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08 - İnsana Yakışır İş ve Ekonomik Büyüme

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İnsana Yakışır İş ve Ekonomik Büyüme İstikrarlı, kapsayıcı ve sürdürülebilir ekonomik büyümeyi, tam ve üretken istihdamı ve herkes için insana yakışır işleri desteklemek

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Now showing 1 - 10 of 36
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    Urogenital myiasis caused by Psychoda albipennis in a child
    (2015-03-01T00:00:00Z) Demir, Aysegul Dogan; Iraz, Meryem; SAYIN İPEK, DUYGU NEVAL
    Urogenital myiasis results when flies lay their eggs near the exit of the urethra and the larvae proceed upward along the urogenital tract. In this case report, a 10 year-old female patient diagnosed with urogenital myiasis was reported. The patient presented with complaints including painful and frequent urination, genital pruritus and moving larvae in urine. The patient had received Enterobius vermicularis treatment previously for two times. A 24-hour urine sample was collected and two black larvae were found in the urine. It was found that these larvae were fourth-stage larvae of Psychoda albipennis. Although there was no risk factor, the patient was affected with this rare parasitological disease. This case was presented to draw attention to myiasis in children. Myiasis may be observed in individuals with a favourable hygiene status and a high socioeconomical level. If a detailed history is not taken and appropriate laboratory tests are not performed, the diagnosis may be missed.
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    Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro
    (2011-04-01T00:00:00Z) HOSEK, Jan; BARTOS, Milan; CHUDIK, Stanislav; DALL'ACQUA, Stefano; INNOCENTI, Gabbriella; Kartal, MURAT; KOKOSKA, Ladislav; KOLLAR, Peter; KUTIL, Zsofia; LANDA, Premysl; MAREK, Radek; ZAVALOVA, Veronika; ZEMLICKA, Milan; SMEJKAL, Karel; KARTAL, MURAT
    Cudraflavone B (1) is a prenylated flavonoid found in large amounts in the roots of Morus alba, a plant used as a herbal remedy for its reputed anti-inflammatory properties. The present study shows that this compound causes a significant inhibition of inflammatory mediators in selected in vitro models: Thus, 1 was identified as a:potent inhibitor of tumor necrosis factor a (TNF alpha) gene expression and secretion by blocking the translocation of nuclear factor kappa B (NF-kappa B) from the cytoplasm to the nucleus in macrophages derived from a THP-1 human monocyte cell line. The NF-kappa B activity reduction resulted in the inhibition of cyclooxygenase 2 (COX-2) gene expression. Compound Cads as a COX-2 and COX-1 inhibitor with higher selectivity toward COX-2 than indomethacin. Pretreament of cells by 1 shifted the peak in an regulatory gene zinc finger protein 36 (ZFP36) expression assay. This natural product has noticeable anti-inflammatory properties suggesting that 1 potentially could be Used for development as a nonsteroidal anti inflammatory drug lead
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    Palliative Care in High and Low Resource Countries
    (2021-01-01T00:00:00Z) KEBUDİ, Rejin; ÇAKIR, FATMA BETÜL; Silbermann, Michael; ÇAKIR, FATMA BETÜL
    Palliative Care (PC) is defined by the World Health Organization (WHO) as a support provided by multiple disciplines in order to improve the quality of life of both patients and their caregivers, throughout the disease course, from diagnosis to end- of-life. PC aims to prevent and treat symptoms and side effects of the disease and its treatment. PC is well developed in most high-income countries; however in most low-income settings, where approximately 80% of patients with cancer requiring PC care for advanced disease live, PC services are still uncommon. Health indicators monitoring global PC development are policy, education, use of medicines, service provision and professional activity. Globally, PC development may be categorized as Group 1 (no known hospice-PC activity), Group 2 (capacity-building activity), Groups 3a Isolated PC provided, 3b Generalized PC provided, 4a hospice-PC services at a stage of integration into regular service provision, and 4b hospice-PC services at a stage of advanced integration into regular service provision. Spirituality is an essential element of patient-centered PC. The use of Complementary and Traditional Medicine (CTM) in Middle Eastern countries is widespread. There are wide discrepancies in cancer care and PC in many regions of the world. The Individualized Care Planning and Coordination (ICPC) Model is designed to facilitate the advance care planning with continuity of all the measures like symptom control or emotional, social and spiritual care of both the patient and the family during the disease steps like relapse or end of life.
