2015-11-19, CELIK, K, ÇıKRıKÇıOĞLU, MA, HALAC, G, KILIC, ERDEM, AYHAN, S, OZARAS, N, Karatoprak, CUMALİ, YILDIZ, KEMALETTİN, YILDIZ, RS, ZORLU, MEHMET, CAKIRCA, MUSTAFA, KıSKAÇ, MUHARREM, KILIÇ, ERDEM, YILDIZ, KEMALETTİN, ZORLU, MEHMET, KARATOPRAK, CUMALİ, ÇAKIRCA, MUSTAFA, KISKAÇ, MUHARREM

Background: Endocan is a recently introduced marker of endothelial dysfunction. The objective of this study was to compare serum endocan levels in patients with restless legs syndrome (RLS) and control subjects in order to elucidate whether RLS is associated with endothelial dysfunction. Methods: A total of 31 drug naïve female patients with RLS and 31 age- and BMI-matched women were included in the study. Patients with pathological or physiological conditions or with a history of medication use that could potentially influence endothelial functions were excluded, as well as those with alcohol or drug abuse history. The two groups were compared with routine blood tests and serum endocan levels. Results: Patients with RLS had lower serum endocan levels than the controls (P=0.037). There was a negative bivariate correlation between RLS severity score and serum endocan levels (r=-0.406, P=0.023). While white blood cell count was significantly higher in RLS group, 25-hydroxy vitamin D3, vitamin B12, transferrin saturation rate, and HDL-cholesterol were significantly lower. Creatininemia and diastolic blood pressure were also marginally insignificantly lower in RLS group. Due to the presence of differences between two groups in these variables, a linear regression analysis was performed that showed a positive association between endocan and creatininemia (β=0.310, P=0.022), and a negative association between endocan and RLS (β=-0.502, P,0.001). Conclusion: The results of this study seem to suggest that patients with RLS may have better endothelial functions when compared with the general population and that these patients may be better protected against atherosclerosis

2021-01-01T00:00:00Z, ZORLU, MEHMET, Kiskac, Nese, KISKAÇ, MUHARREM, ZORLU, MEHMET, KISKAÇ, MUHARREM

Objectives: Our aim was to evaluate the participants with the COVID-19 scale in order to see the effects of the COVID-19 pandemic on people, which has affected the whole world along with our country, to be able to take the necessary precautions for the current pandemic and similar pandemics and to minimize the negative aspects globally. Methods: A total of 1010 people who aged 18 and older (between the ages of 18-76) were included in the research. Besides from the personal information of people who aged 18 and older such as a city of residence, age, gender, profession, education, the number of people who live in the same house, their chronic illnesses, marital status, and the existence of a child, a 20-question phobia of COVID-19 scale was carried out. The results were 95% reliable, and their significance was evaluated to be on p<0.05 level. Result: The COVID-19 Phobia Scale point for women was 54.97±14.44 while it was 51.28±14.06 for men, and between the two groups, there is a high level of significant difference (p<0.05) statistically, COVID-19 Phobia Scale point of people who have chronic illnesses is 56.51±15.84, meanwhile, the point of people who have no chronic illnesses was found to be 52.96±13.99, and it was detected that this difference was statistically significant (p<0.05). Conclusion: Besides the COVID-19 pandemic affecting the whole society, we see that the women population and people who have chronic illnesses are going through much more fear and anxiety.

2021-01-01T00:00:00Z, KISKAÇ, MUHARREM, ŞEKERCİ, ABDÜSSELAM, Guler, Eray Metin, TUNÇ, MUHAMMED, ÇAKIRCA, MUSTAFA, ZORLU, MEHMET, KISKAÇ, MUHARREM, ŞEKERCİ, ABDÜSSELAM, TUNÇ, MUHAMMED, ÇAKIRCA, MUSTAFA, KARATOPRAK, CUMALİ, ZORLU, MEHMET

Objective: Many chronic diseases such as malignancy, cardiovascular diseases, endothelial dysfunction, and autoimmune diseases, which have been shown to be related to vitamin D in various studies; have similar relations with CTRP-9, TNFα, and thiol-disulfide hemostasis. We aimed to contribute to the literature by evaluating the relationship between CTRP-9, TNFα, and thiol-disulfide hemostasis and vitamin D levels, which we thought may have some effects on the pathogenesis of vitamin D deficiency. Methods: In our study, 78 female volunteers older than 18 years were included. Volunteers were divided into three groups according to the reference values of vitamin D levels. Biochemical parameters, CTRP-9, TNFα, and thiol/disulfide hemostasis tests taken from all volunteers were studied. Results: In this study, there was a significant difference in CTRP-9, TNFα, total thiol (TT), native thiol (NT), DIS (disulfide), TT/DIS, and NT/DIS levels in vitamin D groups (p<0.05). There was a significant negative correlation between vitamin D and TNFα and DIS, while a significant positive correlation was found with CTRP-9, TT, NT, TT/DIS, and NT/DIS (p<0.05). Conclusions: It was determined that vitamin D deficiency causes a significant decrease in CTRP-9 level and a significant increase in TNFα level, as well as an increase in thiol/disulfide hemostasis in favor of disulfide, which may be a risk factor for increased oxidative stress. We considered that these changes may play mediator roles for many chronic diseases and metabolic disorders that are increasing in frequency due to vitamin D deficiency.

2016-07-01, Zorlu, MEHMET, Kiskac, MUHARREM, Cakirca, MUSTAFA, Guler, E. M., CELIK, K., GULTEPE, I., CIKRIKCIOGLU, M. A., Kocyigit, ABDÜRRAHİM, ZORLU, MEHMET, KISKAÇ, MUHARREM, ÇAKIRCA, MUSTAFA, KARATOPRAK, CUMALİ, GÜLER, ERAY METİN, KOÇYİĞİT, ABDÜRRAHİM

Introduction: Vitamin D deficiency is a common health problem seen worldwide. Adipokines released from adipose tissue play important roles in the control of appetite and satiety, modulation of body fat distribution, regulation of insulin sensitivity and secretion, control of blood pressure, and regulation of endothelial functions and inflammation. The aim of the present study is to investigate how vitamin D levels affect serum vaspin and omentin levels.

2021-01-01T00:00:00Z, Kiskac, Nese, KISKAÇ, MUHARREM, ŞEKERCİ, ABDÜSSELAM, ZORLU, MEHMET, KISKAÇ, MUHARREM, ŞEKERCİ, ABDÜSSELAM, ZORLU, MEHMET

OBJECTIVE: This research was carried out to evaluate people-s knowledge of adult vaccination and their attitude and to observe the effect of the pandemic era on this situation. METHODS: A total of 1,425 people (18-80 years old) were included in this study. The types of questions like the province where they live, age, gender, occupation, education status, and the presence of chronic diseases, as well as knowing which vaccines are used in adult vaccination, which of these vaccines they had in the last 10 years, which ones they plan to have this year, and whether COVID-19 pandemic changed their perspective on adult vaccinations or not were asked to people. RESULTS: In the last 10 years, while participants stated that they had the highest rate of tetanus vaccine with 29.8%, hepatitis B vaccine with 23.1%, influenza vaccine with 22.7%, human papillomavirus vaccine with 1.3%, and zoster vaccine with 0.3% were the lowest levels of vaccines. CONCLUSIONS: As a result, it seems that we are far from the goals set by the health authorities for adult vaccination. We observed that the COVID-19 pandemic raised awareness toward pneumococcus and influenza vaccines and interest toward adult vaccinations and at the same time changed the thoughts against adult vaccinations.