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08 - İnsana Yakışır İş ve Ekonomik Büyüme

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İnsana Yakışır İş ve Ekonomik Büyüme İstikrarlı, kapsayıcı ve sürdürülebilir ekonomik büyümeyi, tam ve üretken istihdamı ve herkes için insana yakışır işleri desteklemek

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Now showing 1 - 9 of 9
  • PublicationOpen Access
    Temporary materials: comparison of in vivo and in vitro performance
    (2020-06-01T00:00:00Z) Sari, Tugrul; Usumez, Aslihan; Strasser, Thomas; ŞAHİNBAŞ, ABDURRAHMAN; Rosentritt, Martin; ŞAHİNBAŞ, ABDURRAHMAN
    Objective The aim of this investigation was to compare clinical performance and in vitro wear of temporary CAD/CAM and cartridge crowns. This study is an approach to estimate the influence of in vivo use and laboratory simulation on temporary crowns. Materials and methods A total of 90 crowns were fabricated from each temporary CAD/CAM or cartridge material. Also, 10 crowns of each material were clinically applied for 14 days, and 80 identical duplicate restorations were investigated in the laboratory after storage in water (14 days; 37 degrees C) and subsequent thermal cycling and mechanical loading (TCML, 240.000 x 50N ML, 600 x 5 degrees C/55 degrees C). After in vivo application or in vitro aging, facture force, superficial wear (mean and maximum), surface roughness (Ra, Rz), thermal weight loss (TGA), and heat of reaction (DSC) were determined for all crowns. Statistics: Bonferroni post hoc test; one-way analysis of variance (ANOVA);alpha = 0.05). Results The fracture resistance of the temporary materials varied between 1196.4 (CAD in vivo) and 1598.3 N (cartridge crown in vitro). Mean (maximum) wear data between 204.7 (386.7 mu m; cartridge in vitro) and 353.0 mu m (621.8 mu m; CAD in vitro) were found. Ra values ranged between 4.4 and 4.9 mu m and Rz values between 36.0 and 40.8 mu m. DSC and TG analysis revealed small differences between the materials but a strong influence of the aging process. Conclusions Comparison of in vivo and in vitro aging led to no significant differences in fracture force and wear but differences in roughness, DSC, and TGA. SEM evaluation confirmed comparability. Comparison of CAD/CAM and cartridge temporary materials partially showed significant differences.
  • PublicationOpen Access
    State and trait anxiety among medical staff during the first month of COVID-19 pandemic: A sample from Turkey
    (2021-08-01T00:00:00Z) ŞAHAN, EBRU; TANGİLNTİZ, AİSE; ŞAHAN, EBRU; TANGİLNTİZ, AİSE
    Objectives During the COVID-19 pandemic, excessive workload, a rapidly changing workplace environment, the danger of carrying the virus and transmitting the disease to their families, relatives and those they live with creates stress for the medical workers. In our study, we aimed to evaluate the state and trait anxiety levels of healthcare professionals who encounter patients with suspected COVID-19 infection and related factors. Method Data were collected from healthcare professionals working with patients diagnosed or suspected with COVID-19 via online self-report questionnaire between 9-19 April 2020. The state (STAI-S) and trait anxiety (STAI-T) scale was used to measure anxiety. Results A total of 291 healthcare professionals, 216 women and 75 men, participated in the study. Women-s state and trait anxiety were significantly higher than men-s. 11 participants without any lifetime psychiatric illness experienced psychiatric symptoms and consulted to a psychiatrist. The state anxiety of those who have children, nurses and those working in branches directly related to the pandemic (Infectious Diseases, Respiratory Diseases, Emergency Medicine, Internal Medicine, Radiology, Anesthesiology and Reanimation) was higher than others. The state anxiety of those who thought they were not protected with personal protective equipment and those who did not stay in their own home was higher than others. Conclusions At the forefront of the fight against COVID-19, there are medical personnel who pay a serious psychological cost. Especially in terms of anxiety, we should pay attention to women, workers with children, nurses and people working in branches that are directly related to pandemics.