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    Impact of training on practical skills of Iraqi health providers towards integrated management of neonate and child health - a multicentre cross sectional study
    (2018-05-01T00:00:00Z) Al-Ezzi, Saad Ahmed Ali; AL-EZZI, SAAD AHMED ALİ
    Background:This study aims to assess the mandatory practical skills of caregivers towards the implementation of the Integrated Management of Neonatal and Childhood Illness (IMNCI) strategy in primary health care (PHC) centers of Salah al-Din governorate in Iraq.Methods:A cross-sectional comparative study was conducted from January to May 2014. An equal sample of 42 trained and 42 non-trained caregivers who are working in 20 PHC centers in Tikrit city and other districts of Salah al-Din governorate of Iraq were included. The study tool was a semi-structured questionnaire with 20 questions covering different required practical skills that caregivers should have. The total score was 100 and in a range of 4- 6 points for each question. An independent sample t-test was used to compare the means of numerical variables.Results:The mean age of total respondents were (33.18 ± 5.82Years), and the vast majority (63, 75.0%) were females. More than two-third (58, 69.0%) were paramedical compared to 26 (31.0%), who were doctors. Trained caregivers had statistically significant better practice (73.48 ± 13.46) compared to non- trained caregivers (63.95 ± 17.44). Trained doctors had statistically significant better practice (88.15 ± 2.70) compared to trained paramedical staff (66.90 ± 10.84). Trained caregivers from Tikrit city had statistically significantly better practice (80.26 ± 7.38) compared to trained caregivers from districts (67.89± 14.85). The highest proportion (97.5%) of trained caregivers felt the child for fever or body hotness appropriately, and the lowest proportion (59.5%) of them recorded age, height, and weight correctly.Conclusion:This study showed that training has a positive influence on the implementation of IMNCI interventions. IMNCI-trained caregivers were more likely to correctly classify illnesses than non-trained caregivers.
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    Brachial plexus injury complicating the labor: mother is the victim at this time
    (2014-09-01T00:00:00Z) Ozaras, Nihal; Ergin, Onder; Demir, Saliha Eroglu; Sariyildiz, Mustafa Akif
    Objective: Postpartum nerve injuries are rare complications of labor and the lower extremity peripheral nerves are the frequently affected ones. In this case report, we are presenting a patient who developed brachial plexus injury after a forceful vaginal delivery.
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    Bir Sosyal Değişim Katalizörü Olarak Sosyal Girişimcilik
    (2021-12-01T00:00:00Z) Kati, Beyza Gökçin; Toker, Kerem; TOKER, KEREM
    Bu çalışmanın amacı, sosyal girişimcilik kavramını incelemek, tartışmak ve uygulama örnekleri ile sosyal girişimcilik alanında farkındalık yaratmaktır. Bu amaçla, çalışmada ilk olarak literatür incelenmiş ve sosyal girişimcilik kavramının farklı anlamları tartışılmıştır. Ayrıca, sosyal girişimciliğin amacı, önemi, boyutları ve faaliyet alanları açıklanmıştır. Ardından, geleneksel girişimcilik ve sosyal girişimcilik arasında karşılaştırma yapılmıştır. Sosyal girişimciliğe yönelik yapılan eleştiriler, sosyal girişimcilik eğitimi ve toplumda oluşan sosyal etki incelenmiştir. Sonrasında ise, Türkiye’deki sosyal girişimcilik uygulamaları detaylı anlatım ve örneklerle açıklanmıştır. Elde edilen sonuçlar, Türkiye’deki sosyal girişimcilik faaliyetlerinin 2000 yılından sonra artış gösterdiğini fakat kavramın herkes tarafından bilinmediğini ve bir kavram karmaşası yaşandığını göstermektedir. Son olarak, günümüzde sosyal girişimcilik, işletmeler ve bireyler bazında desteklenmektedir. Yapılan projelerle birlikte sosyal girişimcilik alanı daha da gelişmekte ve başta gençler olmak üzere sosyal girişimciliğe yönelen girişimci sayısında artış görülmektedir.
