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Comparative antifungal efficacy of light-activated disinfection and octenidine hydrochloride with contemporary endodontic irrigants
2015-02-01T00:00:00Z, Eldeniz, Ayce Unverdi, Guneser, MEHMET BURAK, Akbulut, Makbule Bilge, GÜNEŞER, MEHMET BURAK
The aim of this study was to evaluate the antifungal effects of light-activated disinfection (LAD) in comparison with contemporary root canal irrigation solutions: sodium hypochlorite and 2 % chlorhexidine gluconate and a new wound antiseptic, octenidine hydrochloride. Seventy extracted teeth having single root canals were contaminated with Candida albicans for 14 days. The samples were divided into five experimental (n = 10) and two control (positive and negative) groups (n = 10): (1) LAD with toluidine blue O, (2) octenidine hydrochloride (OCT), (3) 2.5 % sodium hypochlorite (2.5 % NaOCl), (4) 5.25 % sodium hypochlorite (5.25 % NaOCl) and (5) 2 % chlorhexidine. Five millilitres of each test solution was applied for 3 min, and irradiation time used for LAD was 30 s. After treatment, the dentin chips were collected from inner canal walls into vials containing phosphate buffered saline, vortexed, serially diluted, seeded on Tryptic Soy Agar plates and incubated (37 A degrees C, 48 h). The number of colony-forming units was then counted. Differences between LAD group and positive control group were statistically significant (P < 0.05). All Candida cells were totally eliminated in root canals irrigated with OCT, 2.5 % NaOCl, 5.25 % NaOCl and 2 % chlorhexidine groups (CFU = 0). Within the limitations of this ex vivo study, LAD had minimal antimicrobial effect on C. albicans when used 30 s, and further modifications in LAD protocol are required to improve its antifungal capability. A new wound antiseptic, octenidine hydrochloride, demonstrated better potential than LAD in elimination of Candida albicans cells and may be a promising alternative to NaOCl and chlorhexidine solutions in future.
Malnutrition in elderly patients with renal failure: Importance of pre-dialysis period
2014-10-01, Kazancioglu, RÜMEYZA, CINAR, A., Soysal, P., GORCIN, B., Isik, A. T., KAZANCIOĞLU, RÜMEYZA, BÜYÜKAYDIN, BANU
Background and aims: In elderly, renal failure is one of the major comorbidities. Malnutrition is another clinical problem in these patients- follow-up. In this study, we compared nutritional states of elderly patients with different renal functions.
Effects of Malnutrition on Neutrophil/Mononuclear Cell Apoptotic Functions in Children with Acute Lymphoblastic Leukemia
2017-04-01, ÇAKIR, FATMA BETÜL, Berrak, Su Gülsün, Aydoğan, Gönül, Tulunay, Aysin, Timur, Cetin, Canpolat, Cengiz, ÇAKIR, FATMA BETÜL
Background: Recent studies claim that apoptosis may explain immune dysfunction observed in malnutrition. Objective: The objective of this study was to determine the effect of malnutrition on apoptotic functions of phagocytic cells in acute lymphoblastic leukemia (ALL). Materials and Methods: Twenty-eight ALL patients (13 with malnutrition) and thirty controls were enrolled. Neutrophil and mononuclear cell apoptosis of ALL patients and the control group were studied on admission before chemotherapy and repeated at a minimum of three months after induction of chemotherapy or when the nutritional status of leukemic children improved. Results: The apoptotic functions of both ALL groups on admission were significantly lower than those of the control group. The apoptotic functions were lower in ALL patients with malnutrition than those in ALL patients without malnutrition, but this was not statistically significant. The repeated apoptotic functions of both ALL groups were increased to similar values with the control group. This increase was found to be statistically significant. Conclusions: The apoptotic functions in ALL patients were not found to be affected by malnutrition. However, after dietary intervention, increased apoptotic functions in both ALL patient groups deserve mentioning. Dietary intervention should always be recommended as malnutrition or cachexia leads to multiple complications. Enhanced apoptosis might originate also from remission state of cancer.
The prevalence and co-incidence of geriatric syndromes in older patients with early-stage Alzheimer-s disease and dementia with Lewy bodies.