  • PublicationOpen Access
    Multisystem inflammatory syndrome in children associated with COVID-19 in 101 cases from Turkey (Turk-MISC study)
    (2022-02-01T00:00:00Z) Yilmaz Ciftdogan, Dilek; Ekemen Keles, Yildiz; Karbuz, Adem; ÇETİN, BENHUR ŞİRVAN; Elmas Bozdemir, Sefika; KEPENEKLİ KADAYİFCİ, EDA; Metin Akcan, Ozge; Ozer, Arife; Erat, Tugba; Sutcu, Murat; Buyukcam, Ayse; BELET, NURŞEN; Erdeniz, Emine Hafize; Dalgic Karabulut, Nazan; Hancerli Torun, Selda; ÖNCEL, SELİM; ORBAK, Zerrin; TÜREL, Özden; GAYRETLİ AYDIN, ZEYNEP GÖKÇE; KILIÇ, ÖMER; Yahsi, Aysun; Kara Aksay, Ahu; Ergenc, Zeynep; Petmezci, Mey Talip; OFLAZ, MEHMET BURHAN; Sarikaya, Remzi; Otar Yener, Gulcin; Ozen, Seval; Gul, Doruk; ARSLAN, GAZİ; Kara, Soner Sertan; Demirkol, Demet; YAZICI ÖZKAYA, PINAR; YOZGAT, YILMAZ; Varan, Celal; Kara, Manolya; ARGA, GÜL; YAKUT, NURHAYAT; Kilic, Ahmet Osman; ÇAKICI, ÖZLEM; Kucuk, Mehmet; Kaba, Ozge; KARAOĞLU ASRAK, HATİCE; BURSAL DURAMAZ, BURCU; Dalkiran, Tahir; Berna Anil, Ayse; TURĞUT, MEHMET; KARAPINAR, BÜLENT; Somer, Ayper; ELMALI, FERHAN; DİNLEYİCİ, ENER ÇAĞRI; ÇİFTCİ, ERGİN; KARA, ATEŞ; TÜREL, ÖZDEN; YOZGAT, YILMAZ; BURSAL DURAMAZ, BURCU
    Aim Multisystem inflammatory syndrome in children (MIS-C) may cause shock and even death in children. The aim of this study is to describe the clinical features, laboratory characteristics and outcome of children diagnosed with MIS-C in 25 different hospitals in Turkey. Methods The retrospective study was conducted between 8 April and 28 October 2020 in 25 different hospitals from 17 cities. Data were collected from patients- medical records using a standardised form. Clinical and laboratory characteristics and outcomes according to different age groups, gender and body mass index percentiles were compared using multivariate logistic regression analysis. Results The study comprised 101 patients, median age 7 years (interquartile range (IQR) 4.6-9.3); 51 (50.5%) were boys. Reverse-transcriptase polymerase chain reaction (PCR) assay was positive in 21/100 (21%) patients; 62/83 (74.6%) patients had positive serology for SARS-CoV-2. The predominant complaints were fever (100%), fatigue (n = 90, 89.1%), and gastrointestinal symptoms (n = 81, 80.2%). Serum C-reactive protein (in 101 patients, median 165 mg/L; range 112-228), erythrocyte sedimentation rate (73/84, median 53 mm/s; IQR 30-84) and procalcitonin levels (86/89, median 5 mu g/L; IQR 0.58-20.2) were elevated. Thirty-eight patients (37.6%) required admission to intensive care. Kawasaki disease (KD) was diagnosed in 70 (69.3%) patients, 40 of whom had classical KD. Most patients were treated with intravenous immunoglobulin (n = 92, 91%) and glucocorticoids (n = 59, 58.4%). Seven patients (6.9%) died. Conclusion The clinical spectrum of MIS-C is broad, but clinicians should consider MIS-C in the differential diagnosis when persistent fever, fatigue and gastrointestinal symptoms are prominent. Most patients diagnosed with MIS-C were previously healthy. Immunomodulatory treatment and supportive intensive care are important in the management of cases with MIS-C. Glucocorticoids and intravenous immunoglobulins are the most common immunomodulatory treatment options for MIS-C. Prompt diagnosis and prompt treatment are essential for optimal management.