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    Bradycardia Seen In Children With Crimean-Congo Hemorrhagic Fever
    (2013-11-01T00:00:00Z) OFLAZ, Mehmet Burhan; KÜÇÜKDURMAZ, ZEKERİYA; GUVEN, A. Sami; KARAPINAR, HEKİM; KAYA, Ali; SANCAKDAR, ENVER; DEVECİ, KÖKSAL; GÜL, İBRAHİM; Erdem, Alim; CEVIT, Omer; Icagasioglu, F. Dilara; İÇAĞASIOĞLU, DİLARA FÜSUN
    Introduction: Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic viral disease with a high mortality rate. In clinical practice, we observed bradycardia in some pediatric patients with CCHF during the clinical course. So we aimed to report CCHF cases that presented bradycardia during the clinical course and the relation of bradycardia with the clinical findings and ribavirin therapy. Methods: Charts of all hospitalized pediatric CCHF patients were reviewed with respect to age, sex, history of tick bite or history of removing a tick, other risk factors for CCHF transmission, and interval between the tick bite and the onset of symptoms. Outcomes and clinical and laboratory findings and medications were recorded for each patient. We searched the patient records for information regarding the existence of bradycardia. Bradycardia was accepted as the heart rate 2 standard deviations (SD) lower than the suspected heart rate based on age. Results: Fifty-two patients (mean age 11.24.4 years, 31 female) were enrolled into the study. Bradycardia was seen in seven patients. Six patients with bradycardia were male and only one was female, and the mean age was 13.1 +/- 1.6 years. It was observed that male gender is frequent among patients with bradycardia, as compared with those without bradycardia (p=0.01). Bleeding was found to be more frequent in patients with bradycardia (p=0.02). There were significant differences between the bradycardia and nonbradycardia groups with regard to the requirements for fresh frozen plasma transfusion, the number of platelet suspension given, requirement for intravenous immune globulin (IVIG) and in the days of stay in hospital (p=0.01, p=0.03, p=0.03, p=0.04, respectively). Conclusion: Reversible bradycardia might be seen in the clinical course of pediatric CCHF patients, and the clinicians must be aware of this finding. The possibility that ribavirin may potentiate bradycardia cannot be assessed without a placebo-control study. So further studies may help to reveal the cause of the bradycardia, the disease itself, or the ribavirin therapy. Hence this study supports the need for a randomized, placebo-controlled study to assess intravenous ribavirin in treating CCHF and to support approval of the drug.
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    Anxiety symptoms among informal caregivers in 47 low- and middle-income countries: a cross-sectional analysis of community-based surveys.
    (2021-11-14T00:00:00Z) Smith, Lee; Shin, Jae Il; Oh, Hans; López Sánchez, Guillermo F; Underwood, Benjamin; Jacob, Louis; Veronese, Nicola; Soysal, PINAR; Butler, Laurie; Barnett, Yvonne; Tully, Mark A; Koyanagi, Ai; SOYSAL, PINAR
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    High-Content Quantification of Single-Cell Immune Dynamics
    (2016-04-01T00:00:00Z) Junkin, Michael; Kaestli, Alicia J.; Cheng, Zhang; Jordi, Christian; Albayrak, CEM; Hoffmann, Alexander; Tay, Savas; ALBAYRAK, CEM
    Cells receive time-varying signals from the environment and generate functional responses by secreting their own signaling molecules. Characterizing dynamic input-output relationships in single cells is crucial for understanding and modeling cellular systems. We developed an automated microfluidic system that delivers precisely defined dynamical inputs to individual living cells and simultaneously measures key immune parameters dynamically. Our system combines nanoliter immunoassays, microfluidic input generation, and time-lapse microscopy, enabling study of previously untestable aspects of immunity by measuring time-dependent cytokine secretion and transcription factor activity from single cells stimulated with dynamic inflammatory inputs. Employing this system to analyze macrophage signal processing under pathogen inputs, we found that the dynamics of TNF secretion are highly heterogeneous and surprisingly uncorrelated with the dynamics of NF-kappa B, the transcription factor controlling TNF production. Computational modeling of the LPS/TLR4 pathway shows that post-transcriptional regulation by TRIF is a key determinant of noisy and uncorrelated TNF secretion dynamics in single macrophages.
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    The relationship between bifidobacteria and allergic asthma and/or allergic dermatitis: A prospective study of 0-3 years-old children in Turkey
    (2014-08-01T00:00:00Z) Akay, Hatice Kubra; Tokman, Hrisi Bahar; Hatipoglu, Nevin; Hatipoglu, Huseyin; Siraneci, Rengin; Demirci, Mehmet; Borsa, Baris Ata; Yuksel, Pelin; Karakullukcu, Asiye; Kangaba, Achille Aime; Sirekbasan, Serhat; Aka, Sibel; Torun, Muzeyyen Mama; Kocazeybek, Bekir S.; YÜKSEL MAYDA, PELİN
    Bifidobacteria are beneficial bacteria for humans. These bacteria are particularly effective at protecting against infectious diseases and modulating the immune response. It was shown that in newborns, the fecal distribution of the colonizing Bifidobacterium species influences the prevalence of allergic diseases. This study aimed to compare the faecal Bifidobacterium species of allergic children to those of healthy children to detect species level differences in faecal distribution. Stool samples were obtained from 99 children between 0 and 3 years of age whose clinical symptoms and laboratory reports were compatible with atopic dermatitis and allergic asthma. Samples were also obtained from 102 healthy children who were similar to the case group with respect to age and sex. Bifidobacteria were isolated by culture and identified at the genus level by API 20 A. In addition, 7 unique species-specific primers were used for the molecular characterization of bifidobacteria. The McNemar test was used for statistical analyses, and p < 0.05 was accepted as significant. Bifidobacterium longum was detected in 11(11.1%) of the allergic children and in 31 (30.3%) of the healthy children.