2021-01-28T00:00:00Z, Soysal, PINAR, Tan, Semen Gokce, SOYSAL, PINAR
Malnutrition in older age
2019-11-01T00:00:00Z, Kalan, Ugur, Arik, Ferhat, Soysal, Pınar, SOYSAL, PINAR
Effects of Black Cumin Seed (Nigella sativa) and Garlic (Allium sativum) Extracts on Aluminum Induced Cytotoxicity and Genotoxicity in Human Lymphocyte Culture
2015-09-01T00:00:00Z, Celik, Hakim, KOÇYİĞİT, ABDÜRRAHİM, Bagci, Cahit, Koyuncu, Ismail, Karakilcik, Ali Ziya, KOÇYİĞİT, ABDÜRRAHİM
Fatty Acid Composition of Juniperus Species (Juniperus Section) Native to Turkey
2012-07-01T00:00:00Z, Guvenc, Aysegul, Kucukboyaci, Nurgun, Goren, AHMET CEYHAN, GÖREN, AHMET CEYHAN
Fatty acid compositions of seeds of five taxa of the Juniperus section of the genus Juniperus L. (Cupressaceae), i.e. J. drupacea Lab.. J. communis L. var. communis, J. communis var. saxatilis Pall., J. oxycedrus L. subsp. oxycedrus, and J. oxycedrus subsp. macrocarpa (Sibth. & Sm.) Ball, were investigated. Methyl ester derivatized fatty acids of the lipophylic extracts of the five species were comparatively analyzed by capillary gas chromatography-mass spectrometry (GC-MS). Juniperus taxa showed uniform fatty acid patterns, among which linoleic (25.8-32.5%), pinolenic (11.9-24.1%) and oleic acids (12.4-17.2%) were determined to be the main fractions in the seed oils. Juniperonic acid was found to be remarkably high in J. cumnunis var. saxatilis (11.4 %), J. oxycedrus subsp. oxycedrus (10.4 %), and J. communis var. communis (10.1 %). To the best of our knowledge, the present work discloses the first report on the fatty acid compositions of seeds of this Juniperus section grown in Turkey.
Fatty Acid Methyl Ester Composition of Some Turkish Apiaceae Seed Oils: New Sources for Petroselinic Acid
2016-11-01T00:00:00Z, Kucukboyaci, Nurgun, Ayaz, Fatma, Adiguzel, Nezaket, Bani, Baris, Goren, AHMET CEYHAN, GÖREN, AHMET CEYHAN
The seed oils of twenty-six species of Apiaceae belonging to the genera Bunium, Cnidium, Ferula, Ferulago, Heracleum, Hippomarathrztm, Malabaila, Myrrhoides, Olymposciadium, Pimpinella, Prangos, Szovitsia, Trigonasciadium, Trinia and Zosima, collected in Turkey, were investigated for their oil content, and amount of petroselinic acid (PA), as well as for the composition of their fatty acid methyl esters (FAMEs) by GC-MS. Seed oil content ranged from 7.1% in Szovitsia callicarpa to 29.3% in Ferula haussknechtii. The results showed that the seed oils of the studied species contained high amounts of PA (1.2-72.2%), followed by significant amounts of linoleic (LA, 13.8-50.8%) and oleic (OA, 4.2-61.6%) acids. PA was found in all the analyzed species, except for Olymposciadium caespitosum, which belongs to a monotypic endemic genus of the family. According to data from our study, PA was found to be predominantly in the seed oils of Hippomarathrum cristatum (72.2%), Trinia glauca (64.9%) and Bunium microcarpum (59.7%) and, therefore these species might be considered as new sources of PA, and represent a potential oleochemical raw material. This is the first extensive study of the composition of Turkish Apiaceae species. The high amounts of PA may also have chemotaxonomic significance.
Malnutrition and Malnutrition Risk Can Be Associated with Systolic Orthostatic Hypotension in Older Adults.
2018-01-01T00:00:00Z, Kocyıgıt, Se, Soysal, Pınar, Ates, Bulut, Isık, At, SOYSAL, PINAR
Development and validation of a GC-FID method to quantify thymoquinone in black cumin seed oils
2019-01-01T00:00:00Z, Demirbolat, Ilker, KARTAL, MURAT, Karik, Unal, KARTAL, MURAT
Black cumin (Nigella sativa L.) is a very popular medicinal plant around the world. Pharmacological effects have been widely studied over the years. It has an economic importance and being cultivated in many parts of Turkey and neighbour countries. Thymoquinone (TQ) is a volatile compound found in black cumin seeds and a major compound of its essential and fixed oils which has been reported as anticancer, antidiabetic, spasmolytic, immunomodulator, bronchodilator, antimicrobial, analgesic, anti-inflammatory, antioxidant etc. The quality of black cumin seed oil depends on extraction technics (expression, super critic CO2 extraction etc.), quality of seeds, storage time and thymoquinone content. In this study we developed and validated a rapid quantification GC-FID method to determine the thymoquinone levels in seed oils which uses diethyl phthalate (DEP) as an internal standard.