  • PublicationOpen Access
    COVID-19 associated multisystemic inflammatory syndrome in 614 children with and without overlap with Kawasaki disease-Turk MIS-C study group
    (2022-02-01T00:00:00Z) ÇİFTDOĞAN, DİLEK YILMAZ; Keles, Yildiz Ekemen; ÇETİN, BENHUR ŞİRVAN; Karabulut, Nazan Dalgic; EMİROĞLU, MELİKE; Bagci, Zafer; Buyukcam, Ayse; Erdeniz, Emine Hafize; ARGA, GÜL; Yesil, Edanur; ÇAKICI, ÖZLEM; Karbuz, Adem; ŞAHBUDAK BAL, ZÜMRÜT; Kara, Soner Sertan; Ozer, Arife; AKCAN, ÖZGE METİN; Bozdemir, Sefika Elmas; ANIL, AYŞE BERNA; Uygun, Hatice; KILIÇ, ÖMER; Torun, Selda Hancerli; Umit, Zuhal; Sutcu, Murat; Ozmen, Berfin Ozgokce; KARAOĞLU ASRAK, HATİCE; Alkan, Gulsum; Aksay, Ahu Kara; Ugur, Cuneyt; Birbilen, Ahmet Ziya; BURSAL DURAMAZ, BURCU; Ozkan, Esra Akyuz; Burakay, Ozgur; Arslan, Sema Yildirim; Oncel, Eda Karadag; Celik, Serkan Fazli; Kilic, Ahmet Osman; Ozen, Seval; Sarikaya, Remzi; Demirkol, Demet; ARSLAN, GAZİ; TÜREL, Özden; SERT, AHMET; Sari, Ergul; ORBAK, Zerrin; Sahin, Irfan Oguz; Varan, Celal; Akturk, Hacer; Oz, Sadiye Kubra Tuter; Durak, Fatih; OFLAZ, MEHMET BURHAN; Kara, Manolya; Karpuz, Derya; Petmezci, Mey Talip; Hatipoglu, Nevin; ÖNCEL, SELİM; TURĞUT, MEHMET; ELMALI, FERHAN; Somer, Ayper; KUYUCU, NECDET; DİNLEYİCİ, ENER ÇAĞRI; KURUGÖL, NURİ ZAFER; ÇİFTCİ, ERGİN; KARA, ATEŞ; BURSAL DURAMAZ, BURCU; TÜREL, ÖZDEN
    Multisystemic inflammatory syndrome (MIS-C) diagnosis remains difficult because the clinical features overlap with Kawasaki disease (KD). The study aims to highlight the clinical and laboratory features and outcomes of patients with MISC whose clinical manifestations overlap with or without KD. This study is a retrospective analysis of a case series designed for patients aged 1 month to 18 years in 28 hospitals between November 1, 2020, and June 9, 2021. Patient demographics, complaints, laboratory results, echocardiographic results, system involvement, and outcomes were recorded. A total of 614 patients were enrolled; the median age was 7.4 years (interquartile range (IQR) 3.9-12 years). A total of 277 (45.1%) patients with MIS-C had manifestations that overlapped with KD, including 92 (33.3%) patients with complete KD and 185 (66.7%) with incomplete KD. Lymphocyte and platelet counts were significantly lower in patients with MISC, overlapped with KD (lymphocyte count 1080 vs. 1280 cells × μL, p = 0.028; platelet count 166 vs. 216 cells × 103/μL, p < 0.001). The median serum procalcitonin levels were statistically higher in patients overlapped with KD (3.18 vs. 1.68 µg/L, p = 0.001). Coronary artery dilatation was statistically significant in patients with overlap with KD (13.4% vs. 6.8%, p = 0.007), while myocarditis was significantly more common in patients without overlap with KD features (2.6% vs 7.4%, p = 0.009). The association between clinical and laboratory findings and overlap with KD was investigated. Age > 12 years reduced the risk of overlap with KD by 66% (p < 0.001, 95% CI 0.217-0.550), lethargy increased the risk of overlap with KD by 2.6-fold (p = 0.011, 95% CI 1.244-5.439), and each unit more albumin (g/dl) reduced the risk of overlap with KD by 60% (p < 0.001, 95% CI 0.298-0.559). Conclusion: Almost half of the patients with MISC had clinical features that overlapped with KD; in particular, incomplete KD was present. The median age was lower in patients with KD-like features. Lymphocyte and platelet counts were lower, and ferritin and procalcitonin levels were significantly higher in patients with overlap with KD.
