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17 - Amaçlar için Ortaklıklar

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Amaçlar için Ortaklıklar Uygulama araçlarını güçlendirmek ve sürdürülebilir kalkınma için küresel ortaklığı canlandırmak. Hedefler, tüm hedefleri başarmak üzere ulusal planları desteklemek suretiyle Kuzey-Güney ve Güney-Güney işbirliğini artırma amacını güdüyor. Uluslararası ticaretin geliştirilmesi ve gelişmekte olan ülkelerin ihracatını artırmalarına destek verilmesi, adil ve açık, herkesin yararına olan, evrensel kurallara dayalı ve hakkaniyetli bir ticaret sistemini oluşturmanın unsurlarıdır.

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    Synthesis and Comprehensive in Vivo Activity Profiling of Olean-12-en-28-ol, 3β-Pentacosanoate in Experimental Autoimmune Encephalomyelitis: A Natural Remyelinating and Anti-Inflammatory Agent
    (2023-01-01) Şenol H.; Özgün Acar Ö.; Dağ A.; Eken A.; Güner H.; Aykut Z. G.; Topçu G.; Şen A.; ŞENOL, HALIL; DAĞ, AYDAN; TOPÇU, GÜLAÇTI
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    PublicationOpen Access
    Synthesis and anticancer activity of novel derivatives of α,β‐unsaturated ketones based on oleanolic acid: in vitro and in silico studies against prostate cancer cells
    (2023-08-01) Şenol H.; Ghaffari-Moghaddam M.; Bulut Ş.; Akbaş F.; Köse A.; Topçu G.; ŞENOL, HALIL; AKBAŞ, FAHRİ; TOPÇU, GÜLAÇTI
    Herein, new derivatives of α,β-unsaturated ketones based on oleanolic acid (4 a-i) were designed, synthesized, characterized, and tested against human prostate cancer (PC3). According to the in vitro cytotoxic study, title compounds (4 a-i) showed significantly lower toxicity toward healthy cells (HUVEC) in comparison with the reference drug doxorubicin. The compounds with the lowest IC50 values on PC3 cell lines were 4 b (7.785 μM), 4 c (8.869 μM), and 4 e (8.765 μM). The results of the ADME calculations showed that the drug-likeness parameters were within the defined ranges according to Lipinski's and Jorgensen's rules. For the most potent compounds 4 b, 4 c, and 4 e, a molecular docking analysis using the induced fit docking (IFD) protocol was performed against three protein targets (PARP, PI3K, and mTOR). Based on the IFD scores, compound 4 b had the highest calculated affinity for PARP1, while compound 4 c had higher affinities for mTOR and PI3K. The MM-GBSA calculations showed that the most potent compounds had high binding affinities and formed stable complexes with the protein targets. Finally, a 50 ns molecular dynamics simulation was performed to study the behavior of protein target complexes under in silico physiological conditions.
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    PublicationOpen Access
    Relationship between emotional intelligence and disaster response self-efficacy: A comparative study in nurses
    (2023-08-01) Kuday A. D.; Erdoğan Ö.; ERDOĞAN, ÖZCAN
    Background: Nurses who constitute an important part of the health system play a critical role in all stages of disaster management, especially in providing care for disaster victims. It is essential for nurses to have adequate education and qualifications to reduce disaster-related mortality and morbidity rates in the community. The qualifications of nurses depend not only on their knowledge and skills but also on their emotional abilities such as empathy and stress management. Emotions can impact individuals' levels of self-efficacy in disaster response, and it may help explain the differences in self-efficacy among nurses. Objective: This study aimed to investigate the relationship between emotional intelligence and disaster response self-efficacy, and compare the scores between hospital nurses and National Medical Rescue Team nurses. Design: A cross-sectional design. Settings: This research was conducted at Bezmialem Foundation University Hospital and National Medical Rescue Team in Istanbul, Turkey. Participants: This study included 565 nurses from two different institutions. Methods: A survey consisting of the Demographic Information Form, the Modified Schutte Emotional Intelligence Scale, and the Disaster Response Self-Efficacy Scale was administered to the nurses. The data collected from March to April of 2022 was analyzed using SPSS 25.0 program. The differences and relationships among variables were determined by using Chi-square tests, student's t-tests, Pearson correlation, and linear regression analyses. Results: Of the 565 participants, 219 (38.8%) were hospital nurses and 346 (61.2%) were NMRT nurses. NMRT nurses scored significantly higher in emotional intelligence (131.45 ± 6.15 versus 129.75 ± 6.01) and disaster response self-efficacy (80.71 ± 11.38 versus 77.77 ± 11.33) than hospital nurses (p < 0.05). In addition, emotional intelligence was found to be significantly and positively correlated to disaster response self-efficacy (r = 0.885, p < 0.05). Conclusions: The emotional intelligence and disaster response self-efficacy were positively correlated, and both levels of NMRT nurses higher than hospital nurses. These findings suggest that healthcare organizations should take the emotional intelligence of nurses as an important means to improve their disaster response selfefficacy. It can improve the quality of disaster response to obtain well self-efficacy by developing the emotional intelligence of nurses.
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    The Challenge of Preoperative Panel Reactive Antibody Positivity in Parathyroid Transplantation
    (2024-02-01) Göncü B. S.; Yücesan E.; Selepcioğlu Kaya H.; Kazancıoğlu R.; Ersoy Y. E.; Akçakaya A.; GÖNCÜ, BEYZA SERVET; SELEPCİOĞLU KAYA, HARİKA; KAZANCIOĞLU, RÜMEYZA; ERSOY, YELIZ EMINE; AKÇAKAYA, ADEM
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    An Alternative and Up-To-Date Recommendation for a Proper Site for Parathyroid Transplantation: The Omentum
    (2024-02-01) Ersoy Y. E.; Göncü B. S.; Yücesan E.; Selepcioğlu Kaya H.; Kazancıoğlu R.; Akçakaya A.; ERSOY, YELIZ EMINE; GÖNCÜ, BEYZA SERVET; SELEPCİOĞLU KAYA, HARİKA; KAZANCIOĞLU, RÜMEYZA; AKÇAKAYA, ADEM
    Objectives: Various sites have been used for parathyroid allotransplant, such as injection into the forearm, sternocleidomastoid, or deltoid muscles. However, transplant efficiency in these regions varies according to the results reported in the literature and also obtained from our previous studies. Using the omentum "as a natural incubator" for composite tissue-derived cell transplants to increase transplant success is possible. Materials and methods: To examine the efficiency of transplant sites for parathyroid allotransplant, we compared clinical cases from the literature and our experience with 23 cases. The omental transplant process is performed under general anesthesia by laparoscopic intervention. The abdominal cavity is visualized with an endocamera from a 5-mm trocar. With the help of a flexible catheter from another 5-mm trocar, microencapsulated or naked parathyroid cells are deposited on the omentum in approximately 30 mL of isotonic saline. The trocar sites are then sutured, and the surgery is terminated. Recipients were followed for 6 months with examination of biochemical parameters (parathormone, calcium, and phosphorus levels), medication use, and clinical scoring. Results: In the 23 patients who received parathyroid allotransplants over the omentum, 7 recipients did not exhibit any changes according to the scoring system criteria. However, on average, serum calcium and phosphorus levels remained within the healthy reference range. In addition, use of oral medications among patients decreased, indicating successful transplant survival. These results were consistent with a significant decrease in hypocalcemia symptoms among patients. Conclusions: In the 23 patients, the success rate was 69.5% for the first 6-month period after transplant. Recent developments and large cohorts are needed to demonstrate the higher efficacy of parathyroid allotransplant over the omentum.