Goal: 08 - İnsana Yakışır İş ve Ekonomik Büyüme
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İnsana Yakışır İş ve Ekonomik Büyüme
İstikrarlı, kapsayıcı ve sürdürülebilir ekonomik büyümeyi, tam ve üretken istihdamı ve herkes için insana yakışır işleri desteklemek
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Publication Metadata only Synthesis and Comprehensive in Vivo Activity Profiling of Olean-12-en-28-ol, 3β-Pentacosanoate in Experimental Autoimmune Encephalomyelitis: A Natural Remyelinating and Anti-Inflammatory Agent(2023-01-01) Şenol H.; Özgün Acar Ö.; Dağ A.; Eken A.; Güner H.; Aykut Z. G.; Topçu G.; Şen A.; ŞENOL, HALIL; DAĞ, AYDAN; TOPÇU, GÜLAÇTIPublication Open Access Synthesis of oleanolic acid hydrazide-hydrazone hybrid derivatives and investigation of their cytotoxic effects on A549 human lung cancer cells(2022-01-01T00:00:00Z) Şenol, Halil; Mercümek, Berre; Şahin, Rabia Büşra; Kapucu, Halil Burak; Hacıosmanoğlu, Ebru; ŞENOL, HALIL; MERCÜMEK, BERRE; HACIOSMANOĞLU, EBRUPublication Metadata only Synthesis, Characterization and Molecular Docking Studies of Highly Selective New Hydrazone Derivatives of Anthranilic Acid and Their Ring Closure Analogue Quinazolin-4(3H)-ones Against Lung Cancer Cells A549(2023-02-01) Tokalı F. S.; Şenol H.; Bulut Ş.; Hacıosmanoğlu Aldoğan E.; ŞENOL, HALILPublication Metadata only Synthesis, characterization, molecular docking and in vitro anti-cancer activity studies of new and highly selective 1,2,3-triazole substituted 4-hydroxybenzohyrdazide derivatives(2023-02-01) Şenol H.; Ağgül A. G.; Atasoy S.; Güzeldemirci N.; ŞENOL, HALIL; ATASOY, SEZENPublication Open Access Synthesis and Evaluation of Quinazolin-4(3H)-one Derivatives as Multitarget Metabolic Enzyme Inhibitors: A Biochemistry-Oriented Drug Design(2023-07-01) Tokalı F. S.; Taslimi P.; Sadeghi M.; Şenol H.; ŞENOL, HALILIn this study, imines bearing quinazolin-4(3H)-one were synthesized and their inhibitory properties were investigated against some metabolic enzymes including Acetylcholinesterase (AChE), Butyrylcholinesterase (BChE), & alpha;-Glycosidase (& alpha;-Gly), and human Carbonic Anhydrase I-II (hCA I-II). All compounds had inhibitory strength with K-i values in the range of 38.55 & PLUSMN;4.08-159.05 & PLUSMN;10.68 nM and 41.04 & PLUSMN;6.73-177.12 & PLUSMN;8.06 nM against hCA I and hCA-II, respectively in comparison to the standard acetazolamide (AZA) K-i=125.15 & PLUSMN;0.78 nM (for hCA-I) and K-i=148.75 & PLUSMN;0.92 nM (for hCA-II). The compounds showed potent inhibitory activity against & alpha;-Gly enzyme with IC50 value 0.34-2.28 nM (standard inhibitor acarbose (ACR): 3.18 nM). Also, these analogs had potent inhibitory strength with K-i values in the range of 4.20 & PLUSMN;0.15-26.10 & PLUSMN;2.36 nM against AChE and 1.22 & PLUSMN;0.05-16.09 & PLUSMN;0.88 nM against BChE in comparison to the standard tacrine (TAC) K-i=37.62 & PLUSMN;6.86 nM (for AChE) and K-i=26.75 & PLUSMN;5.79 nM (for BChE). Additionally, the molecular docking and molecular dynamics simulation study was carried out for the determination of ligand-enzyme interactions. The docking scores of the most active compound were calculated as -7.31, -7.59, -6.66, -6.93 and -7.11 kcal/mol for AChE, BChE, hCA I, hCA II, and & alpha;-Gly, respectively.Publication Metadata only Investigation of the potential use of Euphorbia latex as an insecticide in biological control against Dendroctonus micans(2021-06-01T00:00:00Z) Gülmez, Özlem; Albayrak İskender, Nurcan; Şenol, Halil; Algur, Ömer Faruk; ŞENOL, HALILPublication Unknown Novel Thiosemicarbazone and Thiazolidin‐4‐one Derivatives Containing Vanillin Core: Synthesis, Characterization and Anticancer Activity Studies(2023-01-01) Tokalı F. S.; Şenol H.; Dağ A.; Gençoğlu Katmerlikaya T.; Şendil K.; ŞENOL, HALIL; DAĞ, AYDAN