  • PublicationOpen Access
    Synthesis of oleanolic acid hydrazide-hydrazone hybrid derivatives and investigation of their cytotoxic effects on A549 human lung cancer cells
    (2022-01-01T00:00:00Z) Şenol, Halil; Mercümek, Berre; Şahin, Rabia Büşra; Kapucu, Halil Burak; Hacıosmanoğlu, Ebru; ŞENOL, HALIL; MERCÜMEK, BERRE; HACIOSMANOĞLU, EBRU
  • PublicationOpen Access
    Evaluating compliance to stimulants in adults with attention deficit and hyperactivity disorder
    (2021-12-03T00:00:00Z) Kılıç, Özge; Boylu, Muhammed Emin; KILIÇ, ÖZGE; BOYLU, MUHAMMED EMİN
    Objective: Attention deficit hyperactivity disorder (ADHD) has several negative psychosocial outcomes including poor work performance, academic failure, problems in social relationships, and criminality. However, it is among the most treatable mental disorders given the safety and efficacy of stimulants. We aimed to explore compliance levels to methylphenidate and associated sociodemographic factors in adults with ADHD.Methods: Patients with ADHD who have been following up in a single-center outpatient psychiatry clinic of a university hospital were included in the study. Diagnoses were established according to the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) during a face-to-face clinical interview. Sociodemographic data form and Morisky medication adherence scale were utilized.Results: Among 64 patients (36 males, 28 females) (mean age ± SD = 25.2 ± 6.8) with ADHD, 19 (29.7 %) and 29 (45.3%) patients showed high and medium adherence to methylphenidate respectively. However, 16 (25 %) had low adherence. Men and women did not significantly differ in compliance levels to stimulants (X2 (2) = 1.639, p = 0.441). Compliance was not found to be related to education, marital and economic status, living conditions, smoking. The number of patients who consume alcohol tends to be higher in the low adherent group although not reaching statistical significance.Discussion: One-fourth of adult patients with ADHD had low adherence to methylphenidate. Men and women did not differ in adherence levels. No significant difference has been observed in the mean ages between the three adherence groups. Our results were in line with some earlier studies on treatment adherence in ADHD but not with others that showed adherence was higher in females and younger patients. The reason for these discrepancies could be that the studies with contrary results have recruited both children and adolescents. Longitudinal multicenter studies are needed to draw conclusions on the factors affecting compliance in ADHD.Keywords: attention deficit and hyperactivity disorder, drugs/medication, pharmacology, treatment compliance, treatment adherence, demographic
  • PublicationOpen Access
    Synthesis and Evaluation of Quinazolin-4(3H)-one Derivatives as Multitarget Metabolic Enzyme Inhibitors: A Biochemistry-Oriented Drug Design
    (2023-07-01) Tokalı F. S.; Taslimi P.; Sadeghi M.; Şenol H.; ŞENOL, HALIL
    In this study, imines bearing quinazolin-4(3H)-one were synthesized and their inhibitory properties were investigated against some metabolic enzymes including Acetylcholinesterase (AChE), Butyrylcholinesterase (BChE), & alpha;-Glycosidase (& alpha;-Gly), and human Carbonic Anhydrase I-II (hCA I-II). All compounds had inhibitory strength with K-i values in the range of 38.55 & PLUSMN;4.08-159.05 & PLUSMN;10.68 nM and 41.04 & PLUSMN;6.73-177.12 & PLUSMN;8.06 nM against hCA I and hCA-II, respectively in comparison to the standard acetazolamide (AZA) K-i=125.15 & PLUSMN;0.78 nM (for hCA-I) and K-i=148.75 & PLUSMN;0.92 nM (for hCA-II). The compounds showed potent inhibitory activity against & alpha;-Gly enzyme with IC50 value 0.34-2.28 nM (standard inhibitor acarbose (ACR): 3.18 nM). Also, these analogs had potent inhibitory strength with K-i values in the range of 4.20 & PLUSMN;0.15-26.10 & PLUSMN;2.36 nM against AChE and 1.22 & PLUSMN;0.05-16.09 & PLUSMN;0.88 nM against BChE in comparison to the standard tacrine (TAC) K-i=37.62 & PLUSMN;6.86 nM (for AChE) and K-i=26.75 & PLUSMN;5.79 nM (for BChE). Additionally, the molecular docking and molecular dynamics simulation study was carried out for the determination of ligand-enzyme interactions. The docking scores of the most active compound were calculated as -7.31, -7.59, -6.66, -6.93 and -7.11 kcal/mol for AChE, BChE, hCA I, hCA II, and & alpha;-Gly, respectively.
