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08 - İnsana Yakışır İş ve Ekonomik Büyüme

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İnsana Yakışır İş ve Ekonomik Büyüme İstikrarlı, kapsayıcı ve sürdürülebilir ekonomik büyümeyi, tam ve üretken istihdamı ve herkes için insana yakışır işleri desteklemek

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2012 - 20143
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Start date: 2010 × End date: 2019 × Author: İÇAĞASIOĞLU, DİLARA FÜSUN ×

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Now showing 1 - 3 of 3
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    Bradycardia Seen In Children With Crimean-Congo Hemorrhagic Fever
    (2013-11-01T00:00:00Z) OFLAZ, Mehmet Burhan; KÜÇÜKDURMAZ, ZEKERİYA; GUVEN, A. Sami; KARAPINAR, HEKİM; KAYA, Ali; SANCAKDAR, ENVER; DEVECİ, KÖKSAL; GÜL, İBRAHİM; Erdem, Alim; CEVIT, Omer; Icagasioglu, F. Dilara; İÇAĞASIOĞLU, DİLARA FÜSUN
    Introduction: Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic viral disease with a high mortality rate. In clinical practice, we observed bradycardia in some pediatric patients with CCHF during the clinical course. So we aimed to report CCHF cases that presented bradycardia during the clinical course and the relation of bradycardia with the clinical findings and ribavirin therapy. Methods: Charts of all hospitalized pediatric CCHF patients were reviewed with respect to age, sex, history of tick bite or history of removing a tick, other risk factors for CCHF transmission, and interval between the tick bite and the onset of symptoms. Outcomes and clinical and laboratory findings and medications were recorded for each patient. We searched the patient records for information regarding the existence of bradycardia. Bradycardia was accepted as the heart rate 2 standard deviations (SD) lower than the suspected heart rate based on age. Results: Fifty-two patients (mean age 11.24.4 years, 31 female) were enrolled into the study. Bradycardia was seen in seven patients. Six patients with bradycardia were male and only one was female, and the mean age was 13.1 +/- 1.6 years. It was observed that male gender is frequent among patients with bradycardia, as compared with those without bradycardia (p=0.01). Bleeding was found to be more frequent in patients with bradycardia (p=0.02). There were significant differences between the bradycardia and nonbradycardia groups with regard to the requirements for fresh frozen plasma transfusion, the number of platelet suspension given, requirement for intravenous immune globulin (IVIG) and in the days of stay in hospital (p=0.01, p=0.03, p=0.03, p=0.04, respectively). Conclusion: Reversible bradycardia might be seen in the clinical course of pediatric CCHF patients, and the clinicians must be aware of this finding. The possibility that ribavirin may potentiate bradycardia cannot be assessed without a placebo-control study. So further studies may help to reveal the cause of the bradycardia, the disease itself, or the ribavirin therapy. Hence this study supports the need for a randomized, placebo-controlled study to assess intravenous ribavirin in treating CCHF and to support approval of the drug.
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    Tularemia in children: evaluation of clinical, laboratory and therapeutic features of 27 tularemia cases
    (2012-03-01T00:00:00Z) KAYA, ALİ; DEVECI, Koksal; UYSAL, İSMAİL ÖNDER; GÜVEN, AHMET SAMİ; DEMİR, MEVLÜT; UYSAL, ELİF BİLGE; GÜLTEKİN, ASIM; İÇAĞASIOĞLU, FÜSUN DİLARA; İÇAĞASIOĞLU, DİLARA FÜSUN
    Kaya A, Deveci K, Uysal IO, Guven AS, Demir M, Uysal EB, Gultekin A, Icagasioglu FD. Tularemia in children: evaluation of clinical, laboratory and therapeutic features of 27 tularemia cases. Mirk J Pediatr 2012; 54: 105-112.
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    Resting Heart Rate in Children with Crimean-Congo Hemorrhagic Fever: A Tool to Identify Patients at Risk?
    (2014-01-01T00:00:00Z) OFLAZ, MEHMET BURHAN; BOLAT, FATİH; KAYA, ALİ; GÜVEN, AHMET SAMİ; KÜÇÜKDURMAZ, ZEKERİYA; KARAPINAR, HEKİM; GÜLSEVER, OSMAN; Dogan, Melih; Cevit, Omer; İÇAĞASIOĞLU, FÜSUN DİLARA; İÇAĞASIOĞLU, DİLARA FÜSUN
    Objective: We aimed to assess the association between resting heart rate (RHR) and severe infection in children with Crimean-Congo hemorrhagic fever (CCHF). Methods: In all, 121 patients under 18 years of age with a laboratory-confirmed diagnosis of CCHF were enrolled in the study. Patients were classified into two groups based on disease severity (severe group and nonsevere group). RHR was measured by electrocardiography (ECG) on admission. Maximum P-wave duration (Pmax), P-wave dispersion (Pd), QRS duration, corrected QT interval, and QT dispersion were also measured. Results: Mean age was 11.43.9 years and 84 patients were male. Twenty-six patients were classified as severe. Patients in this group had a higher RHR (103.6 +/- 10.4vs. 80.5 +/- 8.1, p=0.001) than those with nonsevere disease. There was no difference in Pmax, Pd, QRS duration, QTcmax, or QTc dispersion. The optimal cutoff value of RHR to predict disease severity was>96 beats per minute (bpm), with 70.6% sensitivity and 50.1% specificity. Bleeding, thrombocytopenia (80x10(9)/L), elevated aspartate transaminase (AST) (>208IU/L), elevated alanine transaminase (ALT) (>87IU/L), elevated lactate dehydrogenase (LDH) (>566IU/L), long activated partial thromboplastin time (aPTT) (>42s), and increased hospitalization days were more frequent in patients with RHR >96bpm. Multivariate logistic regression analysis revealed low platelet count (42s), high LDH (>566IU/L), and elevated RHR (>96bpm) as independent risk factors for severe disease. Conclusions: We conclude that elevated RHR was significantly associated with severe disease in children with CCHF, thus offering the potential to identify patients with increased risk.