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  Investigation of the use of gabapentinoid drugs in pain management

  (Scientific Scholar, 2024-12-21)

  Ebru Yılmaz

  ;

  Duygu Güler

  ;

  Özlem Toluk

  ;

  TOLUK, ÖZLEM

  ;

  YILMAZ, EBRU

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  Objectives: This study aimed to investigate the kind of painful conditions and preferred drug doses for which gabapentinoids were used for pain management for the musculoskeletal and nervous systems. Materials and Methods: The study included 364 patients over the age of 18 who applied to the physical therapy and rehabilitation outpatient clinic with complaints of musculoskeletal and nervous system pain. Demographic characteristics of the patients including age, gender, body mass index, smoking, disease diagnoses, preferred gabapentinoid drug, and dosage were recorded. Moreover, the estimation of the severity of pain by the Visual Analog Scale (VAS) before and 6 months after the treatments was collected from medical records. Results: The mean age of the patients was 59.54 ± 11.59 years and 82.1% were female and 17.9% were male. The diseases preferred for drug use were lumbar disc herniation (39.3%), cervical disc herniation (13.7%), spondylolisthesis (11.3%), diabetic neuropathy (11%), frozen shoulder (10.7%), gonarthrosis (10.4%), psoriatic arthritis (8.5%), spondylosis (8%), fibromyalgia (4.9%), carpal tunnel syndrome (4.7%), complex regional pain syndrome (2.7%), restless leg syndrome (1.1%), coxarthrosis (0.8%), postherpetic neuralgia (0.8%), and hemiplegia (0.5%), respectively. There was significant female gender superiority in both pregabalin and gabapentin groups ( P < 0.001). In whole chronic pain conditions, the VAS scores before and after 6 months of treatment were significantly reduced in both groups, except for restless legs syndrome ( P = 0.066). According to the results of the study, it was determined that the indication for gabapentinoid use was mainly related to neuropathic pain and gabapentinoid doses were below the recommended amounts. Conclusion: Originally developed as anticonvulsants, gabapentin, and pregabalin are increasingly used in the treatment of various types of pain, including neuropathic and musculoskeletal pain. Although they raise concerns about addiction, it should not be overlooked that gabapentinoids are useful in the treatment of chronic painful conditions when used in the correct indications and doses.

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  Abstract 4367615: The Cardiovascular Paradox of Gout Prophylaxis: A Systematic Review and Meta-analysis

  (Ovid Technologies (Wolters Kluwer Health), 2025-11-04)

  Ibrahim Kuyucu

  ;

  Omer Faruk Canavar

  ;

  Riza Deha Dogruer

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  Azra Dila Altin

  ;

  Recep Aktas

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  Introduction: Colchicine and NSAIDs are commonly used as flare prophylaxis during urate-lowering therapy (ULT) in gout, a chronic inflammatory condition linked to elevated cardiovascular risk. Oxidative stress and endothelial dysfunction may contribute to major adverse cardiovascular events (MACE). Although colchicine shows cardioprotective effects in non-gout populations and NSAIDs remain widely used despite risks, their effect on MACE in gout patients is unclear. Research Question: Does flare prophylaxis with colchicine or NSAIDs alter the cardiovascular risk profile in patients with gout initiating ULT therapy? Methods: This review followed PRISMA guidelines and was registered in PROSPERO (CRD420251017700). MEDLINE, EMBASE, and CENTRAL were searched through April 2025 for studies of gout patients initiating ULT with flare prophylaxis using colchicine, NSAIDs, or no prophylaxis. Studies involving non-gout crystal arthropathies, isolated hyperuricemia, or prophylaxis without ULT were excluded. The primary outcome was MACE, defined as a composite of all-cause mortality, myocardial infarction, stroke, and coronary revascularization. Log-transformed hazard ratios (HRs) were pooled using a random-effects meta-analysis. Results: Five studies from the UK, US, and Canada were included: three retrospective cohorts, one observational reanalysis of an RCT, and one target trial emulation. To avoid duplication with Cipolletta et al., only the CPRD GOLD subset was extracted from Roddy et al. Across four studies, 148,345 gout patients were included, with Singh et al. reporting 10,195 person-years of follow-up. Among them, 37,168 (25.1%) received colchicine and 19,461 (13.1%) received NSAIDs. Colchicine prophylaxis was not significantly associated with MACE risk compared to no prophylaxis [log(HR) = 0.005; 95% CI: -0.21 to 0.22, Figure 1]. NSAIDs also showed no significant difference [log(HR) = 0.19; 95% CI: -0.18 to 0.57, Figure 2]. Risk was similar between colchicine and NSAID groups [log(HR) = -0.02; 95% CI: -0.32 to 0.28, Figure 3]. Conclusion: Our meta-analysis found that flare prophylaxis with colchicine or NSAIDs did not reduce cardiovascular event risk in gout patients. These findings may contradict recent evidence of colchicine’s cardioprotective effects compared to NSAIDs. Further studies are needed to guide cardiovascular risk management in this high-risk population.

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  Refined Adjustment with Rotational Septal Extension Graft in Rhinoplasty for Tip Rotation and Projection

  (SAGE Publications, 2023-09-01)

  Erkan Soylu

  ;

  Alper Yenigun

  ;

  Orhan Ozturan

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  YENİGÜN, ALPER

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  ÖZTURAN, ORHAN

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  Background: Precise adjustment of tip rotation and projection harmonious with nasal dorsum is important in rhinoplasty. The use of septal extension graft for rotation and projection enhancement has been the most reliable surgical technique recently. It is also an efficient graft to increase the tip projection effectively and permanently. Objective: The aim of this study is to demonstrate the ability to adjust tip rotation and projection with the use of rotational septal extension graft in accordance with the needs of the patient. Materials and Methods: Rotational septal extension graft was applied in 21 patients who underwent rhinoplasty. It is fixed with a dental needle to provide desired projection to the caudal septum. In this way, the rotation of the graft pivoting around the needle in caudal or dorsal direction can allow precise adjustment. In the position where rotation and projection are evaluated appropriate, the graft is fixed with sutures. They were followed in average 12 months (between 6 and 18 months). Results: Eight of these patients were revision cases and 13 were primary cases. The targeted rotation and projection results were achieved in all patients. All patients had satisfactory aesthetic results. Conclusions: Rotational septal extension graft allows effective rotation adjustment as well as adequate projection and can be rotated in the desired direction around the dental needle. No competing financial interests exist. No funding was received for this article. Runtime of video: 1 mins 13 secs

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  Effect of Home-Based Regular Exercise Training Program in Females with Asthma: A Randomized Controlled Trial

  (Elsevier BV, 2024-01-01)

  Ayse Sena Manzak Dursun

  ;

  Semiramis Ozyilmaz

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  Pinar Atagun Guney

  ;

  Aysegul Yabaci Tak

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  DURSUN, AYŞE ESRA

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  Circadian Variations in the Pharmacokinetics of Capecitabine in Mice

  (Elsevier BV, 2022-01-01)

  Yasemin Kübra Akyel

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  Dilek Ozturk Civelek

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  Narin Ozturk Seyhan

  ;

  Seref Gul

  ;

  Isil Gazioglu

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