  • PublicationOpen Access
    Natural Alkaloids as Potential Anti-Coronavirus Compounds
    (2020-12-01T00:00:00Z) Topçu, Gülaçtı; Şenol, Halil; Alim Toraman, Gülbahar Özge; Altan, Vecdi Melih; TOPÇU, GÜLAÇTI; ŞENOL, HALIL; ALİM TORAMAN, GÜLBAHAR ÖZGE; ALTAN, VECDİ MELİH
    Coronaviruses are causative agents of the last three epidemics/pandemic; Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) and the last one Severe Acute Respiratory Syndrome-Cov-2 (SARS-CoV-2). Although meta-analysis of treatment studies against these three coronaviruses found no clear benefit of any spesific regimen, currently, remdesivir and favipiravir are promising potential therapies for SARS-CoV-2. On the other hand, since natural products have always played a crucial role in drug discovery and development process against various diseases, many groups in the world, are now trying to find new or repurposed natural or naturally originated drugs against viruses and coronaviruses. Secondary metabolites of the plants, particularly alkaloids and terpenoids have been exhibited strong antimicrobial and anticancer activities besides synthetic drugs and other natural compounds (nucleosides and nucleotides and bacterial and fungi originated ones). The first isolated secondary metabolites have been converted into important drugs since 1800’s such as morphine, codeine, cocaine, and quinine have alkaloid skeleton as well as some of the recent anticancer drugs vinblastine, vincristine, taxol, etc. This review includes the last two decades of publications about natural alkaloids rather than their plant extracts which showed some promising results against coronaviruses. Marine organisms are also another rich source to discover new lead drugs, however they were excluded in the present review article.
  • PublicationOpen Access
    Synthesis and anticancer activity of novel derivatives of α,β‐unsaturated ketones based on oleanolic acid: in vitro and in silico studies against prostate cancer cells
    (2023-08-01) Şenol H.; Ghaffari-Moghaddam M.; Bulut Ş.; Akbaş F.; Köse A.; Topçu G.; ŞENOL, HALIL; AKBAŞ, FAHRİ; TOPÇU, GÜLAÇTI
    Herein, new derivatives of α,β-unsaturated ketones based on oleanolic acid (4 a-i) were designed, synthesized, characterized, and tested against human prostate cancer (PC3). According to the in vitro cytotoxic study, title compounds (4 a-i) showed significantly lower toxicity toward healthy cells (HUVEC) in comparison with the reference drug doxorubicin. The compounds with the lowest IC50 values on PC3 cell lines were 4 b (7.785 μM), 4 c (8.869 μM), and 4 e (8.765 μM). The results of the ADME calculations showed that the drug-likeness parameters were within the defined ranges according to Lipinski's and Jorgensen's rules. For the most potent compounds 4 b, 4 c, and 4 e, a molecular docking analysis using the induced fit docking (IFD) protocol was performed against three protein targets (PARP, PI3K, and mTOR). Based on the IFD scores, compound 4 b had the highest calculated affinity for PARP1, while compound 4 c had higher affinities for mTOR and PI3K. The MM-GBSA calculations showed that the most potent compounds had high binding affinities and formed stable complexes with the protein targets. Finally, a 50 ns molecular dynamics simulation was performed to study the behavior of protein target complexes under in silico physiological conditions.