-01) Ersöz C.; İlktaç A.; Kalkan S.; Kayalı Y.; Akbulut H.; Toprak H.; Doğan B.; ERSÖZ, CEVPER; İLKTAÇ, ABDULLAH; KALKAN, SENAD; AKBULUT, HABİB; TOPRAK, HÜSEYİN; DOĞAN, BAYRAM
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    Cross-sectional study: long term follow-up care for pediatric cancer survivors in a developing country, Turkey: current status, challenges, and future perspectives
    (2020-01-01T00:00:00Z) Incesoy Ozdemir, Sonay; TAÇYILDIZ, NURDAN; VARAN, ALİ; KEBUDİ, Rejin; ZÜLFİKAR, Osman Bülent; Celkan, Tiraje; Sahin, Gurses; Corapcioglu, Funda; Keskin Yildirim, Zuhal; PINARLI, FARUK GÜÇLÜ; Olgun, Nur; Sari, Neriman; Dagdemir, Ayhan; Ozyoruk, Derya; Eren, Tuba; ÇAKIR, FATMA BETÜL; Adakli Aksoy, Basak; Bozkurt, Ceyhun; Guler, Elif; Ozguven, Ali Aykan; Erbey, Fatih; Berber, Melda; Dincaslan, Handan; Unal, Emel; Kantar, Mehmet; ÇAKIR, FATMA BETÜL
    Aim: The main purpose of this study is to determine the current status of long-term follow-up (LTFU) for childhood cancer survivors and the challenges of LTFU for pediatric cancer survivors at pediatric oncology institutions in Turkey.
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    The Effect of Intratumoral Budding and Other Histological Features in Predicting Treatment Response in Breast Cancer Patients Receiving Neoadjuvant Therapy
    (2022-11-01) Ozturk C.; DUMAN ÖZTÜRK S.; OKCU O.; Sen B.; YASİN A. İ.; BEDİR R.; YASİN, AYŞE İREM
    Introduction: Neoadjuvant chemotherapy (NAC) is used with increasing frequency in breast cancers. Various clinicopathological parameters predict treatment response (TR). Tumor budding (TB), which is a prognostic parameter in many cancers, can be considered the first stage of the metastatic process. In our study, the relationship between TR and clinicopathological parameters and TB in core biopsy samples of patients before NAC was investigated.
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    Design and synthesis of new heterocyclic compounds containing 5-[(1H-1,2,4-triazol-1-yl)methyl]-3H-1,2,4-triazole-3-thione structure as potent hEGFR inhibitors
    (2023-01-01) KOLCUOĞLU Y.; BEKİRCAN O.; Fazli H.; Sahin E.; TÜRE A.; AKDEMİR A.; Hamarat Sanlier S.; AKDEMİR, ATİLLA
    © 2023 Informa UK Limited, trading as Taylor & Francis Group.EGFR is one of the important mediators of the signaling cascade that determines key roles in various biological processes such as growth, differentiation, metabolism and apoptosis in the cell in response to external and internal stimuli. In recent years, it has been proven that although this enzyme activity is tightly regulated in normal cells, if the enzyme activity cannot be controlled, it can lead to malignancy. EGFR is also considered a prominent macromolecule in targeted cancer chemotherapy. For this purpose, a comprehensive modeling studies were conducted against EGFR protein and novel molecules containing 5-[(1H-1,2,4-triazol-1-yl)methyl]-3H-1,2,4-triazole-3-thione structure were suggested to be synthesized. Among the synthesized molecules, compounds 7c, 8c, 8f and 8g were determined to have significant IC50 values. Compound 8g was found to have the IC50 value closest to the very well-known EGFR inhibitor Gefitinib with its noncompetitive inhibition form. K i value of compound 8g was calculated as 0.00232 µM. Communicated by Ramaswamy H. Sarma.
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    MAPK6 genini hedefleyen siRNA yüklü PLGA nanopartiküllerinin meme kanseri hücre dizilerinde antikanser etkilerinin değerlendirilmesi
    (2022-11-23) TORUNTAY C.; POYRAZ F. Ş.; SÜSGÜN S.; YÜCESAN E.; MANSUROĞLU B.; SÜSGÜN, SEDA
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    Association between accepting the illness and effective insulin administration in patients with type 2 Diabetes Mellitus
    (2021-06-01T00:00:00Z) Korkmaz Binay, Şengül; Aştı, Türkinaz; AŞTI, TÜRKINAZ
    Purpose: Patients with type 2 diabetes will be easier to adapt to treatment if they accept their illness. To investigatethe association between individual, disease-related and care-related properties of the individuals and theiraccepting the disease, and effective insulin administration.Material and Methods: 103 diabetic patients were included in the study. The Acceptance of Illness Scale (AIS)and the Diabetes Fear of Injecting and Self-Testing Questionnaire (D-FISQ) were used for the data collection. Thedata were analyzed using the descriptive statistics.Results: The Cronbach alpha was 0.96 for AIS, 0.95 for fear of self-injecting (FSI), 0.80 for fear of self-testing(FST) and 0.85 for total D-FISQ. A negative association was determined between the AIS score, and FSI, FST,total D-FISQ; a positive association was found between the FSI score and FST, total D-FISQ scores and betweenFST and the total D-FISQ scores. The FSI score was found to be higher among females.Conclusion: Accepting the disease affects an effective insulin administration behavior. Hence, nursing care andeducation of the individuals should be planned and implemented so as to improve the acceptance level of diabetes